MediCube PDRN Pink Cica Soothing Toner Versus MediCube PDRN Pink Niacinamide Milky Toner
Updated on April 23, 2025
Overview
What they are
These products are both cruelty-free and reef safe toners. They have a total of 16 ingredients in common
Cool Features
They both contain hyaluronic acid, niacinamide and peptides
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots
Free From
They both do not contain any harsh alcohols, common allergens, parabens, silicones or sulfates
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
MediCube PDRN Pink Cica Soothing Toner 36 ingredients
MediCube PDRN Pink Niacinamide Milky Toner 81 ingredients
About this product
About this product
At a glance
Click on any of the items below to learn more
MediCube PDRN Pink Cica Soothing Toner 36 ingredients
MediCube PDRN Pink Niacinamide Milky Toner 81 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningButylene Glycol
Humectant
Glycerin
Humectant
Niacinamide
Smoothing
1,2-Hexanediol
Skin ConditioningXylitol
HumectantSodium Citrate
BufferingEthylhexylglycerin
Skin ConditioningAllantoin
Skin Conditioning
Caprylyl Glycol
EmollientCitric Acid
Buffering
Adenosine
Skin Conditioning
Polyglyceryl-10 Laurate
Skin Conditioning
Disodium EDTA
Polyglyceryl-4 Laurate
Emulsifying
Caprylyl/Capryl Glucoside
CleansingCyanocobalamin
Skin ConditioningRosa Damascena Extract
MaskingSodium Dna
Skin ConditioningGluconolactone
Skin Conditioning
Prunus Mume Fruit Extract
HumectantPyrus Malus Fruit Extract
Skin ConditioningCarica Papaya Fruit Extract
Skin ConditioningVitis Vinifera Fruit Extract
Skin ConditioningCentella Asiatica Leaf Extract
Skin Conditioning
Centella Asiatica Extract
Cleansing
Sodium Hyaluronate
Humectant
Zea Mays Leaf Extract
Skin ConditioningCopper Tripeptide-1
Skin Conditioning
Acetyl Hexapeptide-8
Humectant
Palmitoyl Pentapeptide-4
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Glycine
Buffering
Glutamic Acid
HumectantArginine
Masking
Water, Butylene Glycol, Glycerin, Niacinamide, 1,2-Hexanediol, Xylitol, Sodium Citrate, Ethylhexylglycerin, Allantoin, Caprylyl Glycol, Citric Acid, Adenosine, Polyglyceryl-10 Laurate, Disodium EDTA, Polyglyceryl-4 Laurate, Caprylyl/Capryl Glucoside, Cyanocobalamin, Rosa Damascena Extract, Sodium Dna, Gluconolactone, Prunus Mume Fruit Extract, Pyrus Malus Fruit Extract, Carica Papaya Fruit Extract, Vitis Vinifera Fruit Extract, Centella Asiatica Leaf Extract, Centella Asiatica Extract, Sodium Hyaluronate, Zea Mays Leaf Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Glycine, Glutamic Acid, Arginine
Water
Skin ConditioningGlycerin
Humectant
Niacinamide
Smoothing
Cetyl Ethylhexanoate
EmollientCaprylic/Capric Triglyceride
Masking1,2-Hexanediol
Skin ConditioningPentaerythrityl Tetraethylhexanoate
EmollientEthylhexyl Palmitate
Emollient
Polyglyceryl-3 Distearate
Emulsifying
Octyldodecanol
EmollientDiisostearyl Malate
EmollientC12-14 Alketh-12
EmulsifyingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingTromethamine
BufferingGlyceryl Stearate
Emollient
Ethylhexylglycerin
Skin ConditioningTrehalose
HumectantGlyceryl Stearate Citrate
Emollient
Adenosine
Skin Conditioning
Disodium EDTA
Cyanocobalamin
Skin ConditioningSaccharide Hydrolysate
HumectantOryza Sativa Bran Oil
Emollient
Oryza Sativa Bran Water
Masking
Butylene Glycol
Humectant
Prunus Amygdalus Amara Kernel Oil
Masking
Camellia Sinensis Leaf Extract
Antimicrobial
Pyrus Malus Leaf Extract
Skin ConditioningSorbitol
Humectant
Panthenol
Skin Conditioning
Propanediol
SolventVanilla Planifolia Fruit Extract
