MEDI-PEEL Cica Antio Cream

MEDI-PEEL Cica Antio Cream

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Overview

What it is

General moisturizer with 84 ingredients that contains ceramides, hyaluronic acid, niacinamide, peptides and Vitamin E

Cool Features

It is cruelty-free and reef safe

Suited For

It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

It doesn't contain any harsh alcohols, oils, parabens or sulfates

Fun facts

MEDI-PEEL is from South Korea. This product is used in 10 routines created by our community.

We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.

What's inside

Ingredients List

50
22
12

Water

Skin Conditioning

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconGood for Barrier Repair Icon

Caprylic/Capric Triglyceride

Masking
Coconut Derived IconHelps hydrate Dry Skin IconGood for Barrier Repair Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconCoconut Derived IconBad for Acne Prone Skin IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon

Dipropylene Glycol

Humectant

Niacinamide

Smoothing
Niacinamide IconHelps fight Acne IconHelps with Anti-Aging IconHelps brighten skin IconHelps reduce irritation IconGood for Oily Skin IconGood for Minimizing Pores IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Dark Spots IconGood for Skin Texture IconGood for Barrier Repair Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

PEG-100 Stearate

Surfactant
0 / 0 Not safe for Fungal Acne Icon

Morinda Citrifolia Fruit Extract

Skin Conditioning

Betaine

Humectant
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Barrier Repair Icon

Sorbitan Stearate

Emulsifying
0 / 1 Not safe for Fungal Acne Icon

Arginine

Masking
Helps hydrate Dry Skin IconGood for Scar Healing Icon

Carbomer

Emulsion Stabilising
1 / 0

Hydroxyacetophenone

Antioxidant
Antioxidant IconHelps reduce irritation IconHelps reduce Skin Redness Icon

Dimethicone

Emollient
1 / 0 Silicon IconGood for Scar Healing Icon

Caprylyl Glycol

Emollient
Fatty Alcohol Icon

Melia Azadirachta Leaf Extract

Skin Conditioning

Dipotassium Glycyrrhizate

Humectant
Helps reduce irritation IconHelps reduce Skin Redness Icon

Triticum Vulgare Sprout Extract

Skin Conditioning

Centella Asiatica Extract

Cleansing
Helps with Anti-Aging IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Skin Texture IconGood for Barrier Repair Icon

Melia Azadirachta Flower Extract

Skin Conditioning

Coccinia Indica Fruit Extract

Skin Conditioning

Ethylhexylglycerin

Skin Conditioning

Curcuma Longa Root Extract

Masking
Fragrance Icon

Eclipta Prostrata Extract

Skin Conditioning
Helps reduce irritation Icon

Adenosine

Skin Conditioning
Helps with Anti-Aging IconHelps reduce irritation IconGood for Scar Healing Icon

Corallina Officinalis Extract

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce Skin Redness Icon

Ocimum Sanctum Leaf Extract

Skin Conditioning

Glyceryl Acrylate/Acrylic Acid Copolymer

Humectant

Solanum Melongena Fruit Extract

Skin Conditioning

Disodium EDTA

Allantoin

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Barrier Repair Icon

Aloe Barbadensis Flower Extract

Emollient

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant IconHelps brighten skin Icon

Panthenol

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Barrier Repair Icon

Propylene Glycol

Humectant
0 / 0 Helps hydrate Dry Skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Propanediol

Solvent
Helps hydrate Dry Skin IconGood for Barrier Repair Icon

Beta-Glucan

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Barrier Repair Icon

Squalane

Emollient
1 / 0 Helps with Anti-Aging IconHelps hydrate Dry Skin IconGood for Barrier Repair Icon

Palmitoyl Tetrapeptide-7

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing IconGood for Skin Texture Icon

Palmitoyl Tripeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing IconGood for Skin Texture Icon

Fructan

Skin Conditioning

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin IconGood for Barrier Repair Icon

