SkinBetter Science Alto Defense Serum Versus Paula's Choice Calm Repairing Serum
Updated on April 14, 2025
Overview
What they are
These products are both reef safe serums. They have a total of 16 ingredients in common
Cool Features
They both contain ceramides and Vitamin E
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, scar healing and dark spots
Free From
They both do not contain any harsh alcohols, common allergens, oils, parabens or sulfates
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
SkinBetter Science Alto Defense Serum 64 ingredients
Paula's Choice Calm Repairing Serum 39 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
SkinBetter Science Alto Defense Serum 64 ingredients
Paula's Choice Calm Repairing Serum 39 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningButylene Glycol
Humectant
Propanediol
Solvent
Ethylhexyl Olivate
Skin Conditioning
Cetearyl Alcohol
Emollient
Chlorogenic Acids
Antioxidant
Hydrolyzed Sodium Hyaluronate
Skin Conditioning
Lauryl Lactate
EmollientDimethyl Isosorbide
SolventGlycyrrhiza Glabra Root Extract
Bleaching
Tetrahexyldecyl Ascorbate
Antioxidant
Ergothioneine
Antioxidant
Benzylidene Dimethoxydimethylindanone
Skin ProtectingArabidopsis Thaliana Extract
Antioxidant
Carnosine
Skin Conditioning
Camellia Sinensis Leaf Extract
Antimicrobial
Vitis Vinifera Seed Extract
Antimicrobial
Theobroma Cacao Seed Extract
Antioxidant
Curcuma Longa Root Extract
Masking
Olea Europaea Fruit Extract
BleachingEuterpe Oleracea Fruit Extract
Trifluoroacetyl Tripeptide-2
Skin Conditioning
Buddleja Officinalis Flower Extract
UV FilterCoffea Arabica Leaf Cell Extract
Antioxidant
Crocus Sativus Leaf Cell Culture Extract
Skin ProtectingSuperoxide Dismutase
Antioxidant
Ubiquinone
Antioxidant
Zingiber Officinale Root Extract
Masking
Ceramide NP
Skin Conditioning
Ceramide AP
Skin Conditioning
Ceramide EOP
Skin Conditioning
Linoleic Acid
Cleansing
Linolenic Acid
Cleansing
Sea Whip Extract
Skin ConditioningBisabolol
Masking
Tocopherol
Antioxidant
Tocopheryl Acetate
Antioxidant
Cholesterol
Emollient
Phytosphingosine
Skin Conditioning
Jojoba Esters
Emollient
Sodium PCA
Humectant
Pentylene Glycol
Skin ConditioningMethyl Gluceth-20
Humectant
Glycerin
Humectant
Helianthus Annuus Seed Wax
Skin Conditioning
Acacia Decurrens Flower Wax
Emollient
Lecithin
Emollient
Sodium Lauroyl Lactylate
EmulsifyingDicetyl Phosphate
EmulsifyingPropanediol Dicaprylate/Caprate
EmollientPolyglycerin-3
Humectant
Ceteth-20 Phosphate
CleansingDiisostearyl Malate
EmollientXanthan Gum
EmulsifyingSteareth-2
EmulsifyingAcacia Senegal Gum
MaskingCarbomer
Emulsion StabilisingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingDextran
Sodium Hydroxide
BufferingCitric Acid
Buffering
Disodium EDTA
Ethylhexylglycerin
Skin ConditioningPhenoxyethanol
Preservative
Water, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Hydrolyzed Sodium Hyaluronate, Lauryl Lactate, Dimethyl Isosorbide, Glycyrrhiza Glabra Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Benzylidene Dimethoxydimethylindanone, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract, Theobroma Cacao Seed Extract, Curcuma Longa Root Extract, Olea Europaea Fruit Extract, Euterpe Oleracea Fruit Extract, Trifluoroacetyl Tripeptide-2, Buddleja Officinalis Flower Extract, Coffea Arabica Leaf Cell Extract, Crocus Sativus Leaf Cell Culture Extract, Superoxide Dismutase, Ubiquinone, Zingiber Officinale Root Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Linoleic Acid, Linolenic Acid, Sea Whip Extract, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium PCA, Pentylene Glycol, Methyl Gluceth-20, Glycerin, Helianthus Annuus Seed Wax, Acacia Decurrens Flower Wax, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate/Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dextran, Sodium Hydroxide, Citric Acid, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol
Hyaluronic Acid
Humectant
Ceramide AP
Skin Conditioning
Chrysanthemum Parthenium Extract
Skin ConditioningGlycyrrhiza Glabra Root Extract
Bleaching
Glycerin
Humectant
Sodium Lauroyl Lactylate
EmulsifyingSodium Hyaluronate
Humectant
Polysorbate 20
Emulsifying
Caprylic/Capric Triglyceride
Masking
PEG/PPG-14/4 Dimethicone
Emulsifying
Xanthan Gum
EmulsifyingDisodium EDTA
Sodium Cocoyl Amino Acids
CleansingCeramide NP
Skin Conditioning
Ethylhexylglycerin
Skin ConditioningEpilobium Angustifolium Extract
Skin ConditioningCholesterol
Emollient
Phytosphingosine
Skin Conditioning
Beta-Glucan
Skin Conditioning
Sarcosine
Skin ConditioningCarbomer
Emulsion StabilisingChrysanthemum Parthenium Flower Extract
Skin ConditioningSea Whip Extract
Skin ConditioningGlycine Soja Seed Extract
Skin Conditioning
Ceramide EOP
Skin Conditioning
Magnesium Aspartate
Skin ConditioningPotassium Aspartate
Skin ConditioningUbiquinone
Antioxidant
Phenoxyethanol
Preservative
1,2-Hexanediol
Skin Conditioning
Caprylyl Glycol
EmollientLeuconostoc/Radish Root Ferment Filtrate
Antimicrobial
Calcium Chloride
AstringentPropylene Glycol
Humectant
Tocopherol
Antioxidant
Sodium Metabisulfite
