Dr.Leo 377 VC Whitening & Spot Fading Essence Versus Numbuzin 9+ NMN Bio Liftingsil Essence
Updated on April 02, 2025
Overview
What they are
These products are both cruelty-free and reef safe essences. They have a total of 24 ingredients in common
Cool Features
They both contain hyaluronic acid, niacinamide, peptides, Vitamin C and Vitamin E
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any harsh alcohols, common allergens, parabens or sulfates
What's Inside
They both contain oils and silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Dr.Leo 377 VC Whitening & Spot Fading Essence 55 ingredients
Numbuzin 9+ NMN Bio Liftingsil Essence 121 ingredients
About this product
About this product
At a glance
Click on any of the items below to learn more
Dr.Leo 377 VC Whitening & Spot Fading Essence 55 ingredients
Numbuzin 9+ NMN Bio Liftingsil Essence 121 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterDimethicone is a type of synthetic silicone created from natural materials such as quartz.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
- It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
- It is a humectant, which means that it helps attract moisture into the skin.
- It helps improve product application.
- It has mild preservative properties.
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about Glycerin1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Ammonium Acryloyldimethyltaurate/Vp Copolymer (let's call it AAVC for short) is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
AAVC is able to increase the consistency and viscosity of products due to its large molecule size. It also prevents ingredients from separating.
Niacinamide has emerged as an all-star ingredient due to its many benefits.
It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.
Other benefits include smoothing wrinkles and minimizing redness.
The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.
Learn more about NiacinamidePropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolCarbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Tromethamine helps balance the pH and improve the texture of a product. It is synthetically created.
As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.
Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
Learn more about TromethamineEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolSteareth-20 is a waxy compound used to emulsify ingredients. It is created from stearyl alcohol.
It possesses surfactant properties. This means it reduces surface tension and helps oils, dirt, and pollutants to be washed away.
The 20 stands for the number of ethylene oxide used to create this ingredient.
Learn more about Steareth-20Tremella Fuciformis Extract comes from the tremella fuciformis mushroom, also known as snow mushroom or white jelly mushroom.
The snow mushroom has moisturizing and antioxidant properties.
Snow mushroom is rich in polysaccharides, giving it moisturizing benefits. As a humectant, snow mushroom helps draw moisture from the air to the skin. Polysaccharides are able to mimic our skin's natural carbohydrates to help the skin retain water.
Snow mushroom has been shown to help with anti-aging due to its antioxidants. It increases the presence of superoxide dismutase in our brain and liver. Superoxide is a by-product of oxygen metabolism. It left unregulated, superoxide causes cell damage. Thus, superoxide dismutase acts as an antioxidant to protect our living cells.
Another study from 2016 showed snow mushroom extract blocks the skin from creating melanin when exposed to UVB. Thus, it may help protect against the signs of aging from sun exposure. However, more studies are needed to confirm this. Another study from 2021 found snow mushroom to protect against UVA damage as well.
This white mushroom is native to Asian countries such as China, Korea, Japan, and Thailand. It is a common ingredient in traditional Chinese cuisine and medicine.
Learn more about Tremella Fuciformis ExtractHydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.
This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateTripeptide-1 is a peptide. It can help to reduce the effects of aging.
Acetyl Tetrapeptide-9 is a signal peptide. Signal peptides tell your skin to create collagen or start tissue repair.
This peptide plays a role in key skin components such as collagen, lumican, and glycosaminoglycans (GAGs). Lumican is used in collagen organization and regulation, while GAGs are a component that holds water in our skin.
The manufacturer claims this ingredient is effective at firming the skin and enhancing skin hydration.
Learn more about Acetyl Tetrapeptide-9Hexapeptide-9 is a peptide.
Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolYou might know this ingredients as Matrixyl, a famous peptide.
Peptides are building blocks for protein. Palmitoyl Pentapeptide-4 consists of five amino acids. These amino acids include: 2 lysines, 2 threonines, and serine
This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Thus, Matrixyl may help improve the look of wrinkles.
Read more about other common types of peptides here:
Learn more about Palmitoyl Pentapeptide-4Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.
Argireline has a similar function to botox; it prevents muscle movement and contractions slightly. By preventing muscles from moving, argireline also prohibits the formation of fine lines and wrinkles. However, research is lacking in proving this ingredient to be as effective as botox.
On the other hand, argireline tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Acetyl Hexapeptide-8Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.
This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.
This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.
By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.
Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).
As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.
If you spot Citric Acid near the end of an ingredient list, it's likely there as a pH adjuster rather than an active ingredient.
Read more about some other popular AHA's here:
Learn more about Citric AcidIngredient Ratings
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