Versus

Drunk Elephant Protini Polypeptide Cream - US Versus Clinique Superdefense Broad Spectrum SPF 25 Fatigue + 1st Signs Of Age Multi-Correcting Cream

General Moisturizer
Day Moisturizer
American Brand United States
American Brand United States

Updated on March 19, 2025

Overview

Cool Features

They both contain hyaluronic acid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, scar healing and dark spots

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

What's Inside

They both contain oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside

What's inside

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Protini Polypeptide Cream

Water

Skin Conditioning

Dicaprylyl Carbonate

Emollient

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cetearyl Olivate

Not safe for Fungal Acne Icon

Sorbitan Olivate

Emulsifying
Not safe for Fungal Acne Icon

Sclerocarya Birrea Seed Oil

Humectant
Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Bacillus/Folic Acid Ferment Filtrate Extract

Antioxidant
Antioxidant Icon

Nymphaea Alba Root Extract

Skin Conditioning

Sh-Oligopeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sh-Oligopeptide-2

Skin Conditioning
Peptide Icon

Sh-Polypeptide-1

Skin Conditioning
Peptide Icon

Sh-Polypeptide-9

Skin Conditioning
Peptide Icon

Sh-Polypeptide-11

Peptide IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Copper Palmitoyl Heptapeptide-14

Skin Conditioning
Peptide Icon

Heptapeptide-15 Palmitate

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Palmitoyl Tetrapeptide-7

Skin Conditioning
Peptide IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-1

Skin Conditioning
Peptide IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Alanine

Masking

Arginine

Masking
Good for Scar Healing IconNot safe for Fungal Acne Icon

Glycine

Buffering
Helps hydrate Dry Skin Icon

Histidine

Humectant
Helps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Isoleucine

Skin Conditioning

Phenylalanine

Masking
Helps hydrate Dry Skin IconGood for Scar Healing Icon

Proline

Skin Conditioning

Serine

Masking
Helps hydrate Dry Skin Icon

Threonine

Helps hydrate Dry Skin Icon

Valine

Masking

Acetyl Glutamine

Skin Conditioning

Coconut Alkanes

Emollient
Not safe for Fungal Acne Icon

Coco-Caprylate/Caprate

Emollient
Not safe for Fungal Acne Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

Aspartic Acid

Masking
Helps hydrate Dry Skin Icon

Linoleic Acid

Cleansing
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Linolenic Acid

Cleansing
Fragrance IconHelps hydrate Dry Skin IconHelps reduce irritation IconGood for Dark Spots IconNot safe for Fungal Acne Icon

Lecithin

Emollient
Helps hydrate Dry Skin Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Polyvinyl Alcohol

Sodium Lactate

Buffering

Sodium PCA

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

PCA

Humectant
Helps hydrate Dry Skin Icon

Sorbitan Isostearate

Emulsifying
1-2 / 0 Not safe for Fungal Acne Icon

Carbomer

Emulsion Stabilising
1 / 0

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Polysorbate 60

Emulsifying
Not safe for Fungal Acne Icon

Lactic Acid/Glycolic Acid Copolymer

Skin Conditioning

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Xanthan Gum

Emulsifying

Isomalt

Humectant

1,2-Hexanediol

Skin Conditioning
Helps hydrate Dry Skin Icon

Caprylyl Glycol

Emollient

Chlorphenesin

Antimicrobial
Preservative Icon

Phenoxyethanol

Preservative
Preservative Icon

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sodium Benzoate

Masking
Preservative Icon

Phenylpropanol

Masking
Fragrance Icon

Glyceryl Caprylate

Emollient

Symphytum Officinale Callus Culture Extract

Skin Conditioning
Superdefense Broad Spectrum SPF 25 Fatigue + 1st Signs Of Age Multi-Correcting Cream

Water

Skin Conditioning

Ethylhexyl Salicylate

UV Absorber
0 / 0 Chemical UV Filter IconNon-Reef-Safe IconMay worsen Rosacea Icon

Homosalate

Skin Conditioning
Chemical UV Filter IconNon-Reef-Safe Icon

Butyloctyl Salicylate

Skin Conditioning
Non-Reef-Safe Icon

Dimethicone

Emollient
1 / 0 Silicon Icon

Polyester-8

Skin Conditioning
Non-Reef-Safe Icon

Butyl Methoxydibenzoylmethane

UV Absorber
Chemical UV Filter IconMay cause irritation IconMay worsen Rosacea Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

PEG-100 Stearate

0 / 0 Not safe for Fungal Acne Icon

Shea Butter Ethyl Esters

Emollient
Not safe for Fungal Acne Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Petrolatum

Emollient
Oil IconNot safe for Fungal Acne Icon

Styrene/Acrylates Copolymer

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Trehalose

Humectant
Helps hydrate Dry Skin Icon

Vp/Eicosene Copolymer

Daucus Carota Sativa Root Extract

Skin Conditioning
Helps reduce irritation Icon

Brassica Oleracea Gemmifera Extract

Astringent

Vaccinium Macrocarpon Fruit Extract

Astringent

Resveratrol

Antioxidant
Antioxidant IconHelps reduce irritation IconHelps with Anti-Aging IconGood for Dark Spots Icon

Brassica Oleracea Italica Extract

Astringent

Acetyl Carnitine Hcl

Skin Conditioning

Vaccinium Angustifolium Fruit Extract

Skin Protecting
Helps reduce Skin Redness IconHelps reduce irritation Icon

Salicylic Acid

Masking
BHA IconPreservative IconGood for Oily Skin IconGood for Minimizing Pores IconHelps fight Acne IconHelps brighten skin IconCan worsen Dry Skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Brassica Oleracea Acephala Leaf Extract

