Y.O.U Acneplus Spot Care Pro Serum
A serum with 71 ingredients, including BHA, PHA, and niacinamide.
This acne serum is formulated around Niacinamide and Salicylic Acid to clear breakouts and calm redness.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningPropanediol
SolventNiacinamide
SmoothingEthylhexyl Palmitate
EmollientPolysorbate 60
EmulsifyingPropylene Glycol
HumectantCaprylic/Capric Triglyceride
MaskingCetearyl Alcohol
EmollientDimethicone
EmollientSorbitan Stearate
EmulsifyingHydroxyethylpiperazine Ethane Sulfonic Acid
BufferingHydroxypropyl Cyclodextrin
MaskingIsononyl Isononanoate
EmollientGlyceryl Stearate
EmollientPEG-100 Stearate
SurfactantPanthenol
Skin ConditioningCetyl Alcohol
EmollientLaurocapram
Skin ConditioningGalla Rhois Gallnut Extract
AntimicrobialPolyacrylate-13
Phenoxyethanol
PreservativeGlycerin
HumectantButylene Glycol
HumectantTriethanolamine
BufferingHydroxyacetophenone
AntioxidantMenthol
MaskingSalvia Miltiorrhiza Root Extract
Skin ConditioningPaeonol
AntioxidantDipotassium Glycyrrhizate
HumectantScutellaria Baicalensis Root Extract
AstringentAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingPolyisobutene
Xanthan Gum
EmulsifyingDisodium EDTA
Polysorbate 20
EmulsifyingCamphor
MaskingSorbitan Isostearate
EmulsifyingSalicylic Acid
MaskingAllantoin
Skin ConditioningGluconolactone
Skin ConditioningAstragalus Membranaceus Root Extract
EmollientSclerotium Gum
Emulsion Stabilising1,2-Hexanediol
Skin ConditioningCaprylyl Glycol
EmollientSaposhnikovia Divaricata Root Extract
AntimicrobialPapain
Skin ConditioningPentylene Glycol
Skin ConditioningCalendula Officinalis Flower Extract
MaskingAlbizia Julibrissin Flower Extract
Skin ConditioningGastrodia Elata Root Extract
Skin ConditioningCentella Asiatica Extract
CleansingQuaternium-73
Gentiana Scabra Root Extract
Skin ConditioningCapryloyl Glycine
CleansingHexylene Glycol
EmulsifyingMelaleuca Alternifolia Leaf Oil
AntioxidantPhellodendron Amurense Bark Extract
Skin ConditioningSophora Angustifolia Root Extract
Skin ConditioningRheum Palmatum Root Extract
AstringentSarcosine
Skin ConditioningMadecassoside
AntioxidantCinnamomum Zeylanicum Bark Extract
AntimicrobialAsiaticoside
AntioxidantAnthemis Nobilis Flower Oil
MaskingGlyceryl Caprylate
EmollientHydroxycinnamic Acid
Skin ConditioningRutin
AntioxidantAsiatic Acid
Skin ConditioningStephania Tetrandra Root Extract
Skin ConditioningMadecassic Acid
Skin ConditioningZinc PCA
HumectantWater, Propanediol, Niacinamide, Ethylhexyl Palmitate, Polysorbate 60, Propylene Glycol, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Dimethicone, Sorbitan Stearate, Hydroxyethylpiperazine Ethane Sulfonic Acid, Hydroxypropyl Cyclodextrin, Isononyl Isononanoate, Glyceryl Stearate, PEG-100 Stearate, Panthenol, Cetyl Alcohol, Laurocapram, Galla Rhois Gallnut Extract, Polyacrylate-13, Phenoxyethanol, Glycerin, Butylene Glycol, Triethanolamine, Hydroxyacetophenone, Menthol, Salvia Miltiorrhiza Root Extract, Paeonol, Dipotassium Glycyrrhizate, Scutellaria Baicalensis Root Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Polyisobutene, Xanthan Gum, Disodium EDTA, Polysorbate 20, Camphor, Sorbitan Isostearate, Salicylic Acid, Allantoin, Gluconolactone, Astragalus Membranaceus Root Extract, Sclerotium Gum, 1,2-Hexanediol, Caprylyl Glycol, Saposhnikovia Divaricata Root Extract, Papain, Pentylene Glycol, Calendula Officinalis Flower Extract, Albizia Julibrissin Flower Extract, Gastrodia Elata Root Extract, Centella Asiatica Extract, Quaternium-73, Gentiana Scabra Root Extract, Capryloyl Glycine, Hexylene Glycol, Melaleuca Alternifolia Leaf Oil, Phellodendron Amurense Bark Extract, Sophora Angustifolia Root Extract, Rheum Palmatum Root Extract, Sarcosine, Madecassoside, Cinnamomum Zeylanicum Bark Extract, Asiaticoside, Anthemis Nobilis Flower Oil, Glyceryl Caprylate, Hydroxycinnamic Acid, Rutin, Asiatic Acid, Stephania Tetrandra Root Extract, Madecassic Acid, Zinc PCA
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideEthylhexyl Palmitate, also known as octyl palmitate, is created from 2-ethylhexyl alcohol and palmitic acid.
