Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum Versus DRMTLGY Needle-Less Serum
Updated on January 08, 2024
Overview
What they are
These products are both cruelty-free and reef safe serums. They have a total of 19 ingredients in common
Cool Features
They both contain ceramides, hyaluronic acid, niacinamide and peptides
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots
Free From
They both do not contain any harsh alcohols, common allergens, oils or parabens
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum 78 ingredients
DRMTLGY Needle-Less Serum 29 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum 78 ingredients
DRMTLGY Needle-Less Serum 29 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
Humectant
Niacinamide
Smoothing
Butylene Glycol
Humectant
Ectoin
Skin Conditioning
Sodium Hyaluronate
Humectant
Hydrolyzed Sodium Hyaluronate
Skin Conditioning
Sodium Acetylated Hyaluronate
Humectant
Sodium Hyaluronate Crosspolymer
Humectant
Acetyl Hexapeptide-8
Humectant
Palmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Oligopeptide-2
Skin Conditioning
Saccharide Isomerate
Humectant
Camellia Sinensis Leaf Extract
Antimicrobial
Centella Asiatica Extract
Cleansing
Vitis Vinifera Seed Extract
Antimicrobial
Sodium Carboxymethyl Beta-Glucan
CleansingBakuchiol
Antimicrobial
Inonotus Obliquus Extract
Skin ConditioningTetrahydrocurcumin
Antioxidant
Ceramide NP
Skin Conditioning
Ceramide AP
Skin Conditioning
Ceramide EOP
Skin Conditioning
Phospholipids
Skin Conditioning
Sphingolipids
EmollientPhytosphingosine
Skin Conditioning
Colloidal Oatmeal
Absorbent
Bisabolol
Masking
Superoxide Dismutase
Antioxidant
Terminalia Ferdinandiana Fruit Extract
Antioxidant
Sodium PCA
Humectant
Glutathione
Squalane
Emollient
Caffeine
Skin Conditioning
Panthenol
Skin Conditioning
Butyrospermum Parkii Butter
Skin Conditioning
Aloe Barbadensis Leaf Juice
Skin Conditioning
Arnica Montana Flower Extract
Masking
Acetyl Glutamine
Skin ConditioningBifida Ferment Lysate
Skin Conditioning
Chamomilla Recutita Flower Extract
Masking
Withania Somnifera Root Extract
Skin Conditioning
Glycolic Acid
Buffering
Mandelic Acid
Antimicrobial
Lactobionic Acid
Buffering
Ethylhexylglycerin
Skin ConditioningCoco-Glucoside
CleansingLauryl Glucoside
CleansingDecyl Glucoside
CleansingPolyglyceryl-10 Laurate
Skin Conditioning
Diheptyl Succinate
EmollientDimethicone
Emollient
Pentylene Glycol
Skin ConditioningSodium Lauroyl Lactylate
EmulsifyingPvm/Ma Decadiene Crosspolymer
Vp/Va Copolymer
Xanthan Gum
EmulsifyingPotassium Hydroxide
BufferingPolysorbate 20
Emulsifying
Dimethicone Crosspolymer
Emulsion StabilisingCarbomer
Emulsion StabilisingCholesterol
Emollient
Capryloyl Glycerin/Sebacic Acid Copolymer
Skin ConditioningLeuconostoc/Radish Root Ferment Filtrate
Antimicrobial
Sodium Citrate
BufferingCitric Acid
Buffering
Sodium Metasilicate
BufferingGluconolactone
Skin Conditioning
Tetrasodium Glutamate Diacetate
Caprylic/Capric Triglyceride
Masking
Jasminum Officinale Flower/Leaf Extract
Masking
Vitis Vinifera Fruit Extract
Skin ConditioningEugenia Caryophyllus Flower Extract
AstringentLavandula Angustifolia Flower/Leaf/Stem Extract
Masking
Raspberry Ketone
Masking
Phenoxyethanol
Preservative
Potassium Sorbate
Preservative
Water, Glycerin, Niacinamide, Butylene Glycol, Ectoin, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Oligopeptide-2, Saccharide Isomerate, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Vitis Vinifera Seed Extract, Sodium Carboxymethyl Beta-Glucan, Bakuchiol, Inonotus Obliquus Extract, Tetrahydrocurcumin, Ceramide NP, Ceramide AP, Ceramide EOP, Phospholipids, Sphingolipids, Phytosphingosine, Colloidal Oatmeal, Bisabolol, Superoxide Dismutase, Terminalia Ferdinandiana Fruit Extract, Sodium PCA, Glutathione, Squalane, Caffeine, Panthenol, Butyrospermum Parkii Butter, Aloe Barbadensis Leaf Juice, Arnica Montana Flower Extract, Acetyl Glutamine, Bifida Ferment Lysate, Chamomilla Recutita Flower Extract, Withania Somnifera Root Extract, Glycolic Acid, Mandelic Acid, Lactobionic Acid, Ethylhexylglycerin, Coco-Glucoside, Lauryl Glucoside, Decyl Glucoside, Polyglyceryl-10 Laurate, Diheptyl Succinate, Dimethicone, Pentylene Glycol, Sodium Lauroyl Lactylate, Pvm/Ma Decadiene Crosspolymer, Vp/Va Copolymer, Xanthan Gum, Potassium Hydroxide, Polysorbate 20, Dimethicone Crosspolymer, Carbomer, Cholesterol, Capryloyl Glycerin/Sebacic Acid Copolymer, Leuconostoc/Radish Root Ferment Filtrate, Sodium Citrate, Citric Acid, Sodium Metasilicate, Gluconolactone, Tetrasodium Glutamate Diacetate, Caprylic/Capric Triglyceride, Jasminum Officinale Flower/Leaf Extract, Vitis Vinifera Fruit Extract, Eugenia Caryophyllus Flower Extract, Lavandula Angustifolia Flower/Leaf/Stem Extract, Raspberry Ketone, Phenoxyethanol, Potassium Sorbate
