Holika Holika Honey Royalactin Intensive Eye Cream
A eye moisturizer with 57 ingredients, including niacinamide, vitamin E, and hyaluronic acid.
This anti-aging eye moisturizer is formulated around Niacinamide and Honey to soften the look of wrinkles and hydrate skin.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningGlycerin
HumectantButylene Glycol
HumectantBetaine
HumectantNiacinamide
SmoothingPentaerythrityl Tetraisostearate
EmollientCyclopentasiloxane
EmollientC14-22 Alcohols
Emulsion StabilisingHydrogenated Polyisobutene
EmollientPentaerythrityl Tetraethylhexanoate
Emollient1,2-Hexanediol
Skin ConditioningButylene Glycol Dicaprylate/Dicaprate
EmollientCetearyl Alcohol
EmollientDipentaerythrityl Hexa C5-9 Acid Esters
Skin ConditioningCetearyl Olivate
Polyglyceryl-3 Distearate
EmulsifyingSorbitan Olivate
EmulsifyingDimethicone
EmollientPhytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate
Skin ConditioningC12-20 Alkyl Glucoside
EmulsifyingCocos Nucifera Oil
MaskingCarbomer
Emulsion StabilisingAloe Barbadensis Leaf Extract
EmollientTromethamine
BufferingEthylhexyl Olivate
Skin ConditioningAmmonium Acryloyldimethyltaurate/Vp Copolymer
Allantoin
Skin ConditioningGlyceryl Stearate Citrate
EmollientSodium Acrylates Copolymer
Tocopheryl Acetate
AntioxidantPolyglyceryl-4 Oleate
EmulsifyingAdenosine
Skin ConditioningHoney
HumectantMelia Azadirachta Flower Extract
Skin ConditioningOcimum Sanctum Leaf Extract
Skin ConditioningDisodium EDTA
Melia Azadirachta Leaf Extract
Skin ConditioningSodium Hyaluronate
HumectantCurcuma Longa Root Extract
MaskingCorallina Officinalis Extract
Skin ConditioningButyrospermum Parkii Butter
Skin ConditioningCaprylic/Capric Triglyceride
MaskingPolyglyceryl-10 Oleate
Skin ConditioningGlucose
HumectantHydrogenated Lecithin
EmulsifyingHydrolyzed Collagen
EmollientHydrolyzed Royal Jelly Protein
Skin ConditioningAcetyl Hexapeptide-8
HumectantCopper Tripeptide-1
Skin ConditioningHydroxydecyl Ubiquinone
AntioxidantPalmitoyl Pentapeptide-4
Skin ConditioningTheobroma Cacao Extract
Skin ConditioningPhenethyl Alcohol
MaskingMaltodextrin
AbsorbentDextrin
AbsorbentEthylhexylglycerin
Skin ConditioningParfum
MaskingWater, Glycerin, Butylene Glycol, Betaine, Niacinamide, Pentaerythrityl Tetraisostearate, Cyclopentasiloxane, C14-22 Alcohols, Hydrogenated Polyisobutene, Pentaerythrityl Tetraethylhexanoate, 1,2-Hexanediol, Butylene Glycol Dicaprylate/Dicaprate, Cetearyl Alcohol, Dipentaerythrityl Hexa C5-9 Acid Esters, Cetearyl Olivate, Polyglyceryl-3 Distearate, Sorbitan Olivate, Dimethicone, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, C12-20 Alkyl Glucoside, Cocos Nucifera Oil, Carbomer, Aloe Barbadensis Leaf Extract, Tromethamine, Ethylhexyl Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Allantoin, Glyceryl Stearate Citrate, Sodium Acrylates Copolymer, Tocopheryl Acetate, Polyglyceryl-4 Oleate, Adenosine, Honey, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Disodium EDTA, Melia Azadirachta Leaf Extract, Sodium Hyaluronate, Curcuma Longa Root Extract, Corallina Officinalis Extract, Butyrospermum Parkii Butter, Caprylic/Capric Triglyceride, Polyglyceryl-10 Oleate, Glucose, Hydrogenated Lecithin, Hydrolyzed Collagen, Hydrolyzed Royal Jelly Protein, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hydroxydecyl Ubiquinone, Palmitoyl Pentapeptide-4, Theobroma Cacao Extract, Phenethyl Alcohol, Maltodextrin, Dextrin, Ethylhexylglycerin, Parfum
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolBetaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
Some studies suggest betaine may support making skin tone more even.
Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
Betaine is also known as trimethylglycine.
Learn more about BetaineNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePentaerythrityl Tetraisostearate is a synthetic emollient and "skin-feel" ingredient that spreads well and leaves a non-sticky finish with high gloss.
In makeup, it also doubles as a pigment-wetting agent for better color payoff.
It's a well-vetted ingredient for safety and does not penetrate into skin due to its large molecule size.
Because it's a long-chain fatty acid ester, this ingredient may not be fungal acne or Malassezia safe.
Learn more about Pentaerythrityl TetraisostearateCyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.
Since D5 is volatile, it does its thing and then evaporates off the skin quickly.
The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics
There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.
Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.
The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.
Learn more about CyclopentasiloxaneThis ingredient is a blend of long-chain fatty alcohols (myristyl, cetyl, stearyl, arachidyl, and behenyl). It is an emulsion stabilizer with emollient properties.
Don't let the word "alcohol" scare you: fatty alcohols are nothing like the drying solvents. This ingredient actually helps soften and smooth the skin.
By the way, the FDA allows products to be labeled "alcohol-free" even when they contain fatty alcohols like this one.
In a formula, it prevents the water and oil phases from separating over time while also contributing to a pleasant, non-greasy slip.
Interestingly, this ingredient can organize into the structures that mimic the skin's own lipid architecture to help support barrier function and reduce transepidermal water loss (TEWL).
The CIR Expert Panel has thoroughly assess the individual fatty alcohols that make up this blend and found no significant toxicity or dermal irritation.
Learn more about C14-22 AlcoholsHydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.
In one study, Hydrogenated Polyisobutene showed better skin hydration levels than Caprylic/Capric Triglyceride. As an emollient, it helps keep your skin soft and hydrated by trapping moisture in.
Hydrogenated Polyisobutene is often used as a mineral oil replacement.
Learn more about Hydrogenated PolyisobutenePentaerythrityl Tetraethylhexanoate is an emollient that helps make your skin smooth and hydrated. It specializes in creating a non-oily and "wet" feeling on skin.
This ingredient comes from isostearic acid, a saturated fatty acid. It is a synthetic ingredient.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
This is a lightweight diester (caprylic/capric acid + butylene glycol) with emollient and skin conditioning properties.
According to a manufacturer, this ingredient can help add a "cushiony" oil phase without making it heavy.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Learn more about Cetearyl AlcoholWe don't have a description for Dipentaerythrityl Hexa C5-9 Acid Esters yet.
Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.
You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.
These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.
This ingredient is well-tolerated and has no significant sensitization data.
Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.
Learn more about Cetearyl OlivatePolyglyceryl-3 Distearate isn't fungal acne safe.
Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.
This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.
This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.
According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.
Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.
Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.
Learn more about Sorbitan OlivateDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeThis is a plant-derived ester that functions as a skin conditioner. It's basically a two linoleic acid molecules combined with fatty alcohols.
In practice, it works as a rich emollient that helps reduce moisture loss and give skin a soft appearance.
The phytosterol part of this ingredient brings an added structural bonus: phytosterols are structurally similar to cholesterol so they can fit right into the stratum corneum's lipid matrix to help reinforce the skin barrier.
Due to its molecular structure, this ingredient delivers a cushiony and glossy feeling without being excessively greasy.
