Neogen Probiotics Relief Cream Ingredients Explained

It is derived from corn or petroleum with a clear color and no scent.

As a surfactant, isopentyldiol is a hydrotrope. Hydrotropes help surfactants (cleansing agents) dissolve into water.

According to the manufacturer, using this ingredient withsorbitol boosts skin hydration and helps close cuticles of damaged hair.

This ingredient is water-soluble.

D5 is an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.

Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

As an emollient, it can help the skin feel soft and hydrated. It is also used to reduce frizz in hair products.

Shea butter is rich in antioxidants. Antioxidants help fight free-radicals, or molecules that may harm the body. It is also full of fatty acids including stearic acid and linoleic acid. These acids help replenish the skin and keep skin moisturized.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

Shea butter may not be fungal acne safe. We recommend speaking with a professional if you have any concerns.

As an emollient, it helps soften skin and supports barrier-replenishing ingredients.

In cosmetics, Glyceryl Stearate is often made from vegetable oils or synthetically produced. The human body also creates Glyceryl Stearate naturally.

They are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent alcohols. FDA allows products labeled "alcohol-free" to have fatty alcohols.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Betaine is naturally created in the skin and body. The form found within cosmetic products can be either plant-dervied or synthetic.

Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.

Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.

In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.

Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

Sodium PCA is a has conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Studies also show this ingredient to be a promising soothing ingredient for sensitive skin.

It also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

Our NMF is formed from amino acids, lactic acid, sugars, minerals, peptides, and electrolytes. As we age, our NMF naturally depletes. Other sources of NMF depletion include harsh and drying ingredients such as denatured alcohol. Sodium lactate can help replenish our NMF, leading to more hydrated and plump skin.

High percentages of Sodium Lactate can have an exfoliating effect.

Sodium Lactate is produced from fermented sugar.

Arginine isn't fungal acne safe when used in the presence of other lipids (fats, fatty acids, oils, esters, etc). Oils and fats occur naturally within the skin, so take caution when using Arginine if you're prone to fungal acne.

Antioxidants help mitigate damage from free-radical molecules. These are molecules that originate from external sources such as pollution, cigarette smoke, or the sun.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid. Caprylic Triglyceride has not been found to be toxic for human use in concentrations under 50%.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.

As collagen is made up of glycine and other amino acids, it is believed Glycine may help our skin produce more collagen. Collagen helps keep skin plump and firm.

Alanine is used by fibrous proteins such as collagen, elastin, and keratin. These three help make a strong skin barrier. Having a healthy skin barrier leads to more plump and youthful skin.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can help ingredients be better absorbed by the skin. The phospholipids in Lecithin can produce liposomes. Liposomes help other ingredients get through the skin barrier.

Studies show Royal Jelly to contain amino acids, fatty acids, and a variety of vitamins, including Vitamin Bs. Many of these components are antioxidants, which help with anti-aging. The fatty acids in Royal Jelly make it a hydrating ingredient.

Several animal studies show Royal Jelly to boost collagen production and reduce inflammation.

The Vitamin Bs found in Royal Jelly include:

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Studies show propolis helps fight against bacteria, viruses, and fungi. This may help with reducing acne and accelerate wound healing.

The flavonoids found in propolis extract are potent antioxidants. Antioxidants may help with reducing the signs of aging.

A study from 2020 found propolis to help reverse skin damage from UV.

Fun facts: This ingredient is created by mixing beeswax, bee saliva, and parts of trees. Bees use propolis as a sealant to close any gaps in their hives.

Since it is an animal-derived product, this ingredient is not considered vegan. For vegan alternatives, check out Galactomyces Ferment Filtrate or Centella Asiatica Extract.

Hydrolyzed Collagen is created by breaking up proteins into smaller peptide bonds. These peptides act as humectants and emollients.

Humectants are great at holding onto water, keeping skin hydrated. Emollients create a thin barrier on the skin to prevent moisture from escaping.

There is ongoing debate about whether hydrolyzed collagen works because it increases skin hydration. Skin hydration is also linked to elasticity and the appearance of wrinkles.

Collagen or peptide ingredients can be used in the morning or night. They will not increase sun sensitivity, but you should always wear sunscreen during the day.

According to a manufacturer, this ingredient is a great hair conditioner as well.

This ingredient can be extracted from different sources, including:

Vegan collagen is derived from yeast, bacteria, or plant sources. Vegan collagen would go by a different INCI name, such as hydrolyzed soy protein.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Jojoba seed oil is a humectant, meaning it helps draw moisture from the air. This helps keep your skin hydrated.

While jojoba has antibacterial properties, it is only able to kill some bacteria. It has also been shown to help in wound healing. Indigenous cultures have used jojoba as a moisturizer and to help treat burns.

It is found to be similar to natural human skin sebum, so it has a great effect on dry skin. Jojoba oil may even help with regulating sebum production.

Although jojoba oil is non-comedogenic, we recommend speaking with a professional about using this ingredient if you have any concerns.

