Versus

KAINE Caffetinal Cream Versus SkinBetter Science AlphaRet Overnight Cream

General Moisturizer
Night Moisturizer
Korean Brand South Korea
American Brand United States

Updated on February 06, 2025

Overview

What they are

These products are both reef safe . They have a total of 12 ingredients in common

Cool Features

They both contain exfoliants, hyaluronic acid, niacinamide, peptides, retinoid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

What's Inside

They both contain silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Caffetinal Cream

Water

Skin Conditioning

Methylpropanediol

Solvent

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Hydrogenated Polydecene

Emollient

Caprylic/Capric Triglyceride

Masking

Dipropylene Glycol

Masking

Pentaerythrityl Tetraethylhexanoate

Emollient

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Betaine

Humectant
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Dark Spots Icon

Vinyldimethicone

Silicon Icon

Caffeine

Skin Conditioning

Methyl Trimethicone

Skin Conditioning
Silicon Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Panthenol

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Hydrogenated Poly(C6-14 Olefin)

Emollient

Ficus Carica Fruit Extract

Humectant

Centella Asiatica Extract

Cleansing
Helps reduce Skin Redness IconHelps reduce irritation Icon

Monarda Didyma Leaf Extract

Skin Conditioning

Salix Alba Bark Extract

Astringent
Good for Oily Skin Icon

Adansonia Digitata Fruit Extract

Emollient

Macadamia Ternifolia Seed Oil

Emollient
Oil IconNot safe for Fungal Acne Icon

Hydrogenated Lecithin

Emulsifying

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid Icon

Simmondsia Chinensis Seed Oil

Emollient
0-2 / 0 Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

1,2-Hexanediol

Skin Conditioning

C10-18 Triglycerides

Emollient
Not safe for Fungal Acne Icon

Sodium Stearoyl Glutamate

Cleansing

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Hydroxyacetophenone

Antioxidant
Antioxidant Icon

Hydroxypropyl Cyclodextrin

Masking

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Jojoba Esters

Emollient
Not safe for Fungal Acne Icon

Glyceryl Stearates

Emollient
Not safe for Fungal Acne Icon

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Cetyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Stearyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Xanthan Gum

Emulsifying

Ethylhexylglycerin

Skin Conditioning

Helianthus Annuus Seed Wax

Skin Conditioning
Not safe for Fungal Acne Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Polyglyceryl-10 Laurate

Skin Conditioning
Not safe for Fungal Acne Icon

Disodium EDTA

Adenosine

Skin Conditioning
Good for Minimizing Pores IconGood for Scar Healing Icon

Retinal

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Silica

Abrasive
Exfoliant IconMay worsen Eczema IconMay worsen Rosacea Icon

Brassica Campestris Sterols

Emollient
Not safe for Fungal Acne Icon

Polyglyceryl-3 Methylglucose Distearate

Emulsifying
Not safe for Fungal Acne Icon

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sorbitan Isostearate

Emulsifying
1-2 / 0 Not safe for Fungal Acne Icon

Aluminum/Magnesium Hydroxide Stearate

Emulsion Stabilising

Sucrose Distearate

Emollient
0 / 2 Not safe for Fungal Acne Icon

Potassium Cetyl Phosphate

Emulsifying

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Antioxidant
Antioxidant Icon

Polyglycerin-3

Humectant

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Caprylyl Glycol

Emollient

Ethyl Hexanediol

Solvent

Acetyl Hexapeptide-8

Humectant
Peptide IconHelps with Anti-Aging Icon
AlphaRet Overnight Cream

Water

Skin Conditioning

Sodium Glycolate

Buffering

Glycolic Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin IconMay worsen Rosacea Icon

Cetearyl Olivate

Not safe for Fungal Acne Icon

Pentylene Glycol

Skin Conditioning

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Emulsifying

Glyceryl Stearate is a mix of glycerin and stearic acid.

It is used to stabilize the mixing of water and oil ingredients. By preventing these ingredients from separating, it can help elongate shelf life. It can also help thicken the product's texture.

As an emollient, it helps soften skin and supports barrier-replenishing ingredients.

In cosmetics, Glyceryl Stearate is often made from vegetable oils or synthetically produced.

This ingredient may not be fungal-acne safe

Fun fact: The human body also creates Glyceryl Stearate naturally.

Learn more about Glyceryl Stearate
Smoothing

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

Learn more about Niacinamide
Skin Conditioning

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Learn more about Panthenol
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.
  • It has mild preservative properties.

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Emollient, Emulsifying, Skin Conditioning

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.

Our bodies use cholestrol to create vitamin D, steroid hormones, and more.

Learn more about Cholesterol

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Antioxidant, Masking, Skin Conditioning

Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.

Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.

Learn more about Tocopherol
Emollient, Skin Conditioning

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Learn more about Squalane

When to use

2 Routines
50% use in am
50% use in pm
100% use every day
113 Routines
1% use in am
99% use in pm
84% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

KAINE Caffetinal Cream 60 ingredients

Caffetinal Cream hasn't been rated yet.
Rate it now

SkinBetter Science AlphaRet Overnight Cream 52 ingredients

3.3 /5
from 3 ratings
Expensive (3) Absorbs Well (2) Light (2)
carr0t's avatar

Caroline Strahan

9 months ago
Review

This is a great - albeit extremely expensive - alternative for people whose skin is too sensitive for tretonoin/retinols or who aren’t able to manage the dryness they can cause.

I’ve been using it for about a month and a half and I truly have noticed a huge difference in my pore size + fine lines. I do like to use a moisturizer afterwards just to be safe, but this could likely work as a Show more

#expensive
#light
#absorbs well
#no scent
beamayo's avatar

Bea Mayo

1 month ago
Review

Truly my holy grail product. It’s certainly pricey but it’s one of two expensive products I have in my routine and it’s worth the investment imo. One fl oz bottle lasts me ~3 months with nightly use. I’ve used this product consistently for 5 months now and have noticed my skin is brighter, more hydrated, and even toned. I was previously using .05% tret and my skin could never really handle it. Show more

#expensive
#light
#absorbs well
#no scent