It did not produce skin irritation or sensitization in clinical studies, and this ingredient is deemed safe to use in cosmetics at current practices.
Because this ingredient contains C16, C18, and C22 fatty chains, it may not be Malassezia/fungal acne safe. The Malassezia yeast potentially feeds on fatty acids in the C11-C24 range.
Learn more about Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer DilinoleateWe don't have a description for C12-20 Alkyl Glucoside yet.
This ingredient is also known as coconut oil. It is a plant-derived ingredient with skin conditioning properties.
The fatty acid profile of coconut oil is mostly lauric acid (~54%), followed by capric, caprylic, palmitic, and myristic acids. This profile allows it to penetrate easily into skin, moisturize, and improve dry skin.
A double-blind study confirmed that extra virgin coconut oil is as effective as mineral oil for treating very dry skin. Another study found it outperformed mineral oil for mild to moderate atopic dermatitis in children.
Another study from 2018 found that virgin coconut oil can soothe inflammation and boost key skin barrier proteins. Just know this evidence is still only from lab settings and not human trials.
It has also been shown to reduce Staphylococcus aureus, a bacteria that commonly overgrows in people with eczema.
Clinical testing shows very minimal skin irritation and no evidence of sensitization or phototoxicity.
Coconut oil gets flagged as a "fragrance" because it has a natural mild scent (not because it's a synthetic perfume). The European Cosmetic ingredient database also lists "perfuming" as a function of this ingredient.
Just so you know, the term "fragrance" is completely unregulated. Some brands still use botanical extracts or essential oils in their "fragrance-free" formulas, but regulatory databases technically classify these under "fragrance".
Coconut oil has a tiny and useless bit of natural SPF. Early lab studies clocked it around SPF 7-8 but a more recent study found the real number closer to SPF 1.2. It also offers no meaningful UVA protection (SPF only overs UVB rays).
The comedogenic rating of 4/5 means it has a high potential to clog pores; but it's worth noting that comedogenicity is highly individual and ratings cannot predict how an overall formula will behave on skin.
Since lauric acid is the dominant fatty acid, this ingredient may not be fungal acne safe. The Malassezia yeast feeds on fatty acids with carbon chain lengths between 11-24, and lauric acid falls within these lengths (C12).
Learn more about Cocos Nucifera OilCarbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Learn more about CarbomerAloe Barbadensis Leaf Extract is a botanical extract pulled from the leaves of aloe vera and one of the most studied plant ingredients in cosmetics.
The inner leaf gel it comes from is mostly water (~99-99.5%) and the remaining fraction is made up of pretty good stuff: polysaccharides, vitamins, phenolics, and enzymes.
Its headline job is hydration.
The star polysaccharide in aloe, acemannan, is a humectant that retains moisture and helps reduce trans-epidermal water loss.
Aloe also has real soothing credentials; it contains anti-inflammatory compounds like bradykinase and C-glucosyl chromone that help calm irritation and redness.
On the repair side, lab work shows that acemannan wakes up your skin's repair cells (fibroblasts), prompting them to multiply and speed up healing.
There's some human data for cosmetic benefit too: a cream containing 10% Aloe Barbadensis leaf extract improved skin hydration and elasticity in a real-use study.
Safety-wise, this ingredient is well-regarded with just one rare downside; there have been some case reports of acute eczema, contact urticaria, and dermatitis in people who applied aloe-derived ingredients topically. Those with a known aloe or Liliaceae sensitivity should patch test.
Typical use levels range widely, from under 1% up to 90%+ depending on the format and the effect you are after.
Learn more about Aloe Barbadensis Leaf ExtractTromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Learn more about TromethamineEthylhexyl Olivate isn't fungal acne safe.
Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.
The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:
Due to its large molecular size, it sits on the surface of skin rather than penetrating it.
