Hexapeptide-9
Explained
Hexapeptide-9 is a signaling peptide that is made to mimic a fragment found naturally in collagen IV and XVII.
It is classified as a matrikine peptide and works by telling your skin cells (especially fibroblasts) to ramp up collagen and hyaluronic acid production.
In-vitro studies show it can enhance epidermal regeneration, boost synthesis of collagen types I, III, and IV, and improved markers of skin differentiation.
Think of skin differentiation like this: your skin cells are born at the bottom and slowly travel up to the surface as they "grow up". As they move up, they start producing specific proteins that make your skin do its job well. Two of these proteins are keratin (it makes your skin tough) and filaggrin (it breaks apart into tiny molecules to keep your skin hydrated). So Hexapeptide-9 has shown to help skin cells grow up properly and make stronger, more hydrated skin.
A manufacturer also reports increased collagen production by 117% and hyaluronic acid production by 267%.
Just know much of the published data comes from manufacturer-sponsored studies. There is a recent clinical trial showing promising anti-aging results but the evidence base is still growing.
Generally, this ingredient is well-tolerated and there's no harm in using it as a supportive ingredient in your routine.
See all 864 products with Hexapeptide-9
