Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum Versus Biologique Recherche Lotion P50 PIGM 400
This barrier-repair serum is formulated around Niacinamide and Ectoin to strengthen the skin barrier and soften the look of wrinkles.
This brightening toner is formulated around Niacinamide and Lactic Acid to fade the look of dark spots and brighten dull-looking skin.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
HumectantNiacinamide
SmoothingButylene Glycol
HumectantEctoin
Skin ConditioningSodium Hyaluronate
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningSodium Acetylated Hyaluronate
HumectantSodium Hyaluronate Crosspolymer
HumectantAcetyl Hexapeptide-8
HumectantPalmitoyl Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningOligopeptide-2
Skin ConditioningSaccharide Isomerate
HumectantCamellia Sinensis Leaf Extract
AntimicrobialCentella Asiatica Extract
CleansingVitis Vinifera Seed Extract
AntimicrobialSodium Carboxymethyl Beta-Glucan
CleansingBakuchiol
AntimicrobialInonotus Obliquus Extract
Skin ConditioningTetrahydrocurcumin
AntioxidantCeramide NP
Skin ConditioningCeramide AP
Skin ConditioningCeramide EOP
Skin ConditioningPhospholipids
Skin ConditioningSphingolipids
EmollientPhytosphingosine
Skin ConditioningColloidal Oatmeal
AbsorbentBisabolol
AntioxidantSuperoxide Dismutase
AntioxidantTerminalia Ferdinandiana Fruit Extract
AntioxidantSodium PCA
HumectantGlutathione
Squalane
EmollientCaffeine
Skin ConditioningPanthenol
Skin ConditioningButyrospermum Parkii Butter
Skin ConditioningAloe Barbadensis Leaf Juice
Skin ConditioningArnica Montana Flower Extract
MaskingAcetyl Glutamine
Skin ConditioningBifida Ferment Lysate
Skin ConditioningChamomilla Recutita Flower Extract
MaskingWithania Somnifera Root Extract
Skin ConditioningGlycolic Acid
BufferingMandelic Acid
AntimicrobialLactobionic Acid
BufferingEthylhexylglycerin
Skin ConditioningCoco-Glucoside
CleansingLauryl Glucoside
CleansingDecyl Glucoside
CleansingPolyglyceryl-10 Laurate
Skin ConditioningDiheptyl Succinate
EmollientDimethicone
EmollientPentylene Glycol
Skin ConditioningSodium Lauroyl Lactylate
EmulsifyingPvm/Ma Decadiene Crosspolymer
Vp/Va Copolymer
Xanthan Gum
EmulsifyingPotassium Hydroxide
BufferingPolysorbate 20
EmulsifyingDimethicone Crosspolymer
Emulsion StabilisingCarbomer
Emulsion StabilisingCholesterol
EmollientCapryloyl Glycerin/Sebacic Acid Copolymer
Skin ConditioningLeuconostoc/Radish Root Ferment Filtrate
AntimicrobialSodium Citrate
BufferingCitric Acid
BufferingSodium Metasilicate
BufferingGluconolactone
Skin ConditioningTetrasodium Glutamate Diacetate
Caprylic/Capric Triglyceride
MaskingJasminum Officinale Flower/Leaf Extract
MaskingVitis Vinifera Fruit Extract
Skin ConditioningEugenia Caryophyllus Flower Extract
AstringentLavandula Angustifolia Flower/Leaf/Stem Extract
MaskingRaspberry Ketone
MaskingPhenoxyethanol
PreservativePotassium Sorbate
PreservativeWater, Glycerin, Niacinamide, Butylene Glycol, Ectoin, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Oligopeptide-2, Saccharide Isomerate, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Vitis Vinifera Seed Extract, Sodium Carboxymethyl Beta-Glucan, Bakuchiol, Inonotus Obliquus Extract, Tetrahydrocurcumin, Ceramide NP, Ceramide AP, Ceramide EOP, Phospholipids, Sphingolipids, Phytosphingosine, Colloidal Oatmeal, Bisabolol, Superoxide Dismutase, Terminalia Ferdinandiana Fruit Extract, Sodium PCA, Glutathione, Squalane, Caffeine, Panthenol, Butyrospermum Parkii Butter, Aloe Barbadensis Leaf Juice, Arnica Montana Flower Extract, Acetyl Glutamine, Bifida Ferment Lysate, Chamomilla Recutita Flower Extract, Withania Somnifera Root Extract, Glycolic Acid, Mandelic Acid, Lactobionic Acid, Ethylhexylglycerin, Coco-Glucoside, Lauryl Glucoside, Decyl Glucoside, Polyglyceryl-10 Laurate, Diheptyl Succinate, Dimethicone, Pentylene Glycol, Sodium Lauroyl Lactylate, Pvm/Ma Decadiene Crosspolymer, Vp/Va Copolymer, Xanthan Gum, Potassium Hydroxide, Polysorbate 20, Dimethicone Crosspolymer, Carbomer, Cholesterol, Capryloyl Glycerin/Sebacic Acid Copolymer, Leuconostoc/Radish Root Ferment Filtrate, Sodium Citrate, Citric Acid, Sodium Metasilicate, Gluconolactone, Tetrasodium Glutamate Diacetate, Caprylic/Capric Triglyceride, Jasminum Officinale Flower/Leaf Extract, Vitis Vinifera Fruit Extract, Eugenia Caryophyllus Flower Extract, Lavandula Angustifolia Flower/Leaf/Stem Extract, Raspberry Ketone, Phenoxyethanol, Potassium Sorbate
