SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum Versus DRX DNA Repair Concentrate Photolyase & Endonuclease Pro
This anti-aging serum is formulated around Dipeptide Diaminobutyroyl Benzylamide Diacetate and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.
This anti-aging moisturizer is formulated around Bakuchiol to soften the look of wrinkles.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningNiacinamide
SmoothingGluconolactone
Skin ConditioningButylene Glycol
HumectantPEG/PPG/Polybutylene Glycol-8/5/3 Glycerin
HumectantAlcohol Denat.
AntimicrobialPentylene Glycol
Skin ConditioningMethyl Gluceth-20
HumectantGlycerin
HumectantPotassium Hydroxide
BufferingHydroxyethylcellulose
Emulsion StabilisingSalicylic Acid
MaskingChlorphenesin
AntimicrobialPhytic Acid
Adenosine
Skin ConditioningSodium Benzoate
MaskingLaminaria Digitata Extract
Skin ProtectingDipeptide Diaminobutyroyl Benzylamide Diacetate
Skin ConditioningAcetyl Hexapeptide-8
HumectantWater, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8
Water
Skin ConditioningCyclopentasiloxane
EmollientGlycerin
HumectantButylene Glycol
HumectantButyrospermum Parkii Butter
Skin ConditioningCetearyl Alcohol
EmollientGlyceryl Stearate
EmollientGalactoarabinan
PEG-100 Stearate
SurfactantDimethicone Crosspolymer
Emulsion StabilisingBakuchiol
AntimicrobialCetyl Palmitate
Emollient1,2-Hexanediol
Skin ConditioningHydroxyacetophenone
AntioxidantDimethicone
EmollientDimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningTocopheryl Acetate
AntioxidantSorbitol
HumectantDipotassium Glycyrrhizate
HumectantLeontopodium Alpinum Extract
Skin ConditioningSodium Lauroyl Lactylate
EmulsifyingXanthan Gum
EmulsifyingScutellaria Baicalensis Root Extract
AstringentO-Cymen-5-Ol
AntimicrobialParfum
MaskingPhenoxyethanol
PreservativeBeta-Glucan
Skin ConditioningAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingDimethiconol
EmollientPotassium Hydroxide
BufferingLecithin
EmollientLaminaria Digitata Extract
Skin ProtectingDisodium EDTA
ChelatingMarrubium Vulgare Extract
Skin ConditioningHydrolyzed Opuntia Ficus-Indica Flower Extract
AbrasivePolyglyceryl-10 Diisostearate
EmulsifyingPolyglyceryl-10 Laurate
Skin ConditioningCaprylyl Glycol
EmollientCeramide NP
Skin ConditioningEthylhexylglycerin
Skin ConditioningSodium Chloride
MaskingArabidopsis Thaliana Extract
AntioxidantMicrococcus Lysate
Skin ConditioningPlankton Extract
Skin ConditioningDiatomaceous Earth
AbrasiveCeramide AP
Skin ConditioningCholesterol
EmollientPhytosphingosine
Skin ConditioningCarbomer
Emulsion StabilisingMannitol
HumectantCitric Acid
BufferingSodium Benzoate
MaskingPotassium Sorbate
PreservativeGlyceryl Caprylate
EmollientSodium Citrate
BufferingDisodium Phosphate
BufferingSodium Phosphate
BufferingIsostearic Acid
CleansingPotassium Chloride
Ceramide EOP
Skin ConditioningSh-Oligopeptide-1
Skin ConditioningWater, Cyclopentasiloxane, Glycerin, Butylene Glycol, Butyrospermum Parkii Butter, Cetearyl Alcohol, Glyceryl Stearate, Galactoarabinan, PEG-100 Stearate, Dimethicone Crosspolymer, Bakuchiol, Cetyl Palmitate, 1,2-Hexanediol, Hydroxyacetophenone, Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer, Tocopheryl Acetate, Sorbitol, Dipotassium Glycyrrhizate, Leontopodium Alpinum Extract, Sodium Lauroyl Lactylate, Xanthan Gum, Scutellaria Baicalensis Root Extract, O-Cymen-5-Ol, Parfum, Phenoxyethanol, Beta-Glucan, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Potassium Hydroxide, Lecithin, Laminaria Digitata Extract, Disodium EDTA, Marrubium Vulgare Extract, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Polyglyceryl-10 Diisostearate, Polyglyceryl-10 Laurate, Caprylyl Glycol, Ceramide NP, Ethylhexylglycerin, Sodium Chloride, Arabidopsis Thaliana Extract, Micrococcus Lysate, Plankton Extract, Diatomaceous Earth, Ceramide AP, Cholesterol, Phytosphingosine, Carbomer, Mannitol, Citric Acid, Sodium Benzoate, Potassium Sorbate, Glyceryl Caprylate, Sodium Citrate, Disodium Phosphate, Sodium Phosphate, Isostearic Acid, Potassium Chloride, Ceramide EOP, Sh-Oligopeptide-1
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinLaminaria Digitata Extract comes from the big brown seaweed (or kelp) that grows in the North Atlantic. In skincare, it's mostly used as a skin protectant and conditioning agent.
The most interesting stuff inside is mostly just sugars and minerals: fucoidan (a sulfated polysaccharide), laminarin (a beta-glucan), alginates, and phlorotannins (seaweed polyphenols).
Any antioxidant and soothing claims mostly come from those polysaccharides; crude laminarin and fucoidan from Laminaria digitata do show antioxidant and anti-inflammatory activity in lab assays.
Just know that the lab assays are test-tube work on isolated compounds and not clinical trials on the finished extract.
Realistically, this ingredient is a nice-feeling and hydrating skin conditioner (not really an active).
Safety-wise, it's one of the better documented seaweeds and safe to be used in cosmetics according to the CIR Expert Panel.
Industry surveys find that usage concentrations run can be found up to 5% in bubble baths and leave-on usage is more likely 0.1-3%.
The risk of allergy is also quite low as human repeat insult patch tests (under 5% and blends containing 8-12%) came back non-irritating and non-sensitizing. Rabbit studies came back negative too, though one trade mixture at 1.5-2.5% in water + propylene glycol did cause moderate irritation at 30 minutes.
Reported seaweed allergies in the literature are almost all occupational (people handling wet kelp) or from a totally unrelated blue/green alga.
You'll see seaweed listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to.
The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally.
And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter.
What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of studies that found algae compounds may actually help acne.
However, plenty of people do report breaking out from algae-containing products. Skin is individual and it's worth avoiding if yours has reacted to algae before.
The 0-5 scale comes from applying ingredients to the inside of an albino rabbit's ear. Rabbit follicles are far more reactive than human ones so it over-predicts. Even petrolatum was reassigned as non-comedogenic by the original scientist, Kligman.
Here are three more problems of comedogenic ratings:
Learn more about Laminaria Digitata ExtractPotassium Hydroxide (also known as potash) is a strong alkaline ingredient that does one job: it nudges a product's pH up so the whole formula lands in a skin-friendly range.
It's also the base that turns oils into liquid soap during the soap making process.
An expert safety panel reviewed it and found it safe when formulations are made to be non-irritating.
As a pH adjuster, it's typically used well under 1% though regulatory caps go much higher: 5% in nail cuticle removers and 2-4.5% in hair straighteners.
Though there is some concern for irritation from raw or high pH material, a well-balanced formula will be a non-issue for the vast majority of people.
Learn more about Potassium HydroxideSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water