ZO Skin Health Renewal Crème Versus Estée Lauder Revitalizing Supreme+ Global Anti-Aging Cell Power Creme SPF 15
This barrier-repair moisturizer is formulated around Lactococcus Ferment Lysate and Avena Sativa Kernel Extract to strengthen the skin barrier and soften the look of wrinkles.
This anti-aging moisturizer is formulated around Moringa Oleifera Seed Extract and Acetyl Glucosamine to soften the look of wrinkles and hydrate skin.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningIsocetyl Stearate
EmollientIsopropyl Palmitate
EmollientCetearyl Alcohol
EmollientGlycerin
HumectantLactococcus Ferment Lysate
Skin ConditioningJojoba Esters
EmollientSilica
AbrasiveSteareth-21
CleansingSteareth-2
EmulsifyingPolysorbate 60
EmulsifyingPolysorbate 20
EmulsifyingCocos Nucifera Oil
MaskingGlycine Soja Oil
EmollientAvena Sativa Kernel Extract
AbrasiveEpilobium Angustifolium Flower/Leaf/Stem Extract
Skin ConditioningGardenia Taitensis Flower Extract
Skin ConditioningPlankton Extract
Skin ConditioningGlycine Soja Sterols
EmollientTocopherol
AntioxidantRetinol
Skin ConditioningMagnesium Ascorbyl Phosphate
AntioxidantEctoin
Skin ConditioningCaprylyl Glycol
EmollientPolyglutamic Acid
Skin ConditioningHexylene Glycol
EmulsifyingHydrogenated Lecithin
EmulsifyingLecithin
EmollientUbiquinone
AntioxidantAcetyl Hexapeptide-8
HumectantTetrasodium EDTA
ChelatingSodium Hyaluronate
HumectantCarbomer
Emulsion StabilisingSodium Hydroxide
BufferingCitric Acid
BufferingPhenoxyethanol
PreservativeEthylhexylglycerin
Skin ConditioningSodium Benzoate
MaskingSorbic Acid
PreservativePotassium Sorbate
PreservativeWater, Isocetyl Stearate, Isopropyl Palmitate, Cetearyl Alcohol, Glycerin, Lactococcus Ferment Lysate, Jojoba Esters, Silica, Steareth-21, Steareth-2, Polysorbate 60, Polysorbate 20, Cocos Nucifera Oil, Glycine Soja Oil, Avena Sativa Kernel Extract, Epilobium Angustifolium Flower/Leaf/Stem Extract, Gardenia Taitensis Flower Extract, Plankton Extract, Glycine Soja Sterols, Tocopherol, Retinol, Magnesium Ascorbyl Phosphate, Ectoin, Caprylyl Glycol, Polyglutamic Acid, Hexylene Glycol, Hydrogenated Lecithin, Lecithin, Ubiquinone, Acetyl Hexapeptide-8, Tetrasodium EDTA, Sodium Hyaluronate, Carbomer, Sodium Hydroxide, Citric Acid, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Sorbic Acid, Potassium Sorbate
Water
Skin ConditioningOctocrylene
UV AbsorberButyloctyl Salicylate
Skin ConditioningEthylhexyl Salicylate
UV AbsorberGlycerin
HumectantButyl Methoxydibenzoylmethane
UV AbsorberPolysorbate 60
EmulsifyingCetyl Alcohol
EmollientSorbitan Stearate
EmulsifyingDimethicone
EmollientTridecyl Stearate
EmollientButylene Glycol
HumectantPentylene Glycol
Skin ConditioningMoringa Oleifera Seed Extract
Skin ConditioningOpuntia Tuna Fruit Extract
Skin ConditioningHordeum Vulgare Extract
EmollientCucumis Sativus Fruit Extract
EmollientNarcissus Tazetta Bulb Extract
AstringentSigesbeckia Orientalis Extract
Skin ConditioningPyrus Malus Fruit Extract
Skin ConditioningLens Esculenta Fruit Extract
Skin ConditioningWhey Protein
Skin ConditioningCitrullus Lanatus Fruit Extract
Skin ConditioningCaffeine
Skin ConditioningAlgae Extract
EmollientLaminaria Digitata Extract
Skin ProtectingTocopheryl Acetate
AntioxidantAcetyl Glucosamine
Skin ConditioningAstrocaryum Murumuru Seed Butter
EmollientSucrose
HumectantTridecyl Trimellitate
EmollientDipentaerythrityl Hexacaprylate/Hexacaprate
EmulsifyingPEG-100 Stearate
SurfactantTrehalose
HumectantCetyl Palmitate
EmollientSorbitol
HumectantAcetyl Hexapeptide-8
HumectantSodium Lactate
BufferingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingSodium Benzoate
MaskingSorbitan Palmitate
EmulsifyingSorbitan Olivate
EmulsifyingEthylhexylglycerin
Skin ConditioningSodium PCA
HumectantVp/Hexadecene Copolymer
Sodium Polyacrylate
AbsorbentPropylene Glycol Dicaprate
EmollientSodium Hyaluronate
HumectantIsoceteth-20
EmulsifyingHelianthus Annuus Seedcake
AbrasivePolyethylene
AbrasiveParfum
MaskingTetrahexyldecyl Ascorbate
AntioxidantSodium Hydroxide
BufferingDisodium EDTA
ChelatingBHT
AntioxidantPhenoxyethanol
PreservativeChlorphenesin
AntimicrobialCI 19140
Cosmetic ColorantCI 14700
Cosmetic ColorantWater, Octocrylene, Butyloctyl Salicylate, Ethylhexyl Salicylate, Glycerin, Butyl Methoxydibenzoylmethane, Polysorbate 60, Cetyl Alcohol, Sorbitan Stearate, Dimethicone, Tridecyl Stearate, Butylene Glycol, Pentylene Glycol, Moringa Oleifera Seed Extract, Opuntia Tuna Fruit Extract, Hordeum Vulgare Extract, Cucumis Sativus Fruit Extract, Narcissus Tazetta Bulb Extract, Sigesbeckia Orientalis Extract, Pyrus Malus Fruit Extract, Lens Esculenta Fruit Extract, Whey Protein, Citrullus Lanatus Fruit Extract, Caffeine, Algae Extract, Laminaria Digitata Extract, Tocopheryl Acetate, Acetyl Glucosamine, Astrocaryum Murumuru Seed Butter, Sucrose, Tridecyl Trimellitate, Dipentaerythrityl Hexacaprylate/Hexacaprate, PEG-100 Stearate, Trehalose, Cetyl Palmitate, Sorbitol, Acetyl Hexapeptide-8, Sodium Lactate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Benzoate, Sorbitan Palmitate, Sorbitan Olivate, Ethylhexylglycerin, Sodium PCA, Vp/Hexadecene Copolymer, Sodium Polyacrylate, Propylene Glycol Dicaprate, Sodium Hyaluronate, Isoceteth-20, Helianthus Annuus Seedcake, Polyethylene, Parfum, Tetrahexyldecyl Ascorbate, Sodium Hydroxide, Disodium EDTA, BHT, Phenoxyethanol, Chlorphenesin, CI 19140, CI 14700
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolPolysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water