Cosnori Panthenol Barrier Emulsion
A highly rated emulsion with 53 ingredients, including niacinamide, vitamin E, and hyaluronic acid.
This barrier-repair emulsion is formulated around Panthenol and Niacinamide to strengthen the skin barrier and calm redness.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningGlycerin
HumectantPanthenol
Skin ConditioningPropanediol
Solvent1,2-Hexanediol
Skin ConditioningDipropylene Glycol
HumectantHydrogenated Polydecene
EmollientMacadamia Integrifolia Seed Oil
Skin ConditioningNiacinamide
SmoothingTerminalia Ferdinandiana Fruit Extract
AntioxidantSqualane
EmollientCetearyl Olivate
Butylene Glycol
HumectantCetearyl Alcohol
EmollientGlyceryl Stearate
EmollientSorbitan Olivate
EmulsifyingCarbomer
Emulsion StabilisingTromethamine
BufferingHydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingCaprylic/Capric Triglyceride
MaskingTocopherol
AntioxidantHelianthus Annuus Seed Oil
EmollientEthylhexylglycerin
Skin ConditioningHydrogenated Lecithin
EmulsifyingLactobacillus
Skin ConditioningSaccharomyces/Potato Extract Ferment Filtrate
HumectantAdenosine
Skin ConditioningLactobacillus/Soybean Ferment Extract
Skin ConditioningLactobacillus/Rice Ferment
Skin ConditioningSaccharomyces/Coix Lacryma-Jobi Ma-Yuen Seed Ferment Filtrate
Skin ConditioningDisodium EDTA
Butyrospermum Parkii Butter
Skin ConditioningSorbitan Isostearate
EmulsifyingBetaine
HumectantCeramide NP
Skin ConditioningHyaluronic Acid
HumectantHydrolyzed Hyaluronic Acid
HumectantSodium Hyaluronate
HumectantPentylene Glycol
Skin ConditioningMadecassoside
AntioxidantCholesterol
EmollientCeramide AP
Skin ConditioningCeramide Ns
Skin ConditioningCeramide As
Skin ConditioningDecyl Glucoside
CleansingEucalyptus Globulus Leaf Extract
PerfumingCaprylyl Glycol
EmollientCentella Asiatica Extract
CleansingAsiaticoside
AntioxidantAsiatic Acid
Skin ConditioningMadecassic Acid
Skin ConditioningPhytosphingosine
Skin ConditioningCeramide EOP
Skin ConditioningWater, Glycerin, Panthenol, Propanediol, 1,2-Hexanediol, Dipropylene Glycol, Hydrogenated Polydecene, Macadamia Integrifolia Seed Oil, Niacinamide, Terminalia Ferdinandiana Fruit Extract, Squalane, Cetearyl Olivate, Butylene Glycol, Cetearyl Alcohol, Glyceryl Stearate, Sorbitan Olivate, Carbomer, Tromethamine, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylic/Capric Triglyceride, Tocopherol, Helianthus Annuus Seed Oil, Ethylhexylglycerin, Hydrogenated Lecithin, Lactobacillus, Saccharomyces/Potato Extract Ferment Filtrate, Adenosine, Lactobacillus/Soybean Ferment Extract, Lactobacillus/Rice Ferment, Saccharomyces/Coix Lacryma-Jobi Ma-Yuen Seed Ferment Filtrate, Disodium EDTA, Butyrospermum Parkii Butter, Sorbitan Isostearate, Betaine, Ceramide NP, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Pentylene Glycol, Madecassoside, Cholesterol, Ceramide AP, Ceramide Ns, Ceramide As, Decyl Glucoside, Eucalyptus Globulus Leaf Extract, Caprylyl Glycol, Centella Asiatica Extract, Asiaticoside, Asiatic Acid, Madecassic Acid, Phytosphingosine, Ceramide EOP
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about Propanediol1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.
This ingredient helps:
Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene GlycolHydrogenated Polydecene is a synthetic emollient. It forms a non-occlusive film on the skin's surface to provide a silky feel without being greasy.
In vivo studies in volunteers with atopic and dry skin showed no irritation or intolerance. The volunteers also saw a positive effect in dryness, scaling, and roughness after 28 days of use.
