Clinique Smart Clinical Repair Wrinkle Correcting Serum Versus Wellderma Retinol Peptide Lifting Restore Ampoule
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture.
This anti-aging ampoule is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningDimethicone
Emollient
Isododecane
EmollientButylene Glycol
Humectant
Glycerin
Humectant
Polysilicone-11
Ascorbyl Glucoside
Antioxidant
Sodium Hyaluronate
Humectant
Tocopheryl Acetate
Antioxidant
Squalane
Emollient
Hypnea Musciformis Extract
Skin Protecting
Gelidiella Acerosa Extract
Skin Protecting
Sigesbeckia Orientalis Extract
Skin ConditioningHelianthus Annuus Seed Extract
Skin Conditioning
Hordeum Vulgare Extract
EmollientTriticum Vulgare Germ Extract
Skin ConditioningCucumis Sativus Fruit Extract
Emollient
Caffeine
Skin Conditioning
Acetyl Hexapeptide-8
Humectant
Palmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Palmitoyl Hexapeptide-12
Skin Conditioning
PEG-10 Dimethicone
Skin Conditioning
Glycyrrhetinic Acid
Skin Conditioning
Whey Protein
Skin ConditioningIsohexadecane
EmollientPropylene Glycol Dicaprate
EmollientCaprylyl Glycol
Emollient
Hydroxypinacolone Retinoate
Skin Conditioning
Acetyl Glucosamine
Skin Conditioning
Cholesterol
Emollient
PEG-8
HumectantFaex Extract
Skin ConditioningPEG-6
HumectantDimethyl Isosorbide
SolventGlyceryl Polymethacrylate
Polysorbate 20
Emulsifying
Sodium Phosphate
BufferingSynthetic Fluorphlogopite
Polysorbate 80
Emulsifying
Carbomer
Emulsion StabilisingHexylene Glycol
EmulsifyingAmmonium Acryloyldimethyltaurate/Vp Copolymer
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingPotassium Hydroxide
BufferingTin Oxide
Abrasive
Disodium Phosphate
BufferingCitric Acid
Buffering
Disodium EDTA
ChelatingSodium Citrate
BufferingPhenoxyethanol
Preservative
Potassium Sorbate
Preservative
CI 77891
Cosmetic ColorantWater, Dimethicone, Isododecane, Butylene Glycol, Glycerin, Polysilicone-11, Ascorbyl Glucoside, Sodium Hyaluronate, Tocopheryl Acetate, Squalane, Hypnea Musciformis Extract, Gelidiella Acerosa Extract, Sigesbeckia Orientalis Extract, Helianthus Annuus Seed Extract, Hordeum Vulgare Extract, Triticum Vulgare Germ Extract, Cucumis Sativus Fruit Extract, Caffeine, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, PEG-10 Dimethicone, Glycyrrhetinic Acid, Whey Protein, Isohexadecane, Propylene Glycol Dicaprate, Caprylyl Glycol, Hydroxypinacolone Retinoate, Acetyl Glucosamine, Cholesterol, PEG-8, Faex Extract, PEG-6, Dimethyl Isosorbide, Glyceryl Polymethacrylate, Polysorbate 20, Sodium Phosphate, Synthetic Fluorphlogopite, Polysorbate 80, Carbomer, Hexylene Glycol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Potassium Hydroxide, Tin Oxide, Disodium Phosphate, Citric Acid, Disodium EDTA, Sodium Citrate, Phenoxyethanol, Potassium Sorbate, CI 77891
Hippophae Rhamnoides Extract
MaskingMethylpropanediol
SolventButylene Glycol
Humectant
Niacinamide
Smoothing
Glyceryl Glucoside
Humectant
Rosmarinus Officinalis Extract
AntimicrobialCamellia Japonica Flower Extract
EmollientCalendula Officinalis Extract