Sodium Hyaluronate Crosspolymer

Humectant
Hyaluronic Acid IconHelps hydrate Dry Skin IconGood for Scar Healing Icon

Glyceryl Polymethacrylate

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Hydrolyzed Glycosaminoglycans

Humectant

Butyrospermum Parkii Butter

Skin Conditioning
Helps hydrate Dry Skin IconGood for Barrier Repair IconBad for Acne Prone Skin IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon

1,2-Hexanediol

Skin Conditioning
Helps hydrate Dry Skin Icon

Olea Europaea Leaf Extract

Perfuming
Fragrance Icon

Mannan

Glycyrrhiza Glabra Root Extract

Bleaching
Helps hydrate Dry Skin IconHelps brighten skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Dark Spots IconGood for Barrier Repair Icon

Taraxacum Officinale Leaf Extract

Skin Conditioning

Benzyl Glycol

Solvent

Ceramide NP

Skin Conditioning
Ceramide IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Phytosphingosine

Skin Conditioning
Helps with Anti-Aging IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Hydrolyzed Hyaluronic Acid

Humectant
Hyaluronic Acid IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconGood for Scar Healing Icon

Rosa Damascena Flower Extract

Masking
EU Allergen Icon

Rhodiola Rosea Root Extract

Emollient

Origanum Vulgare Leaf Extract

Skin Conditioning

Palmitoyl Tripeptide-5

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Skin Texture Icon

Chamaecyparis Obtusa Leaf Extract

Skin Conditioning

Salix Alba Bark Extract

Astringent
Helps reduce irritation IconGood for Oily Skin IconGood for Dark Spots Icon

Usnea Barbata Extract

Zanthoxylum Piperitum Fruit Extract

Skin Conditioning

Pulsatilla Koreana Extract

Skin Conditioning

Lactobacillus/Soybean Ferment Extract

Skin Conditioning

Portulaca Oleracea Extract

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness Icon

Citric Acid

Buffering
AHA IconHelps brighten skin IconMay worsen Rosacea Icon

Cinnamomum Cassia Bark Extract

Masking
May worsen Eczema Icon

Scutellaria Baicalensis Root Extract

Astringent
Helps reduce Skin Redness Icon

Raspberry Ketone

Masking
Fragrance Icon

Hyaluronic Acid

Humectant
Hyaluronic Acid IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconGood for Scar Healing IconGood for Barrier Repair Icon

Acetyl Hexapeptide-8

Humectant
Peptide IconHelps with Anti-Aging Icon

Copper Tripeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing IconGood for Barrier Repair Icon

Oligopeptide-29

Antioxidant
Peptide IconAntioxidant Icon

Oligopeptide-32

Antiseborrhoeic
Peptide Icon

Palmitoyl Oligopeptide

Cleansing
Peptide IconHelps with Anti-Aging IconHelps hydrate Dry Skin Icon

Palmitoyl Pentapeptide-4

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Skin Texture Icon

Parfum

Masking
Synthetic Fragrance IconFragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Hexyl Cinnamal

Perfuming
Synthetic Fragrance IconFragrance IconMay cause irritation IconEU Allergen Icon

Limonene

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Rosacea IconEU Allergen Icon

Linalool

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Rosacea IconEU Allergen Icon

Citronellol

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Rosacea IconEU Allergen Icon