Skin ConditioningJasminum Officinale Flower Water
MaskingXylitylglucoside
HumectantAnhydroxylitol
HumectantHelianthus Annuus Seed Oil
Emollient
Dipropylene Glycol
MaskingSucrose Stearate
EmollientXylitol
HumectantBeta-Carotene
Skin ConditioningSodium Dna
Skin ConditioningPolyglyceryl-10 Oleate
Skin Conditioning
Vaccinium Myrtillus Fruit Extract
Skin ConditioningCentella Asiatica Root Extract
Skin Conditioning
Centella Asiatica Leaf Extract
Skin Conditioning
Centella Asiatica Extract
Cleansing
Tocopherol
Antioxidant
Pueraria Lobata Root Extract
HumectantPentylene Glycol
Skin ConditioningMadecassoside
Antioxidant
Milk Protein Extract
Lycopodium Clavatum Extract
Skin ConditioningEquisetum Arvense Extract
AstringentPhragmites Communis Extract
Skin ConditioningPrunus Amygdalus Dulcis Fruit Extract
Skin ConditioningLecithin
EmollientTremella Fuciformis Extract
HumectantTabebuia Impetiginosa Bark Extract
Skin ConditioningTrifolium Pratense Extract
Skin ConditioningAcetyl Glutamine
Skin ConditioningAsiatic Acid
Skin ConditioningBacillus/Soybean Ferment Extract
Skin ConditioningMadecassic Acid
Skin Conditioning
Asiaticoside
Antioxidant
Hydrolyzed Wheat Protein
Skin ConditioningHydrolyzed Soy Protein
HumectantHydrolyzed Rice Protein
Skin ConditioningHydrolyzed Rice Bran Protein
Skin ConditioningHydrolyzed Corn Protein
Skin ConditioningCaprylyl Glycol
EmollientSodium Hyaluronate
Humectant
Folic Acid
Skin ConditioningPalmitoyl Pentapeptide-4
Skin Conditioning
Ceramide Ns
Skin Conditioning
Ceramide NP
Skin Conditioning
Ceramide EOP
Skin Conditioning
Ceramide AP
Skin Conditioning
Oligopeptide-3
Skin Conditioning
Oligopeptide-2
Skin Conditioning
Oligopeptide-1
Skin Conditioning
Hexapeptide-11
Skin Conditioning
Water, Glycerin, Niacinamide, Cetyl Ethylhexanoate, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Pentaerythrityl Tetraethylhexanoate, Ethylhexyl Palmitate, Polyglyceryl-3 Distearate, Octyldodecanol, Diisostearyl Malate, C12-14 Alketh-12, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Glyceryl Stearate, Ethylhexylglycerin, Trehalose, Glyceryl Stearate Citrate, Adenosine, Disodium EDTA, Cyanocobalamin, Saccharide Hydrolysate, Oryza Sativa Bran Oil, Oryza Sativa Bran Water, Butylene Glycol, Prunus Amygdalus Amara Kernel Oil, Camellia Sinensis Leaf Extract, Pyrus Malus Leaf Extract, Sorbitol, Panthenol, Propanediol, Vanilla Planifolia Fruit Extract, Jasminum Officinale Flower Water, Xylitylglucoside, Anhydroxylitol, Helianthus Annuus Seed Oil, Dipropylene Glycol, Sucrose Stearate, Xylitol, Beta-Carotene, Sodium Dna, Polyglyceryl-10 Oleate, Vaccinium Myrtillus Fruit Extract, Centella Asiatica Root Extract, Centella Asiatica Leaf Extract, Centella Asiatica Extract, Tocopherol, Pueraria Lobata Root Extract, Pentylene Glycol, Madecassoside, Milk Protein Extract, Lycopodium Clavatum Extract, Equisetum Arvense Extract, Phragmites Communis Extract, Prunus Amygdalus Dulcis Fruit Extract, Lecithin, Tremella Fuciformis Extract, Tabebuia Impetiginosa Bark Extract, Trifolium Pratense Extract, Acetyl Glutamine, Asiatic Acid, Bacillus/Soybean Ferment Extract, Madecassic Acid, Asiaticoside, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Hydrolyzed Rice Protein, Hydrolyzed Rice Bran Protein, Hydrolyzed Corn Protein, Caprylyl Glycol, Sodium Hyaluronate, Folic Acid, Palmitoyl Pentapeptide-4, Ceramide Ns, Ceramide NP, Ceramide EOP, Ceramide AP, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
- It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
- It is a humectant, which means that it helps attract moisture into the skin.
