Estée Lauder Perfectionist Pro Rapid Firm + Lift Treatment with Acetyl Hexapeptide-8 Versus Medik8 Liquid Peptides Advanced MP
This anti-aging serum is formulated around Acetyl Glucosamine and Acetyl Hexapeptide-8 to soften the look of wrinkles.
This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Palmitoyl Tripeptide-5 to soften the look of wrinkles and refine skin texture.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningDimethicone
EmollientButylene Glycol
HumectantCaprylic/Capric Triglyceride
MaskingGlycerin
HumectantBis-PEG-18 Methyl Ether Dimethyl Silane
EmollientPolysorbate 20
EmulsifyingLauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Skin ConditioningPolysilicone-11
Mangifera Indica Seed Butter
Skin ConditioningPhoenix Dactylifera Fruit Extract
EmollientPisum Sativum Extract
Skin ConditioningCucumis Sativus Fruit Extract
EmollientCrithmum Maritimum Extract
Skin ConditioningLaminaria Ochroleuca Extract
Skin ConditioningCommiphora Mukul Resin Extract
Skin ConditioningTriticum Vulgare Germ Extract
Skin ConditioningBambusa Vulgaris Extract
Skin ConditioningChlorella Vulgaris Extract
Skin ConditioningLaminaria Saccharina Extract
Skin ProtectingBrassica Campestris Sterols
EmollientHelianthus Annuus Seed Extract
Skin ConditioningAlgae Extract
EmollientHypnea Musciformis Extract
Skin ProtectingSigesbeckia Orientalis Extract
Skin ConditioningNymphaea Alba Flower Extract
Skin ConditioningAcetyl Glucosamine
Skin ConditioningCaffeine
Skin ConditioningGelidiella Acerosa Extract
Skin ProtectingCoffea Arabica Seed Extract
MaskingSodium Hyaluronate
HumectantLactic Acid
BufferingPropylene Glycol Dicaprate
EmollientSaccharide Isomerate
HumectantMethyl Gluceth-20
HumectantEthylhexylglycerin
Skin ConditioningAcrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingHelianthus Annuus Seedcake
AbrasiveCaprylyl Glycol
EmollientIsohexadecane
EmollientTocopheryl Acetate
AntioxidantAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingGlyceryl Polymethacrylate
Sodium Polyacrylate Starch
AbsorbentSqualane
EmollientSodium PCA
HumectantUrea
BufferingZea Mays Kernel Extract
Whey Protein
Skin ConditioningPalmaria Palmata Extract
Skin ProtectingPolysorbate 80
EmulsifyingAcetyl Hexapeptide-8
HumectantTriolein
Skin ConditioningHydrolyzed Rice Extract
Skin ConditioningLinoleic Acid
CleansingTrehalose
HumectantGlycine Soja Protein
EmulsifyingGlucosamine Hcl
Phospholipids
Skin ConditioningLaminaria Digitata Extract
Skin ProtectingHordeum Vulgare Extract
EmollientPolyquaternium-51
Skin ConditioningPalmitoyl Hexapeptide-12
Skin ConditioningErgothioneine
AntioxidantAminopropyl Ascorbyl Phosphate
AntioxidantPEG-8
HumectantPhytosteryl Canola Glycerides
Skin ConditioningPentylene Glycol
Skin ConditioningOleic Acid
EmollientPalmitic Acid
EmollientXanthan Gum
EmulsifyingParfum
MaskingSodium Hydroxide
BufferingCitric Acid
BufferingSilica
AbrasiveCalcium Chloride
AstringentStearic Acid
CleansingDipropylene Glycol
HumectantSodium Palmitoyl Proline
Skin ConditioningDisodium EDTA
ChelatingBHT
AntioxidantPotassium Sorbate
PreservativePhenoxyethanol
PreservativeMica
Cosmetic ColorantCI 77891
Cosmetic ColorantCI 77491
Cosmetic ColorantCI 77492
Cosmetic ColorantCI 77499
Cosmetic ColorantWater, Dimethicone, Butylene Glycol, Caprylic/Capric Triglyceride, Glycerin, Bis-PEG-18 Methyl Ether Dimethyl Silane, Polysorbate 20, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Polysilicone-11, Mangifera Indica Seed Butter, Phoenix Dactylifera Fruit Extract, Pisum Sativum Extract, Cucumis Sativus Fruit Extract, Crithmum Maritimum Extract, Laminaria Ochroleuca Extract, Commiphora Mukul Resin Extract, Triticum Vulgare Germ Extract, Bambusa Vulgaris Extract, Chlorella Vulgaris Extract, Laminaria Saccharina Extract, Brassica Campestris Sterols, Helianthus Annuus Seed Extract, Algae Extract, Hypnea Musciformis Extract, Sigesbeckia Orientalis Extract, Nymphaea Alba Flower Extract, Acetyl Glucosamine, Caffeine, Gelidiella Acerosa Extract, Coffea Arabica Seed Extract, Sodium Hyaluronate, Lactic Acid, Propylene Glycol Dicaprate, Saccharide Isomerate, Methyl Gluceth-20, Ethylhexylglycerin, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Helianthus Annuus Seedcake, Caprylyl Glycol, Isohexadecane, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Polymethacrylate, Sodium Polyacrylate Starch, Squalane, Sodium PCA, Urea, Zea Mays Kernel