Water, Glycerin, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Dipropylene Glycol, Niacinamide, Glyceryl Stearate, PEG-100 Stearate, Morinda Citrifolia Fruit Extract, Betaine, Sorbitan Stearate, Arginine, Carbomer, Hydroxyacetophenone, Dimethicone, Caprylyl Glycol, Melia Azadirachta Leaf Extract, Dipotassium Glycyrrhizate, Triticum Vulgare Sprout Extract, Centella Asiatica Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Ethylhexylglycerin, Curcuma Longa Root Extract, Eclipta Prostrata Extract, Adenosine, Corallina Officinalis Extract, Ocimum Sanctum Leaf Extract, Glyceryl Acrylate/Acrylic Acid Copolymer, Solanum Melongena Fruit Extract, Disodium EDTA, Allantoin, Aloe Barbadensis Flower Extract, Tocopheryl Acetate, Panthenol, Propylene Glycol, Propanediol, Beta-Glucan, Squalane, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Fructan, Butylene Glycol, Sodium Hyaluronate Crosspolymer, Glyceryl Polymethacrylate, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Butyrospermum Parkii Butter, 1,2-Hexanediol, Olea Europaea Leaf Extract, Mannan, Glycyrrhiza Glabra Root Extract, Taraxacum Officinale Leaf Extract, Benzyl Glycol, Ceramide NP, Phytosphingosine, Hydrolyzed Hyaluronic Acid, Rosa Damascena Flower Extract, Rhodiola Rosea Root Extract, Origanum Vulgare Leaf Extract, Palmitoyl Tripeptide-5, Chamaecyparis Obtusa Leaf Extract, Salix Alba Bark Extract, Usnea Barbata Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Lactobacillus/Soybean Ferment Extract, Portulaca Oleracea Extract, Citric Acid, Cinnamomum Cassia Bark Extract, Scutellaria Baicalensis Root Extract, Raspberry Ketone, Hyaluronic Acid, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Oligopeptide, Palmitoyl Pentapeptide-4, Parfum, Hexyl Cinnamal, Limonene, Linalool, Citronellol

Key Ingredients

Benefits

Concerns

Ingredients Explained

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Masking, Skin Conditioning

This ingredient is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid. Though it behaves like an oil, it is not technically one due to its chemical composition. It is very stable, resistant to oxidation, and unlikely to go rancid. In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Be sure to patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

Learn more about Caprylic/Capric Triglyceride
Emollient, Emulsifying, Emulsion Stabilising

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

Learn more about Cetearyl Alcohol
Humectant, Masking, Solvent

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ā€˜good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Learn more about Dipropylene Glycol
Smoothing

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Learn more about Niacinamide
Emollient, Emulsifying

Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.

Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Learn more about Glyceryl Stearate

Peg-100 Stearate is an emollient and emulsifier. As an emollient, it helps keep skin soft by trapping moisture in. On the other hand, emulsifiers help prevent oil and water from separating in a product.

PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.

Morinda Citrifolia Fruit Extract is also known as yaeyama aoki, noni, or the great morinda. This fruit is packed with bioactive compounds that give it skin conditioning and antioxidant properties.

Research on this ingredient has shown some interesting results: a clinical trial on 49 women (ages 38-55) found the daily use of noni-based skincare improved skin firmness and elasticity by up to ~42.4% over six weeks.

Lab studies have also demonstrated that some of the compounds can inhibit tyrosinase ans elastase, enzymes involved in pigmentation and the breaking down of skin's elastic fibers.

Fun fact: This ingredient has been used in Polynesian folk medicine for over 2,000 years.

Learn more about Morinda Citrifolia Fruit Extract
Humectant, Skin Conditioning

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Learn more about Betaine
Emulsifying

Sorbitan Stearate comes from sorbitol and stearic acid. Sorbitol is a type of sugar and stearic acid is a fatty acid.

It is used as an emulsifier and helps ingredients stay together by creating water-in-oil emulsions.

This ingredient may not be Malassezia folliculitis, or fungal-acne safe.

Masking, Skin Conditioning

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Learn more about Arginine
Emulsion Stabilising, Gel Forming

Carbomer is a high-molecular weight polymer of acrylic acid. It is used to form gels and thicken formulas.

Due to its large molecular size, carbomer has minimal skin penetration and is considered an inert ingredient.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Learn more about Carbomer
Antioxidant

Hydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.

Though naturally occuring in Norwegian spruce needles, this ingredient is usually synthetically created.

This ingredient is not irritating or sensitizing. Recent research also suggests it may have skin-brightening effects through tyrosinase inhibition.

