Sesderma Sesretinal Mature Skin Facial Gel Cream - Russia Versus Sesderma Sesretinal Liposomal Serum
Updated on February 23, 2025
Overview
What they are
These products are both cruelty-free . They have a total of 43 ingredients in common
Cool Features
They both contain AHA, hyaluronic acid, peptides, PHA, retinoid and Vitamin E
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any common allergens or parabens
What's Inside
They both contain harsh alcohols, fragrances, oils, silicones and sulfates
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Sesderma Sesretinal Mature Skin Facial Gel Cream 66 ingredients
Sesderma Sesretinal Liposomal Serum 61 ingredients
What's inside
What's inside
At a glance
Click on any of the items below to learn more
Sesderma Sesretinal Mature Skin Facial Gel Cream 66 ingredients
Sesderma Sesretinal Liposomal Serum 61 ingredients
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Alcohol comes in many different forms. Different types of alcohol will have different effects on skin. This ingredient is usually an astringent alcohol.
These alcohols are drying on the skin. They may strip away your skin's natural oils and even damage your skin barrier. Astringent alcohols may also irritate skin.
Other types of astringent alcohols include:
According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.
Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.
Fatty alcohols come from plant oils such as coconut oil. These can help hydrate the skin and are non-irritating. Some fatty alcohols include cetyl and stearyl alcohol.
Learn more about AlcoholAmmonium Acryloyldimethyltaurate/Vp Copolymer (let's call it AAVC for short) is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
AAVC is able to increase the consistency and viscosity of products due to its large molecule size. It also prevents ingredients from separating.
Bakuchiol is a plant-derived antioxidant (it's vegan!). It is often called the replacement for retinol although it is not part of the same family.
It has similar effects as retinol: skin smoothing, reducing discoloration, and preventing wrinkles. It does not cause as much irritation as traditional retinoids.
Bakuchiol works by breaking down free radicals and stimulating collagen production in skin.
Combining bakuchiol with retinol will not have adverse side effects. Studies show using them will just boost the benefits. Bakuchiol is also found to help stabilize retinol.
While bakuchiol does not make the skin more sun sensitive, we recommend wearing SPF on a daily basis.
Read more about traditional retinol
Learn more about BakuchiolWe don't have a description for Bidens Pilosa Extract yet.
We don't have a description for Ceteth-20 yet.
Dipotassium Phosphate is an inorganic salt. This just means it has a different structure than organic salts. It is a stabilizing and pH adjusting ingredient.
This ingredient is soluble in water.
Disodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAElaeis Guineensis Oil comes from the African Palm tree. This tree is native to Western and Southwestern Africa.
This oil is rich in antioxidants such as Vitamin E. Antioxidants may help with anti-aging.
The Vitamin E and fatty acid content give palm oil a skin-hydrating property. Emollients help trap moisture in by creating a film on the skin.
Palm oil is created by either squeezing the fruit or crushing the kernel at the center of the fruit. In the 1800s, archaeologists discovered a 6000 year old Egyptian tomb containing palm oil.
Palm oil is controversial due to its social and environmental impacts. Several organizations are working to make palm oil harvest more sustainable, such as the RSPO.
Learn more about Elaeis Guineensis OilEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Gluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.
When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.
PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.
Gluconolactone has some interesting properties:
In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily.
This ingredient is is an created by reacting gluconic acid with an alcohol.
Learn more about GluconolactoneWe don't have a description for Glucosamine Hcl yet.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlyceryl Stearate is a mix of glycerin and stearic acid.
It is used to stabilize the mixing of water and oil ingredients. By preventing these ingredients from separating, it can help elongate shelf life. It can also help thicken the product's texture.
As an emollient, it helps soften skin and supports barrier-replenishing ingredients.
In cosmetics, Glyceryl Stearate is often made from vegetable oils or synthetically produced.
This ingredient may not be fungal-acne safe
Fun fact: The human body also creates Glyceryl Stearate naturally.
Learn more about Glyceryl StearateGlycolic Acid is arguably the most famous alpha hydroxy acid (AHA) with tons of research backing its benefits.
It is found naturally in sugar cane but the form used in skincare is usually synthetic for purity and stability.
Glycolic acid removes the top layer of dead skin cells to allow newer and fresher ones to emerge.
AHAs work by breaking down the structural “glue” that holds old skin cells in place. When that buildup is gone, your skin can renew itself more efficiently.
Research also shows glycolic acid stimulates collagen production, helping to firm and thicken the skin over time. This is one of its biggest advantages over other AHAs.
Overall, glycolic acid helps with:
Fun fact: Glycolic acid boosts skin hydration by helping it produce molecules that increase hyaluronic acid naturally.
To work best, glycolic acid products should have a pH between 3-4 (that’s where exfoliation is most effective but still gentle on skin).
The pH and concentration of a product are key to its effectiveness:
It is normal to feel a slight stinging sensation when using glycolic acid. This usually fades as your skin adjusts.
Because glycolic acid has the smallest molecular size in the AHA family, it can penetrate deeper, which enhances its effectiveness but also makes it more likely to irritate sensitive skin.
If your skin is very sensitive or prone to rosacea, glycolic acid may be too strong; in that case, try milder options like lactic acid or a PHA instead.
Recent studies suggest glycolic acid might even help protect against UV damage. But don’t skip sunscreen! Freshly exfoliated skin is more sensitive to the sun.
Glycolic acid is a skincare superstar. It smooths, brightens, hydrates, and firms the skin. Unless you’re highly sensitive, it’s well worth adding to your routine.
Read more about some other popular AHA's here:
Learn more about Glycolic AcidGlycyrrhetinic acid is a compound found in licorice. It has skin conditioning, skin soothing, antibacterial, and antioxidant properties.
Not only is this a great ingredient for soothing inflammation, studies show this compound is effective at protecting skin against UV-B induced damage.
Fun fact: This ingredient is also used to mask the bitter taste of medicine.
Learn more about Glycyrrhetinic AcidGossypium Herbaceum Seed Oil is AKA cotton seed oil.
Cotton seed oil is rich in omega-6 fatty acids. The majority of these fatty acids include linoleic (~54%) and oleic (~19%). It is structurally similar to sunflower seed oil.
When used in cosmetics, this ingredient is refined and purified to remove toxins naturally found in the plant.
This ingredient may not be fungal-acne safe due to the presence of fatty acids.
Learn more about Gossypium Herbaceum Seed OilHydrochloric Acid can be found in the human body. It used to adjust pH levels of basic solutions.
Lactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.
Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.
Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.
Like glycolic acid, it can:
Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.
Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.
To get results, choose products with a pH between 3-4.
Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.
Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.
Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.
Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.
Read more about some other popular AHA's here:
Learn more about Lactic AcidLinum Usitatissimum Seed Oil is the expressed oil from the dried ripe seed of the Linseed, Linum usitatissimum L., Linaceae
Lycium Barbarum Fruit Extract comes from the Goji Berry. Goji berries are native to China and can be found across Eurasia.
Goji berries contain polysaccharides, carotenoids and flavonoids. Antioxidants help your body fight off free-radical molecules. These molecules are unstable and may damage your skin. By making free-radicals more stable, antioxidants can help with anti-aging.
Polysaccharides help hydrate the top layer of skin due to its ability to mimic natural carbohydrates.
Learn more about Lycium Barbarum Fruit ExtractMandelic Acid is an alpha hydroxy acid (AHA).
Like other AHAs, it helps exfoliate the surface of the skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
Mandelic acid helps with:
Due to it having a larger molecular size than glycolic acid, mandelic acid is able to penetrate the skin more slowly and evenly. This makes it gentler and less irritating, making it a great option for sensitive or beginner skin.
Despite being milder, mandelic acid is still an effective exfoliant that improves skin texture and tone over time.
What makes mandelic acid stand out from other AHAs? It has antibacterial and antioxidant properties.
These traits make it a great option for acne-prone or problem skin by reducing active breakouts and fading post-acne marks. Studies show that mandelic acid (especially when combined with salicylic acid) can significantly reduce pimples and hyperpigmentation while causing fewer side effects than stronger acids.