In cosmetics, it plays many roles:
One thing worth noting: a controlled study found this ingredient applied under occlusion to acne-prone subjects increased microcomedones. Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day.
For most people, this is a well-tolerated and lightweight ingredient.
This ingredient may not be fungal acne safe because it is an ester of palmitic acid, a C16 fatty acid that falls within the C11-24 range that Malassezia can metabolize.
Learn more about Ethylhexyl PalmitatePolysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideCetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Learn more about Cetearyl AlcoholDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeSorbitan Stearate is an emulsifier made by reacting sorbitol with stearic acid.
It's mostly used to keep oil and water mixed so your formulas stay smooth and stable.
The Cosmetic Ingredient Review has found 4% of this ingredient in repeat-insult patch tests on humans to be non-sensitizing. There is a caveat that some reactions have shown up in patients with damaged or diseased skin.
Because it is an ester of a C18 fatty acid, it falls into the C11-24 range that the Malassezia yeast can metabolize. This means this ingredient may not be fungal acne safe.
Learn more about Sorbitan StearateWe don't have a description for Hydroxyethylpiperazine Ethane Sulfonic Acid yet.
This ingredient is used in skincare as a delivery system.
It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.
According to a manufacturer, it also offer some moisturizing effects.
Learn more about Hydroxypropyl CyclodextrinIsononyl Isononanoate is a synthetic skin-conditioner and texture enhancer. It is created from nonanoic acid, a fatty acid found in cocoa and lavender oil.
As an emollient, Isononyl Isononanoate helps keep your skin soft and smooth. This is because emollients create a barrier on the skin to trap moisture in.
Isononyl Isononanoate helps give products a velvet feel and improves spreadability.
Learn more about Isononyl IsononanoateGlyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Learn more about Glyceryl StearatePeg-100 Stearate is an emollient and emulsifier. As an emollient, it helps keep skin soft by trapping moisture in. On the other hand, emulsifiers help prevent oil and water from separating in a product.
PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolCetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Learn more about Cetyl AlcoholWe don't have a description for Laurocapram yet.
Galla Rhois Gallnut Extract is an antioxidant.
Polyacrylate-13 is a type of acrylate polymer. Acrylate polymers are commonly used as adhesives in cosmetics.
Polyacrylate-13 creates a film to protect the skin. It is also used to thicken and stabilize a product. It works by making water a gel-like consistency. This gel consistency helps suspend particles.
Polyacrylate-13 is a copolymer of acrylic acid, acrylamide, sodium acrylate, sodium acryloyldimethyltaurate monomers
Learn more about Polyacrylate-13Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolTriethanolamine (TEA) is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.
As an emulsifier, it prevents ingredients from separating and enhances texture by adding volume to a product.
PH adjusters are common in cosmetic products. The pH of a product can affect the effectiveness of other ingredients. A product with a high pH may also irritate the skin.
If you are looking for the tea leaf ingredient, click here.
Learn more about TriethanolamineHydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
Learn more about HydroxyacetophenoneMenthol is a compound found in mint plants, such as peppermint. In its pure form, it is a clear crystalline substance.
Menthol is known for its cooling sensation; however, the cooling is actually from your skin being sensitized. Menthol can worsen rosacea. We recommend speaking with a professional if you have concerns.
Menthol also has antimicrobial properties.
Learn more about MentholWe don't have a description for Salvia Miltiorrhiza Root Extract yet.
Paeonol is an antioxidant.
Dipotassium Glycyrrhizate comes from licorice root.
Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.
One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.
Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.
Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.
Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.
Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.