Learn more about Hydroxyacetophenone
Emollient, Skin Conditioning, Skin Protecting

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Learn more about Dimethicone
Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid or alcohol, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Learn more about Caprylyl Glycol
Skin Conditioning

Melia Azadirachta Leaf Extract is extract from the neem plant.

The leaves of this tree contain flavonoids and polyphenols. These two compounds are antioxidants, anti-inflammatory, and antibacterial. Further research is needed as to their effects when applied on skin.

Humectant, Skin Conditioning

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Learn more about Dipotassium Glycyrrhizate
Skin Conditioning, Skin Protecting

This ingredient comes from the young shoots of wheat (Triticum vulgare) and has skin conditioning/protecting properties. It's packed with vitamins, antioxidants, and amino acids.

One study found that an aqueous Triticum vulgare:

Please know that anyone with a wheat or gluten allergy should proceed with caution since this ingredient is wheat-derived.

Learn more about Triticum Vulgare Sprout Extract
Cleansing, Skin Conditioning, Smoothing

Centella Asiatica Extract (Centella) is derived from an herb native to Southeast Asia. It is famous for its anti-inflammatory and soothing properties.

Centella is rich in antioxidants and amino acids, such as Madecassic Acid and Asiaticoside.

Studies show the compounds in centella help with:

The combination of all these properties makes centella effective at soothing, hydrating, and protecting the skin.

Other great components of centella include Vitamin A, vitamin C, several B vitamins, and Asiatic Acid.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Learn more about Centella Asiatica Extract

Melia Azadirachta Flower Extract is from the Neem tree. Neem trees originate from India.

Melia Azadirachta Flower Extract contains antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.

The flowers of this tree are lilac colored.

Learn more about Melia Azadirachta Flower Extract
Skin Conditioning

Coccinia Indica Fruit Extract is also known as Ivy Gourd Fruit Extract. It has skin conditioning properties.

The fruit is rich in flavonoids, phenolic acids, terpenoids, and sterols that show antioxidant and anti-inflammatory effect in vitro. This is because the fruit contains a thick mucilage that forms a protective and soothing layer on the skin's surface.

The extract itself has demonstrated antioxidant, soothing, and potential anti-allergy properties.

Most of this research is done in vitro and dedicated clinical studies on topical application are still limited.

Learn more about Coccinia Indica Fruit Extract
Skin Conditioning

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Learn more about Ethylhexylglycerin
Masking, Perfuming

Curcuma Longa Root Extract is from the spice, turmeric. Besides being a healthy and delicious spice, turmeric also has plenty of skincare benefits. It has anti-inflammatory, antioxidant, and anti-microbial properties.

Turmeric contains curcumin, an antioxidant. Antioxidants help neutralize unstable free-radical molecules. Free-radical molecules may damage your skin's cells and DNA. Curcumin may help with anti-aging.

Curcumin also has anti-inflammatory properties and can help soothe skin and reduce irritation. On top of that, curcumin has been shown to help prevent hyperpigmentation from sun damage.

The anti-microbial property of turmeric can make it effective in treating acne. This property has also been shown to help regulate the production of sebum.

Learn more about Curcuma Longa Root Extract
Skin Conditioning

This ingredient is also known as Bhringaraj extract or False Daisy. It is a skin conditioning ingredient that keeps skin soft and hydrated.

Research shows it has antioxidant properties; lab studies have found it can protect skin cells from UV-induced damage and help suppress inflammation.

There's also some interesting research on its potential to support hair growth by promoting the growth phase of the hair cycle.

Those with an allergy to plants in the daisy family may want to patch test this ingredient. This ingredient is generally well-tolerated otherwise.

Learn more about Eclipta Prostrata Extract
Skin Conditioning

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine
Skin Conditioning

Corallina Officinalis Extract is from the red seaweed, Corallina Officinalis. This seaweed is found all over the world but is most common in the rocky shores of Great Britain and Ireland.

Corallina Officinalis Extract contains antioxidant and emollient properties.