Concentrations up to 100% in guinea pig tests found it to be non-sensitizing and completely safe for use in cosmetics.
Learn more about Hydrogenated PolydeceneThis ingredient is also known as Macadamia Seed Oil. It's an emollient with a fatty acid profile that closely mirrors the skin's own lipid makeup.
The palmitoleic acid content is especially notable as it's somewhat rare in plant oils. Palmitoleic acid is something your skin already makes naturally. It helps keep cell membranes structured and plays a role in fighting off harmful microbes.
This palmitoleic content is also part of why macademia seed oil absorbs quickly and doesn't leave much of a greasy residue.
It also contains oleic acid, linoleic acid, and phytosterols that can help reduce redness.
In vitro research has shown the oil to have meaningful antioxidant activity, protect fats in the skin from oxidative damage, and slow down the enzyme that breaks down hyaluronic acid.
A 2024 clinical study found it effective at improving skin hydratino and reducing wrinkle appearance when formulated into nanoemulsions.
Because it carries oleic acid (C18) and palmitic acid (C16), this ingredient may not be fungal acne safe. This is because the Malassezia yeast metabolizes in the C11-24 chain length range.
You'll also see this ingredient listed as: Macadamia Ternifolia Seed Oil.
This is the same ingredient; M. ternifolia is an older INCI naming convention for the edible macadamia nut, while M. integrifolia is the species actually cultivated for oil production. Both names refer to the same oil.
Learn more about Macadamia Integrifolia Seed OilNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideTerminalia Ferdinandiana Fruit Extract is from the Kakadu plum. The Kakadu plum is native to northern Australia. The Kakadu plum holds the record for having the highest amount of natural vitamin C.
This ingredient is an antioxidant. Antioxidants help fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material. Antioxidants help stabilize free-radicals and thus may reduce the signs of aging.
The high vitamin C content of Kakadu plum also helps lighten skin. Vitamin C has been shown to block the process of skin darkening that leads to hyperpigmentation.
Kakadu plums have been used by indigenous cultures as medicine to help treat colds and as an antiseptic.
Learn more about Terminalia Ferdinandiana Fruit ExtractSqualane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Learn more about SqualaneCetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.
You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.
These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.
This ingredient is well-tolerated and has no significant sensitization data.
Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.
Learn more about Cetearyl OlivateButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Learn more about Cetearyl AlcoholGlyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Learn more about Glyceryl StearateSorbitan Olivate is created from the fatty acids in olive oil and sorbitol.
This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.
This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.
According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.
Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.
Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.
Learn more about Sorbitan OlivateCarbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Learn more about CarbomerTromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Learn more about TromethamineThis is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolHelianthus Annuus Seed Oil is a plant oil derived from the seeds of a sunflower.
It is rich in fatty acids, primarily linoleic acid and oleic acid. This gives it emollient and skin conditioning properties.
The reason this ingredient is so effective is because it forms a thin film on the skin that reduces transepidermal water loss (TEWL) while supplying linoleic acid to the stratum corneum to improve barrier strength.
The high linoleic acid content is particularly noteworthy for acne-prone skin.
Research suggests that acne-prone skin tends to be deficient in linoleic acid in sebum. Topical application may help replenish this to support a healthier follicular environment and less comedone-promoting sebum.
One randomized study found sunflower seed oil preserved skin barrier integrity in adult volunteers with and without atopic dermatitis (outperforming olive oil).
This ingredient is well-studied, gentle, and an effective emollient suitable for most skin types.
On fungal acne: This ingredient may not be Fungal acne (Malassezia folliculitis) safe. This is because it contains fatty acids with carbon chain lengths in the C11-C24 range.
Learn more about Helianthus Annuus Seed OilEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinLactobacillus is the INCI name for the live, whole lactic bacteria culture itself and is classified as a skin conditioning agent.
It is the same genus of probiotic that you can find in yogurt or fermented foods and it shows up at low levels naturally on human skin.
This ingredient is more of a microbiome agent rather than an active; it helps rebalance the skin's microbial community.
The bacteria and their metabolites produce lactic acid and other antimicrobial compounds that crowd out the "bad bacteria". Research on Lactobacillus strains shows activity against pathogens and acne-causing bacteria.
One strain, Lactobacillus plantarum, has also been shown to boost collagen synthesis and lower melanin synthesis in lab and clinical observation.
