Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment
Updated on February 06, 2025
Overview
Cool Features
They both contain exfoliants and Vitamin E
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any common allergens, oils or parabens
What's Inside
They both contain silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 56 ingredients
Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment 45 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 56 ingredients
Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment 45 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
Humectant
Rosa Centifolia Flower Water
Skin ConditioningIsopropyl Myristate
Emollient
Squalane
Emollient
Mannitol
Humectant
Butylene Glycol
Humectant
Natto Gum
Tripeptide-10 Citrulline
Skin Conditioning
Acetyl Octapeptide-3
Humectant
Palmitoyl Hexapeptide-12
Skin Conditioning
Acetyl Tetrapeptide-11
Skin Conditioning
Acetyl Hexapeptide-8
Humectant
Acetyl Hexapeptide-1
Skin Conditioning
Palmitoyl Oligopeptide
Cleansing
Acetyl Tetrapeptide-9
Skin Conditioning
Acetyl Tetrapeptide-2
Skin Conditioning
Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Hexapeptide-11
Skin Conditioning
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Skin Conditioning
Palmitoyl Tripeptide-5
Skin Conditioning
Trifluoroacetyl Tripeptide-2
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Sodium Polyglutamate
HumectantSodium Hyaluronate
Humectant
Tocopheryl Acetate
Antioxidant
Retinyl Palmitate
Skin Conditioning
Ascorbic Acid
Antioxidant
Hydrolyzed Soy Protein
Humectant
Hydrolyzed Wheat Protein
Skin ConditioningLecithin
Emollient
Pseudoalteromonas Ferment Extract
Humectant
Acrylates Copolymer
Magnesium Chloride
Polysorbate 20
Emulsifying
Dimethyl Isosorbide
SolventAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingLeuconostoc/Radish Root Ferment Filtrate
Antimicrobial
PEG-8 Dimethicone
Emulsifying
Disodium Phosphate
BufferingCarbomer
Emulsion StabilisingDextran
Sodium Lactate
BufferingTetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Skin ConditioningXanthan Gum
EmulsifyingTriethanolamine
BufferingSodium Phosphate
BufferingOctyldodecanol
EmollientSilica
Abrasive
Sodium Propoxyhydroxypropyl Thiosulfate Silica
Sodium Hydroxide
BufferingCaprylyl Glycol
EmollientPotassium Sorbate
Preservative
Sodium Benzoate
Masking
Phenoxyethanol
Preservative
Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Ferment Extract, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc/Radish Root Ferment Filtrate, PEG-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
Water
Skin ConditioningNiacinamide
Smoothing
Isononyl Isononanoate
EmollientDimethyl Isosorbide
SolventTranexamic Acid
Astringent
Dimethicone
Emollient
Propanediol
Solvent
Pentylene Glycol
Skin ConditioningCaprylic/Capric Triglyceride
Masking
Alpha-Arbutin
Antioxidant
Glyceryl Stearate
Emollient
C9-12 Alkane
SolventCetyl Alcohol
Emollient
Butyrospermum Parkii Butter
Skin Conditioning
Citric Acid
Buffering
Kojic Acid
Antioxidant
Morus Alba Root Extract
BleachingResveratrol
Antioxidant
Scutellaria Lateriflora Extract
Skin ConditioningHydrangea Arborescens Root Extract
Skin ConditioningSqualane
Emollient
Hydrolyzed Vegetable Protein
Skin ConditioningPhenoxyethanol
Preservative
PEG-100 Stearate
Tocopheryl Acetate
Antioxidant
Polyacrylate Crosspolymer-6
Emulsion StabilisingPEG-75 Stearate
Ceteareth-20
Cleansing
Steareth-20
CleansingSilica
Abrasive
Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer
Emulsion StabilisingDimethiconol
Emollient
Coco-Caprylate/Caprate
Emollient
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingTitanium Dioxide
Cosmetic Colorant
Sodium Phytate
Diethylhexyl Syringylidenemalonate
Skin ProtectingPotassium Sorbate
Preservative
Sodium Benzoate
Masking
Polysorbate 60
Emulsifying
Polysorbate 20
Emulsifying
T-Butyl Alcohol
Perfuming
Caprylyl Glycol
EmollientHexylene Glycol
EmulsifyingSorbitan Isostearate
Emulsifying
Water, Niacinamide, Isononyl Isononanoate, Dimethyl Isosorbide, Tranexamic Acid, Dimethicone, Propanediol, Pentylene Glycol, Caprylic/Capric Triglyceride, Alpha-Arbutin, Glyceryl Stearate, C9-12 Alkane, Cetyl Alcohol, Butyrospermum Parkii Butter, Citric Acid, Kojic Acid, Morus Alba Root Extract, Resveratrol, Scutellaria Lateriflora Extract, Hydrangea Arborescens Root Extract, Squalane, Hydrolyzed Vegetable Protein, Phenoxyethanol, PEG-100 Stearate, Tocopheryl Acetate, Polyacrylate Crosspolymer-6, PEG-75 Stearate, Ceteareth-20, Steareth-20, Silica, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Dimethiconol, Coco-Caprylate/Caprate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Titanium Dioxide, Sodium Phytate, Diethylhexyl Syringylidenemalonate, Potassium Sorbate, Sodium Benzoate, Polysorbate 60, Polysorbate 20, T-Butyl Alcohol, Caprylyl Glycol, Hexylene Glycol, Sorbitan Isostearate
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterSqualane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.
Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.
Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.
Research shows that squalane is non-irritating (even at 100% concentration).
In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.
The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.
Is squalane vegan?
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Is squalane an oil?
Squalane is often called an oil, but it’s technically not; it’s a hydrocarbon, meaning it’s only made of carbon and hydrogen, unlike true oils which are triglycerides made of fatty acids and glycerol.
The term “oil-free” isn’t regulated, so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
While some people avoid oils thinking they cause breakouts, the right kind of oil (or oil-like ingredient like squalane) can actually help balance and hydrate your skin. It’s worth testing out simple oils or squalane to see what works best for your skin.
Learn more about SqualaneTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetatePolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Dimethyl Isosorbide is a solvent and helps deliver actives into your skin. It is created from sorbitol.
As a solvent, dimethyl isosorbide helps dissolve other ingredients. This helps ensure even distribution of an ingredient. It may also be used to decrease the thickness of a product.
Studies show dimethyl isosorbide is able to penetrate skin to deliver other ingredients into the skin, making them more effective.
Learn more about Dimethyl IsosorbideSilica is a mineral naturally found in our skin. It helps to thicken and smooth the texture of a product. It also acts as an agent for other ingredients by increasing the absorption of other ingredients into the skin.
Silica is often used for absorption and can help reduce shine when products are applied. Silica occurs in naturally in materials like clay and sandstone, and it can also be produced synthetically.
Silica is present naturally within the skin during collagen production and when reducing inflammation.
Learn more about SilicaCaprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolPotassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoatePhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Ingredient Ratings
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