Extracted polysaccharides, galactose and xylose, in red algae showed antioxidant activity. Antioxidants help with anti-aging by neutralizing free-radical molecules. Free-radical molecules may damage your skin cells and DNA. Galactose is also a PHA.

Corallina Officinalis is structurally similar to coral due to its high calcium content.

Learn more about Corallina Officinalis Extract
Skin Conditioning

Ocimum Sanctum Leaf Extract comes from the Holy Basil plant. Holy Basil is native to India.

Holy Basil is rich in antioxidants due to its high romarinic acid, ferulic acid, and rutin content. This gives it skin brightening and soothing properties.

While Holy Basil has many claims to help fight acne, more research is needed.

One thing to note is the presence of tannins; tannins are naturally found in nature. However, this compound may be skin-sensitizing.

Learn more about Ocimum Sanctum Leaf Extract

Glyceryl Acrylate/Acrylic Acid Copolymer is made up of glycerin and polyacrylic acid. It helps hydrate your skin as a humectant.

This ingredient forms a hydrogel that delivers moisturizing, water-based ingredients to the skin. It is also used to thicken a product and to give it a smooth texture.

Acrylic acid itself is toxic, but the polymer form (this ingredient) is too large to penetrate skin, making it non-toxic.

Learn more about Glyceryl Acrylate/Acrylic Acid Copolymer

This ingredient comes from eggplant (or aubergine). It has skin conditioning properties due to its abundance of antioxidants like Chlorogenic Acid, Caffeic Acid, and Nasunin.

Nasunin is the pigment concentrated in the purple peel and has demonstrated the abilityu to neutralize free radicals and bind excess iron in lab studies.

Lab studies have shown that eggplant extracts can lower oxidative stress and protect skin cell membranes from damage. A 2025 study found that specific compounds in eggplant (particularly a phenolamide called N-Trans-Feruloylputrescine) may support skin health by neutralizing 2-nonenal, a byproduct linked to aging skin.

Overall, this is a gentle, well-tolerated ingredient that adds a little extra antioxidant support to your routine.

Those with nighshade vegetable allergies (tomatoes, peppers, potatoes) should patch test as eggplant is part of the same family.

Learn more about Solanum Melongena Fruit Extract

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Learn more about Disodium EDTA
Skin Conditioning, Skin Protecting, Soothing

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Learn more about Allantoin
Emollient, Skin Conditioning

Aloe Barbadensis Flower Extract is an extract of the flowers of the aloe, Aloe barbadensis, Liliaceae

Aloe contains the antioxidants Vitamins A, C, and E.

It also contains sugars in the form of monosaccharides and polysaccharides, folic acid, choline, many common minerals such as calcium, 12 anthraquinones, fatty acids, amino acids, and Vitamin B12.

Aloe is known to be anti-inflammatory, moisturizing, antiseptic, healing, and protect against UV rays.

Learn more about Aloe Barbadensis Flower Extract
Antioxidant, Skin Conditioning

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

Learn more about Tocopheryl Acetate
Skin Conditioning

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Learn more about Panthenol
Humectant, Skin Conditioning, Solvent

Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.

As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.

The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Learn more about Propylene Glycol
Solvent

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.Ā 

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Learn more about Propanediol
Skin Conditioning

Beta-Glucan is a polysaccharide. It can be derived from the cell walls of seaweed, oats, yeast, and fungi. It hydrates the skin and helps boost your skin's natural barrier.

As an antioxidant, beta-glucan helps fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.

Studies show this ingredient may be an effective wrinkle reducer as it can deeply penetrate into skin. It has also been show to help with wound healing.

Learn more about Beta-Glucan
Emollient, Skin Conditioning

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term ā€œoil-freeā€ isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Learn more about Squalane
Skin Conditioning

Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".

"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.

This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.

Clinical testing showed statistically significant improvements in:

Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.

You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.

Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Learn more about Palmitoyl Tetrapeptide-7
Skin Conditioning

Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.