Antioxidant
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Antioxidant
Sodium Benzoate
Masking
Potassium Sorbate
Preservative
Hyaluronic Acid, Ceramide AP, Chrysanthemum Parthenium Extract, Glycyrrhiza Glabra Root Extract, Glycerin, Sodium Lauroyl Lactylate, Sodium Hyaluronate, Polysorbate 20, Caprylic/Capric Triglyceride, PEG/PPG-14/4 Dimethicone, Xanthan Gum, Disodium EDTA, Sodium Cocoyl Amino Acids, Ceramide NP, Ethylhexylglycerin, Epilobium Angustifolium Extract, Cholesterol, Phytosphingosine, Beta-Glucan, Sarcosine, Carbomer, Chrysanthemum Parthenium Flower Extract, Sea Whip Extract, Glycine Soja Seed Extract, Ceramide EOP, Magnesium Aspartate, Potassium Aspartate, Ubiquinone, Phenoxyethanol, 1,2-Hexanediol, Caprylyl Glycol, Leuconostoc/Radish Root Ferment Filtrate, Calcium Chloride, Propylene Glycol, Tocopherol, Sodium Metabisulfite, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Benzoate, Potassium Sorbate
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.
One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.
Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.
Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.
Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.
Learn more about Glycyrrhiza Glabra Root ExtractUbiquinone (Coenzyme Q10) is a molecule already found in our bodies. It is a potent antioxidant and skin-soothing ingredient.
Aging and environmental exposure diminishes our skin's natural ubiquinone levels. This is much like our natural collagen and elastin.
The good news is: studies show applying this ingredient topically replenishes ubiquinone levels in our skin. This also comes with a ton of skin benefits. These benefits include:
Ubiquinone is considered a large molecule and cannot be absorbed into the lower layers of skin. This is why it is believed to be such an effective antioxidant: it protects our skin in the upper layers and prevents damage in the deeper layers.
When used in sunscreen, ubiquinone is shown to increase ingredient stability, increase SPF factor, and add to infrared protection.
Fun fact: ubiquinone is fat-soluble.
Learn more about UbiquinoneCeramide NP is a type of ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide AP Ceramide EOP
Learn more about Ceramide NPCeramide AP is a type of Ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. Having a strong skin barrier leads to more firm and hydrated skin.
They are known for their ability to hold water and thus are a great ingredient for dry skin. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide NP Ceramide EOP
Learn more about Ceramide APCeramide EOP is a type of Ceramide.
EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.
Ceramides are intercellular lipids naturally found in our skin. They bind dead skin cells together to create a barrier. The ceramides in our skin have the ability to hold water to keep our skin hydrated.
Ceramides are an important building block for our skin barrier. A strong skin barrier helps with:
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Learn more about Ceramide EOPWe don't have a description for Sea Whip Extract yet.
Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolCholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.
Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.
Our bodies use cholestrol to create vitamin D, steroid hormones, and more.
Learn more about CholesterolPhytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.
Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.
Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.
Fun fact: Phytosphingosine is abundant in plants and fungi.
More ingredients that help boost collagen in skin:
Learn more about PhytosphingosineGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinSodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.
Sodium Lauroyl Lactylate is an emulsifier and surfactant.
Emulsifiers help stabilize a product. They do this by preventing ingredients from separating, such as oils and water which do not mix naturally. Surfactants reduce surface tension, making it easier to rinse pollutants off skin.
Due to its relation to lauric acid, it may provide antimicrobial benefits.
Learn more about Sodium Lauroyl LactylateXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumCarbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Disodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Ingredient Ratings
Here's what our community thinks of the ingredients in these products.
When to use
SkinBetter Science Alto Defense Serum 64 ingredients
Paula's Choice Calm Repairing Serum 39 ingredients
Reviews
Here's what our community thinks
SkinBetter Science Alto Defense Serum 64 ingredients
Paula's Choice Calm Repairing Serum 39 ingredients
I tried this on and off over a year- and it just irritates my skin- I don’t know why. I have super sensitive and rosacea skin, but hyaluronic acid is normally not a problem. My skin feels amazing when I first apply it, but 1 minute later it is irritated ):
Doesn’t irritate my skin. Seems hydrating.