Water
Skin ConditioningGlycerin
HumectantNiacinamide
SmoothingSodium Gluconate
Skin ConditioningTriethanolamine
BufferingLactic Acid
BufferingSodium Lactate
BufferingLactobacillus/Wasabia Japonica Root Ferment Extract
AntioxidantMagnesium Chloride
Mandelic Acid
AntimicrobialPalmaria Palmata Extract
Skin ProtectingMicrocitrus Australasica Fruit Extract
Prunus Persica Leaf Extract
EmollientSpiraea Ulmaria Extract
AstringentPyrus Malus Fruit Extract
Skin ConditioningRubus Idaeus Fruit Extract
AstringentPhytic Acid
Citric Acid
BufferingGluconolactone
Skin ConditioningSalicylic Acid
MaskingAscorbic Acid
AntioxidantMaltodextrin
AbsorbentSodium Salicylate
PreservativeVinegar
Propylene Glycol
HumectantMagnesium Sulfate
Alcohol Denat.
AntimicrobialSodium Benzoate
MaskingPotassium Sorbate
PreservativeSodium Bisulfite
AntioxidantWater, Glycerin, Niacinamide, Sodium Gluconate, Triethanolamine, Lactic Acid, Sodium Lactate, Lactobacillus/Wasabia Japonica Root Ferment Extract, Magnesium Chloride, Mandelic Acid, Palmaria Palmata Extract, Microcitrus Australasica Fruit Extract, Prunus Persica Leaf Extract, Spiraea Ulmaria Extract, Pyrus Malus Fruit Extract, Rubus Idaeus Fruit Extract, Phytic Acid, Citric Acid, Gluconolactone, Salicylic Acid, Ascorbic Acid, Maltodextrin, Sodium Salicylate, Vinegar, Propylene Glycol, Magnesium Sulfate, Alcohol Denat., Sodium Benzoate, Potassium Sorbate, Sodium Bisulfite
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Learn more about Citric AcidGluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.
When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.
PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.
Gluconolactone has some interesting properties:
In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily.
This ingredient is is an created by reacting gluconic acid with an alcohol.
Learn more about GluconolactoneGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinMandelic Acid is an alpha hydroxy acid (AHA).
Like other AHAs, it helps exfoliate the surface of the skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
Mandelic acid helps with:
Due to it having a larger molecular size than glycolic acid, mandelic acid is able to penetrate the skin more slowly and evenly. This makes it gentler and less irritating, making it a great option for sensitive or beginner skin.
Despite being milder, mandelic acid is still an effective exfoliant that improves skin texture and tone over time.
What makes mandelic acid stand out from other AHAs? It has antibacterial and antioxidant properties.
These traits make it a great option for acne-prone or problem skin by reducing active breakouts and fading post-acne marks. Studies show that mandelic acid (especially when combined with salicylic acid) can significantly reduce pimples and hyperpigmentation while causing fewer side effects than stronger acids.
Mandelic acid is effective in concentrations of 5% and up with an ideal pH range of 3-4 for at-home use.
Like other AHAs, it’s important to wear sunscreen daily to protect your newly exfoliated skin.
However, unlike glycolic acid, mandelic acid is light-sensitive. Be sure your mandelic acid is packaged in opaque containers to ensure it stays stable and effective.
In short, mandelic acid is a gentle yet powerful AHA that exfoliates, brightens, and helps clarify skin while keeping irritation low. Its antibacterial action makes it especially beneficial for those with acne-prone, sensitive, or uneven skin, offering smoother, clearer, and more even-toned results over time.
Read more about some other popular AHA's here:
Learn more about Mandelic AcidNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePotassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water