That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.

Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.

In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.

Human clinical data is promising, but modest:

A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.

A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.

You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.

Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Learn more about Palmitoyl Tripeptide-1
Skin Conditioning

We don't have a description for Fructan yet.

Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Humectant, Skin Conditioning

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Learn more about Sodium Hyaluronate Crosspolymer

This is a synthetic polymer made by combining glycerin with polymethacrylic acid.

It is a non-drying, non-greasy moisturizer that helps enhance the feel and slip of formulations, helps stabilize emulsions, creates a film, and controls viscosity.

As a film former, it creates a light and flexible layer on the skin's surface. This helps lock in moisture without feeling heavy.

It's typically used at concentrations up to 1.9% in leave-on products. CIR has concluded that these ingredients are safe in cosmetics at current use levels.

Due to its large molecule size, it doesn't readily penetrate into skin and mostly just sits on the surface. A large UK-based patch test study of over 1,300 patients found that sensitization to related acrylate copolymers is rare.

Learn more about Glyceryl Polymethacrylate
Humectant, Skin Conditioning

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Learn more about Sodium Hyaluronate
Humectant, Skin Conditioning

We don't have a description for Hydrolyzed Glycosaminoglycans yet.

Skin Conditioning

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Learn more about Butyrospermum Parkii Butter
Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.Ā 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservativesĀ 
Perfuming, Skin Conditioning

Olive tree leaves contain more antioxidants than olive fruit.

This is due to its rich flavonoid and polyphenol content. However, the antioxidant content varies depending on plant variety, harvesting method, leaf maturity, and extraction method.

This ingredient also has a natural fragrance. Read more about fragrance in cosmetics here.

Learn more about Olea Europaea Leaf Extract

We don't have a description for Mannan yet.

Bleaching, Emollient, Skin Conditioning

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Learn more about Glycyrrhiza Glabra Root Extract

This ingredient is also known as Dandelion leaf extract.

Studies show the leaf, stem, and roots of this plant are rich in antioxidants such as caffeic acid and polysaccharides, which act as humectants to help hydrate the skin.

Solvent

We don't have a description for Benzyl Glycol yet.

Skin Conditioning

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Learn more about Ceramide NP
Skin Conditioning

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Learn more about Phytosphingosine
Humectant, Skin Conditioning

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Learn more about Hydrolyzed Hyaluronic Acid

Rosa Damascena Flower Extract is from the Damask rose. This ingredient has tonic and masking properties.

This ingredient has tonic properties; tonics are used to remove soap residue. As a masking ingredient, it is used to cover unpleasant smells from other ingredients.

Emollient, Skin Protecting

We don't have a description for Rhodiola Rosea Root Extract yet.

Skin Conditioning

Oregano leaf is a culinary and medicinal herb with skin conditioning properties.

Skin Conditioning

This synthetic peptide is created from lysine, valine, and palmitic acid.

According to the manufacturer, in-vitro studies show tissue growth and collagen synthesis. Another in-vivo study found 60 volunteers saw a significant reduction in wrinkles after 84 days.

Due to its palmitic acid base, this peptide may not be fungal-acne safe.

Learn more about Palmitoyl Tripeptide-5

This ingredient comes from the leaves of the Japanese cypress tree that is also called Hinoki. The leaves are rich in flavonoids with quercitrin being one of its key actives.

A 2023 study tested a 70% ethanol extract on UVA-stressed, collagen-producing skin cells. Across multiple antioxidant tests, this extract protected skin from free radicals at meaningful rates.

And the coolest part? At 1000 µg/mL, it blocked two enzymes (collagenase and elastase) almost as well as vitamin C did at the same dose. Collagenase and elastase are the enzymes that break down your skin's collagen and elastin over time.

The same study found this ingredient lowered skin-breakdown enzymes and inflammation signals while bumping up collagen production in UV-stressed cells.

