Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum Ingredients Explained

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

• It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
• It is a humectant, which means that it helps attract moisture into the skin.
• It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Ectoin is a compound found naturally in some species of bacteria. It can be synthetically created for skincare use.

This ingredient is an osmolyte; Osmolytes help organisms survive osmotic shock (it protects them from extreme conditions). It does this by influencing the properties of biological fluids within cells.

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

This ingredient is created by putting sodium hyaluronate through hydrolysis.

You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Sodium Hyaluronate Crosspolymer is a type of hyaluronic acid. In fact, it is modified version of hyaluronic acid.

The structure of Sodium Hyaluronate Crosspolymer allows it to stay in the skin's top layer for a longer period of time. This allows for even more hydration and humectant action than hyaluronic acid.

Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.

Argireline has a similar function to botox. It prevents muscle movement and contractions. By preventing muscles from moving, Argireline also prohibits the formation of fine lines and wrinkles. However, research is lacking in proving this ingredient to be as effective as botox.

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tripeptide-1 is a signal peptide. This means it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

Oligopeptide-2 is a peptide.

Saccharide Isomerate comes from sugars found in corn. It is a skin hydrator.

The structure of this ingredient can be altered to be more similar to the carbohydrates found in our skin. This ability to mimic our skin gives it hydrating properties.

Camellia Sinensis Leaf Extract is derived from the leaves of the tea plant. Black tea, green tea, and oolong tea are all harvested from this plant.

This ingredient has many skin benefits:

Centella Asiatica Extract (Centella) is derived from an herb native to Southeast Asia. It is famous for its anti-inflammatory and soothing properties.

Centella is rich in antioxidants and amino acids, such as Madecassic Acid and Asiaticoside.

Vitis Vinifera Seed Extract comes from the grape vine. Grape seeds are a byproduct of creating grape juice or wine.

The components of grape seeds have many skin benefits. Research has found it to be antimicrobial and anti-inflammatory. It also contains many potent antioxidants such as Vitamin E , Vitamin C, proanthocyanidins, polyphenols, flavonoids, and anthocyanins. Proanthocyanidin has been shown to help even out skin tone.

We don't have a description for Sodium Carboxymethyl Beta-Glucan.

Bakuchiol is a plant-derived antioxidant (it's vegan!). It is often called the replacement for retinol although it is not part of the same family.

It has similar effects as retinol: skin smoothing, reducing discoloration, and preventing wrinkles. It does not cause as much irritation as traditional retinoids.

We don't have a description for Inonotus Obliquus Extract.

Tetrahydrocurcumin is an antioxidant.

Ceramide NP is a type of ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramide AP is a type of Ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. Having a strong skin barrier leads to more firm and hydrated skin.

Ceramide EOP is a type of Ceramide.

EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.

Phospholipids are naturally found in our skin as they are the main component of cell membranes. Phospholipids have humectant, emollient, antioxidant properties.

The phospholipids in our skin can be naturally depleted. Replenishing the phospholipids in our skin can help hydrate your skin. Due to their hygroscopic nature, they act as humectants and emollients. Humectants draw moisture from the air to your skin, while emollients help trap moisture in. This ingredient is non-occlusive.

We don't have a description for Sphingolipids.

Phytosphingosine is a phospholipid naturally found in our skin. It helps moisturize, soothe, and protect skin.

Phytosphingosine is already present in our skin. On our skin, it is a building block for ceramides.

According to INCI standards, this ingredient refers to the physical ground up oatmeal. If you are looking for colloidal oatmeal in skincare, you'll most likely see Avena Sativa Kernel Extract on your ingredient list.

Physical colloidal oatmeal is an abrasive meaning it provides physical exfoliation.

Bisabolol is pimarily used to add fragrance to a product. However, it is also famous for helping soothe skin.

Bisabolol comes from German chamomile essential oil. Synthetic Bisabolol has been shown to be less effective.

Superoxide Dismutase is found in all living cells. This ingredient is AKA as 'SOD'.

SOD is a strong antioxidant. It protects living cells against oxidative damage by breaking down radical molecules into regular oxygen and hydrogen peroxide.

Terminalia Ferdinandiana Fruit Extract is from the Kakadu plum. The Kakadu plum is native to northern Australia. The Kakadu plum holds the record for having the highest amount of natural vitamin C.

Terminalia Ferdinandiana Fruit Extract is an antioxidant. Antioxidants help fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material. Antioxidants help stabilize free-radicals and thus may reduce the signs of aging.

Sodium PCA is the sodium salt of pyroglutamic acid and is naturally occurring on human skin.

The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.

Glutathione is an antioxidant naturally found in our bodies. It is made up of three amino acids: glycine, cysteine, and glutamic acid.

As an antioxidant, it prevents oxidative damage to parts of our cell.

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.

Caffeine is most associated with coffee, tea, and cacao. In skincare, it helps with calming inflammation and anti-aging.

Caffeine is an antioxidants, which help with the signs of aging. This is because antioxidants help fight skin-damaging free radical molecules.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.

This ingredient is also referred to as pro-vitamin B5 or dexpanthenol in dermatology.

Butyrospermum Parkii Butter is a plant lipid from the fruit of the Shea Tree. It is an effective skin hydrator and emollient.

Emollients help soothe and soften your skin. It does this by creating a protective film on your skin. This barrier helps trap moisture and keeps your skin hydrated. Emollients may be effective at treating dry or itchy skin.

Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.

Aloe is packed with good stuff including Vitamins A, C, and E. These vitamins are antioxidants, which help fight free-radicals and the damage they may cause. Free-radicals are molecules that may damage your skin cells, such as pollution.

