Versus

Sesderma Azelac RU Liposomal Serum Versus Sesderma Azelac Ru Crema Gel

Serum
General Moisturizer
Spanish Brand Spain
Spanish Brand Spain

Updated on February 08, 2024

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 28 ingredients in common

Cool Features

They both contain retinoid, Vitamin C and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any parabens or sulfates

What's Inside

They both contain harsh alcohols, fragrances, oils and silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Azelac RU Liposomal Serum
Azelac Ru Crema Gel

Water

Skin Conditioning

Propanediol

Solvent

Paraffinum Liquidum

Emollient
0-2 / 0 Oil IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon

Cyclopentasiloxane

Emollient
Silicon Icon

Lecithin

Emollient

Arachidyl Alcohol

Emollient

Alcohol

Antimicrobial
Alcohol IconCan worsen Dry Skin IconMay worsen Oily Skin IconMay cause irritation IconMay worsen Eczema IconMay worsen Rosacea Icon

Cetyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Undecylenoyl Phenylalanine

Skin Conditioning

Tranexamic Acid

Astringent
Good for Dark Spots IconGood for Scar Healing Icon

Retinol

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Retinal

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Palmitoyl Tripeptide-5

Skin Conditioning
Peptide IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Nicotiana Benthamiana Sh-Polypedtide-7

Skin Conditioning

Niacin

Smoothing
Helps hydrate Dry Skin IconGood for Dark Spots Icon

Morus Alba Root Extract

Bleaching

Glycyrrhetinic Acid

Skin Conditioning

Diacetyl Boldine

Skin Conditioning

Bellis Perennis Flower Extract

Skin Conditioning

Bakuchiol

Antimicrobial
Antioxidant IconHelps with Anti-Aging IconHelps brighten skin Icon

Azelaic Acid

Buffering
Helps reduce Skin Redness IconHelps reduce irritation IconGood for Skin Texture IconGood for Minimizing Pores IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne Icon

Ascorbyl Glucoside

Antioxidant
Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores IconHelps brighten skin Icon

4-Butylresorcinol

Antioxidant
Antioxidant Icon

3-O-Ethyl Ascorbic Acid

Skin Conditioning
Vitamin C IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores Icon

Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1

Skin Conditioning
Peptide Icon

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-2

Skin Conditioning
Peptide Icon

Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76

Skin Conditioning
Peptide Icon

Dimethicone/Vinyl Dimethicone Crosspolymer

Skin Conditioning

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Arachidyl Glucoside

Emulsifying

Triticum Vulgare Germ Extract

Skin Conditioning

Propylene Glycol

Humectant
0 / 0 Helps hydrate Dry Skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Carbomer

Emulsion Stabilising
1 / 0

Cyclohexasiloxane

Emollient
Silicon Icon

Xanthan Gum

Emulsifying

Dimethicone

Emollient
1 / 0 Silicon Icon

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Citrus Grandis Fruit Extract

Astringent
Fragrance Icon

Sodium Cholate

Skin Conditioning

Polysilicone-11

Sodium Hydroxide

Buffering

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

BHT

Antioxidant
Antioxidant Icon

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant Icon

Disodium EDTA

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Ascorbyl Palmitate

Antioxidant
2 / 0 Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Scar Healing IconHelps brighten skin IconNot safe for Fungal Acne Icon

Silica

Abrasive
Exfoliant IconMay worsen Eczema IconMay worsen Rosacea Icon

Sodium Chloride

Masking
Can worsen Dry Skin IconBad for Acne Prone Skin IconMay worsen Rosacea Icon

Isoceteth-10

Emulsifying

Caprylic/Capric Triglyceride

Masking

Glyceryl Oleate

Emollient
Fragrance IconNot safe for Fungal Acne Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Decyl Glucoside

Cleansing

Citric Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconGood for Scar Healing IconHelps brighten skin IconMay worsen Rosacea Icon

Tromethamine

Buffering

Hydrochloric Acid

Buffering

BHA

Antioxidant
Antioxidant Icon

Hexylene Glycol

Emulsifying
0-2 / 0-1

Caprylyl Glycol

Emollient

Dipotassium Phosphate

Buffering

Hydroxypropyl Cyclodextrin

Masking

Potassium Phosphate

Buffering

Phenoxyethanol

Preservative
Preservative Icon

Ethylhexylglycerin

Skin Conditioning

Potassium Sorbate

Preservative
Preservative Icon

Parfum

Masking
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Solvent

Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.

Another role of this ingredient is preventing a product from melting or freezing. Propylene glycol also adds antimicrobrial properties to a product, elongating product lifespan.

This ingredient is considered an organic alcohol and commonly added into both cosmetics and foods.

Those with sensitive skin or conditions may develop a rash when using this ingredient.

Learn more about Propylene Glycol
Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of mixture of phospholipids.

This ingredient has emollient and emulsifying properties.

As an emollient, lecithen helps soften the skin and creates a barrier to keep moisture in.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can also help ingredients be better absorbed by the skin.

This is because the phospholipids in lecithin produce liposomes. Liposomes help other ingredients get through the skin barrier.

Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that feeds fungal acne.

We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.

Learn more about Lecithin
Antimicrobial, Astringent, Masking

Alcohol comes in many different forms. Different types of alcohol will have different effects on skin. This ingredient is usually an astringent alcohol.

These alcohols are drying on the skin. They may strip away your skin's natural oils and even damage your skin barrier. Astringent alcohols may also irritate skin.