Humectant

Creatine

Skin Conditioning

Spinacia Oleracea Leaf Extract

Skin Conditioning

Cucumis Sativus Fruit Extract

Emollient
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Lactobacillus Ferment

Skin Conditioning

Adenosine Phosphate

Skin Conditioning

Hordeum Vulgare Extract

Emollient

Sigesbeckia Orientalis Extract

Skin Conditioning

Albizia Julibrissin Bark Extract

Masking

Arabidopsis Thaliana Extract

Antioxidant
Antioxidant Icon

Plankton Extract

Skin Conditioning

Isohexadecane

Emollient

Oryza Sativa Bran Extract

Skin Conditioning
Helps hydrate Dry Skin Icon

Potassium Cetyl Phosphate

Emulsifying

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant Icon

Caffeine

Skin Conditioning
Helps reduce irritation IconHelps with Anti-Aging Icon

Ethylhexylglycerin

Skin Conditioning

Algae Extract

Emollient
May worsen Oily Skin Icon

Micrococcus Lysate

Skin Conditioning

Ergothioneine

Antioxidant
Antioxidant IconHelps reduce irritation IconGood for Dark Spots Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

7-Dehydrocholesterol

Emulsion Stabilising

Caprylyl Glycol

Emollient

Biosaccharide Gum-4

Skin Conditioning
Helps hydrate Dry Skin Icon

Hydrogenated Palm Glycerides

Emollient
Not safe for Fungal Acne Icon

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Emulsion Stabilising

Propylene Glycol Dicaprate

Emollient

PEG-8 Laurate

Emulsifying
Not safe for Fungal Acne Icon

Helianthus Annuus Seedcake

Abrasive
Exfoliant IconNot safe for Fungal Acne Icon

Polyethylene

Abrasive
Exfoliant Icon

Yeast Extract

Skin Conditioning
Not safe for Fungal Acne Icon

Tromethamine

Buffering

Dimethiconol

Emollient
Silicon Icon

Sodium Rna

Skin Conditioning

Polysorbate 80

Emulsifying
0 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon

Lecithin

Emollient
Helps hydrate Dry Skin Icon

Sea Whip Extract

Skin Conditioning

Xanthan Gum

Emulsifying

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Emulsion Stabilising

Tetrahexyldecyl Ascorbate

Antioxidant
Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores IconHelps brighten skin Icon

Propylene Glycol Caprylate

Skin Conditioning

Phytic Acid

AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconHelps brighten skin IconMay worsen Rosacea Icon

Disodium EDTA

BHT

Antioxidant
Antioxidant Icon

Phenoxyethanol

Preservative
Preservative Icon

Mica

Cosmetic Colorant
May worsen Eczema Icon

CI 77891

Cosmetic Colorant

Water, Ethylhexyl Salicylate, Homosalate, Butyloctyl Salicylate, Dimethicone, Polyester-8, Butyl Methoxydibenzoylmethane, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Shea Butter Ethyl Esters, Butylene Glycol, Petrolatum, Styrene/Acrylates Copolymer, Glycerin, Niacinamide, Trehalose, Vp/Eicosene Copolymer, Daucus Carota Sativa Root Extract, Brassica Oleracea Gemmifera Extract, Vaccinium Macrocarpon Fruit Extract, Resveratrol, Brassica Oleracea Italica Extract, Acetyl Carnitine Hcl, Vaccinium Angustifolium Fruit Extract, Salicylic Acid, Brassica Oleracea Acephala Leaf Extract, Creatine, Spinacia Oleracea Leaf Extract, Cucumis Sativus Fruit Extract, Lactobacillus Ferment, Adenosine Phosphate, Hordeum Vulgare Extract, Sigesbeckia Orientalis Extract, Albizia Julibrissin Bark Extract, Arabidopsis Thaliana Extract, Plankton Extract, Isohexadecane, Oryza Sativa Bran Extract, Potassium Cetyl Phosphate, Tocopheryl Acetate, Caffeine, Ethylhexylglycerin, Algae Extract, Micrococcus Lysate, Ergothioneine, Sodium Hyaluronate, 7-Dehydrocholesterol, Caprylyl Glycol, Biosaccharide Gum-4, Hydrogenated Palm Glycerides, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Propylene Glycol Dicaprate, PEG-8 Laurate, Helianthus Annuus Seedcake, Polyethylene, Yeast Extract, Tromethamine, Dimethiconol, Sodium Rna, Polysorbate 80, Lecithin, Sea Whip Extract, Xanthan Gum, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Tetrahexyldecyl Ascorbate, Propylene Glycol Caprylate, Phytic Acid, Disodium EDTA, BHT, Phenoxyethanol, Mica, CI 77891

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol
Emollient, Emulsifying, Emulsion Stabilising

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.

Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne.

Due to the fatty acid base, this ingredient may not be Malassezia folliculitis safe.

Learn more about Cetearyl Alcohol
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of mixture of phospholipids.

This ingredient has emollient and emulsifying properties.

As an emollient, lecithen helps soften the skin and creates a barrier to keep moisture in.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can also help ingredients be better absorbed by the skin.

This is because the phospholipids in lecithin produce liposomes. Liposomes help other ingredients get through the skin barrier.

Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that feeds fungal acne.

We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.

Some other names for this ingredient include soy lecithin and deoiled soy lecithin.

Learn more about Lecithin
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum

When to use

639 Routines
51% use in am
49% use in pm
94% use every day
When to use See routines that use it ->
10 Routines
90% use in am
10% use in pm
100% use every day

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Expensive 69% Hydrating 46% Light 38%
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