Skin Conditioning
Chamomilla Recutita Extract
Skin Conditioning
Dipropylene Glycol
HumectantGeranium Maculatum Extract
TonicLavandula Angustifolia Extract
Skin Conditioning
Thymus Vulgaris Extract
Perfuming
Origanum Vulgare Flower/Leaf/Stem Extract
Skin ConditioningMilk Protein Extract
Avena Sativa Kernel Extract
Abrasive
Camellia Sinensis Leaf Extract
Antimicrobial
Citrus Limon Fruit Extract
Masking
Brassica Oleracea Italica Extract
AstringentBrassica Oleracea Acephala Leaf Extract
HumectantSolanum Lycopersicum Fruit Extract
Antioxidant
Diospyros Kaki Leaf Extract
Skin Protecting
Fragaria Vesca Fruit Extract
AstringentBrassica Oleracea Capitata Leaf Extract
Skin ConditioningAsparagus Officinalis Extract
Skin ConditioningCapsicum Annuum Fruit Extract
Antimicrobial
Salicornia Herbacea Extract
Skin ConditioningPhragmites Communis Extract
Skin ConditioningDaucus Carota Sativa Root Extract
Skin Conditioning
Ilex Paraguariensis Leaf Extract
Perfuming
Borago Officinalis Extract
Emollient
Corchorus Olitorius Leaf Extract
Skin ConditioningFicus Carica Fruit Extract
Humectant
Punica Granatum Fruit Extract
Antioxidant
Morus Alba Fruit Extract
Antioxidant
Ginkgo Biloba Nut Extract
Skin ConditioningCentella Asiatica Extract
Cleansing
Saccharomyces/Rice Bran Ferment
Humectant
Helianthus Annuus Seed Oil
Emollient
Madecassoside
Antioxidant
Mangifera Indica Seed Butter
Skin Conditioning
Astrocaryum Murumuru Seed Butter
Emollient
Theobroma Grandiflorum Seed Butter
Skin Conditioning
Butyrospermum Parkii Butter
Skin Conditioning
Hydrolyzed Pea Protein
EmollientHydrolyzed Collagen
Emollient
Desamido Collagen
Skin Conditioning
Collagen
Moisturising
Procollagen
Skin Conditioning
Atelocollagen
Skin Conditioning
Soluble Collagen
Humectant
Collagen Amino Acids
Moisturising
Sodium Hyaluronate
Humectant
Hydrolyzed Glycosaminoglycans
HumectantSodium Hyaluronate Crosspolymer
Humectant
Hydrolyzed Hyaluronic Acid
Humectant
Sodium Acetylated Hyaluronate
Humectant
Hyaluronic Acid
Humectant
Hydroxypropyltrimonium Hyaluronate
Panthenol
Skin Conditioning
Hydrogenated Lecithin
Emulsifying
Retinol
Skin Conditioning
Ceramide NP
Skin Conditioning
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingGlycerin
Humectant
Allantoin
Skin Conditioning
Hydroxyethylcellulose
Emulsion StabilisingOctyldodecanol
Emollient
Asiaticoside
Antioxidant
Inulin Lauryl Carbamate
Emulsion StabilisingDipotassium Glycyrrhizate
Humectant
Pantolactone
Humectant
Ascorbic Acid
Antioxidant
Hydrolyzed Elastin
EmollientCyanocobalamin
Skin ConditioningPyridoxine Hcl
Skin ConditioningTocopherol
Antioxidant
Glycine
Buffering
Serine
Masking
Aspartic Acid
Masking
Leucine
Skin ConditioningAlanine
Masking
Lysine
Skin ConditioningTyrosine
MaskingPhenylalanine
Masking
Valine
MaskingThreonine
Proline
Skin Conditioning
Isoleucine
Skin ConditioningHistidine
Humectant
Methionine
Skin ConditioningCysteine
Antioxidant
Caffeoyl Tripeptide-1
Antioxidant
Palmitoyl Pentapeptide-4
Skin Conditioning
Sh-Octapeptide-4
Antioxidant
Sh-Pentapeptide-19
Skin Conditioning