The most eye-catching data comes from acne research, a topical cream with live lactobacilli was well-tolerated and improved skin hydration by 37.3% after 14 days of use and 45.6% after 28 days.
Sources for this ingredient are usually fermented substrates like dairy, soy, or rice.
In general, this is a low-irritation and well-tolerated ingredient that plays nice with most of your routine.
One thing to keep in mind is that live bacteria are hard to keep alive inside of a skincare product. They struggle to survive on the shelf and don't get along with the preservatives that stop products from spoiling.
That's why you'll see ferment and postbiotic forms instead, like Lactobacillus Ferment or Lactobacillus Ferment Lysate.
There isn't a fixed percentage for this ingredient since it is dosed by strain and viable count.
On the fungal acne front: Lactobacillus is a bacterium (not a fungus). The whole culture contains no fatty acids, esters, or oils that Malassezia can feed on so it is considered fungal acne safe.
Learn more about LactobacillusSaccharomyces/Potato Extract Ferment Filtrate isn't fungal acne safe.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineLactobacillus/Soybean Ferment Extract is the result of fermenting soybeans with the Lactobacillus bacteria. It mainly acts as a skin conditioning agent in a formula, and the interesting part is what fermentation does to the soy.
Fermenting soy:
The isoflavones are the workhorses behind the common claims; lab and animal studies show they mop up free radicals, help protect skin cells from UVB damage, and nudge fibroblasts to make more collagen while slowing the enzymes that break collagen down.
One controlled clinical study using an isoflavone cream reported softer wrinkles and better skin texture over time. A topical fermented soy extract also improved hydration and elasticity in an animal aging model.
The big caveat is that most of this evidence comes from soy isoflavones and related fermented soy extracts rather than this exact INCI. Some of the strongest data also comes from oral studies.
So it's best to think of this ingredient as a gentle, antioxidant-leaning conditioning agent rather than a proven wrinkle eraser.
At this time, there's no published concentration levels for this specific ferment but it usually shows up at modest levels in real products (~1% or less).
One last thing for people with soy allergies: it's always worth patch testing this ingredient despite the lowered allergy risk.
Learn more about Lactobacillus/Soybean Ferment ExtractThis ingredient is created by fermenting the lactobacillus bacteria with rice.
Lactobacillus is a great ingredient at keeping skin barrier healthy and rice ferment has great anti-aging benefits.
Saccharomyces/Coix Lacryma-Jobi Ma-Yuen Seed Ferment Filtrate isn't fungal acne safe.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAThis ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.
Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).
In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).
Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.
Shea butter also contains vitamins A and E which may contribute to antioxidant activity.
While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.
This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.
Learn more about Butyrospermum Parkii ButterSorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Learn more about Sorbitan IsostearateBetaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
Some studies suggest betaine may support making skin tone more even.
Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
Betaine is also known as trimethylglycine.
Learn more about BetaineCeramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Learn more about Ceramide NPHyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Learn more about Hyaluronic AcidHydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Learn more about Hydrolyzed Hyaluronic AcidSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronatePentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolMadecassoside is one of four active compounds found in Centella asiatica and is one of the main reasons Centella is so effective at calming irritated skin and supporting the moisture barrier.
There's a solid body of peer-reviewed research backing Madecassoside for several skin benefits. Studies have found:
Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.
Learn more about MadecassosideCholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.
It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).
This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.
Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.
Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.
Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.
Learn more about CholesterolCeramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.
You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.
The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.
Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.
Learn more about Ceramide APCeramide NS is formally known as Ceramide 2. It is one of the major ceramides in the stratum corneum (outermost layer of skin) plays a role in forming a protective barrier.
Due to its structure, skin lipids can be packed tightly and in turn, this strengthens the barrier and reduces water loss.
Studies show conditions like atopic dermatitis can worsen when ceramide NS levels are low.
Learn more about Ceramide NsCeramide AS is formally known as Ceramides 4 and 5.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Decyl Glucoside is a plant-derived surfactant and emulsion stabilizer. It is created by reacting glucose with the fatty acids from plants.
Like all surfactants, it works by lowering the surface tension between water and oil. This makes it so that dirt, sebum, and makeup can be lifted off your skin and rinsed away. It also produces a dense and creamy foam.
