Versus

Centellian24 Madeca Cream Time Reverse Versus Dr. Althea 345 Relief Cream

General Moisturizer
General Moisturizer
Korean Brand South Korea
Korean Brand South Korea

Updated on May 27, 2025

Overview

What they are

These products are both cruelty-free and reef safe general moisturizers. They have a total of 14 ingredients in common

Cool Features

They both contain ceramides, hyaluronic acid, niacinamide and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots

Free From

They both do not contain any harsh alcohols, parabens or sulfates

What's Inside

They both contain common allergens and silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside

What's inside

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Madeca Cream Time Reverse

Lactis Proteinum Extract

Skin Conditioning

Dipropylene Glycol

Masking

Hydrogenated Polydecene

Emollient

Capric Acid

Cleansing
2 / 2 Fragrance Icon

Caprylic/Capric Triglyceride

Masking
Helps hydrate Dry Skin Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Pentaerythrityl Tetraethylhexanoate

Emollient
Helps hydrate Dry Skin Icon

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Cyclohexasiloxane

Emollient
Silicon Icon

Cetyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Polyglyceryl-6 Distearate

Emulsifying
Not safe for Fungal Acne Icon

Water

Skin Conditioning

Dicaprylyl Ether

Emollient
Helps hydrate Dry Skin Icon

Vinyldimethicone

Silicon Icon

Asiaticoside

Antioxidant
Antioxidant IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Madecassic Acid

Skin Conditioning
Helps reduce irritation IconHelps with Anti-Aging Icon

Boric Acid

Antimicrobial

Madecassoside

Antioxidant
Antioxidant IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon

Polypeptide-1

Skin Conditioning
Peptide Icon

Hydrolyzed Hyaluronic Acid

Humectant
Hyaluronic Acid IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing IconHelps brighten skin Icon

Bourbon Extract

Astringent

Inula Racemosa Root Extract

Skin Conditioning

Palau White Clay Extract

Humectant

Macadamia Ternifolia Seed Oil

Emollient
Oil IconNot safe for Fungal Acne Icon

Donkey Oil

Emollient
Oil Icon

Hydrogenated Lecithin

Emulsifying
Helps hydrate Dry Skin Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

Polyglyceryl-10 Laurate

Skin Conditioning
Not safe for Fungal Acne Icon

Stearyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Beeswax

Emulsion Stabilising
0-2 / 0 May worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Xylitylglucoside

Humectant
Helps hydrate Dry Skin Icon

2-Hydroxyethyl Acrylate

Sodium Acryloyldimethyltaurate Crosspolymer

Emulsion Stabilising

Jojoba Esters

Emollient
Not safe for Fungal Acne Icon

Anhydroxylitol

Humectant
Helps hydrate Dry Skin Icon

Polyglyceryl-3 Beeswax

Emulsifying
Not safe for Fungal Acne Icon

1,2-Hexanediol

Skin Conditioning
Helps hydrate Dry Skin Icon

Hydroxyacetophenone

Antioxidant
Antioxidant IconHelps reduce irritation Icon

Xylitol

Humectant
Helps hydrate Dry Skin Icon

Methylpropanediol

Solvent

Propanediol

Solvent
Helps hydrate Dry Skin Icon

Glucose

Humectant
Helps hydrate Dry Skin Icon

Xanthan Gum

Emulsifying

Ethoxydiglycol

Humectant
0 / 0

Disodium Azelate

Adenosine

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sorbitan Isostearate

Emulsifying
1-2 / 0 Not safe for Fungal Acne Icon

Ethylhexylglycerin

Skin Conditioning

Sodium Laurate

Cleansing

Cyclodextrin

Absorbent

Lauric Acid

Cleansing
4 / 1 May worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Sodium Polyacrylate

Absorbent
Helps hydrate Dry Skin Icon

Pvp

Emulsion Stabilising
0 / 0

Pvm/Ma Copolymer

Emulsion Stabilising

Octyldodecanol

Emollient

Glycolide

Humectant

Caffeine

Skin Conditioning
Helps reduce irritation IconHelps with Anti-Aging Icon

C12-13 Alketh-9

Emulsifying

Collagen Amino Acids

Moisturising
Helps hydrate Dry Skin IconHelps with Anti-Aging Icon

Ceramide Eos

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Resveratrol

Antioxidant
Antioxidant IconHelps reduce irritation IconHelps with Anti-Aging IconGood for Dark Spots Icon