- It helps improve product application.
- It has mild preservative properties.
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinNiacinamide has emerged as an all-star ingredient due to its many benefits.
It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.
Other benefits include smoothing wrinkles and minimizing redness.
The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.
Learn more about Niacinamide1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.Â
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservativesÂ
Xylitol is a humectant and prebiotic. It can help with dry skin.
In studies, xylitol has been shown to improve dry skin. It decreased transepidermal water loss, or when water passes through the skin and evaporates. Xylitol also showed to help improve the biomechanical properties of the skin barrier.
The prebiotic property of xylitol may also help reinforce our skin's natural microbiome. Having a healthy microbiome prevents infection by bad bacteria and helps with hydration.
As a humectant, Xylitol helps draw moisture from both the air and from deeper skin layers. This helps keep skin hydrated.
Xylitol is a sugar alcohol and commonly used as a sugar substitute. It is naturally occurring in plants such as strawberries and pumpkin.
Learn more about XylitolEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolAdenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.
Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.
Studies have found adenosine may also help with wound healing.
In skincare products, Adenosine is usually derived from yeast.
Learn more about AdenosineDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTACyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.
Sodium DNA is an emerging anti-aging ingredient.
It is created by taking deoxyribonucleic acid (DNA) and purifying it with sodium hydroxide.
The DNA is extracted from several different animal sources, including: calf thymus, the gonadic tissue of a male sturgeon, or herring / salmon sperm.
You have probably seen this ingredient in anti-aging skincare. But what is it?
DNA is composed of nucleotides, or chemical building blocks. Nucleotides include adenine (A), thymine (T), guanine (G), and cytosine (C). Talk about a flashback to biology! Nucleosides are formed from these nucleotides.
The science behind Sodium DNA is based on an ingredient called Polydeoxyribonucleotide or PDRN.
PDRN are DNA fragments mainly extracted from the sperm cells of trout or salmon. Meaning, PDRN can be derived from Sodium DNA.
PDRN consists of chains of nucleotides and nucleosides mentioned above. They can range anywhere from 80 - 2000 pairs.
Studies show PDRN has the following properties:
Further studies are needed to truly confirm this ingredients anti-aging ability (Remember, retinol has decades of research!).
When using this ingredient, is is best to ask a brand about the source of their Sodium DNA. You'll want to find products where the Sodium DNA is sourced from fish. Some Sodium DNA is derived from calf / cow thymus.
Learn more about Sodium DnaCentella Asiatica Leaf Extract comes from the leaves of an herb plant native to Southeast Asia. Centella Asiatica is rich in antioxidants and amino acids. It can help reduce irritation and soothe the skin.
Many active components found in centella asiatica, such as Madecassic Acid and Asiaticoside, encourage the skin to naturally produce hyaluronic acid. This helps keep our skin hydrated. Many of these components also show antioxidant activity and may help reduce the signs of aging.
Research shows centella asiatica can help increase Type I collagen production by increasing fibroblast production. Fibroblast helps form connective tissue.
The combination of all these properties makes centella asiatica leaf extract effective at soothing the skin.
Other components of centella asiatica leaf extract include Vitamin A, vitamin C, several B vitamins, and Asiatic Acid.
Recent studies found madecassoside may help prevent damage from UV rays by preventing UV-induced inflammation. Further research is needed.
This plant has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica Leaf ExtractCentella Asiatica Extract (Centella) is derived from an herb native to Southeast Asia. It is famous for its anti-inflammatory and soothing properties.
Centella is rich in antioxidants and amino acids, such as Madecassic Acid and Asiaticoside.
Studies show the compounds in centella help with:
The combination of all these properties makes centella effective at soothing, hydrating, and protecting the skin.
Other great components of centella include Vitamin A, vitamin C, several B vitamins, and Asiatic Acid.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractSodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateYou might know this ingredients as Matrixyl, a famous peptide.
Peptides are building blocks for protein. Palmitoyl Pentapeptide-4 consists of five amino acids. These amino acids include: 2 lysines, 2 threonines, and serine
This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Thus, Matrixyl may help improve the look of wrinkles.
Read more about other common types of peptides here:
Learn more about Palmitoyl Pentapeptide-4Ingredient Ratings
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When to use
MediCube PDRN Pink Cica Soothing Toner 36 ingredients
MediCube PDRN Pink Niacinamide Milky Toner 81 ingredients
