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Acetyl Hexapeptide-8, commonly known as Argireline or Acetyl Hexapeptide-3, is a popular peptide in skincare. It’s often referred to as a “Botox-like” ingredient because it helps reduce muscle movement.

By relaxing these micro-movements, Argireline may help minimize the appearance of fine lines and wrinkles. That said, it’s not as powerful as Botox, and research on its long-term effectiveness is still limited.

Beyond smoothing, Argireline may also support collagen production. Collagen is the protein that helps keep your skin firm, bouncy, and well-hydrated by strengthening the skin barrier.

So while Argireline isn’t a miracle fix, it can be a helpful addition to a routine focused on both prevention and skin health.

Read more about other common types of peptides here:

Learn more about Acetyl Hexapeptide-8

Alanine

Masking, Skin Conditioning

Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.

Arginine

Masking, Skin Conditioning

Arginine is an amino acid that is important for human development. Your body uses is it to produce hair keratin and skin collagen.

As a cosmetic ingredient, Arginine has antioxidant properties and can also help repair damaged skin. This ingredient is derived either synthetically or from animals.

Arginine isn't fungal acne safe when used in the presence of other lipids (fats, fatty acids, oils, esters, etc). Oils and fats occur naturally within the skin, so take caution when using Arginine if you're prone to fungal acne.

Learn more about Arginine

Aspartic Acid

Masking, Skin Conditioning

Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.

Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.

Butylene Glycol

Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol

Caprylyl Glycol

Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol

Copper Tripeptide-1

Skin Conditioning

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Learn more about Copper Tripeptide-1

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Skin Conditioning

This small molecule peptide has similar benefits to Argireline, the "botox" peptide.

According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.

While this seems promising, research is lacking in proving this ingredient to be as effective as botox.

Learn more about Dipeptide Diaminobutyroyl Benzylamide Diacetate

Ethylhexylglycerin

Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Glucose

Humectant

Glucose is a simple sugar and is the most important source of energy in all organisms.

In skincare, glucose is used to hydrate the skin. It also acts as a prebiotic for our natural biome.

Glucose is hydrating due to its humectant property. As a humectant, glucose draws moisture from the air and from deeper levels in the skin.

Our skin contains many sugars that act as prebiotics and help strengthen our natural microbiome. Having a healthy microbiome helps protect our skin from harmful bacteria and other contaminants.

Studies show glucose may help with fading discoloration and pigmentation. This is because our skin metabolizes glucose into lactic acid. Lactic acid is an AHA that helps exfoliate the top layer of skin.

Learn more about Glucose

Glycerin

Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin

Glycine

Buffering, Skin Conditioning

This ingredient is an amino acid that helps build proteins and moisturizes skin. It is already present in our skin as our bodies produce them naturally.

Glycine already plays a role in helping keep our skin moisturized as amino acids transport moisture throughout our skin.

As collagen is made up of glycine and other amino acids, it is believed glycine may help our skin produce more collagen.

Learn more about Glycine

Histidine

Humectant, Skin Conditioning

Histidine is a semi-essential amino acid used by our bodies to create protein. It has humectant and skin conditioning properties.

Our bodies use histidine to create filaggrin - filaggrin is a structural protein that the skin uses in maintaining skin barrier.

One study found histidine and carnosine to be a dynamic duo for your skin:

Oral histidine has also been found to help with filaggrin-deficit skin disorders such as atopic dermatitis.

Why is it considered a semi-essential amino acid? This is because adults are able to create it but children must get it from their diet.

Learn more about Histidine

Hydroxypropyl Cyclodextrin

Masking, Skin Conditioning

This ingredient is used in skincare as a delivery system.

It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.

According to a manufacturer, it also offer some moisturizing effects.

Learn more about Hydroxypropyl Cyclodextrin

Isoleucine

Skin Conditioning

Isoleucine is an amino acid that helps reinforce our skin barrier. This amino acid plays a role in creating protein for the body.

Fun fact: Isoleucine is found in meat, fish, dairy, legumes, and nuts.

Palmitoyl Tetrapeptide-7

Skin Conditioning

Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).

This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.

Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.

Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.

Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).

Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Skin Conditioning

Palmitoyl Tripeptide-1 is also known as pal-GHK. It is made up of 3 amino acids and palmitic acid, a fatty acid that helps it absorb into skin more easily.

This peptide is as a signal peptide, meaning it tells the skin to produce more collagen. Collagen is the key protein that helps form the skin's structure and keep it plump, firm, and hydrated.

By boosting collagen production, this ingredient supports a stronger skin barrier and helps reduce the appearance of wrinkles.

You'll most likely see this ingredient paired with Palmitoyl Tetrapeptide-7 in the well-known Matrixyl 3000 complex. While results from in-house testing should be viewed cautiously, this peptide duo is among the most studied and widely used in modern skincare.

Due to its palmitic acid base, this ingredient may not be safe for Malassezia folliculitis.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1

Pentylene Glycol

Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

Learn more about Pentylene Glycol

Phenylalanine

Masking, Skin Conditioning

Phenylalanine is an amino acid. It is a skin soothing and hydrating ingredient. Amino acids play a crucial role in wound healing and skin hydration.

This ingredient is also used to help even out skin tone due to its ability to disrupt the melanin production process.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

Learn more about Phenylalanine

Polysorbate 20

Emulsifying

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20

Proline

Skin Conditioning

Proline is an amino-acid. It helps moisturize the skin and plays an important role in creating proteins.

Our skin uses proline as one of the building blocks for producing collagen.

In medicine, proline is used as an osmoprotectant. This means it helps prevent oxidative degradation in other drugs.

Our bodies are able to produce proline naturally, but certain conditions may inhibit this production. In that case, proline can be obtained from eating egg whites, soy protein, dairy products, asparagus, mushrooms, and seaweed.

Learn more about Proline

Serine

Masking, Skin Conditioning

Serine is an amino acid naturally found in our body. Our bodies use amino acids to create protein.

Amino-acids help give keep our skin hydrated. They play an important role in the skin barrier, which keeps the skin plump and firm.

Serine is a non-essential amino acid, meaning we don't need to obtain it from eating foods.

Learn more about Serine

Sodium Benzoate

Masking, Preservative

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Learn more about Sodium Benzoate

Sodium Hyaluronate

Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate

Sodium Hyaluronate Crosspolymer

Humectant, Skin Conditioning

Sodium Hyaluronate Crosspolymer is a type of hyaluronic acid. In fact, it is modified version of hyaluronic acid.

The structure of Sodium Hyaluronate Crosspolymer allows it to stay in the skin's top layer for a longer period of time. This allows for even more hydration and humectant action than hyaluronic acid.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate Crosspolymer

Threonine

Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.

Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.

Valine

Masking, Skin Conditioning

Valine is an essential amino acid. It is used by our bodies for tissue repair and muscle growth.

An essential amino acid is one in which our bodies cannot naturally produce so we must get them through diet. Foods such as eggs, dairy, red meat, and fish contain valine.

This ingredient can either be derived from an animal product or be synthetically created.

Learn more about Valine

Water

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

Xanthan Gum

Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum