Versus

Sesderma Sesretinal Liposomal Serum Versus CeraVe Skin Renewing Retinol Serum

Serum
Serum
Spanish Brand Spain
American Brand United States

Updated on February 03, 2025

Overview

What they are

These products are both reef safe serums. They have a total of 17 ingredients in common

Cool Features

They both contain ceramides, hyaluronic acid, retinoid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any common allergens or parabens

What's Inside

They both contain harsh alcohols, silicones and sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Sesretinal Liposomal Serum

Water

Skin Conditioning

Bis-PEG-18 Methyl Ether Dimethyl Silane

Emollient

Hydrogenated Polydecene

Emollient

Ceteth-20

Cleansing

Propanediol

Solvent

C12-15 Alkyl Benzoate

Antimicrobial

Cyclopentasiloxane

Emollient
Silicon Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Gluconolactone

Skin Conditioning
PHA IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Scar Healing IconHelps brighten skin Icon

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1

Skin Conditioning
Peptide Icon

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5

Skin Conditioning
Peptide Icon

Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40

Skin Conditioning
Peptide Icon

Alcohol

Antimicrobial
Alcohol IconCan worsen Dry Skin IconMay worsen Oily Skin IconMay cause irritation IconMay worsen Eczema IconMay worsen Rosacea Icon

Bakuchiol

Antimicrobial
Antioxidant IconHelps with Anti-Aging IconHelps brighten skin Icon

BHT

Antioxidant
Antioxidant Icon

Bidens Pilosa Extract

Humectant

Carbomer

Emulsion Stabilising
1 / 0

Ceramide AP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Ceramide EOP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Copper Sulfate

Skin Conditioning
Sulfate Icon

Dipotassium Phosphate

Buffering

Disodium EDTA

Elaeis Guineensis Oil

Emollient
Oil IconNot safe for Fungal Acne Icon

Ethylhexylglycerin

Skin Conditioning

Glucosamine Hcl

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Glycolic Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin IconMay worsen Rosacea Icon

Glycyrrhetinic Acid

Skin Conditioning

Gossypium Herbaceum Seed Oil

Skin Conditioning
3 / 2 Oil IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Hydrochloric Acid

Buffering

Lactic Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Linum Usitatissimum Seed Oil

Perfuming
Fragrance IconOil IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon

Lycium Barbarum Fruit Extract

Astringent

Mandelic Acid

Antimicrobial
AHA IconGood for Oily Skin IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin IconMay worsen Rosacea Icon

Niacin

Smoothing
Helps hydrate Dry Skin IconGood for Dark Spots Icon

Nicotiana Benthamiana Sh-Polypedtide-7

Skin Conditioning

Parfum

Masking
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Phenoxyethanol

Preservative
Preservative Icon

Phosphatidylcholine

Emulsifying

Phytosphingosine

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation Icon

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Potassium Phosphate

Buffering

Potassium Sorbate

Preservative
Preservative Icon

Retinal

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Retinyl Palmitate

Skin Conditioning
1-3 / 1-3 Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconNot safe for Fungal Acne IconMay worsen Rosacea Icon

Sodium Benzoate

Masking
Preservative Icon

Sodium Chloride

Masking
Can worsen Dry Skin IconBad for Acne Prone Skin IconMay worsen Rosacea Icon

Sodium Cholate

Skin Conditioning

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid Icon

Sodium Hydroxide

Buffering

Sodium Lauroyl Lactylate

Emulsifying

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant Icon

Triethanolamine

Buffering
2 / 0

Tromethamine

Buffering

Xanthan Gum

Emulsifying

Zinc Chloride

Soothing
Skin Renewing Retinol Serum

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Emollient, Skin Conditioning, Solvent

Cyclopentasiloxane, or D5, is a silicone used to improve texture of products and trap moisture.

D5 is considered lightweight and volatile. Volatile means it evaporates quickly after application. Once evaporated, D5 leaves a thin barrier that helps keep skin hydrated.

It is also an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.

Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.

Learn more about Cyclopentasiloxane
Antimicrobial, Astringent, Masking

Alcohol comes in many different forms. Different types of alcohol will have different effects on skin. This ingredient is usually an astringent alcohol.

These alcohols are drying on the skin. They may strip away your skin's natural oils and even damage your skin barrier. Astringent alcohols may also irritate skin.

Other types of astringent alcohols include:

According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.

Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.

Fatty alcohols come from plant oils such as coconut oil. These can help hydrate the skin and are non-irritating. Some fatty alcohols include cetyl and stearyl alcohol.

Learn more about Alcohol
Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Emollient, Emulsifying, Emulsion Stabilising

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.

Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne.

Due to the fatty acid base, this ingredient may not be Malassezia folliculitis safe.

Learn more about Cetearyl Alcohol
Emollient, Emulsifying, Skin Conditioning

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.

Our bodies use cholestrol to create vitamin D, steroid hormones, and more.

Learn more about Cholesterol
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Skin Conditioning

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Learn more about Phytosphingosine
Emulsifying

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20

Potassium Phosphate is the term for the salts of potassium and phosphate ions. Our bodies naturally create and use potassium phosphate.

In cosmetics, potassium phosphate is used to adjust the pH level of products. Our skin has a natural pH level. Maintaining this pH level is important for our skin barrier. If the skin barrier is disrupted, our skin can experience dehydration and irritation.

This ingredient is used in medicine to help treat low blood levels of phosphorus.

Learn more about Potassium Phosphate
Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Learn more about Sodium Hydroxide

Sodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.

Sodium Lauroyl Lactylate is an emulsifier and surfactant.

Emulsifiers help stabilize a product. They do this by preventing ingredients from separating, such as oils and water which do not mix naturally. Surfactants reduce surface tension, making it easier to rinse pollutants off skin.

Due to its relation to lauric acid, it may provide antimicrobial benefits.

Learn more about Sodium Lauroyl Lactylate
Antioxidant, Masking, Skin Conditioning

Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.

Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.

Learn more about Tocopherol
Buffering, Emulsifying, Masking

Triethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.

As an emulsifier, it prevents ingredients from separating and enhances texture by adding volume to a product.

PH adjusters are common in cosmetic products. The pH of a product can affect the effectiveness of other ingredients. A product with a high pH may also irritate the skin.

Learn more about Triethanolamine
Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum

When to use

1 Routine
0% use in am
100% use in pm
100% use every other_day
212 Routines
12% use in am
88% use in pm
68% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Sesderma Sesretinal Liposomal Serum 61 ingredients

Sesretinal Liposomal Serum hasn't been rated yet.
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CeraVe Skin Renewing Retinol Serum 37 ingredients

3.0 /5
from 1 rating
Sticky (1)
melissasecrest's avatar

Melissa Secrest

9 months ago
Review

Going back to Cerave's Resurfacing retinol. This bottle seemed less product than that. I don't think it worked as hard as the other retinol serum to prevent breakouts. Renewal had an unattractive yellow color, and a strange texture that takes a long time to sink in. Don't plan to repurchase this.

#sticky