Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Isononyl Isononanoate is a synthetic skin-conditioner and texture enhancer. It is created from nonanoic acid, a fatty acid found in cocoa and lavender oil.

As an emollient, Isononyl Isononanoate helps keep your skin soft and smooth. This is because emollients create a barrier on the skin to trap moisture in.

Isononyl Isononanoate helps give products a velvet feel and improves spreadability.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

• It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
• It is a humectant, which means that it helps attract moisture into the skin.
• It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Bakuchiol is a plant-derived antioxidant (it's vegan!). It is often called the replacement for retinol although it is not part of the same family.

Bakuchiol does offer similar effects to retinol: skin smoothing, reducing discoloration, and help preventing wrinkles. It does not cause as much irritation as traditional Retinols.

Combining bakuchiol with retinol will not have adverse side effects as the benefits from both will compound. Bakuchiol is also found to stabilize retinol.

Read more about traditional retinol

We don't have a description for Arachidyl Alcohol.

We don't have a description for Glyceryl Polymethacrylate.

Dimethicone Crosspolymer is a silicone created by modifying dimethicone with hydrocarbon side chains. Due to its large size, it does not penetrate skin. It is considered non-occlusive.

Dimethicone Crosspolymer is used to stabilize and thicken products. It also helps give products a silky feel.

A type of fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product. They are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as traditional alcohols.

Emollients help keep your skin soft and hydrated by creating a film that traps moisture in.

Behenyl Alcohol is usually derived from the fats in vegetable oils.

In 2000, Behenyl Alcohol was approved by the US as medicine to reduce the duration of cold sores.

Glycerin is already naturally found in your skin and helps moisturize and protect your skin. A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

Glycerin is a humectant, helping the skin retain moisture by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin. Having moisturized skin helps improve the skin barrier. Your skin barrier protects against skin irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, animal sources include tallow. It is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English while British English uses Glycerol/Glycerine.

We don't have a description for Peg-75 Shea Butter Glycerides.

Glyceryl Stearate is a mix of glycerin and stearic acid.

Glyceryl Stearate is used to stabilize the mixing of water and oil ingredients. By preventing these ingredients from separating, it can help elongate shelf life. It can also help thicken the product's texture.

As an emollient, it helps soften skin and supports barrier-replenishing ingredients.

In cosmetics, Glyceryl Stearate is often made from vegetable oils or synthetically produced. The human body also creates Glyceryl Stearate naturally.

C12-15 Alkyl Benzoate is made up of Benzoic Acid and long chain alcohols. It has a low molecular weight.

C12-15 Alkyl Benzoate is an emollient and texture enhancer. Due to its solubility, it is often used in sunscreens to help evenly distribute active ingredients.

As an emollient, C12-15 Alkyl Benzoate helps soften and hydrate your skin. Emollients create a film on your skin that traps moisture within.

This ingredient has been reported to cause eye irritation.

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 is not fungal acne safe.

Ascorbyl Tetraisopalmitate is a version of ascorbic acid, or pure Vitamin C.

Ascorbyl Tetraisopalmitate has many benefits including reducing wrinkles, skin soothing, dark spot fading, and fighting against free radicals.

Ascorbyl Tetraisopalmitate interferes with the process of skin darkening, helping to reduce hyperpigmentation. It also encourages the skin to produce more collagen.

As an antioxidant, it helps fight free-radicals. Free-radicals are molecules that may damage your skin cells.

One study found Ascorbyl Tetraisopalmitate to degrade in sunlight, but is stabilized when conbined with acetyl zingerone.

Retinol, AKA Vitamin A. Unlike AHA's, retinol does not remove the top layer of old and dead skin cells. Instead, it travels directly to the middle layer and gets to work. It neutralizes free radicals, boosting elastin and collagen production. This in turn makes retinol effective in removing fine lines, wrinkles, and enlarged pores.

Retinol is sensitive to breakdown when exposed to sun and air. It will also make your skin more sensitive to the sun, so it is recommended to wear SPF after applying retinol.

It is not recommended to use any retinols while pregnant. Retinol may cause irritation in some people.

Read about Tretinoin

Ceramide NG is a type of Ceramide. The NG stands for a sphinganine base.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.

If you would like to eat ceramides, sweet potatoes contain a small amount.

Read more about other common types of ceramides here:
Ceramide AP
Ceramide EOP
Ceramide NP

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein. Palmitoyl Tetrapeptide-7 consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

• Palmitoyl Tripeptide-1
• Acetyl Hexapeptide-8
• Copper Tripeptide-1

Palmitoyl Hexapeptide-12 is a peptide.

Sodium Hyaluronate is hyaluronic acid's salt form.

Sodium Hyaluronate is great at holding water and acts as a humectant. It plays a role in hydrating and soothing skin.

It is naturally occurring in our bodies and is mostly found in eye fluid and joints; it is commonly derived from sodium salt of hyaluronic acid.

These are some other common types of Hyaluronic Acid:

• Hyaluronic Acid
• Hydrolyzed Hyaluronic Acid
• Sodium Hyaluronate Crosspolymer

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. Licorice Root Extract has been found to have several benefits.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Avena Sativa Kernel Extract is more commonly known as Colloidal Oatmeal. It is formed from grounded oatmeal and a liquid base.