Water
Skin ConditioningGlycerin
Humectant
Sodium Chondroitin Sulfate
Skin Conditioning
Sodium Hyaluronate
Humectant
Pisum Sativum Extract
Skin ConditioningBambusa Vulgaris Leaf/Stem Extract
HumectantPalmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Ceramide EOP
Skin Conditioning
Glucosamine Hcl
Glycosaminoglycans
EmollientCeramide NP
Skin Conditioning
Palmitoyl Tripeptide-5
Skin Conditioning
Ceramide AP
Skin Conditioning
Phytosphingosine
Skin Conditioning
Cholesterol
Emollient
Niacinamide
Smoothing
Sodium Lauroyl Lactylate
EmulsifyingMethylglucoside Phosphate
Skin ConditioningCopper Lysinate/Prolinate
Skin ConditioningPanthenol
Skin Conditioning
Tocopheryl Acetate
Antioxidant
Phenoxyethanol
Preservative
Polysorbate 20
Emulsifying
Ethylhexylglycerin
Skin ConditioningDisodium EDTA
Butylene Glycol
Humectant
Carbomer
Emulsion StabilisingXanthan Gum
EmulsifyingWater, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine Hcl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolSodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronatePalmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.
This ingredient is a signal peptide, meaning it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tripeptide-1Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.
This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.
This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.
By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.
Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Ceramide NP is a type of ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide AP Ceramide EOP
Learn more about Ceramide NPCeramide AP is a type of Ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. Having a strong skin barrier leads to more firm and hydrated skin.
They are known for their ability to hold water and thus are a great ingredient for dry skin. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide NP Ceramide EOP
Learn more about Ceramide APCeramide EOP is a type of Ceramide.
EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.
Ceramides are intercellular lipids naturally found in our skin. They bind dead skin cells together to create a barrier. The ceramides in our skin have the ability to hold water to keep our skin hydrated.
Ceramides are an important building block for our skin barrier. A strong skin barrier helps with:
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Learn more about Ceramide EOPPhytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.
Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.
Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.
Fun fact: Phytosphingosine is abundant in plants and fungi.
More ingredients that help boost collagen in skin:
Learn more about PhytosphingosinePanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Sodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.
Sodium Lauroyl Lactylate is an emulsifier and surfactant.
Emulsifiers help stabilize a product. They do this by preventing ingredients from separating, such as oils and water which do not mix naturally. Surfactants reduce surface tension, making it easier to rinse pollutants off skin.
Due to its relation to lauric acid, it may provide antimicrobial benefits.
Learn more about Sodium Lauroyl LactylateXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumPolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.
Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.
Our bodies use cholestrol to create vitamin D, steroid hormones, and more.
Learn more about CholesterolPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Ingredient Ratings
Here's what our community thinks of the ingredients in these products.
When to use
Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum 78 ingredients
DRMTLGY Needle-Less Serum 29 ingredients
Reviews
Here's what our community thinks
DRMTLGY Needle-Less Serum 29 ingredients
The scent feels a bit artificial, and I’m not sure about its wrinkle-improving effects. However, it absorbs quickly and feels fresh without any stickiness. It helps smooth out skin texture well, but the hydration level is on the lower side.