A 2024 follow-up tested a fermented version (fermented with mushroom) and it calmed down several key inflammation markers in irritated immune cells. So besides anti-aging, this ingredient can also help soothe skin.

Most of the data right now is still at the cell-culture stage rather than from human clinical trials. However, there's no harm in adding this ingredient to your routine.

Just be sure to patch test if you have a history of sensitivity toward botanical extracts.

Learn more about Chamaecyparis Obtusa Leaf Extract
Astringent, Skin Conditioning, Soothing

Salix Alba Bark Extract comes from the bark of the white willow tree. The official CosIng listing states this ingredient to have astringent, skin conditioning, soothing, and tonic properties.

Its star compound is salicin, a natural glucoside that is chemically related to salicylic acid. That's why you'll often see it marketed as a "natural BHA alternative" but that's a bit of a stretch.

Your skin can't convert salicin to salicylic acid because it needs specific enzymes that aren't present on the skin's surface. It won't behave like true salicylic acid, especially at the concentrations used in cosmetics.

However, this ingredient has its own perks. It contains flavonoids, polyphenols, and tannins that give it proven antioxidant and soothing properties.

An 8-week clinical study found a cream with 2% of this extract improved skin microcirculation, elasticity, and dark circles. This is most likely due to its role in increasing hyaluronic acid synthesis in fibroblasts and improved vascular integrity.

Another study found a topical serum with 0.5% salicin showed improvements in visible signs of aging, hyperpigmentation, and texture.

Just be careful if you have a known aspirin/salicylate allergy and be sure to consult with a medical professional about using this ingredient if you do.

Fun fact: Willow Bark extract has been used for thousands of years and ancient civilizations used white willow to help treat pain and fevers.

Learn more about Salix Alba Bark Extract

We don't have a description for Usnea Barbata Extract yet.

Zanthoxylum Piperitum Fruit Extract comes from the Japanese Pepper, also known as the Prickly Ash. This plant is native to the Korean peninsula and Japan.

The pepper has antioxidant properties. It may help reduce the signs of aging.

For those with fragrance sensitivities, Zanthoxylum Piperitum Fruit Extract contains limonene.

If you have concerns, we recommend speaking with a professional about using this ingredient.

The Japanese Pepper is related to the Sichuan Pepper.

Learn more about Zanthoxylum Piperitum Fruit Extract
Skin Conditioning

Pulsatilla Koreana Extract comes from the Korean pasque flower. This flower is used in traditional Korean medicine.

This ingredient is created by fermenting soybean extract with the bacteria, lactobacillus.

Some studies have shown it to have antioxidant properties. One study found this ingredient to have stronger properties than non-fermented soybean extract.

Another study found in increase of isoflavones, amino acids, and peptides in fermented soy milk.

Learn more about Lactobacillus/Soybean Ferment Extract
Skin Conditioning

This extract comes from Purslane, a succulent. It has anti-inflammatory, antioxidant, and hydrating properties.

Purslane is very nutritious. It contains omega-3 fatty acids, NMFs, many vitamins, minerals, and antioxidants. The vitamins found in purslane include: Vitamin C, Vitamin A, and Vitamin E.

Fun fact: Purslane is a succulent with an extensive habitat. It is used in traditional Korean medicine to treat irritated skin.

Nowadays, purslane is becoming a superfood due to its highly nutritious content.

Learn more about Portulaca Oleracea Extract
Buffering, Masking

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Read more about some other popular AHA's here:

Learn more about Citric Acid

This ingredient comes from the cinnamon tree native to southern China.

Though cinnamon has a wonderful taste, it can cause skin irritation due to its rich coumarins, cinnamaldehyde, and styrene content.

Astringent, Humectant, Soothing

Scutellaria Baicalensis Root Extract comes from the Baikal skullcap or Chinese skullcap plant. This plant is native to Northeast Asia and can be found in China, Mongolia, Korea, and Siberia.

In cosmetics, Scutellaria Baicalensis Root Extract provides antioxidant and anti-inflammatory benefits. This is due to the flavonoid composition of Scutellaria Baicalensis Root Extract.

