Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47

This is a synthetic "recombinant" collagen peptide and the long name basically describes how it's made.

The active part, Sh-Polypeptide-47, is a peptide built from the human gene that codes for Collagen Alpha-1 while the Nicotiana Benthamiana Hexapeptide-40 part tells you it's grown from Nicotiana benthamiana, a tobacco-relative plant that's been turned into a tiny biological factory.

Scientists insert the human collagen gene into the plant and the plant produces the peptide either through a transient expression system or by transgenesis.

The end result is a vegan, animal-free peptide that's bio-identical to a piece of your own collagen.

In a formula, this ingredient is a skin conditioner and provides anti-aging support. Peptides like this tell your fibroblasts to ramp up their own collagen, elastin, and hyaluronic acid.

On the evidence front, the studies that exist are mostly on the category of recombinant human collagen peptides rather than this precise fusion peptide.

For example, work on recombinant human Collagen Alpha-1 Type V peptides showed measurable gains in skin elasticity, density, and barrier function over 2-4 weeks of use. Recombinant human collagen peptides have also shown promise across wound healing.

While everything looks promising, there's no independent trials on this ingredient specifically.

Usage concentrations are rarely published for this ingredient. Like most of its peptide cousins, it's used at low