Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum Versus Shiseido Vital Perfection LiftDefine Radiance Serum
Updated on October 06, 2025
Overview
What they are
These products are both reef safe serums. They have a total of 10 ingredients in common
Cool Features
They both contain Vitamin C and Vitamin E
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, reducing pores, scar healing and better texture
Free From
They both do not contain any parabens
What's Inside
They both contain fragrances, oils and silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum 72 ingredients
Shiseido Vital Perfection LiftDefine Radiance Serum 55 ingredients
What's inside
What's inside
At a glance
Click on any of the items below to learn more
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum 72 ingredients
Shiseido Vital Perfection LiftDefine Radiance Serum 55 ingredients
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Dimethicone
Emollient
Water
Skin ConditioningPolysilicone-11
Hdi/Trimethylol Hexyllactone Crosspolymer
Silica
Abrasive
Butylene Glycol
Humectant
Caprylyl Methicone
Skin Conditioning
Sigesbeckia Orientalis Extract
Skin ConditioningSalvia Sclarea Extract
AntiseborrhoeicColeus Forskohlii Root Extract
EmollientChamomilla Recutita Flower Extract
Masking
PEG-10 Dimethicone
Skin Conditioning
Hydrolyzed Collagen
Emollient
Palmaria Palmata Extract
Skin ProtectingGlycyrrhiza Glabra Root Extract
Bleaching
Silybum Marianum Extract
Skin ConditioningHordeum Vulgare Extract
EmollientPadina Pavonica Thallus Extract
Skin ConditioningArtemia Extract
Skin ConditioningPantethine
EmollientAlgae Extract
Emollient
Chlorella Vulgaris Extract
Skin Conditioning
Cholesterol
Emollient
Squalane
Emollient
Boswellia Serrata Extract
Skin ConditioningZea Mays Kernel Extract
Glycine Soja Protein
EmulsifyingCaffeine
Skin Conditioning
Whey Protein
Skin ConditioningLinoleic Acid
Cleansing
Lecithin
Emollient
Collagen
Moisturising
Acetyl Hexapeptide-8
Humectant
Palmitoyl Oligopeptide
Cleansing
Glycerin
Humectant
Yeast Extract
Skin Conditioning
Polyquaternium-51
Skin Conditioning
Phytosphingosine
Skin Conditioning
Triticum Vulgare Germ Oil
Emollient
Decarboxy Carnosine Hcl
Skin ConditioningPolysorbate 40
Emulsifying
Pentylene Glycol
Skin ConditioningPropanediol
Solvent
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Skin Conditioning
Ethylhexylglycerin
Skin ConditioningAmmonium Acryloyldimethyltaurate/Vp Copolymer
Sodium PCA
Humectant
Polymethylsilsesquioxane
Glyceryl Polymethacrylate
Zinc PCA
Humectant
Propylene Glycol Dicaprate
EmollientSodium Chondroitin Sulfate
Skin Conditioning
Sodium Hyaluronate
Humectant
Isohexadecane
EmollientPEG-8
HumectantTocopheryl Acetate
Antioxidant
Polysorbate 80
Emulsifying
Disodium Distyrylbiphenyl Disulfonate
UV AbsorberLaureth-12
EmulsifyingAcrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingCaprylyl Glycol
Emollient
Aminopropyl Ascorbyl Phosphate
Antioxidant
Xanthan Gum
EmulsifyingSodium Beta-Sitosteryl Sulfate
Skin Conditioning
Sodium Chloride
Masking
Sodium Hydroxide
BufferingParfum
Masking
Disodium EDTA
BHT
Antioxidant
Phenoxyethanol
Preservative
Mica
Cosmetic Colorant
CI 77891
Cosmetic ColorantDimethicone, Water, Polysilicone-11, Hdi/Trimethylol Hexyllactone Crosspolymer, Silica, Butylene Glycol, Caprylyl Methicone, Sigesbeckia Orientalis Extract, Salvia Sclarea Extract, Coleus Forskohlii Root Extract, Chamomilla Recutita Flower Extract, PEG-10 Dimethicone, Hydrolyzed Collagen, Palmaria Palmata Extract, Glycyrrhiza Glabra Root Extract, Silybum Marianum Extract, Hordeum Vulgare Extract, Padina Pavonica Thallus Extract, Artemia Extract, Pantethine, Algae Extract, Chlorella Vulgaris Extract, Cholesterol, Squalane, Boswellia Serrata Extract, Zea Mays Kernel Extract, Glycine Soja Protein, Caffeine, Whey Protein, Linoleic Acid, Lecithin, Collagen, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Glycerin, Yeast Extract, Polyquaternium-51, Phytosphingosine, Triticum Vulgare Germ Oil, Decarboxy Carnosine Hcl, Polysorbate 40, Pentylene Glycol, Propanediol, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ethylhexylglycerin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Sodium PCA, Polymethylsilsesquioxane, Glyceryl Polymethacrylate, Zinc PCA, Propylene Glycol Dicaprate, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Isohexadecane, PEG-8, Tocopheryl Acetate, Polysorbate 80, Disodium Distyrylbiphenyl Disulfonate, Laureth-12, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Caprylyl Glycol, Aminopropyl Ascorbyl Phosphate, Xanthan Gum, Sodium Beta-Sitosteryl Sulfate, Sodium Chloride, Sodium Hydroxide, Parfum, Disodium EDTA, BHT, Phenoxyethanol, Mica, CI 77891
