Paula's Choice Pro-Collagen Peptide Plumping Intensive Moisturizer Versus Centellian24 Madeca Cream Time Reverse
This anti-aging moisturizer is formulated around Acetyl Sh-Hexapeptide-5 Amide Acetate and Oligopeptide-1 to soften the look of wrinkles and hydrate skin.
This anti-aging moisturizer is formulated around Niacinamide and Asiaticoside to soften the look of wrinkles and strengthen the skin barrier.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningPropanediol
SolventBehenyl Alcohol
EmollientBetaine
HumectantDimethicone
EmollientCaprylic/Capric Triglyceride
MaskingGlycerin
HumectantMyristyl Myristate
EmollientPyrus Malus Fruit Extract
Skin ConditioningBeheneth-20
EmulsifyingOleyl Erucate
EmollientTridecyl Trimellitate
EmollientHydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingDiisostearyl Malate
Emollient1,2-Hexanediol
Skin ConditioningBis-Diglyceryl Polyacyladipate-2
EmollientSqualane
EmollientAdenosine
Skin ConditioningButylene Glycol
HumectantOphiopogon Japonicus Root Extract
Skin ConditioningPentylene Glycol
Skin ConditioningChondrus Crispus
MaskingSorbitan Isostearate
EmulsifyingCitric Acid
BufferingGigartina Stellata Extract
Skin ProtectingGluconolactone
ChelatingCaprylyl Glycol
EmollientSodium Hyaluronate
HumectantTocopherol
AntioxidantAcetyl Sh-Hexapeptide-5 Amide Acetate
Skin ConditioningHelianthus Annuus Seed Oil
EmollientTridecapeptide-1
Skin ConditioningOligopeptide-1
Skin ConditioningSodium Phytate
ChelatingHydroxyacetophenone
AntioxidantCyanocobalamin
Skin ConditioningSodium Benzoate
MaskingPhenoxyethanol
PreservativeWater, Propanediol, Behenyl Alcohol, Betaine, Dimethicone, Caprylic/Capric Triglyceride, Glycerin, Myristyl Myristate, Pyrus Malus Fruit Extract, Beheneth-20, Oleyl Erucate, Tridecyl Trimellitate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Diisostearyl Malate, 1,2-Hexanediol, Bis-Diglyceryl Polyacyladipate-2, Squalane, Adenosine, Butylene Glycol, Ophiopogon Japonicus Root Extract, Pentylene Glycol, Chondrus Crispus, Sorbitan Isostearate, Citric Acid, Gigartina Stellata Extract, Gluconolactone, Caprylyl Glycol, Sodium Hyaluronate, Tocopherol, Acetyl Sh-Hexapeptide-5 Amide Acetate, Helianthus Annuus Seed Oil, Tridecapeptide-1, Oligopeptide-1, Sodium Phytate, Hydroxyacetophenone, Cyanocobalamin, Sodium Benzoate, Phenoxyethanol
Water
Skin ConditioningDipropylene Glycol
HumectantHydrogenated Polydecene
EmollientCaprylic/Capric Triglyceride
MaskingGlycerin
HumectantPentaerythrityl Tetraethylhexanoate
EmollientGlyceryl Stearate
EmollientCyclohexasiloxane
EmollientNiacinamide
SmoothingCetyl Alcohol
EmollientPolyglyceryl-6 Distearate
EmulsifyingVinyldimethicone
Dicaprylyl Ether
EmollientPolyglyceryl-10 Laurate
Skin ConditioningStearyl Alcohol
EmollientJojoba Esters
EmollientBeeswax
Emulsion StabilisingPanthenol
Skin Conditioning1,2-Hexanediol
Skin ConditioningSodium Stearoyl Glutamate
CleansingMadecassic Acid
Skin ConditioningAsiaticoside
AntioxidantXylitylglucoside
HumectantHydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingOlea Europaea Fruit Oil
MaskingHydroxyacetophenone
AntioxidantAnhydroxylitol
HumectantCentella Asiatica Leaf Extract
Skin ConditioningAsiatic Acid
Skin ConditioningGlycoproteins
Skin ConditioningButylene Glycol
HumectantPolyglyceryl-3 Beeswax
EmulsifyingXylitol
HumectantCentella Asiatica Oil
AntimicrobialMethylpropanediol
SolventAllantoin
Skin ConditioningPropanediol
SolventCandida Bombicola/Glucose/Methyl Rapeseedate Ferment
AntimicrobialCitrus Aurantium Dulcis Oil
MaskingXanthan Gum
EmulsifyingHelianthus Annuus Seed Wax
Skin ConditioningEthylhexylglycerin
Skin ConditioningEthoxydiglycol
HumectantCitrus Nobilis Peel Oil
MaskingGlucose
HumectantDisodium EDTA
ChelatingAdenosine
Skin ConditioningSorbitan Isostearate
EmulsifyingLavandula Angustifolia Oil
MaskingSodium Laurate
CleansingCyclodextrin
AbsorbentHydrolyzed Hyaluronic Acid
HumectantCitrus Aurantium Bergamia Fruit Oil
MaskingCitrus Aurantium Dulcis Peel Oil
MaskingRosmarinus Officinalis Leaf Oil
MaskingLitsea Cubeba Fruit Oil
MaskingMacadamia Ternifolia Seed Oil
EmollientPolyglycerin-3
HumectantPvm/Ma Copolymer
Emulsion StabilisingLauric Acid
CleansingSodium Polyacrylate
AbsorbentOctyldodecanol
EmollientGlycine Soja Oil