Arginine

Masking
Good for Scar Healing IconNot safe for Fungal Acne Icon

Glycol

Humectant
Not safe for Fungal Acne Icon

Ectoin

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation Icon

Taurine

Buffering

Hydrolyzed Elastin

Emollient

Retinol

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Maltodextrin

Absorbent
Helps hydrate Dry Skin Icon

Phytosphingosine

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation Icon

Sucrose Stearate

Emollient
0 / 0

Sodium Dna

Skin Conditioning
Helps with Anti-Aging IconGood for Dark Spots Icon

Cyanocobalamin

Skin Conditioning

Glycine

Buffering
Helps hydrate Dry Skin Icon

Glutamic Acid

Humectant
Helps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Helianthus Annuus Seed

Skin Conditioning
Not safe for Fungal Acne Icon

Polyglycerin-3

Humectant
Helps hydrate Dry Skin Icon

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Artemisia Vulgaris Extract

Skin Conditioning
Helps reduce Skin Redness IconHelps reduce irritation Icon

Vanilla Planifolia Fruit Extract

Skin Conditioning
Helps reduce irritation Icon

Olea Europaea Fruit Oil

Masking
0-2 / 0 Fragrance IconOil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Orange Roughy Oil

Skin Conditioning
Oil Icon

Lavandula Angustifolia Oil

Masking
Fragrance IconOil IconMay cause irritation IconEU Allergen Icon

Citrus Aurantium Bergamia Fruit Oil

Masking
Fragrance IconOil Icon

Pelargonium Roseum Leaf Oil

Perfuming
Fragrance IconOil Icon

Fruit Fly Larva Oil

Emollient
Oil Icon

Curcuma Aromatica Root Oil

Skin Conditioning
Oil Icon

Abies Balsamea Bark Oil

Masking
Oil Icon

Rosa Centifolia Flower Oil

Masking
Oil Icon

Marmot Oil

Oil Icon

Rosa Damascena Flower Oil

Masking
Oil Icon

Geranium Maculatum Oil

Masking
Oil Icon

Myroxylon Pereirae Resin

Masking
May cause irritation IconEU Allergen Icon

Linalool

Perfuming
Fragrance IconMay cause irritation IconEU Allergen IconMay worsen Eczema IconMay worsen Rosacea Icon

Limonene

Perfuming
Fragrance IconMay cause irritation IconEU Allergen IconMay worsen Eczema IconMay worsen Rosacea Icon

Pinus Mugo Leaf Oil

Masking
Fragrance IconOil IconMay cause irritation IconEU Allergen Icon

Lactis Proteinum Extract, Dipropylene Glycol, Hydrogenated Polydecene, Capric Acid, Caprylic/Capric Triglyceride, Glycerin, Glyceryl Stearate, Pentaerythrityl Tetraethylhexanoate, Niacinamide, Cyclohexasiloxane, Cetyl Alcohol, Polyglyceryl-6 Distearate, Water, Dicaprylyl Ether, Vinyldimethicone, Asiaticoside, Madecassic Acid, Boric Acid, Madecassoside, Polypeptide-1, Hydrolyzed Hyaluronic Acid, Bourbon Extract, Inula Racemosa Root Extract, Palau White Clay Extract, Macadamia Ternifolia Seed Oil, Donkey Oil, Hydrogenated Lecithin, Sodium Hyaluronate, Polyglyceryl-10 Laurate, Stearyl Alcohol, Beeswax, Xylitylglucoside, 2-Hydroxyethyl Acrylate, Sodium Acryloyldimethyltaurate Crosspolymer, Jojoba Esters, Anhydroxylitol, Polyglyceryl-3 Beeswax, 1,2-Hexanediol, Hydroxyacetophenone, Xylitol, Methylpropanediol, Propanediol, Glucose, Xanthan Gum, Ethoxydiglycol, Disodium Azelate, Adenosine, Sorbitan Isostearate, Ethylhexylglycerin, Sodium Laurate, Cyclodextrin, Lauric Acid, Sodium Polyacrylate, Pvp, Pvm/Ma Copolymer, Octyldodecanol, Glycolide, Caffeine, C12-13 Alketh-9, Collagen Amino Acids, Ceramide Eos, Resveratrol, Arginine, Glycol, Ectoin, Taurine, Hydrolyzed Elastin, Retinol, Maltodextrin, Phytosphingosine, Sucrose Stearate, Sodium Dna, Cyanocobalamin, Glycine, Glutamic Acid, Helianthus Annuus Seed, Polyglycerin-3, Tocopherol, Artemisia Vulgaris Extract, Vanilla Planifolia Fruit Extract, Olea Europaea Fruit Oil, Orange Roughy Oil, Lavandula Angustifolia Oil, Citrus Aurantium Bergamia Fruit Oil, Pelargonium Roseum Leaf Oil, Fruit Fly Larva Oil, Curcuma Aromatica Root Oil, Abies Balsamea Bark Oil, Rosa Centifolia Flower Oil, Marmot Oil, Rosa Damascena Flower Oil, Geranium Maculatum Oil, Myroxylon Pereirae Resin, Linalool, Limonene, Pinus Mugo Leaf Oil