Arnica Montana Flower is more commonly known as Wolf's Bane. While this flower has been used in traditional medicine, its skin benefits are in question.

The FDA considers Wolf's Bane to be an unsafe herb. They advise against taking it orally or applying it to broken skin.

We don't have a description for Acetyl Glutamine.

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Having a healthy microbiome helps protect our skin against infection. It also helps our skin stay hydrated and healthy.

Chamomilla Recutita Flower Extract comes from the Chamomile flower.

Chamomile is rich in antioxidants and has anti-inflammatory properties. Several compounds found in chamomile help with soothing, such as bisbolol.

Withania Somnifera Root Extract is also known as Ashwaganda extract. Ashwaganda is an evergreen shrub grown in India, the Middle East, and parts of Africa.

Ashwaganda contains many antioxidant compounds. Antioxidants may help with anti-aging as they neutralize free-radical molecules. These molecules may damage skin cells and DNA. By neutralizing them, antioxidants may help slow the signs of aging.

Glycolic Acid is arguably the most famous AHA with a ton of research to back up its benefits.

Its main role is to remove the top layer of dead skin cells, allowing newer skin cells to emerge.

Mandelic Acid helps exfoliate skin. It also contains antioxidant properties.

As an AHA, Mandelic Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and look more even.

Lactobionic Acid is a PHA. PHAs are the gentle cousins to AHAS.

Like AHAs, they exfoliate the top layer of skin. Lactobionic acid also exhibits significant antioxidant activity.

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Coco-Glucoside is a surfactant, or a cleansing ingredient. It is made from glucose and coconut oil.

Surfactants help gather dirt, oil, and other pollutants from your skin to be rinsed away. Coco-Glucoside is considered gentle and non-comedogenic.

Lauryl Glucoside sugar- and lipid-based cleansing agent. It is created from glucose and lauryl alcohol.

Lauryl Glucoside makes it easier to rinse oil, dirt, and other polluants away.

Decyl Glucoside is a glucose-based surfactant. Surfactants help clean the skin by trapping oil, sebum, and dirt to be washed away.

It is created by reacting glucose with the fatty acids from plants.

Polyglyceryl-10 Laurate is an ester of lauric acid and Polyglycerin-10.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier. It helps gather dirt, oil, and other pollutants to be rinsed away. As an emulsifier, it helps prevent ingredients from separating, such as oil and water.

We don't have a description for Diheptyl Succinate.

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

Dimethicone has been found increase absorption in skin, boosting the benefits of other ingredients. While there is concern for the safety of dimethicone, the levels used in skincare are safe for use.

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.

Sodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.

Sodium Lauroyl Lactylate is an emulsifier and surfactant.

We don't have a description for Pvm/Ma Decadiene Crosspolymer.

We don't have a description for Vp/Va Copolymer.

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Potassium hydroxide is commonly known as caustic potash. It is used to fix the pH of a product or as a cleaning agent in soap. In cleansers, it is used for the saponification of oils.

Sapnification is the process of creating fatty acid metal salts from triglycerides and a strong base. During this process, Potassium Hydroxide is used up and is not present in the final product.

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Dimethicone Crosspolymer is a silicone created by modifying dimethicone with hydrocarbon side chains. Due to its large size, it does not penetrate skin. It is considered non-occlusive.

Dimethicone Crosspolymer is used to stabilize and thicken products. It also helps give products a silky feel.

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

Carbomer is commonly found in many types of cosmetics products. It is found to be safe in concentrations up to 15%. However, a high amount of carbomer can cause pilling or balling up of products. Most products contain 1% of less of carbomer.

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.

We don't have a description for Capryloyl Glycerin/Sebacic Acid Copolymer.

Leuconostoc/Radish Root Ferment Filtrate is a natural preservative. It comes from fermenting radish roots with a bacteria called leuconostoc. Leuconostoc comes from lactic acid. This bacteria is used to make the traditional Korean side-dish, kimchi. It is also used to make sourdough bread (both incredibly yummy foods).

Leuconostoc/Radish Root Ferment Filtrate has antimicrobial properties and helps prevent the growth of bacteria in a product.

Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.

Sodium Citrate helps maintain the pH of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).

As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.

We don't have a description for Sodium Metasilicate.

Gluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.

When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.

Tetrasodium Glutamate Diacetate is a chelating agent. Chelating agents help prevent metal ions from binding to other ingredients. This helps prevent unwanted effects and reactions from a product. These metal ions may come from water and are found in miniscule amounts.

Tetrasodium Glutamate Diacetate can also help other preservatives be more effective.

Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

Within a product, Caprylic Triglyceride can thicken the product and make spreadability easier by dissolving clumping compounds. An added benefit of Caprylic Triglyceride is its antioxidant properties.

Jasmine flower and leaf has perfuming, antioxidant, and antimicrobial properties.

The antioxidant activity in Jasmine comes from flavonoids - a compound found in many plants. While antioxidants are great - Jasmine flowers also contain coumarin, a known EU allergen.

Vitis Vinifera Fruit Extract comes from grapes.

Grape extract has many skin benefits. It also contains many potent antioxidants such as Vitamin E , Vitamin C, proanthocyanidins, polyphenols, flavonoids, and anthocyanins. Proanthocyanidin has been shown to help even out skin tone.

We don't have a description for Eugenia Caryophyllus Flower Extract.

Lavandula Angustifolia Flower/Leaf/Stem Extract is a fragrance.

Raspberry Ketone is a fragrance.

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.