Learn more about Dipotassium GlycyrrhizateScutellaria Baicalensis Root Extract comes from the Baikal skullcap or Chinese skullcap plant. This plant is native to Northeast Asia and can be found in China, Mongolia, Korea, and Siberia.
In cosmetics, Scutellaria Baicalensis Root Extract provides antioxidant and anti-inflammatory benefits. This is due to the flavonoid composition of Scutellaria Baicalensis Root Extract.
In Chinese traditional folk medicine, Scutellaria Baicalensis Root Extract is used to help treat lung issues and hypertension.
Learn more about Scutellaria Baicalensis Root ExtractAcrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Learn more about Acrylates/C10-30 Alkyl Acrylate CrosspolymerPolyisobutene is a synthetic polymer made from isobutene.
It is a film-forming agent and helps bind ingredients together.
Polyisobutene is not absorbed by the skin.
Learn more about PolyisobuteneXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAPolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Camphor is a waxy solid with a strong scent. It is made using turpentine oil.
This ingredient is used for medicinal purposes due to its cooling effect. In medicine, camphor is a common anti-inflammation ingredient.
Camphor also possesses antibacterial and antifungal properties.
One study found camphor to be a potential anti-wrinkle ingredient. This might be due to its ability to increase elastin and collagen production. Collagen and elastin are responsible for plump and youthful looking skin.
It is best to use cosmetics with a small amount of camphor under 11%. Using topical camphor may induce irritation and redness.
In the past, camphor was traditionally made by distilling the wood of the camphor tree.
Learn more about CamphorSorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Learn more about Sorbitan IsostearateSalicylic Acid (also known as beta hydroxy acid or BHA) is a well-known ingredient for treating skin that struggles with acne and clogged pores. It exfoliates both the skin's surface and deep within the pores to help clear out buildup, control oil, and reduce inflammation.
Unlike AHAs (alpha hydroxy acids), salicylic acid is oil-soluble. This allows it to penetrate into pores which makes it especially effective for treating blackheads and preventing future breakouts.
Salicylic acid is also known for its soothing properties. It has a similar structure to aspirin and can calm inflamed or irritated skin, making it a good option for acne-prone skin that is also sensitive.
Concentrations of 0.5-2% are recognized by the U.S. FDA as an over-the-counter topical acne product.
It can cause irritation and/or dryness if one's skin already has a compromised moisture barrier, so it's best to focus on repairing that before introducing this ingredient into your routine.
While salicylic acid does not increase sun sensitivity, it’s still important to wear sunscreen daily to protect your skin.
If you are looking for the ingredient called BHA or Butylated Hydroxyanisole, click here.
Learn more about Salicylic AcidAllantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Learn more about AllantoinGluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.
When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.
PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.
Gluconolactone has some interesting properties:
In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily.
This ingredient is is an created by reacting gluconic acid with an alcohol.
Learn more about GluconolactoneAstragalus Membranaceus Root Extract is from an herb called Huang Qi. The roots of this plant have traditionally used in traditional Chinese medicine.
This ingredient contains hydrating, antioxidant, and anti-inflammatory compounds such as polysaccharides, saponins, and flavonoids. These compounds have also been studied for its effects on skin repair like fibroblast activity, growth-factor signaling, and wound closure models. However, human evidence is still limited.
Recent clinical work on a proprietary Astragalus + Centella saponin system showed improvement in skin aging and quality.
Overall, this ingredient is a great supportive ingredient with low irritation risk.
Learn more about Astragalus Membranaceus Root ExtractSclerotium Gum is a natural sugar-based fiber made by fermenting a fungus called Sclerotium rolfsii. It's often used as the plant-friendly alternative for synthetic thickeners like carbomer.
In skincare, it works as a thickener, gel former, and stabilizer that keeps heavy ingredients suspended so a product does not separate.
It is non-ionic and forms a triple helix in solution. This is just a fancy way of saying it builds a smooth, cushiony, and non-sticky gel that feels silkier than many other gums.
Another perk of this ingredient is that it is very sturdy and holds up across a wide pH range (~2-11). It's also good at resisting heat and hydrolysis.
Since it holds water at the skin surface, it can provide some light hydration as well.
Typical use levels are around 0.25-2%; formulators usually use 0.2-0.5% to thicken lotions and up to 2% for a firmer gel base.
This ingredient has been found safe in cosmetics with no meaningful evidence of skin sensitization.
Learn more about Sclerotium Gum1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolWe don't have a description for Saposhnikovia Divaricata Root Extract yet.
