Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Versus Clinique Smart Clinical MD Multi-Dimensional Age Transformer Resculpt
This anti-aging treatment is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture.
This anti-aging moisturizer is formulated around Acetyl Glucosamine and Dipeptide Diaminobutyroyl Benzylamide Diacetate to soften the look of wrinkles.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningCaprylic/Capric Triglyceride
MaskingPPG-15 Stearyl Ether
EmollientC12-20 Acid PEG-8 Ester
EmulsifyingGlycerin
HumectantNiacinamide
SmoothingPhenyl Trimethicone
Skin ConditioningCaprylic/Capric/Myristic/Stearic Triglyceride
EmollientAlgae Extract
EmollientDimethicone
EmollientHydroxyethyl Urea
HumectantCetyl Alcohol
EmollientRetinol
Skin ConditioningSigesbeckia Orientalis Extract
Skin ConditioningMangifera Indica Seed Butter
Skin ConditioningCoffea Arabica Seed Oil
MaskingSodium Hyaluronate
HumectantCaffeine
Skin ConditioningAscorbic Acid
AntioxidantUrea
BufferingButylene Glycol
HumectantSqualane
EmollientTrehalose
HumectantTriticum Vulgare Germ Extract
Skin ConditioningTocopheryl Acetate
AntioxidantPEG-100 Stearate
SurfactantLinoleic Acid
CleansingGlyceryl Stearate
EmollientHordeum Vulgare Extract
EmollientAcetyl Hexapeptide-8
HumectantSorbitol
HumectantPotassium Cetyl Phosphate
EmulsifyingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingTocopherol
AntioxidantAmmonium Acryloyldimethyltaurate/Vp Copolymer
Behenyl Alcohol
EmollientSodium PCA
HumectantSodium Hydroxide
BufferingCaprylyl Glycol
EmollientCarbomer
Emulsion StabilisingTriacetin
AntimicrobialPolyquaternium-51
Skin ConditioningXanthan Gum
EmulsifyingBHT
AntioxidantDisodium EDTA
Sodium Metabisulfite
AntioxidantChlorphenesin
AntimicrobialPotassium Sorbate
PreservativePhenoxyethanol
PreservativeWater, Caprylic/Capric Triglyceride, PPG-15 Stearyl Ether, C12-20 Acid PEG-8 Ester, Glycerin, Niacinamide, Phenyl Trimethicone, Caprylic/Capric/Myristic/Stearic Triglyceride, Algae Extract, Dimethicone, Hydroxyethyl Urea, Cetyl Alcohol, Retinol, Sigesbeckia Orientalis Extract, Mangifera Indica Seed Butter, Coffea Arabica Seed Oil, Sodium Hyaluronate, Caffeine, Ascorbic Acid, Urea, Butylene Glycol, Squalane, Trehalose, Triticum Vulgare Germ Extract, Tocopheryl Acetate, PEG-100 Stearate, Linoleic Acid, Glyceryl Stearate, Hordeum Vulgare Extract, Acetyl Hexapeptide-8, Sorbitol, Potassium Cetyl Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopherol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Behenyl Alcohol, Sodium PCA, Sodium Hydroxide, Caprylyl Glycol, Carbomer, Triacetin, Polyquaternium-51, Xanthan Gum, BHT, Disodium EDTA, Sodium Metabisulfite, Chlorphenesin, Potassium Sorbate, Phenoxyethanol
Water
Skin ConditioningGlycerin
HumectantCaprylyl Methicone
Skin ConditioningButylene Glycol
HumectantAlcohol Denat.