Water
Skin ConditioningDipropylene Glycol
HumectantDimethicone
Emollient
Glycerin
Humectant
Butylene Glycol
Humectant
Behenyl Alcohol
Emollient
Maltitol
HumectantTriethylhexanoin
MaskingPotassium Methoxysalicylate
BleachingPolyvinyl Alcohol
PEG/PPG-14/7 Dimethyl Ether
Skin ConditioningPhenoxyethanol
Preservative
Trimethylsiloxysilicate
Emollient
Batyl Alcohol
EmollientBehenic Acid
Cleansing
PEG-60 Glyceryl Isostearate
PEG-10 Dimethicone
Skin Conditioning
Parfum
Masking
Phytosteryl/Octyldodecyl Lauroyl Glutamate
Skin ConditioningDisodium EDTA
Myristyl Myristate
Emollient
Tocopheryl Acetate
Antioxidant
Rosa Damascena Flower Water
Masking
Potassium Hydroxide
BufferingSodium Citrate
Buffering2-O-Ethyl Ascorbic Acid
Skin Conditioning
Alcohol
Antimicrobial
Caffeine
Skin Conditioning
Citric Acid
Buffering
Lavandula Angustifolia Oil
Masking
Sodium Metaphosphate
BufferingPPG-3 Dipivalate
Skin ConditioningLimonene
Perfuming
Hexyl Cinnamal
Perfuming
Linalool
Perfuming
Tocopherol
Antioxidant
Glucosamine Hcl
Citronellol
Perfuming
Lilium Candidum Bulb Extract
Skin ConditioningSodium Metabisulfite
Antioxidant
Angelica Acutiloba Root Extract
Skin ConditioningAngelica Keiskei Leaf/Stem Extract
Skin ConditioningOlea Europaea Leaf Extract
Perfuming
Lamium Album Flower/Leaf/Stem Extract
Skin ConditioningCamellia Sinensis Leaf Extract
Antimicrobial
Inositol
Humectant
Carthamus Tinctorius Flower Extract
Skin ConditioningCI 77492
Cosmetic ColorantZiziphus Jujuba Fruit Extract
Skin ConditioningCI 77491
Cosmetic ColorantRosmarinus Officinalis Leaf Extract
AntimicrobialCellulose
AbsorbentNasturtium Officinale Leaf/Stem Extract
Skin ConditioningCinnamomum Cassia Bark Extract
Masking
Bupleurum Falcatum Root Extract
Skin ConditioningWater, Dipropylene Glycol, Dimethicone, Glycerin, Butylene Glycol, Behenyl Alcohol, Maltitol, Triethylhexanoin, Potassium Methoxysalicylate, Polyvinyl Alcohol, PEG/PPG-14/7 Dimethyl Ether, Phenoxyethanol, Trimethylsiloxysilicate, Batyl Alcohol, Behenic Acid, PEG-60 Glyceryl Isostearate, PEG-10 Dimethicone, Parfum, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Disodium EDTA, Myristyl Myristate, Tocopheryl Acetate, Rosa Damascena Flower Water, Potassium Hydroxide, Sodium Citrate, 2-O-Ethyl Ascorbic Acid, Alcohol, Caffeine, Citric Acid, Lavandula Angustifolia Oil, Sodium Metaphosphate, PPG-3 Dipivalate, Limonene, Hexyl Cinnamal, Linalool, Tocopherol, Glucosamine Hcl, Citronellol, Lilium Candidum Bulb Extract, Sodium Metabisulfite, Angelica Acutiloba Root Extract, Angelica Keiskei Leaf/Stem Extract, Olea Europaea Leaf Extract, Lamium Album Flower/Leaf/Stem Extract, Camellia Sinensis Leaf Extract, Inositol, Carthamus Tinctorius Flower Extract, CI 77492, Ziziphus Jujuba Fruit Extract, CI 77491, Rosmarinus Officinalis Leaf Extract, Cellulose, Nasturtium Officinale Leaf/Stem Extract, Cinnamomum Cassia Bark Extract, Bupleurum Falcatum Root Extract
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaffeine is most associated with coffee, tea, and cacao. In skincare, it helps with calming inflammation and is rich in antioxidants.
While caffeine is used to treat cellulite and and dark circles, further studies are needed to prove this. It has been believed to help with these skin conditions due to its ability to dilate blood vessels and increase blood flow.
Some studies are looking into caffeine's ability to protect against UV rays.
Learn more about CaffeineDimethicone is a type of synthetic silicone created from natural materials such as quartz.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumPeg-10 Dimethicone is silicone with conditioner and emulsifier properties. It mostly acts as an emollient in skincare and and humectant in haircare.
According to the manufacturer, acidic formulations decrease the stability of this ingredient. It works best in neutral or near neutral formulations.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterIngredient Ratings
Here's what our community thinks of the ingredients in these products.
When to use
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum 72 ingredients
Shiseido Vital Perfection LiftDefine Radiance Serum 55 ingredients
Reviews
Here's what our community thinks
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum 72 ingredients
Be the first to review Perfectionist CP+R Wrinkle Lifting/Firming Serum
Write the first reviewShiseido Vital Perfection LiftDefine Radiance Serum 55 ingredients
Be the first to review Vital Perfection LiftDefine Radiance Serum
Write the first review