Papain is a proteolytic enzyme extracted from unripe papaya fruit. It is a gentle exfoliator that helps remove the dead skin cells from your outermost layer of skin.
Basically, papain works by dissolving the "glue" holding dead skin cells to your skin's surface. This also promotes cell turnover and smooths texture.
Unlike other exfoliants, papain can work without causing significant irritation.
Beyond exfoliation, its proteolytic action also helps soothe irritated skin and supports the healing of minor wounds.
A 2024 in vivo/in vitro study confirmed its potential to suppress skin inflammation and improve transepidermal water loss (TEWL) in atopic dermatitis models.
Just one thing worth noting: there are reports of allergic responses in individuals with a papaya or latex sensitivity. Be sure to patch test if you're in this camp.
Learn more about PapainPentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolCalendula Officinalis Flower Extract comes from the marigold flower and has been used on skin for centuries for its calming effect.
In the lab, its active compounds appear to calm inflammation and support the early "healing" phase of minor wounds.
This is why Europe's medicines regulator has approved calendula extracts as a traditional remedy for minor skin inflammation and healing small wounds.
The stronger human evidence is around would/ulcer care rather than everyday cosmetic claims; a review that pulled together 14 studies found that calendula helped calm the early, inflamed stage of a wound and helped new skin tissue form faster.
Two studies also showed it shrank leg ulcers (the kind caused by poor circulation). Results were mixed for burns and for the skin irritation people get from radiation treatment, so it's not a sure thing there.
In cosmetics, it's mostly a skin conditioning and soothing agent.
The Cosmetic Ingredient Review panel concluded that calendula-derived ingredients are safe as used and that the ingredients are not irritating, sensitizing, or photosensitizing in clinical tests (though they may be mild eye irritants).
Typical use levels are quite low; industry data reported it used at under 0.5% (one supplier noted a 10-25% extract blend used at 1-10% in the finished product). Historical use goes up to 10%.
The only thing to keep in mind is if you have daisy/ragweed allergies. Calendula is in the same family and one patch-test study found 2% of dermatitis patients reacted to marigold. Be sure to patch test if you have sensitive or allergy-prone skin.
Learn more about Calendula Officinalis Flower ExtractWe don't have a description for Albizia Julibrissin Flower Extract yet.
We don't have a description for Gastrodia Elata Root Extract yet.
Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.
That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.
These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.
Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.
Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.
Here is the short version of what they do in the skin:
So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.
Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:
Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.
Centella is one of the most easygoing actives out there.
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.
On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.
Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.
But as with any new active, a patch test is still a smart move for very reactive skin.
Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).
The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).
In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.
Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractWe don't have a description for Quaternium-73 yet.
We don't have a description for Gentiana Scabra Root Extract yet.
Capryloyl Glycine is created by adding an acyl group to glycine and caprylic acid chloride.
It is a cleanser due to its surfactant properties. Surfactants help dirt, oil, and other polluants be more easily rinsed away. According to manufacturers, Capryloyl Glycine also helps soften the skin and regulate sebum production.
Emerging studies show Capryloyl Glycine may inhibit hair growth. It may also cause allergies for some people. We recommend speaking with a professional if you have any questions about this ingredient.
Learn more about Capryloyl GlycineHexylene Glycol is a multitasker ingredient that works as a solvent, humectant, emulsifier, viscosity reducer, and preservative booster.
It is able to dissolve both water and oil-soluble ingredients to stabilize tricky actives and make products spread more easily.
As a humectant, it pulls water into the skin. But it's a pretty minor moisturizing ingredient compared to other humectants, like glycerin.
Interestingly, it can act as a mild penetration enhancer. One in vitro study on human skin found a 12% concentration upped the absorption of mometasone furoate (a medicinal ingredient used to treat inflammatory skin conditions) up to 7%.
This ingredient is typically used at levels of 0.1-10% depending on the role it's playing.
A patch test study on eczema patients didn't find a significant increase in irritation versus the control group, but the potential for irritation rises at higher concentrations.
Learn more about Hexylene GlycolThis ingredient is also known as tea tree oil. It has antioxidant, anti-inflammatory, and antimicrobial properties.
Tea tree oil is a complex lipophilic (fat-loving) oil that contains around 100 compounds with terpinen-4-ol being the most abundant (~40%).
Terpinen-4-ol is responsible for tea tree oil's broad-spectrum antimicrobial activity and makes it a well-researched option for acne.