Mandelic acid is effective in concentrations of 5% and up with an ideal pH range of 3-4 for at-home use.
Like other AHAs, it’s important to wear sunscreen daily to protect your newly exfoliated skin.
However, unlike glycolic acid, mandelic acid is light-sensitive. Be sure your mandelic acid is packaged in opaque containers to ensure it stays stable and effective.
In short, mandelic acid is a gentle yet powerful AHA that exfoliates, brightens, and helps clarify skin while keeping irritation low. Its antibacterial action makes it especially beneficial for those with acne-prone, sensitive, or uneven skin, offering smoother, clearer, and more even-toned results over time.
Read more about some other popular AHA's here:
Learn more about Mandelic AcidNiacin is the other form of B3, with the other being niacinamide. The two have similar skin benefits: reducing inflammation, strengthening the skin barrier, and fading dark spots.
Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 is a peptide.
We don't have a description for Nicotiana Benthamiana Sh-Polypedtide-7 yet.
Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Potassium Phosphate is the term for the salts of potassium and phosphate ions. Our bodies naturally create and use potassium phosphate.
In cosmetics, potassium phosphate is used to adjust the pH level of products. Our skin has a natural pH level. Maintaining this pH level is important for our skin barrier. If the skin barrier is disrupted, our skin can experience dehydration and irritation.
This ingredient is used in medicine to help treat low blood levels of phosphorus.
Learn more about Potassium PhosphatePotassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbatePropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolRetinyl palmitate is a form of retinoid. Retinoids are the superstar class of anti-aging ingredients that include tretinoin and retinol.
This particular ingredient has had a bumpy year with its rise and fall in popularity.
First, Retinyl palmitate is created from palmitic acid and retinol. It is a retinol ester and considered one of the weaker forms of retinoid.
This is because all retinoids have to be converted to Tretinoin, AKA retinoic acid. Retinyl Palmitate is pretty far down the line and has to go through multiple conversions before its effects are seen.
Due to this long and ineffective conversion line, the benefits of Retinyl Palmitate are debated.
Studies show Retinyl Palmitate to help:
Dermatologists say this ingredient is ineffective because it isn't used in high enough concentrations in cosmetics.
This ingredient used to be found in sunscreens to boost the efficacy of sunscreen filters.
The downfall of Retinyl Palmitate was due to released reports about the ingredient being correlated to sun damage and skin tumors.
While there is a study showing this ingredient to cause DNA damage when exposed to UV-A, there is no concrete proof of it being linked to skin cancer. It is safe to use when used correctly.
All retinoids increase your skin's sensitivity to the sun in the first few months of usage. Be especially careful with reapplying sunscreen when using any form of retinoid.
Currently, this ingredient is still allowed in cosmetics all over the world. In Canada, cosmetics must have a warning label stating the product to contain Retinyl Palmitate
Fun fact: This ingredient is often added to low-fat milk to increase the levels of Vitamin A.
Learn more about Retinyl PalmitateSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateChances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.
This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
There is much debate on whether this ingredient is comedogenic. The short answer - comedogenic ratings don't tell the whole story. Learn more about comegodenic ratings here.
The concensus about this ingredient causing acne seems to be divided. Research is needed to understand if this ingredient does cause acne.
Scrubs may use salt as the primary exfoliating ingredient.
Learn more about Sodium ChlorideWe don't have a description for Sodium Cholate yet.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateTriethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.
As an emulsifier, it prevents ingredients from separating and enhances texture by adding volume to a product.
PH adjusters are common in cosmetic products. The pH of a product can affect the effectiveness of other ingredients. A product with a high pH may also irritate the skin.
Learn more about TriethanolamineTromethamine helps balance the pH and improve the texture of a product. It is synthetically created.
As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.
Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
Learn more about TromethamineWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumZinc chloride is a white crystalline compound. You'll most likely see it in personal care products such as mouthwashes, skincare, hair conditioners, and bath products.
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