Because it has a neutral charge, it is compatible with a wide range of ingredients and stays stable across a broad pH range/water hardiness conditions.
Patch testing has shown it to have the lowest irritation potential among common cleansing surfactants (like SLS).
Typical use levels range from 5-20% in rinse-off cleansers.
One thing worth knowing: The American Contact Dermatitis Society named the parent family, alkyl glucosides, "Allergen of the Year" in 2017. The prevalence of allergy is pretty low but be sure to patch test if you've reacted to "gentle" or sulfate-free cleansers before.
This ingredient is fungal acne safe because the fatty alcohol portion of this ingredient is not within the C11-24 chain length that Malassezia can metabolize.
Learn more about Decyl GlucosideEucalyptus globulus leaf extract comes from the leaves of the blue gum tree. It has perfuming and skin conditioning properties.
According to a manufacturer, this ingredient has antioxidants to help protect skin against free radicals.
This ingredient is water-soluble.
Learn more about Eucalyptus Globulus Leaf ExtractCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolCentella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.
That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.
These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.
Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.
Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.
Here is the short version of what they do in the skin:
So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.
Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:
Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.
Centella is one of the most easygoing actives out there.
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.
On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.
Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.
But as with any new active, a patch test is still a smart move for very reactive skin.
Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).
The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).
In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.
Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractAsiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica. It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside.
Research from 2016-2025 supports its role in:
You'll usually find this in concentrations between 0.2-5%.
Learn more about AsiaticosideAsiatic Acid is one of the four main actives found in Centella Asiatica. Its headline job is stimulating collagen.
Lab tests on human skin cells show Asiatic Acid tells your skin to make more collagen, the protein that keeps skin firm and bouncy.
It also calms inflammation and acts as an antioxidant so it can help skin heal faster, rebuild itself, and repair a damaged barrier.
And on naming, even though "acid" is in the name, it's nothing like an AHA or BHA exfoliant. It's a gentle firming and soothing ingredient that supports your skin barrier.
Concentration-wise, Asiatic Acid is potent at very low doses and usually shows up as a small fraction of a broader centella extract.
Analyses of centella material put Asiatic Acid reported in the range of 0.2-3% of the extract.
This ingredient is non-sensitizing and guinea pig sensitization testing also found it to be a weak sensitizer. That means the risk of acquiring contact sensitivty is quite low.
Allergic contact dermatitis does exist but is also very rare; documented cases tend to involve prolonged use on broken skin plus co-sensitization to fragrance ingredients.
Learn more about Asiatic AcidMadecassic Acid is one of the four star actives in Centella Asiatica. In skincare, it earns its keep as a calming and repairing ingredient.
It works through the same core pathways as the rest of the centella family.
First, it turns down inflammation so it helps with things like redness and general upset skin.
Second, it acts as an antioxidant which means it helps protect skin from daily stress and damage.
And third, it nudges the skin to make more collagen and rebuild its support structure.
That combination is why the whole Centella family is known for calming skin, strengthening the barrier, fading redness, and giving anti-aging benefits.
It's worth being honest about the evidence here; a lot of the strongest data is on the full extract or a Madecassoside/Asiaticoside rather than Madecassic Acid alone. Reviewers also note more long-term clinical trials are needed to confirm the full potential.
Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%.
Finished products typically run somewhere in the 0.1-10% range depending on the format.
In real-world tolerance tests, a repeat-insult patch test on an eye lotion with 0.2% Centella extract showed no irritation or allergic contact dermatitis in 54 subjects. And a mascara with 0.5% Madecassoside caused neither irritation nor sensitization in 109 subjects.
Allergy risk is very low, but not zero. Centella and its constituents are classified as weak contact sensitizers and some rare cases of allergic contact dermatitis exist.
Learn more about Madecassic AcidPhytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.
Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.
Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.
Fun fact: Phytosphingosine is abundant in plants and fungi.
More ingredients that help boost collagen in skin:
Learn more about PhytosphingosineCeramide EOP is formally known as Ceramide 1.
It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.
EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.
What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).
Low levels of Ceramide EOP have been found in people with eczema and psoriasis.
Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.
In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.
You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.
Learn more about Ceramide EOPReviews
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Read more about us· Updated January 9, 2025 • Added by fairyaffie