Clinical studies support 5% tea tree oil as an effective topical treatment for mild to moderate acne. A study with 124 patients compared 5% tea tree oil gel to 5% benzoyl peroxide and both reduced acne (though tea tree oil worked more slowly).
Besides acne, it is also seen in anti-dandruff shampoos and scalp treatments for it's antimicrobial and anti-seborrheic properties.
Safety-wise, the allergic potential of low concentrations on healthy skin is considered low. However, oxidized (old or improperly stored) tea tree oil is a stronger sensitizer.
Irritation can also occur if using the undiluted oil on skin; it's best to use this ingredient as part of a carefully crafted cosmetic formula. This is because regulations require tea tree oil in cosmetics to be stabilized to prevent degradation.
This ingredient has been deemed safe up to 2% in shampoo, 1% in cleansers, and 0.1% in face cream by the EU's Scientific Committee on Consumer Safety (SCCS).
There is some lab evidence that tea tree oil is antifungal against Malassezia, but it is a supportive option at best and not a replacement for proven antifungal treatments.
Learn more about Melaleuca Alternifolia Leaf OilThis ingredient is also known as Amur cork tree bark. It is a botanical extract with skin conditioning and tonic properties.
Amur tree bark is rich in compounds, such as berberine and palmatine, that are widely studied for antioxidant and anti-inflammatory activity.
In lab research, this ingredient has been shown to reduce inflammation in skin cells exposed to pollution. The results were also linked to PAR-2 signaling, a pathway involved in irritation and barrier stress. This is why you'll see this ingredient in "anti-pollution" skincare.
Preclinical work also suggests anti-inflammatory benefits in atopic-dermatitis models when used topically.
Please note that these studies do not offer strong proof because they do not involve humans. However, this ingredient has low irritation/risk and there's no harm in trying it out.
Learn more about Phellodendron Amurense Bark ExtractWe don't have a description for Sophora Angustifolia Root Extract yet.
Rheum Palmatum Root Extract can help to reduce redness.
Sarcosine is a skin conditioning ingredient. It is a synthetic amino acid.
It is an intermediate and byproduct in glycine synthesis and degradation. Glycine is an amino acid naturally found in our skin.
This ingredient also goes by the name of methylglycline.
Learn more about SarcosineMadecassoside is one of four active compounds found in Centella asiatica and is one of the main reasons Centella is so effective at calming irritated skin and supporting the moisture barrier.
There's a solid body of peer-reviewed research backing Madecassoside for several skin benefits. Studies have found:
Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.
Learn more about MadecassosideThis cinnamon tree also called true cinnamon or Ceylon cinnamon. It has antimicrobial, emollient, skin hydrating, and antioxidant properties.
This tree is native to Sri Lanka.
Asiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica. It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside.
Research from 2016-2025 supports its role in:
You'll usually find this in concentrations between 0.2-5%.
Learn more about AsiaticosideThis oil is created by distilling the dried flower heads of the Roman Chamomile flower.
Chamomile is rich in antioxidants and has anti-inflammatory properties. Several compounds found in chamomile help with soothing, such as bisbolol.
Glyceryl Caprylate comes from glycerin and caprylic acid. It is an emollient, co-emulsifier, and preservative booster.
Its short C8 fatty acid chain makes it behave differently from its longer-chain emollient cousins like Glyceryl Stearate. It feels more lightweight, fast-absorbing, and silky instead of rich and waxy.
As a co-emulsifier, its "head" and "tail" sit at the oil-water interface. But overall, the short C8 tail and not being water soluble means it doesn't really have the muscle to emulsify a formula on its own. That's why you'll often see it paired with a primary emulsifier like Cetearyl Glucoside.
Interestingly, Glyceryl Caprylate acts as a preservative booster. This is because its fatty-acid backbone disrupts microbial lipid membranes. It shows excellent activity against bacteria and yeast but is weaker against mold.
Typical concentrations range from 0.5-1% and this ingredient is generally non-irritating.
Because this ingredient has a C8 fatty acid chain, it is outside the range that the Malassezia yeast metabolizes (making it fungal acne safe).
Learn more about Glyceryl CaprylateWe don't have a description for Hydroxycinnamic Acid yet.
Rutin is a plant flavonoid with antioxidant and soothing properties. It helps protect skin from oxidative stress caused by UV exposure and pollution.
You'll see rutin show up in products formulated for redness prone or sensitive skin. This is because research has shown rutin to support capillaries and microcirculation.
