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Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment Versus MediCube Deep Reviving Bakuchiol Retinol Serum

Facial Treatment
Serum
American Brand United States
Korean Brand South Korea

Updated on April 17, 2024

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 12 ingredients in common

Cool Features

They both contain ceramides, exfoliants, hyaluronic acid, retinoid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside (and what isn't)

What's inside (and what isn't)

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Water

Skin Conditioning

Dimethicone

Emollient
1 / 0 Silicon Icon

Pentaerythrityl Tetraisostearate

Emollient
2 / 0 Not safe for Fungal Acne Icon

Isononyl Isononanoate

Emollient

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Bakuchiol

Antimicrobial
Antioxidant IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging IconGood for Dark Spots IconHelps brighten skin Icon

Arachidyl Alcohol

Emollient

Glyceryl Polymethacrylate

Dimethicone Crosspolymer

Emulsion Stabilising

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

PEG-75 Shea Butter Glycerides

Emulsifying
Not safe for Fungal Acne Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

C12-15 Alkyl Benzoate

Antimicrobial

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Tetrahexyldecyl Ascorbate

Antioxidant
Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores IconHelps brighten skin Icon

Retinol

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Ceramide Ng

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Palmitoyl Tetrapeptide-7

Skin Conditioning
Peptide IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Palmitoyl Hexapeptide-12

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

Dipotassium Glycyrrhizate

Humectant
Helps reduce Skin Redness IconHelps reduce irritation IconGood for Dark Spots Icon

Glycyrrhiza Glabra Root Extract

Bleaching
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Dark Spots Icon

Avena Sativa Kernel Extract

Abrasive
Exfoliant IconAntioxidant IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Arctium Lappa Root Extract

Skin Conditioning
Helps reduce irritation Icon

Salix Alba Bark Extract

Astringent
Good for Oily Skin IconHelps reduce irritation Icon

Glycine Soja Sterols

Emollient
0 / 0 Helps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Lecithin

Emollient
Helps hydrate Dry Skin Icon

Allantoin

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant Icon

Hydrolyzed Soy Protein

Humectant
Helps hydrate Dry Skin Icon

Palmitoyl Tripeptide-1

Skin Conditioning
Peptide IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Sodium Hydroxide

Buffering

Tribehenin

Emollient
0 / 0 Not safe for Fungal Acne Icon

Caprylyl Glycol

Emollient

Dipeptide-2

Skin Conditioning
Peptide IconHelps with Anti-Aging Icon

Polygonum Cuspidatum Root Extract

Antioxidant
Antioxidant Icon

PEG-10 Phytosterol

Emulsifying

PEG-8

Humectant

Magnesium Aluminum Silicate

Absorbent
0 / 0

Arachidyl Glucoside

Emulsifying

Chrysin

Skin Conditioning

Pentylene Glycol

Skin Conditioning

Sodium Acrylates Copolymer

Steareth-20

Cleansing
2 / 1

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Coco-Glucoside

Cleansing

Hesperidin Methyl Chalcone

Antioxidant
Antioxidant IconSilicon Icon

N-Hydroxysuccinimide

Skin Conditioning

Disodium EDTA

Phenoxyethanol

Preservative
Preservative Icon

Benzoic Acid

Masking
Preservative IconMay worsen Eczema Icon

Ethylhexylglycerin

Skin Conditioning
Deep Reviving Bakuchiol Retinol Serum

Water

Skin Conditioning

Dipropylene Glycol

Masking

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Propanediol

Solvent
Helps hydrate Dry Skin Icon

1,2-Hexanediol

Skin Conditioning
Helps hydrate Dry Skin Icon

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Macadamia Integrifolia Seed Oil

Skin Conditioning
Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Olea Europaea Fruit Oil

Masking
0-2 / 0 Fragrance IconOil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Simmondsia Chinensis Seed Oil

Emollient
0-2 / 0 Oil IconHelps hydrate Dry Skin IconGood for Scar Healing IconNot safe for Fungal Acne Icon

Vitis Vinifera Seed Oil

Emollient
2-3 / 0 Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Macadamia Ternifolia Seed Oil

Emollient
Oil IconNot safe for Fungal Acne Icon

Retinal

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

Hydrolyzed Collagen

Emollient
Helps hydrate Dry Skin IconHelps with Anti-Aging Icon

Chitosan

Centella Asiatica Extract

Cleansing
Helps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon

Centella Asiatica Leaf Extract

Skin Conditioning
Helps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon

Centella Asiatica Root Extract

Skin Conditioning
Helps reduce Skin Redness IconHelps reduce irritation Icon

Coco-Caprylate/Caprate

Emollient
Not safe for Fungal Acne Icon

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Polyglyceryl-3 Distearate

Emulsifying
Not safe for Fungal Acne Icon

Dimethyl Isosorbide

Solvent

Pentylene Glycol

Skin Conditioning

Panthenol

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

4-T-Butylcyclohexanol

Masking
Fragrance IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Hydrogenated Lecithin