AntimicrobialDimethicone
EmollientIsododecane
EmollientPEG-10 Dimethicone
Skin ConditioningDipropylene Glycol
HumectantPrunus Amygdalus Dulcis Seed Extract
Skin ConditioningCucumis Melo Fruit Extract
Skin ConditioningPersea Gratissima Oil
Skin ConditioningSaccharomyces Lysate Extract
HumectantAcetyl Glucosamine
Skin ConditioningPorphyridium Cruentum Extract
Skin ConditioningDipeptide Diaminobutyroyl Benzylamide Diacetate
Skin ConditioningAcetyl Hexapeptide-8
HumectantPalmitoyl Tetrapeptide-7
Skin ConditioningAcetyl Octapeptide-3
HumectantCholesterol
EmollientDecarboxy Carnosine Hcl
Skin ConditioningAcetyl Carnitine Hcl
Skin ConditioningCaffeine
Skin ConditioningCreatine
Skin ConditioningSigesbeckia Orientalis Extract
Skin ConditioningPalmitoyl Tripeptide-1
Skin ConditioningPolygonum Cuspidatum Root Extract
AntioxidantCentella Asiatica Extract
CleansingGlycine Soja Protein
EmulsifyingErgothioneine
AntioxidantPropylene Glycol Dicaprylate
EmollientPEG-150
HumectantLauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Skin ConditioningJojoba Esters
EmollientWhey Protein
Skin ConditioningAdenosine Phosphate
Skin ConditioningTocopheryl Acetate
AntioxidantLactic Acid
BufferingFaex Extract
Skin ConditioningLinoleic Acid
CleansingSodium Hyaluronate
HumectantPhytantriol
HumectantGlycine Soja Seed Extract
Skin ConditioningDisteardimonium Hectorite
StabilisingPropylene Carbonate
SolventMenthanediol
Skin ConditioningHydroxypropyl Methylcellulose
Emulsion StabilisingPullulan
Polyquaternium-51
Skin ConditioningSodium Hydroxide
BufferingCalcium Chloride
AstringentCarbomer
Emulsion StabilisingSea Whip Extract
Skin ConditioningPolysorbate 20
EmulsifyingCaprylyl Glycol
EmollientTetrahexyldecyl Ascorbate
AntioxidantCitric Acid
BufferingPotassium Sulfate
Sodium Hexametaphosphate
MaskingSodium Citrate
BufferingPotassium Sorbate
PreservativeSodium Benzoate
MaskingPhenoxyethanol
PreservativeWater, Glycerin, Caprylyl Methicone, Butylene Glycol, Alcohol Denat., Dimethicone, Isododecane, PEG-10 Dimethicone, Dipropylene Glycol, Prunus Amygdalus Dulcis Seed Extract, Cucumis Melo Fruit Extract, Persea Gratissima Oil, Saccharomyces Lysate Extract, Acetyl Glucosamine, Porphyridium Cruentum Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Cholesterol, Decarboxy Carnosine Hcl, Acetyl Carnitine Hcl, Caffeine, Creatine, Sigesbeckia Orientalis Extract, Palmitoyl Tripeptide-1, Polygonum Cuspidatum Root Extract, Centella Asiatica Extract, Glycine Soja Protein, Ergothioneine, Propylene Glycol Dicaprylate, PEG-150, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Jojoba Esters, Whey Protein, Adenosine Phosphate, Tocopheryl Acetate, Lactic Acid, Faex Extract, Linoleic Acid, Sodium Hyaluronate, Phytantriol, Glycine Soja Seed Extract, Disteardimonium Hectorite, Propylene Carbonate, Menthanediol, Hydroxypropyl Methylcellulose, Pullulan, Polyquaternium-51, Sodium Hydroxide, Calcium Chloride, Carbomer, Sea Whip Extract, Polysorbate 20, Caprylyl Glycol, Tetrahexyldecyl Ascorbate, Citric Acid, Potassium Sulfate, Sodium Hexametaphosphate, Sodium Citrate, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Learn more about CaffeineCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolCarbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Learn more about CarbomerDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinLinoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.
Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.
Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.
Needless to say, linoleic acid is crucial for having a strong skin barrier.
One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.
This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.
Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.
Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.
Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.
Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.
Learn more about Linoleic AcidPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolPolyquaternium-51 is a polymer salt. It helps hydrate the skin by creating a film on top. This film traps moisture in, keeping your skin soft and hydrated.
Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateWe don't have a description for Sigesbeckia Orientalis Extract yet.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideTocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Learn more about Tocopheryl AcetateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water