345 Relief Cream

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservatives 
Masking, Skin Conditioning

This ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.

Learn more about Caprylic/Capric Triglyceride
Emollient, Skin Conditioning, Solvent

Cyclohexasiloxane is a type of silicone more commonly known as D6. It is an emollient and solvent.

Cyclohexasiloxane is used to evenly distribute ingredients throughout the product. When applied to the skin, Cyclohexasiloxane evaporates and leaves behind a silky feel.

As an emollient, it can help the skin feel soft and hydrated. It is also used to reduce frizz in hair products.

Learn more about Cyclohexasiloxane
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Masking, Skin Conditioning

Hydrogenated Polydecene is an emollient. It creates a non-occlusive film on the skin that offers extra protection for your skin barrier.

The texture of Hydrogenated Polydecene ranges from light and silky to rich.

Hydrogenated Polydecene is the end compound of controlled hydrogenation of Polydecene.

Learn more about Hydrogenated Polydecene
Humectant, Skin Conditioning

Hydrolyzed Hyaluronic Acid is a form of hyaluronic acid. It is created by the hydrolysis of hyaluronic acid with a high molecular weight. Once created, Hydrolyzed Hyaluronic Acid has a low molecular weight.

Low molecular weight HA has been shown to hydrate and increase elasticity of the skin. Increasing elasticity is also associated with reduction of wrinkle depth.

One study found topical low molecular weight hyaluronic acid may be considered for the treatment of rosacea in the adult population. However, we always recommend speaking with a professional about your skin concerns.

Hyaluronic acids are a humectant. This means they draw moisture from the air. Hyaluronic acids help moisturize, soothe, and protect the skin.

Read more about other common forms of hyaluronic acid:

Learn more about Hydrolyzed Hyaluronic Acid
Smoothing

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Learn more about Niacinamide
Humectant

Polyglycerin-3 is a 3-unit glycerin polymer.

Like glycerin, this ingredient is a humectant. Humectants help hydrate your skin by drawing water to it.

Having moisturized skin helps improve the skin barrier. Your skin barrier helps protect against irritants and bacteria.

Learn more about Polyglycerin-3
Solvent

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin. 

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Learn more about Propanediol
Antioxidant, Skin Protecting

Resveratrol is a famous emerging antioxidant. It is a good alternative for sensitive skin types who cannot tolerate retinoids.

This antioxidant is most famous for it's anti-aging benefits. Studies show it combats the signs of aging by:

Besides anti-aging, this ingredient also helps with skin brightening and soothing.

The most effective forms of resveratrol are isobutyrate and butyrate. These have the strongest effect on increasing A1 collagen and reducing inflammation.

A note on it being a retinoid alternative:
Despite it's amazing skin benefits, it is not a replacement for retinoids. However, it is recommended for people with sensitive skin or intolerance to retinoids.

Resveratrol is naturally found in grapes, peanuts, and berries.

Learn more about Resveratrol
Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Antioxidant, Masking, Skin Conditioning

Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.

Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.

Learn more about Tocopherol
Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

When to use

11 Routines
36% use in am
64% use in pm
82% use every day
4,734 Routines
46% use in am
54% use in pm
97% use every day
When to use See routines that use it ->

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Dr. Althea 345 Relief Cream 38 ingredients

2.80
Overall rating
5
4
3
2
1
What people say
Light 44% Absorbs Well 44% Broke Me Out 43%