Emulsifying
Helps hydrate Dry Skin Icon

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Emulsion Stabilising

Sucrose Palmitate

Emollient

Caprylic/Capric Triglyceride

Masking
Helps hydrate Dry Skin Icon

Hydroxypinacolone Retinoate

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Diethylhexyl Syringylidenemalonate

Skin Protecting

Tromethamine

Buffering

Ethylhexylglycerin

Skin Conditioning

Glyceryl Stearate Citrate

Emollient
Not safe for Fungal Acne Icon

Allantoin

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Biosaccharide Gum-1

Skin Conditioning
Helps hydrate Dry Skin Icon

Dipotassium Glycyrrhizate

Humectant
Helps reduce Skin Redness IconHelps reduce irritation IconGood for Dark Spots Icon

Adenosine

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Scar Healing Icon

Retinol

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Bakuchiol

Antimicrobial
Antioxidant IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging IconGood for Dark Spots IconHelps brighten skin Icon

Retinyl Palmitate

Skin Conditioning
1-3 / 1-3 Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconNot safe for Fungal Acne IconMay worsen Rosacea Icon

Brassica Campestris Sterols

Emollient
Not safe for Fungal Acne Icon

Linoleic Acid

Cleansing
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Polyglyceryl-10 Laurate

Skin Conditioning
Not safe for Fungal Acne Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

PPG-13-Decyltetradeceth-24

Emulsifying

Retinyl Linoleate

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconNot safe for Fungal Acne Icon

Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate

Skin Conditioning

Beta-Glucan

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging IconGood for Scar Healing Icon

Aluminum/Magnesium Hydroxide Stearate

Emulsion Stabilising

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Antioxidant
Antioxidant Icon

Potassium Cetyl Phosphate

Emulsifying

Polyglyceryl-3 Methylglucose Distearate

Emulsifying
Not safe for Fungal Acne Icon

Silica

Abrasive
Exfoliant IconMay worsen Eczema IconMay worsen Rosacea Icon

Isopropyl Lauroyl Sarcosinate

Skin Conditioning

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Retinyl Retinoate

Skin Conditioning
Good for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Tris(Tetramethylhydroxypiperidinol)Citrate

Stabilising

Benzotriazolyl Dodecyl P-Cresol

UV Absorber

Xanthan Gum

Emulsifying

Disodium EDTA

Parfum

Masking
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Antimicrobial, Antioxidant, Emollient

Bakuchiol is a plant-derived antioxidant (it's vegan!). It is often called the replacement for retinol although it is not part of the same family.

It has similar effects as retinol: skin smoothing, reducing discoloration, and preventing wrinkles. It does not cause as much irritation as traditional retinoids.

Bakuchiol works by breaking down free radicals and stimulating collagen production in skin.

Combining bakuchiol with retinol will not have adverse side effects. Studies show using them will just boost the benefits. Bakuchiol is also found to help stabilize retinol.

While bakuchiol does not make the skin more sun sensitive, we recommend wearing SPF on a daily basis.

Read more about traditional retinol

Learn more about Bakuchiol
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Skin Conditioning

Retinol is a gold-standard ingredient for anti-aging. It is a form of Vitamin A and belongs to the class of retinoids that also includes tretinoin.

Why is retinol famous?

It has the most scientific studies backing up its skin benefits out of all the non-prescription ingredients.

Retinol is proven to:

This is why retinol is effective at removing wrinkles, fading dark spots, treating acne, and reducing the appearance of pores.

Studies show retinol is less effective when exposed to UV. Be sure to look for appropriate packaging to keep your retinol potent (similar to Vitamin C).

Using retinol or any retinoids will increase sun-sensitivity in the first few months. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.

We recommend speaking with a medical professional about using this ingredient during pregnancy.

Retinol may cause irritation in some people, so be sure to patch test. Experts recommend 'ramping up' retinol use: start using this ingredient once a week and work up to using it daily.

Read about Tretinoin

Learn more about Retinol
Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Humectant, Skin Conditioning

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Learn more about Dipotassium Glycyrrhizate
Skin Conditioning, Skin Protecting, Soothing

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

Some studies have shown this ingredient can promote wound healing with higher concentrations.

Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.

Learn more about Allantoin
Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

Learn more about Pentylene Glycol

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

When to use

131 Routines
5% use in am
95% use in pm
60% use every day
When to use See routines that use it ->
16 Routines
6% use in am
94% use in pm
75% use every day

Reviews

Here's what our community thinks

Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment 54 ingredients

3.7 /5
from 3 ratings
Doesn't Work (1)
alexandria111's avatar

Alexandra

2 months ago
Review

Did absolutely nothing and it was $60😭😭

#doesn't work

MediCube Deep Reviving Bakuchiol Retinol Serum 65 ingredients

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