Besides being a healthy breakfast, oats have many benefits in skincare too.

Colloidal Oatmeal helps sooth, hydrate, and protect the skin. The starches in colloidal oatmeal are able to bind water, keeping the skin hydrated.

The cellulose and fiber in colloidal oatmeal help reduce inflammation. This can also help the skin feel softer.

Colloidal Oatmeal is also an antioxidant. Antioxidants help stabilize free-radical molecules. These molecules may damage skin cells.

Avenacins found in colloidal oatmeal have anti-fungal properties. The saponins have a cleaning affect.

Overall, colloidal oatmeal is great at providing the skin with moisture and help sooth irritation. It also protects the skin in various ways.

Arctium Lappa Root Extract is from the burdock plant. It is an antioxidant and helps soothe skin. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells.

In folk medicine, Arctium Lappa has been used to treat skin inflammation and digestion.

Salix Alba Bark Extract comes from the white willow tree, which is native to Europe and Central Asia.

Salix Alba Bark Extract has often been described as salicylic acid's cousin. This is due to the salicin it contains. However, studies are limited showing salix alba bark to be an effective salicylic acid alternative.

Salicin does have anti-inflammatory and antioxidant properties. It has shown to decrease the formation of inflammatory mediators, such as tumor necrosis factor-α and nuclear factor-kappa B. Salicin also has a mildly exfoliating effect on the skin.

Several other components in salix alba bark extract also contain antioxidant properties, such as flavonoids and polyphenols. Antioxidants may help with anti-aging as they neutralize harmful free-radical molecules.

Willow Bark extract has been used for thousands of years. Ancient civilizations used white willow to help treat pain and fevers.

We don't have a description for Glycine Soja Sterols.

Lecithin is a term for a group of substances found in plants, animals, and humans. They are made up of mixture of fatty acids. These fatty acids usually are a mixture of phosphoric acid's choline ester connected to stearic, oleic, and palmitic acids. Most lecithins are created from plant ingredients scuh as sunflower.

Lecithin is an emollient. Emollients help soften the skin and creates a barrier to keep moisture in.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can help ingredients be better absorbed by the skin. The phospholipids in Lecithin can produce liposomes. Liposomes help other ingredients get through the skin barrier.

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

Some studies have shown this ingredient can promote wound healing with higher concentrations.

Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

We don't have a description for Hydrolyzed Soy Protein.

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tripeptide-1 is a signal peptide. This means it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:
* Palmitoyl Tetrapeptide-7
* Acetyl Hexapeptide-8
* Copper Tripeptide-1

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Tribehenin isn't fungal acne safe.

Caprylyl Glycol is a humectant, meaning it retains and preserves moisture. It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products.

Dipeptide-2 is a peptide.

Polygonum Cuspidatum Root Extract comes from the Japanese Knotweed plant native to Japan, Korea, and China.

This plant contains anti-inflammatory and antioxidant properties. It contains high amounts of resveratrol, a potent antioxidant.

The root of the plant has been used in traditional folk medicine throughout Asia.

We don't have a description for Peg-10 Phytosterol.

We don't have a description for Peg-8.

We don't have a description for Magnesium Aluminum Silicate.

We don't have a description for Arachidyl Glucoside.

We don't have a description for Chrysin.

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.

This property also makes Pentylene Glycol a great texture enhancer. It can help thicken or emulsify a product. Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

We don't have a description for Sodium Acrylates Copolymer.

We don't have a description for Steareth-20.

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as en emulsifier. Emulsifiers help prevent the separation of oils and products. Cetearyl alcohol can also help thicken a product or help create foam.

Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.

Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.

Cetearyl alcohol is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne. In general, it is best to speak with a professional about using this ingredient if you have concerns.

Coco-Glucoside is a surfactant, or a cleansing ingredient. It is made from glucose and coconut oil.

Surfactants help gather dirt, oil, and other pollutants from your skin to be rinsed away. Coco-Glucoside is considered gentle and non-comedogenic.

Hesperidin Methyl Chalcone is an antioxidant and is a type of silicone.

We don't have a description for N-Hydroxysuccinimide.

Disodium EDTA plays a role in making products more stable by aiding other preservatives. It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of ethylenediaminetetraacetic acid and are found to be safe in cosmetic ingredients.

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Benzoic Acid is used to preserve and adjust the pH of products.

The antimicrobial property of Benzoic Acid helps elongate a product's shelf life. Its main role is to reduce fungi growth and is not found to be effective at fighting bacteria. Therefore Benzoic Acid is always added along with other preservatives.

In its pure form, Benzoic Acid looks like a white crystalline solid. It has slight solubility in water.

The name of Benzoic Acid comes from gum benzoin, which used to be the sole source of deriving this ingredient. Benzoic Acid is the most simple aromatic carboxylic acid.

Benzoic Acid is naturally occuring in strawberries, mustard, cinnamon, and cloves. It has a slight scent but is not considered to be a fragrance.

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.