Learn more about Ammonium Acryloyldimethyltaurate/Vp CopolymerAllantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Learn more about AllantoinGlyceryl Stearate Citrate is a citric acid ester of glyceryl stearate.
It is an emulsifier, emollient, and a surfactant.
Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating. Common ingredients include oils and water, which do not mix naturally. Emulsifiers have properties that help keep ingredients such as these together.
Emollients help soothe and soften the skin. They do this by creating a protective film on your skin. This barrier helps trap moisture and keeps your skin hydrated. Emollients may be effective at treating dry or itchy skin.
Surfactants help gather oils, dirt, and other pollutants from the skin. This helps them to be easily rinsed away.
Learn more about Glyceryl Stearate CitrateThis ingredient is a synthetic, salt form polymer built from acrylic acid, ethacrylic acid, or their simple esters. It works as a binder, film former, and viscosity increasing agent.
Typical concentrations start at around 0.5% but can go up to 25% for film-forming or binding.
The CIR Expert Panel assessed the safety of 126 acrylates copolymers and concluded they are safe in cosmetics at current use levels when formulated to be non-irritating. They also noted the levels present in finished cosmetic products are not considered a safety risk and Genotoxicity testing (Ames tests, chromosomal aberration assays) has come back negative across the board.
Though the raw building blocks (like acrylic acid) can be irritating on their own, cosmetic-grade versions go through purification to keep levels extremely low.
Sodium Acrylates Copolymer is a large molecule that doesn't penetrate skin barrier in any meaningful way.
Learn more about Sodium Acrylates CopolymerTocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Learn more about Tocopheryl AcetatePolyglyceryl-4 Oleate isn't fungal acne safe.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineHoney mostly shows up in skincare as a humectant and skin conditioning agent. This is because its natural sugars (fructose and glucose) help hold onto water so skin feels softer and more hydrated.
Beyond hydration, honey also has antibacterial and wound-supporting properties. Its antibacterial action comes from a mix of things:
Manuka-type honey has an extra bacteria-killing compound called methylglyoxal, while all Honey contains a natural antibacterial protein called bee defensin-1.
Honey also nudges your immune cells to release signals that start the healing process. This is why medical-grade Honey is actually used in real wound dressings.
Just keep in mind that most of the strong clinical evidence is for wound care and not everyday cosmetic claims.
On concentrations and safety:
According to industry data, honey is used up to 22% in paste/mud packs, 7% as a honey extract in body/hand products, and face skincare levels sit well below that.
A human repeat insult patch test of 7% honey extract in 112 subjects showed no sensitization.
Allergy-wise, honey itself is a rare sensitizer. The bigger culprit is usually propolis that sometimes tags along in less-refined honey.
People allergic to propolis, conifer, poplar, salicylates, or Balsam of Peru are advised to avoid this ingredient due to shared allergens.
You might see this ingredient listed as either Honey or Mel (they're the same thing). Mel is simply the Latin word for honey.
A lot of people wonder if Honey is vegan, and technically it isn't.
Honey is made by bees; they gather nectar and their natural enzymes turn it into the Honey we know. So because it comes from an animal, it doesn't fit a vegan lifestyle.
And please remember to be kind to bees :). They're vital to so many ecosystems, and many species are struggling so they're worth protecting.
Learn more about HoneyMelia Azadirachta Flower Extract is from the Neem tree. Neem trees originate from India.
Melia Azadirachta Flower Extract contains antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
The flowers of this tree are lilac colored.
Learn more about Melia Azadirachta Flower ExtractOcimum Sanctum Leaf Extract comes from the Holy Basil plant. Holy Basil is native to India.
Holy Basil is rich in antioxidants due to its high romarinic acid, ferulic acid, and rutin content. This gives it skin brightening and soothing properties.
While Holy Basil has many claims to help fight acne, more research is needed.
One thing to note is the presence of tannins; tannins are naturally found in nature. However, this compound may be skin-sensitizing.