EmollientHydrogenated Lecithin
EmulsifyingGlycolipids
Skin ConditioningCaffeine
Skin ConditioningMadecassoside
AntioxidantCentella Asiatica Extract
CleansingC12-13 Pareth-9
EmulsifyingCollagen Amino Acids
MoisturisingCeramide NP
Skin ConditioningCopaifera Officinalis Resin
MaskingCitrus Grandis Peel Oil
MaskingJuniperus Virginiana Oil
MaskingCimicifuga Racemosa Root Extract
AntimicrobialSilybum Marianum Extract
Skin ConditioningResveratrol
AntioxidantArginine
MaskingTaurine
BufferingGlycogen
HumectantHydrolyzed Elastin
EmollientEctoin
Skin ConditioningCedrus Atlantica Bark Oil
MaskingRetinol
Skin ConditioningLepidium Meyenii Root Extract
Skin ConditioningMaltodextrin
AbsorbentAscorbic Acid
AntioxidantHydrolyzed Vegetable Protein
Skin ConditioningPelargonium Graveolens Flower Oil
MaskingPhytosphingosine
Skin ConditioningTocopherol
AntioxidantSucrose Distearate
EmollientSodium Hyaluronate
HumectantSodium DNA
Skin ConditioningJasminum Officinale Oil
MaskingPotassium Sorbate
PreservativePhenoxyethanol
PreservativeArtemisia Absinthium Extract
Skin ConditioningMyrtus Communis Oil
MaskingRose Flower Oil
MaskingVanilla Planifolia Fruit Extract
Skin ConditioningCyanocobalamin
Skin ConditioningAspartic Acid
MaskingFerula Galbaniflua Resin Oil
AntimicrobialGlycine
BufferingGlutamic Acid
HumectantLimonene
PerfumingLinalool
PerfumingCitral
PerfumingCamphor
MaskingBeta-Caryophyllene
MaskingCitrus Aurantium Peel Oil
Citrus Aurantium Bergamia Peel Oil
PerfumingLavandula Oil/Extract
Linalyl Acetate
MaskingPinene
MaskingWater, Dipropylene Glycol, Hydrogenated Polydecene, Caprylic/Capric Triglyceride, Glycerin, Pentaerythrityl Tetraethylhexanoate, Glyceryl Stearate, Cyclohexasiloxane, Niacinamide, Cetyl Alcohol, Polyglyceryl-6 Distearate, Vinyldimethicone, Dicaprylyl Ether, Polyglyceryl-10 Laurate, Stearyl Alcohol, Jojoba Esters, Beeswax, Panthenol, 1,2-Hexanediol, Sodium Stearoyl Glutamate, Madecassic Acid, Asiaticoside, Xylitylglucoside, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Olea Europaea Fruit Oil, Hydroxyacetophenone, Anhydroxylitol, Centella Asiatica Leaf Extract, Asiatic Acid, Glycoproteins, Butylene Glycol, Polyglyceryl-3 Beeswax, Xylitol, Centella Asiatica Oil, Methylpropanediol, Allantoin, Propanediol, Candida Bombicola/Glucose/Methyl Rapeseedate Ferment, Citrus Aurantium Dulcis Oil, Xanthan Gum, Helianthus Annuus Seed Wax, Ethylhexylglycerin, Ethoxydiglycol, Citrus Nobilis Peel Oil, Glucose, Disodium EDTA, Adenosine, Sorbitan Isostearate, Lavandula Angustifolia Oil, Sodium Laurate, Cyclodextrin, Hydrolyzed Hyaluronic Acid, Citrus Aurantium Bergamia Fruit Oil, Citrus Aurantium Dulcis Peel Oil, Rosmarinus Officinalis Leaf Oil, Litsea Cubeba Fruit Oil, Macadamia Ternifolia Seed Oil, Polyglycerin-3, Pvm/Ma Copolymer, Lauric Acid, Sodium Polyacrylate, Octyldodecanol, Glycine Soja Oil, Hydrogenated Lecithin, Glycolipids, Caffeine, Madecassoside, Centella Asiatica Extract, C12-13 Pareth-9, Collagen Amino Acids, Ceramide NP, Copaifera Officinalis Resin, Citrus Grandis Peel Oil, Juniperus Virginiana Oil, Cimicifuga Racemosa Root Extract, Silybum Marianum Extract, Resveratrol, Arginine, Taurine, Glycogen, Hydrolyzed Elastin, Ectoin, Cedrus Atlantica Bark Oil, Retinol, Lepidium Meyenii Root Extract, Maltodextrin, Ascorbic Acid, Hydrolyzed Vegetable Protein, Pelargonium Graveolens Flower Oil, Phytosphingosine, Tocopherol, Sucrose Distearate, Sodium Hyaluronate, Sodium DNA, Jasminum Officinale Oil, Potassium Sorbate, Phenoxyethanol, Artemisia Absinthium Extract, Myrtus Communis Oil, Rose Flower Oil, Vanilla Planifolia Fruit Extract, Cyanocobalamin, Aspartic Acid, Ferula Galbaniflua Resin Oil, Glycine, Glutamic Acid, Limonene, Linalool, Citral, Camphor, Beta-Caryophyllene, Citrus Aurantium Peel Oil, Citrus Aurantium Bergamia Peel Oil, Lavandula Oil/Extract, Linalyl Acetate, Pinene
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideCyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
Learn more about HydroxyacetophenoneThis is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateSorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Learn more about Sorbitan IsostearateTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water