Other types of astringent alcohols include:

According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.

Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.

Fatty alcohols come from plant oils such as coconut oil. These can help hydrate the skin and are non-irritating. Some fatty alcohols include cetyl and stearyl alcohol.

Learn more about Alcohol
Antioxidant

Also known as Rucinol. It's an antioxidant primarily used to treat hyperpigmentation in the outermost layer of skin.

Hyperpigmentation occurs when an enzyme called tyrosinase triggers melanin production in the skin. Melanin is the pigment that gives skin, hair, and eyes their color.

Rucinol works by preventing tyrosinase from creating more melanin. According to a study from 2013, rucinol is more effective than other tyrosinase inhibitors such as hydroquinone, arbutin, and kojic acid.

According to a manufacturer, this ingredient is sensitive to air. Good formulations should account for this to keep your rucinol effective.

Learn more about 4-Butylresorcinol
Antioxidant

Ascorbyl Glucoside is a stable form of Vitamin C. It is created by combining glucose from starch.

When applied to skin, Ascorbyl Glucoside turns into Ascorbic Acid.

Ascorbyl Glucoside is an antioxidant. Antioxidants help fight free-radicals, or molecules that may damage skin cells.

It can help to reduce redness, improve skin texture, reduce the effects of aging, reduce the visibility of dark spots, and brighten skin.

Read more about other types of Vitamin C:

Learn more about Ascorbyl Glucoside
Skin Conditioning

Retinol is a gold-standard ingredient for anti-aging. It is a form of Vitamin A and belongs to the class of retinoids that also includes tretinoin.

Why is retinol famous?

It has the most scientific studies backing up its skin benefits out of all the non-prescription ingredients.

Retinol is proven to:

This is why retinol is effective at removing wrinkles, fading dark spots, treating acne, and reducing the appearance of pores.

Studies show retinol is less effective when exposed to UV. Be sure to look for appropriate packaging to keep your retinol potent (similar to Vitamin C).

Using retinol or any retinoids will increase sun-sensitivity in the first few months. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.

We recommend speaking with a medical professional about using this ingredient during pregnancy.

Retinol may cause irritation in some people, so be sure to patch test. Experts recommend 'ramping up' retinol use: start using this ingredient once a week and work up to using it daily.

Read about Tretinoin

Learn more about Retinol
Buffering, Masking

Azelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.

It has been shown to reduce the growth of acne-causing bacteria and helps reduce inflammation. On top of that, it helps reduce the production of sebum and unclog pores.

Azelaic Acid also has antioxidant properties. Antioxidants protect our skin cells from free-radical damage.

One of the main benefits of azelaic acid is that it is gentle and well-tolerated by most people.

Fun fact: The lab-created form of azelaic acid is typically used within cosmetic products for its shelf-stability.

Learn more about Azelaic Acid
Smoothing

Niacin is the other form of B3, with the other being niacinamide. The two have similar skin benefits: reducing inflammation, strengthening the skin barrier, and fading dark spots.

Skin Conditioning

We don't have a description for Undecylenoyl Phenylalanine yet.

Skin Conditioning

Glycyrrhetinic acid is a compound found in licorice. It has skin conditioning, skin soothing, antibacterial, and antioxidant properties.

Not only is this a great ingredient for soothing inflammation, studies show this compound is effective at protecting skin against UV-B induced damage.

Fun fact: This ingredient is also used to mask the bitter taste of medicine.

Learn more about Glycyrrhetinic Acid
Bleaching, Skin Conditioning

We don't have a description for Morus Alba Root Extract yet.

Skin Conditioning

We don't have a description for Diacetyl Boldine yet.

Skin Conditioning, Skin Protecting

We don't have a description for Sodium Cholate yet.

Emulsifying

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20
Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Antioxidant, Skin Conditioning

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

Learn more about Tocopheryl Acetate
BHT
Antioxidant, Masking

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Learn more about BHT
Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Learn more about Sodium Hydroxide
Masking, Skin Conditioning

This ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.

Learn more about Caprylic/Capric Triglyceride
Masking

Chances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.

This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.

You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.

There is much debate on whether this ingredient is comedogenic. The short answer - comedogenic ratings don't tell the whole story. Learn more about comegodenic ratings here.

The concensus about this ingredient causing acne seems to be divided. Research is needed to understand if this ingredient does cause acne.

Scrubs may use salt as the primary exfoliating ingredient.

Learn more about Sodium Chloride
Masking, Skin Conditioning

We don't have a description for Hydroxypropyl Cyclodextrin yet.

BHA
Antioxidant, Masking

This BHA stands for butylated hydroxyanisole. If you are looking for the beta-hydroxy acid, aka as Salicylic Acid, click here.

In cosmetics, butylated hydroxyanisole is used as a perservative. It also has antioxidant properties. The concentrations usually used in skincare are low and do not penetrate through skin.

It is only considered a carcinogen when ingested.

Butylated Hydroxyanisole is a synthetic and waxy petrochemical. It is used as a preservative in foods and cosmetics.

Learn more about BHA
Buffering

Hydrochloric Acid can be found in the human body. It used to adjust pH levels of basic solutions.

Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Masking, Perfuming

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Learn more about Parfum

When to use

27 Routines
22% use in am
78% use in pm
78% use every day
When to use See routines that use it ->
4 Routines
0% use in am
100% use in pm
75% use every day