Jojoba oil may not be fungal acne safe. We recommend speaking with a professional if you have any concerns.

Jojoba is native to the southwestern US.

These fatty acids help the skin create ceramides. Ceramides play a role in repairing the skin barrier.

Helianthus Annuus Seed Oil helps moisturize the skin. This in turn helps the skin look more rejuvenated and smoother.

Sunflowers are rich in vitamin E.

Historians believe Indigenous cultures of North America domesticated sunflowers before corn. Thus they relied on sunflower oil for a variety of uses. One such use is moisturizing skin and hair.

Sunflower seed oil may not be fungal acne safe. We recommend speaking with a professional if you have any concerns.

Serine is a non-essential amino acid, meaning we don't need to obtain it from eating foods.

Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.

In medicine, proline is used as an osmoprotectant. This means it helps prevent oxidative degradation in other drugs.

Our bodies are able to produce proline naturally, but certain conditions may inhibit this production. In that case, proline can be obtained from eating egg whites, soy protein, dairy products, asparagus, mushrooms, and seaweed.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

What makes hyaluronic acid so hydrating? It has the capacity to bind or hold large amounts of water.

Fun fact: It is already naturally found in our bodies, such as the fluids of our eyes and our joints.

Studies find this ingredient to have anti-inflammatory and anti-microbial properties. This can help speed up wound-healing,

These are some other common types of Hyaluronic Acid:

Vitamin C helps reduce redness, improve skin texture, reduce the effects of aging, reduce the visibility of dark spots, and brighten skin.

Your skin uses Vitamin C to produce collagen and collagen production plays a role in having a strong skin barrier and plump skin. As an antioxidant, this ingredient also helps reduce the signs of aging such as fine-lines and wrinkles.

VItamin C helps brighten skin by blocking the process of skin darkening.

In a 2011 study, Sodium Ascorbyl Phosphate was found to have antibacterial properties. This may help treat acne.

Read more about other types of Vitamin C:

Studies show phospholipids display antioxidant activity and may help with reducing the signs of aging.

Phospholipids are complex lipids that contain glycerin, two fatty acids, and a phosphate group. Some foods that contain phospholipids include soybeans and milk. The phospholipids found in soy come from Lecithin. This ingredient can also be synthetically created.

Some types of phospholipids:

Phytosphingosine tells our skin to increase its natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Phytosphingosine is also abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Boosting collagen and elastin production can help create a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin. It's a win-win situation!

This ingredient helps with scar healing. This is because it breaks down damaged collagen, the main component of scar tissue. It may also help with reducing sunspots, acne scars, and uneven skin tone.

On top of all this, Copper Tripeptide-1 is also an antioxidant. Antioxidants help the body fight off free-radicals. Free radicals are molecules that damage our cells, such as pollution and tobacco smoke.

More benefits: Copper Tripeptide-1 helps maintain tissues in blood vessels and promote natural hyaluronic acid in skin.

Read more about other common types of peptides here:

Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.

If you would like to eat ceramides, sweet potatoes contain a small amount.

Read more about other common types of ceramides here: Ceramide AP Ceramide EOP Ceramide NP

Ceramide 3 (Retired) is the N-acylated phytosphingosine having the erythro structure that conforms generally to the formula, where m has a value ranging from 12 to 28 in which the acyl moiety may be saturated, mono-unsaturated, or di-unsaturated and n has a value ranging from 10 to 20. The INCI Name, Ceramide 3, originally developed in 1997, was designated with a retired status in 2014. For an interim period of time, trade name assignments formerly published with the INCI Name Ceramide 3 will be retained in the retired monograph, and also published with the new name assignment, Ceramide NP.

Not only does it help exfoliate the skin, it helps strengthen the skin's barrier. When applied, lactic acid helps the skin create ceramides.

Lactic acid is an over-the-counter chemical exfoliant that comes from the fermentation of lactose — a carbohydrate found in milk.

Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.

Read more about some other popular AHA's here:

Our bodies use cholestrol to create vitamin D, steroid hormones, and more.

One study found topical low molecular weight hyaluronic acid may be considered for the treatment of rosacea in the adult population. However, we always recommend speaking with a professional about your skin concerns.

Hyaluronic acids are a humectant. This means they draw moisture from the air. Hyaluronic acids help moisturize, soothe, and protect the skin.

Read more about other common forms of hyaluronic acid:

One study found using Madecassoside with ascorbic acid helped reduce the signs of aging and improved skin hydration.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Argireline tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Thus, Matrixyl may help improve the look of wrinkles.

Read more about other common types of peptides here:

Emerging studies show Nonapeptide-1 to help with reducing pigmentation and brightening the skin. It has shown to prevent the activation of tyrosinase, an enzyme in the skin that begins the process of melanin creation. Melanin is responsible for giving skin a tan or dark spots.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

In the US, the alternative name for parfum is 'fragrance'.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.