Compared to newer derivaties like glucosylrutin, rutin is less water-soluble and stable.
Learn more about RutinAsiatic Acid is one of the four main actives found in Centella Asiatica. Its headline job is stimulating collagen.
Lab tests on human skin cells show Asiatic Acid tells your skin to make more collagen, the protein that keeps skin firm and bouncy.
It also calms inflammation and acts as an antioxidant so it can help skin heal faster, rebuild itself, and repair a damaged barrier.
And on naming, even though "acid" is in the name, it's nothing like an AHA or BHA exfoliant. It's a gentle firming and soothing ingredient that supports your skin barrier.
Concentration-wise, Asiatic Acid is potent at very low doses and usually shows up as a small fraction of a broader centella extract.
Analyses of centella material put Asiatic Acid reported in the range of 0.2-3% of the extract.
This ingredient is non-sensitizing and guinea pig sensitization testing also found it to be a weak sensitizer. That means the risk of acquiring contact sensitivty is quite low.
Allergic contact dermatitis does exist but is also very rare; documented cases tend to involve prolonged use on broken skin plus co-sensitization to fragrance ingredients.
Learn more about Asiatic AcidWe don't have a description for Stephania Tetrandra Root Extract yet.
Madecassic Acid is one of the four star actives in Centella Asiatica. In skincare, it earns its keep as a calming and repairing ingredient.
It works through the same core pathways as the rest of the centella family.
First, it turns down inflammation so it helps with things like redness and general upset skin.
Second, it acts as an antioxidant which means it helps protect skin from daily stress and damage.
And third, it nudges the skin to make more collagen and rebuild its support structure.
That combination is why the whole Centella family is known for calming skin, strengthening the barrier, fading redness, and giving anti-aging benefits.
It's worth being honest about the evidence here; a lot of the strongest data is on the full extract or a Madecassoside/Asiaticoside rather than Madecassic Acid alone. Reviewers also note more long-term clinical trials are needed to confirm the full potential.
Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%.
Finished products typically run somewhere in the 0.1-10% range depending on the format.
In real-world tolerance tests, a repeat-insult patch test on an eye lotion with 0.2% Centella extract showed no irritation or allergic contact dermatitis in 54 subjects. And a mascara with 0.5% Madecassoside caused neither irritation nor sensitization in 109 subjects.
Allergy risk is very low, but not zero. Centella and its constituents are classified as weak contact sensitizers and some rare cases of allergic contact dermatitis exist.
Learn more about Madecassic AcidZinc PCA is a clever two-in-one molecule: the zinc salt of pyrrolidone carboxylic acid (PCA).
Think of it as two useful things bonded together; the PCA half is one of your skin's own natural moisturizing factors (NMF) so it helps hold water in the upper layers. On the other hand, the zinc half does the heavy lifting on oil and bacteria.
The zinc part slows down an enzyme that turns testosterone into DHT, the hormone that tells your oil glands to pump out more sebum. Less of that signal means less oil. It also gently fights acne-causing bacteria and soothes redness/irritation.
This is why Zinc PCA often shows up in products for oily, breakout-prone skin and greasy scalps.
One lab study also hinted it might have a small anti-aging perk because it seemed to protect collagen from UVA damage and even helped the skin make a bit more of it. That last bit is still early research done in a dish and not real skin, so take it as a nice bonus rather than a promise for now.
As for scar healing, the picture is more "maybe" than a firm yes. Zinc itself plays a real role in wound repair because it is a cofactor for the enzymes involved in collagen building, calming inflammation, and helping new skin cells cover a wound. Lower zinc levels are also linked to slower healing.
Most of the scar healing research is on zinc oxide or oral zinc rather than zinc PCA specifically, with a focus on healing fresh wounds instead of scars that are already there.
Direct evidence that zinc PCA improves the look of established scars is still limited at this time. Though it would be fair to say zinc PCA supports the general skin-repair environment thanks to its zinc content .
This ingredient is water-soluble and plays nicely with other actives like niacinamide and salicylic acid. It works best at mildly acidic formulas (~4-6 pH) and is effective at low levels. Around 0.1% is enough to be active and finished products commonly use it anywhere up to 4%.
Overall, this is a well-tolerated, low-drama multitasker that suits oily and acne-prone skin.
Learn more about Zinc PCAReviews
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Read more about us· Updated October 10, 2025 • Added by santinomateo