Nicotinoyl Tripeptide-1
Antioxidant
Sh-Decapeptide-9
Skin Conditioning
Caffeoyl Sh-Octapeptide-4
Antioxidant
Acetyl Hexapeptide-8
Humectant
Caprylyl Glycol
Emollient
Benzyl Glycol
SolventHydroxyacetophenone
Antioxidant
Ethylhexylglycerin
Skin ConditioningSodium Surfactin
CleansingRaspberry Ketone
Masking
Propanediol
Solvent
Polysorbate 20
Emulsifying
Polyglyceryl-10 Laurate
Skin Conditioning
Tromethamine
BufferingGlutamic Acid
Humectant
Arginine
Masking
1,2-Hexanediol
Skin Conditioning
Xanthan Gum
EmulsifyingAdenosine
Skin Conditioning
Disodium EDTA
ChelatingHippophae Rhamnoides Extract, Methylpropanediol, Butylene Glycol, Niacinamide, Glyceryl Glucoside, Rosmarinus Officinalis Extract, Camellia Japonica Flower Extract, Calendula Officinalis Extract, Chamomilla Recutita Extract, Dipropylene Glycol, Geranium Maculatum Extract, Lavandula Angustifolia Extract, Thymus Vulgaris Extract, Origanum Vulgare Flower/Leaf/Stem Extract, Milk Protein Extract, Avena Sativa Kernel Extract, Camellia Sinensis Leaf Extract, Citrus Limon Fruit Extract, Brassica Oleracea Italica Extract, Brassica Oleracea Acephala Leaf Extract, Solanum Lycopersicum Fruit Extract, Diospyros Kaki Leaf Extract, Fragaria Vesca Fruit Extract, Brassica Oleracea Capitata Leaf Extract, Asparagus Officinalis Extract, Capsicum Annuum Fruit Extract, Salicornia Herbacea Extract, Phragmites Communis Extract, Daucus Carota Sativa Root Extract, Ilex Paraguariensis Leaf Extract, Borago Officinalis Extract, Corchorus Olitorius Leaf Extract, Ficus Carica Fruit Extract, Punica Granatum Fruit Extract, Morus Alba Fruit Extract, Ginkgo Biloba Nut Extract, Centella Asiatica Extract, Saccharomyces/Rice Bran Ferment, Helianthus Annuus Seed Oil, Madecassoside, Mangifera Indica Seed Butter, Astrocaryum Murumuru Seed Butter, Theobroma Grandiflorum Seed Butter, Butyrospermum Parkii Butter, Hydrolyzed Pea Protein, Hydrolyzed Collagen, Desamido Collagen, Collagen, Procollagen, Atelocollagen, Soluble Collagen, Collagen Amino Acids, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Panthenol, Hydrogenated Lecithin, Retinol, Ceramide NP, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glycerin, Allantoin, Hydroxyethylcellulose, Octyldodecanol, Asiaticoside, Inulin Lauryl Carbamate, Dipotassium Glycyrrhizate, Pantolactone, Ascorbic Acid, Hydrolyzed Elastin, Cyanocobalamin, Pyridoxine Hcl, Tocopherol, Glycine, Serine, Aspartic Acid, Leucine, Alanine, Lysine, Tyrosine, Phenylalanine, Valine, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine, Caffeoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Sh-Octapeptide-4, Sh-Pentapeptide-19, Nicotinoyl Tripeptide-1, Sh-Decapeptide-9, Caffeoyl Sh-Octapeptide-4, Acetyl Hexapeptide-8, Caprylyl Glycol, Benzyl Glycol, Hydroxyacetophenone, Ethylhexylglycerin, Sodium Surfactin, Raspberry Ketone, Propanediol, Polysorbate 20, Polyglyceryl-10 Laurate, Tromethamine, Glutamic Acid, Arginine, 1,2-Hexanediol, Xanthan Gum, Adenosine, Disodium EDTA
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium Hyaluronate