Extract, Whey Protein, Palmaria Palmata Extract, Polysorbate 80, Acetyl Hexapeptide-8, Triolein, Hydrolyzed Rice Extract, Linoleic Acid, Trehalose, Glycine Soja Protein, Glucosamine Hcl, Phospholipids, Laminaria Digitata Extract, Hordeum Vulgare Extract, Polyquaternium-51, Palmitoyl Hexapeptide-12, Ergothioneine, Aminopropyl Ascorbyl Phosphate, PEG-8, Phytosteryl Canola Glycerides, Pentylene Glycol, Oleic Acid, Palmitic Acid, Xanthan Gum, Parfum, Sodium Hydroxide, Citric Acid, Silica, Calcium Chloride, Stearic Acid, Dipropylene Glycol, Sodium Palmitoyl Proline, Disodium EDTA, BHT, Potassium Sorbate, Phenoxyethanol, Mica, CI 77891, CI 77491, CI 77492, CI 77499
Water
Skin ConditioningGlycerin
HumectantDimethicone
EmollientDimethyl Isosorbide
SolventButylene Glycol
HumectantUndecane
EmollientArginine
MaskingInulin
Skin ConditioningMicrocrystalline Cellulose
AbsorbentCeteareth-20
CleansingTridecane
PerfumingTocopherol
AntioxidantHydroxyacetophenone
AntioxidantSodium Hyaluronate
HumectantPalmitoyl Tripeptide-38
Skin ConditioningPanthenol
Skin ConditioningCaprylic/Capric Triglyceride
MaskingPalmitoyl Tripeptide-5
Skin ConditioningPolyacrylate Crosspolymer-6
Emulsion StabilisingPalmitoyl Tripeptide-1
Skin ConditioningPullulan
Tetrapeptide-21
Skin ConditioningPalmitoyl Tetrapeptide-10
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingGlyceryl Linoleate
EmollientAcetyl Hexapeptide-8
HumectantPentapeptide-18
Skin ConditioningOligopeptide-1
Skin ConditioningArginine/Lysine Polypeptide
Skin ConditioningSucrose Palmitate
EmollientCetyl Palmitate
EmollientPhenoxyethanol
PreservativeEthylhexylglycerin
Skin ConditioningCarbomer
Emulsion StabilisingCopper Palmitoyl Heptapeptide-14
Skin ConditioningHeptapeptide-15 Palmitate
Skin ConditioningBenzotriazolyl Dodecyl P-Cresol
UV AbsorberPolysorbate 80
EmulsifyingSorbitan Stearate
EmulsifyingPolysorbate 20
EmulsifyingCarnosine
Skin ConditioningSodium Metabisulfite
AntioxidantDunaliella Salina Extract
Skin ConditioningHelianthus Annuus Seed Oil
EmollientHydroxypropyl Cyclodextrin
MaskingDimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningSodium Benzoate
MaskingHydrogenated Lecithin
EmulsifyingCaprylyl Glycol
EmollientPantolactone
HumectantXanthan Gum
EmulsifyingDisodium EDTA
ChelatingT-Butyl Alcohol
PerfumingPotassium Sorbate
PreservativeCitric Acid
BufferingGlyceryl Caprylate
EmollientLactic Acid/Glycolic Acid Copolymer
Skin ConditioningPolyvinyl Alcohol
Phenylpropanol
MaskingWater, Glycerin, Dimethicone, Dimethyl Isosorbide, Butylene Glycol, Undecane, Arginine, Inulin, Microcrystalline Cellulose, Ceteareth-20, Tridecane, Tocopherol, Hydroxyacetophenone, Sodium Hyaluronate, Palmitoyl Tripeptide-38, Panthenol, Caprylic/Capric Triglyceride, Palmitoyl Tripeptide-5, Polyacrylate Crosspolymer-6, Palmitoyl Tripeptide-1, Pullulan, Tetrapeptide-21, Palmitoyl Tetrapeptide-10, Palmitoyl Tetrapeptide-7, Ammonium Polyacryloyldimethyl Taurate, Glyceryl Linoleate, Acetyl Hexapeptide-8, Pentapeptide-18, Oligopeptide-1, Arginine/Lysine Polypeptide, Sucrose Palmitate, Cetyl Palmitate, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Benzotriazolyl Dodecyl P-Cresol, Polysorbate 80, Sorbitan Stearate, Polysorbate 20, Carnosine, Sodium Metabisulfite, Dunaliella Salina Extract, Helianthus Annuus Seed Oil, Hydroxypropyl Cyclodextrin, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Benzoate, Hydrogenated Lecithin, Caprylyl Glycol, Pantolactone, Xanthan Gum, Disodium EDTA, T-Butyl Alcohol, Potassium Sorbate, Citric Acid, Glyceryl Caprylate, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Phenylpropanol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Learn more about Citric AcidDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolPolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Polysorbate 80 is a synthetic surfactant and emulsifier derived from sorbitol and oleic acid.
It reduces the surface tension between oil and water phases to help them stay mixed and stable in a formulation. In other words, it prevents your formulas from separating into an oily mess.
The CIR Expert Panel has evaluated the scientific data and found this ingredient to be safe, non-irritating, and non-sensitizing at concentrations up to 5% (it's even approved by the FDA as an OTC eye drop ingredient).
Learn more about Polysorbate 80Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan Gum