Learn more about Ocimum Sanctum Leaf ExtractDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAThis ingredient is also known as neem leaf extract. It contains natural compounds like nimbidin, quercetin, and other polyphenols that give it antibacterial, antifungal, and anti-inflammatory activity.
Lab studies have shown neem leaf extract can inhibit acne-related bacteria and help calm skin. Animal studies on wound gels using 1-3% neem leaf extract found it sped up healing without causing irritation.
A wound-healing study testing gels with the extract at 1%, 2%, and 3% concentrations and found none of them irritated the skin.
Most commercial products also use it in a similar low range (typically under 5%).
Allergy-wise, there are some case reports on neem oil causing allergic contact dermatitis so people with plant/botanical sensitivities may want to patch test first.
Learn more about Melia Azadirachta Leaf ExtractSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateCurcuma Longa Root Extract is from the spice, turmeric. Besides being a healthy and delicious spice, turmeric also has plenty of skincare benefits. It has anti-inflammatory, antioxidant, and anti-microbial properties.
Turmeric contains curcumin, an antioxidant. Antioxidants help neutralize unstable free-radical molecules. Free-radical molecules may damage your skin's cells and DNA. Curcumin may help with anti-aging.
Curcumin also has anti-inflammatory properties and can help soothe skin and reduce irritation. On top of that, curcumin has been shown to help prevent hyperpigmentation from sun damage.
The anti-microbial property of turmeric can make it effective in treating acne. This property has also been shown to help regulate the production of sebum.
Learn more about Curcuma Longa Root ExtractCorallina Officinalis Extract is from the red seaweed, Corallina Officinalis. This seaweed is found all over the world but is most common in the rocky shores of Great Britain and Ireland.
Corallina Officinalis Extract contains antioxidant and emollient properties.
Extracted polysaccharides, galactose and xylose, in red algae showed antioxidant activity. Antioxidants help with anti-aging by neutralizing free-radical molecules. Free-radical molecules may damage your skin cells and DNA. Galactose is also a PHA.
Corallina Officinalis is structurally similar to coral due to its high calcium content.
Learn more about Corallina Officinalis ExtractThis ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.
Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).
In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).
Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.
Shea butter also contains vitamins A and E which may contribute to antioxidant activity.
While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.
This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.
Learn more about Butyrospermum Parkii ButterCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglyceridePolyglyceryl-10 Oleate is made by combining ten units of glycerin with oleic acid.
According to a manufacturer, it is a low-irritation and hydrophilic (water loving) skin conditioning agent. It also improves the sensory feel and texture of a product.
Fungal acne note:
Since this ingredient is made from oleic acid, it might not be fungal acne safe. The Malassezia yeast survives by eating certain fats, including oleic acid.
However, it should be noted this oleic acid is chemically bound to a large polyglycerol molecule, so it might not trigger fungal acne for everyone.
Learn more about Polyglyceryl-10 OleateGlucose is a simple sugar (a monosaccharide). In skincare, it is mostly a humectant and skin conditioning agent.
Mechanistically, it has multiple hydroxyl groups that hydrogen-bond to water. This pulls moisture into the upper layers of skin to keep the surface soft and hydrated.
It's worth knowing sugars are already a natural component of the skin's NMF (natural moisturizing factor) so it's a molecule that your stratum corneum is well-acquainted with.
Just so you know, glucose is hydrophilic (water-loving) and the stratum corneum is a strong barrier to hydrophilic compounds. This just means penetration is slow and most of the action is happening on the surface.
Gram-to-gram, glucose is not as efficient as a humectant as glycerin. This is why you'll likely see glycose paired with stronger humectants for a bigger hydration payoff.
In skincare, glucose is typically derived from corn or other starch sources.
Learn more about GlucoseHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinHydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.
In a formula, it works mainly as a skin-conditioning and moisturizing agent.
The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.
This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.
It's worth being realistic here:
Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).
