One Thing Peptide Retinal Serum Versus MediCube Retinol-Some 1.9% NMN Boosting Serum
Updated on May 19, 2025
Overview
What they are
These products are both cruelty-free and reef safe serums. They have a total of 27 ingredients in common
Cool Features
They both contain hyaluronic acid, niacinamide, peptides, retinoid and Vitamin C
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any harsh alcohols, common allergens, fragrances, parabens or sulfates
What's Inside
They both contain oils
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
One Thing Peptide Retinal Serum 58 ingredients
MediCube Retinol-Some 1.9% NMN Boosting Serum 63 ingredients
What's inside
What's inside
At a glance
Click on any of the items below to learn more
One Thing Peptide Retinal Serum 58 ingredients
MediCube Retinol-Some 1.9% NMN Boosting Serum 63 ingredients
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Acetyl Hexapeptide-8, commonly known as Argireline, is a popular peptide in skincare. It’s often referred to as a “Botox-like” ingredient because it helps reduce muscle movement.
By relaxing these micro-movements, Argireline may help minimize the appearance of fine lines and wrinkles. That said, it’s not as powerful as Botox, and research on its long-term effectiveness is still limited.
Beyond smoothing, Argireline may also support collagen production. Collagen is the protein that helps keep your skin firm, bouncy, and well-hydrated by strengthening the skin barrier.
So while Argireline isn’t a miracle fix, it can be a helpful addition to a routine focused on both prevention and skin health.
Read more about other common types of peptides here:
Learn more about Acetyl Hexapeptide-8Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.
Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.
Studies have found adenosine may also help with wound healing.
In skincare products, Adenosine is usually derived from yeast.
Learn more about AdenosineWe don't have a description for Aluminum/Magnesium Hydroxide Stearate yet.
Brassica Campestris Sterols isn't fungal acne safe.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolThis ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.
Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.
Learn more about Caprylic/Capric TriglycerideCetyl Ethylhexanoate is an emollient ester. It comes from cetearyl alcohol and 2-ethylhexanoic acid.
Cetyl Ethylhexanoate is an emollient that adds a velvety feel to skin without being greasy or oily. Emollients help trap moisture into your skin, keeping your skin soft and hydrated.
Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.
Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.
Our bodies use cholestrol to create vitamin D, steroid hormones, and more.
Learn more about CholesterolDipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.
This ingredient helps:
Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene GlycolDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.
This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.
This ingredient is not irritating or sensitizing.
Macadamia Ternifolia Seed Oil is the fixed oil obtained from Macadamia nut.
Macadamia seed oil is rich in fatty acids, including oleic acid (45-75%), palmitoleic acid (7-33%), and palmitic acid (6-12%). They also contain various B vitamins, iron, and magnesium.
Palmitoleic acid has been shown to help soothe inflammation and promote wound healing. It is also naturally found in the fat of our skin.
Macadamia seed oil may not be malassezia folliculitis, or fungal-acne, safe.
Learn more about Macadamia Ternifolia Seed OilNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePalmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).
This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.
Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.
Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.
Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).
Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7This synthetic peptide is created from lysine, valine, and palmitic acid.
According to the manufacturer, in-vitro studies show tissue growth and collagen synthesis. Another in-vivo study found 60 volunteers saw a significant reduction in wrinkles after 84 days.
Due to its palmitic acid base, this peptide may not be fungal-acne safe.
Learn more about Palmitoyl Tripeptide-5Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate (long name, huh?) is a synthetic antioxidant.
It is used to help stabilize other antioxidants or prevent the color from changing in a product.
As an antioxidant, it helps fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material. Thus, antioxidants may reduce the signs of aging.
This ingredient is oil-soluble.
Learn more about Pentaerythrityl Tetra-Di-T-Butyl HydroxyhydrocinnamateWe don't have a description for Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate yet.
Polyacrylate Crosspolymer-6 is a texture enhancer and pH adjuster.
It is be used to thicken water-based products and create a gel-texture with a velvet feel.
One manufacturer claims this ingredient to have a pH range of 2-8 and to be biodegradable.
Learn more about Polyacrylate Crosspolymer-6Polyglyceryl-10 Oleate isn't fungal acne safe.
Potassium Cetyl Phosphate is the potassium salt of a mixture. This mixture consists of the esters from phosphoricacid and cetyl alcohol.
Potassium Cetyl Phosphate is an emulsifier and cleansing agent. Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating.
As a cleansing agent, Potassium Cetyl Phosphate helps gather oils, dirts, and pollutants from your skin. This makes it easier to rinse them away with water.
Learn more about Potassium Cetyl PhosphatePropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolRetinal is a form of retinoid. Retinoids are the gold-standard class of anti-aging ingredients.
Retinal has many benefits as other retinoids: improve skin texture, reduce large pores, reduce the effects of aging, reduce the visibility of dark spots, heal scars, and fight acne.
Studies show retinal may work at a faster rate than retinol due to its structure.
All retinoids have to be converted into retinoic acid before starting to work. Some retinoids take several steps of conversion before binding. Retinal is only one step away, making it more potent.
Like other retinoids, retinal may be irritating. It is best to ease into using this ingredient frequently.
Using the 'ramp up' method, start by using retinol once a week. This gives your skin time to adjust and decrease irritation. Once you feel ready, you can slowly increase the frequency of retinol use.
Using retinoids will increase sun-sensitivity in the first few weeks of use. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.
Learn more about RetinalWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterIngredient Ratings
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One Thing Peptide Retinal Serum 58 ingredients
MediCube Retinol-Some 1.9% NMN Boosting Serum 63 ingredients
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