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Product Comparison

Here's our complete breakdown comparing the ingredients, attributes, and more of Perricone MD Neuropeptide Night Cream versus Drunk Elephant Protini Polypeptide Cream .

Last updated on September 12, 2023. Published on August 27, 2023

Overview

What they are

These products are both vegan, cruelty-free, and reef safe . They have a total of 12 ingredients in common

Cool Features

They both contain hyaluronic acid, peptides and Vitamin E

Suited For

They're both likely to be good for dry skin and brightening skin

Free From

They both do not contain any harsh alcohols, parabens or sulfates

What's Inside

They both contain fragrances

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that need an update? Let us know.

Night Moisturizer American Brand United States
General Moisturizer American Brand United States

Night Moisturizer

Night Moisturizers are marketed to hydrate the skin overnight.

General Moisturizer

All-purpose moisturizers hydrate the top layer of skin cells.

Price

Shop

Buy Neuropeptide Night Cream

Starts at $245.00
Shop

Buy Protini Polypeptide Cream

Starts at $60.00

Ingredient Info

Click any item below to learn more and view relevant ingredients.
alcohol-free
silicon-free
fragrance-free
sulfate-free
paraben-free
oil-free
fungal-acne safe
reef-safe
eu-allergen-free
vegan
cruelty-free
alcohol-free
silicon-free
fragrance-free
sulfate-free
paraben-free
oil-free
fungal-acne safe
reef-safe
eu-allergen-free
vegan
cruelty-free

At a glance

Click on any of the items below to learn more

Notable Ingredients

Vitamin E
Ceramides
Hyaluronic Acid
Peptides (6)

Benefits

Hydrating (5)
Redness Reducing (3)
Reduces Irritation (3)
Skin Texture
Anti-Aging
Dark Spots
Scar Healing
Brightening (2)

Concerns

Drying
May Worsen Oily Skin (2)
Acne Trigger (2)
Rosacea (3)
Eczema (2)

Notable Ingredients

Vitamin E
Hyaluronic Acid
Peptides (9)

Benefits

Hydrating (2)
Brightening (2)

Concerns

May Worsen Oily Skin (2)
Acne Trigger (2)
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Ingredients Compared

Ingredients that are highlighted in purple are present in both products.

Ingredients Side-by-side

Ingredients that are highlighted in purple are present in both products.

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Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1
What it does: Skin Conditioning, Solvent
Community Rating: Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. Talk about multi-purpose! If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

Perricone MD Neuropeptide Night Cream contains this as ingredient number 1.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 1.

2
What it does: Humectant, Skin Conditioning, Skin Protecting, Solvent
Community Rating: Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin

Perricone MD Neuropeptide Night Cream contains this as ingredient number 2.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 3.

3
What it does: Emollient, Emulsifying, Emulsion Stabilising
Community Rating: Very Disliked

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.

Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne.

Due to the fatty acid base, this ingredient may not be Malassezia folliculitis safe.

Learn more about Cetearyl Alcohol

Perricone MD Neuropeptide Night Cream contains this as ingredient number 5.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 4.

4
What it does: Humectant, Masking, Skin Conditioning, Solvent
Community Rating: Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Perricone MD Neuropeptide Night Cream contains this as ingredient number 11.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 37.

5
What it does: Emulsion Stabilising
Community Rating: Disliked

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Perricone MD Neuropeptide Night Cream contains this as ingredient number 12.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 47.

6
What it does: Skin Conditioning
Community Rating: Loved

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7

Perricone MD Neuropeptide Night Cream contains this as ingredient number 22.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 17.

7
What it does: Humectant, Skin Conditioning
Community Rating: Loved

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate

Perricone MD Neuropeptide Night Cream contains this as ingredient number 34.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 32.

8
What it does: Emulsifying
Community Rating: Very Disliked

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Learn more about Polysorbate 60

Perricone MD Neuropeptide Night Cream contains this as ingredient number 40.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 45.

9
What it does: Emollient, Humectant, Skin Conditioning
Community Rating: Liked

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol

Perricone MD Neuropeptide Night Cream contains this as ingredient number 41.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 51.

10
What it does: Buffering, Humectant
Community Rating: Liked

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and used to adjust the pH of a product.

Sodium Lactate is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin.

It also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

Our NMF is formed from amino acids, lactic acid, sugars, minerals, peptides, and electrolytes. As we age, our NMF naturally depletes. Other sources of NMF depletion include harsh and drying ingredients such as denatured alcohol. Sodium lactate can help replenish our NMF, leading to more hydrated and plump skin.

High percentages of Sodium Lactate can have an exfoliating effect.

Sodium Lactate is produced from fermented sugar.

Learn more about Sodium Lactate

Perricone MD Neuropeptide Night Cream contains this as ingredient number 48.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 39.

11
What it does: Humectant, Skin Conditioning
Community Rating: Loved

Sodium PCA is the sodium salt of pyroglutamic acid and is naturally occurring on human skin.

The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.

Sodium PCA is a has conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Learn more about Sodium PCA

Perricone MD Neuropeptide Night Cream contains this as ingredient number 49.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 40.

12
What it does: Preservative
Community Rating: Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Perricone MD Neuropeptide Night Cream contains this as ingredient number 50.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 53.

Here's what our community thinks of the ingredients in these two products.

44% are loved or liked
11% have mixed ratings
35% are disliked or very disliked
9% have no rating yet
52% are loved or liked
12% have mixed ratings
29% are disliked or very disliked
7% have no rating yet

Usage

Here's some more info on how this product is used by our community.

When to use

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Reviews

Here's what our community thinks

Perricone MD Neuropeptide Night Cream 54 ingredients

Neuropeptide Night Cream hasn't been rated yet.
Rate it now

Drunk Elephant Protini Polypeptide Cream 58 ingredients

4.2 /5
from 11 ratings
Expensive (2) Hydrating (2) Works Well (2) Absorbs Well (1) Light (1) Strong Scent (1)
sillygirl's avatar

sillygirl

2 months ago · Sensitive Skin
Review

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and...

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and i found that the 2 worked well with each other. it’s a really nice almost gel-like cream texture with a light fragrance. i found it a little hard to blend while my face was still damp which is when i usually apply moisturizer. i don’t feel like it did much for my skin but moisturize it.. lol definitely wouldn’t pay $70 for it again

zankhaft's avatar

zankhaft

5 months ago · Sensitive Skin
Review

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight...

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight "chemical" smell that I tend to like. I love the pump as well. I use this when I need a good hit of luxury.

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