However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.
Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).
Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.
If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.
The results are varied.
A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.
However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.
Further studies are needed at this time.
Learn more about Hydrolyzed CollagenWe don't have a description for Hydrolyzed Royal Jelly Protein yet.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.
It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.
While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.
Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.
Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.
Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.
For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.
After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.
While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.
Read more about other common types of peptides here:
Learn more about Copper Tripeptide-1Hydroxydecyl Ubiquinone (aka Idebenone) is an antioxidant that helps neutralize free radicals, or the unstable molecules that break down collagen and speed up visible aging.
It's a synthetic analog of Coenzyme Q10 but with a much smaller molecular weight. In theory, this gives it greater potential to penetrate skin.
The headline claim comes from a 2005 study that ranked Idebenone's oxidative-stress protection against five popular antioxidants (Vitamin C, Vitamin E, CoQ10, Kinetin, and Alpha Lipoic Acid). This study found it performed strongly in their testing model.
A companion six-week clinical trial on 41 women with moderately photodamaged skin found a 1% Idebenone formula showed a 26% reduction in skin roughness and dryness, a 37% increase in hydration, a 29% reduction in fine-lines/wrinkles, and a 33% improvement in overall photodamage. One thing worth noting about this study is that there was no vehicle control so not all benefits can be pinned on idebenone alone.
Typical usage for this ingredient sits between 0.5-1% (both concentrations validated in clinical work).
On the safety side, Idebenone is well tolerated by most people. There are a handful of documented allergic contact dermatitis in individual users so be sure to patch test if you have sensitive or reactive skin.
Learn more about Hydroxydecyl UbiquinoneYou might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.
As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.
A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.
The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.
The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.
Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.
Read more about other common types of peptides here:
Learn more about Palmitoyl Pentapeptide-4This ingredient is extracted from the seeds of the cocoa tree.
Cacao seeds contain antioxidants known as polyphenols. These include flavonoids, procyanidins, and epicatechins.
Studies show these polyphenols help improve skin health.
The more famous ingredient from cocoa tree is cocoa butter.
Learn more about Theobroma Cacao ExtractPhenethyl Alcohol is a colorless and aromatic alohol. It is naturally occuring in essential oils.
The scent of this ingredient is floral and often compared to rose.
Like other alcohols, this ingredient helps prevent the growth of bacteria. However, its main purpose is to impact a fragrance.
Learn more about Phenethyl AlcoholMaltodextrin is a plant-derived carbohydrate made by breaking down starch (usually from corn, potato, or rice). In cosmetic formulas, it's a multitasking absorbent, emulsion stabilizer, and skin conditioner.
This ingredient is mostly used to stabilize emulsions and improve the powdery, non-greasy feel of products (like dry shampoos).
Safety-wise, this ingredient is pretty solid; it's even recognized as a food additive. Both animal and clinical studies found no adverse effects at the levels used in cosmetics.
Industry data shows this ingredient is used up to 45.7% in spray products and up to 33% in powder products.
Learn more about MaltodextrinDextrin is a starch-derived polysaccharide. It's made by partially breaking down corn, potato, or other plant starches.
Think of it as "half-processed" starch; it's less complex than the original but not fully broken down into sugar like maltodextrin.
In cosmetics, it mainly functions as a bulking agent, viscosity controller, binder, and absorbent. It helps thicken products, stabilize powders, and get certain textures a less "wet" feel.
This ingredient has a pretty solid safety profile; it's recognized as a safe food additive and its large molecular size means it doesn't meaningfully penetrate skin.
Human repeat insult patch tests using a rinse-off facial product containing 42.69% dextrin found no skin irritation or sensitization in 54 subjects.
Typical real-world usage is much lower: usually under 1% as a texture modifier and up to 40% in masks (rinse off products use less).
Learn more about DextrinEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
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Read more about us· Updated December 5, 2023 • Added by Lapaki