In Chinese traditional folk medicine, Scutellaria Baicalensis Root Extract is used to help treat lung issues and hypertension.

Learn more about Scutellaria Baicalensis Root Extract
Masking, Perfuming, Skin Conditioning

Raspberry Ketone is a fragrance.

Humectant, Moisturising, Skin Conditioning

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Learn more about Hyaluronic Acid
Humectant, Skin Conditioning

Acetyl Hexapeptide-8, commonly known as Argireline or Acetyl Hexapeptide-3, is a popular peptide in skincare. It’s often referred to as a ā€œBotox-likeā€ ingredient because it helps reduce muscle movement.

By relaxing these micro-movements, Argireline may help minimize the appearance of fine lines and wrinkles. That said, it’s not as powerful as Botox, and research on its long-term effectiveness is still limited.

Beyond smoothing, Argireline may also support collagen production. Collagen is the protein that helps keep your skin firm, bouncy, and well-hydrated by strengthening the skin barrier.

So while Argireline isn’t a miracle fix, it can be a helpful addition to a routine focused on both prevention and skin health.

Read more about other common types of peptides here:

Learn more about Acetyl Hexapeptide-8
Skin Conditioning

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Learn more about Copper Tripeptide-1
Antioxidant, Skin Protecting

Oligopeptide-29 is an antioxidant and is a peptide.

Antiseborrhoeic, Skin Conditioning

Oligopeptide-32 is a peptide.

Cleansing, Skin Conditioning, Surfactant

Palmitoyl Oligopeptide is a form of peptide. It is created by blending peptides with palmitic acid. Peptides are building blocks for protein.

Due to the palmitic acid base, it may not be malassezia folliculitis safe.

This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Oligopeptide
Skin Conditioning

You might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.

As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.

A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.

The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.

The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.

Due to its palmitic acid base, it may not be fungal acne safe.

Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.

Read more about other common types of peptides here:

Learn more about Palmitoyl Pentapeptide-4
Masking, Perfuming

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of ā€œFRAGRANCEā€ or ā€œPARFUMā€ according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

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Perfuming

Hexyl Cinnamal is a fragrance ingredient with a similar scent to jasmine. It can be naturally found in chamomile essential oil.

This ingredient is a known EU allergen and may sensitize the skin. The EU requires this ingredient to be listed separately on an ingredients list.

Hexyl Cinnamal is not water soluble but is soluble in oils.

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Perfuming, Solvent

Limonene is a fragrance that adds scent and taste to a formulation.

It's found in the peel oil of citrus fruits and other plants such as lavender and eucalyptus. The scent of limonene is generally described as "sweet citrus".

Limonene acts as an antioxidant, meaning it helps neutralize free radicals.

When exposed to air, oxidized limonene may sensitize the skin. Because of this, limonene is often avoided by people with sensitive skin.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.

Learn more about Limonene
Perfuming

Linalool is a fragrance and helps add scent to products. It's derived from common plants such as cinnamon, mint, citrus, and lavender.

Like Limonene, this ingredient oxidizes when exposed to air. Oxidized linalool can cause allergies and skin sensitivity.

This ingredient has a scent that is floral, spicy tropical, and citrus-like.

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Perfuming

Citronellol is used to add fragrance/parfum to a product. It is often derived from plants such as roses. In fact, it can be found in many essential oils including geranium, lavender, neroli, and more. The scent of Citronellol is often described as "fresh, grassy, and citrus-like".

Since the Citronellol molecule is already unstable, Citronellol becomes irritating on the skin when exposed to air.

Citronellol is a modified terpene. Terpenes are unsaturated hydrocarbons found in plants. They make up the primary part of essential oils.

Citronellol is not able to be absorbed into deeper layers of the skin. It has low permeability,

Citronellol is also a natural insect repellent.

Learn more about Citronellol

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Ā· Updated August 29, 2024 Added by tsmeu