Clinique Smart Clinical Repair Wrinkle Correcting Face Cream Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
Humectant
Isostearyl Neopentanoate
Emollient
Butylene Glycol
Humectant
Glyceryl Stearate
Emollient
PEG-100 Stearate
Surfactant
Dimethicone
Emollient
Cetearyl Alcohol
Emollient
Acetyl Hexapeptide-8
Humectant
Acetyl Octapeptide-3
Humectant
Aminopropyl Ascorbyl Phosphate
Antioxidant
Palmitoyl Tetrapeptide-7
Skin Conditioning
Algae Extract
EmollientSodium Hyaluronate
Humectant
Palmitoyl Hexapeptide-12
Skin Conditioning
Sigesbeckia Orientalis Extract
Skin ConditioningWhey Protein
Skin ConditioningDipeptide Diaminobutyroyl Benzylamide Diacetate
Skin Conditioning
Acetyl Glucosamine
Skin Conditioning
Caffeine
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Glycine Soja Seed Extract
Skin Conditioning
Cetearyl Glucoside
Emulsifying
Tocopheryl Acetate
Antioxidant
Isohexadecane
EmollientPetrolatum
Emollient
Caprylyl Glycol
Emollient
Glycereth-26
Humectant
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingTromethamine
BufferingGlyceryl Polymethacrylate
PEG-8
HumectantPolysorbate 20
Emulsifying
Hexylene Glycol
EmulsifyingPolysorbate 80
Emulsifying
Carbomer
Emulsion StabilisingAcrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingSorbitan Oleate
Emulsifying
Cetyl Alcohol
Emollient
Sodium Citrate
BufferingDisodium EDTA
Phenoxyethanol
Preservative
Potassium Sorbate
Preservative
Sodium Benzoate
Masking
Water, Glycerin, Isostearyl Neopentanoate, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Cetearyl Alcohol, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Aminopropyl Ascorbyl Phosphate, Palmitoyl Tetrapeptide-7, Algae Extract, Sodium Hyaluronate, Palmitoyl Hexapeptide-12, Sigesbeckia Orientalis Extract, Whey Protein, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Glucosamine, Caffeine, Palmitoyl Tripeptide-1, Glycine Soja Seed Extract, Cetearyl Glucoside, Tocopheryl Acetate, Isohexadecane, Petrolatum, Caprylyl Glycol, Glycereth-26, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Glyceryl Polymethacrylate, PEG-8, Polysorbate 20, Hexylene Glycol, Polysorbate 80, Carbomer, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Sorbitan Oleate, Cetyl Alcohol, Sodium Citrate, Disodium EDTA, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate
Water
Skin ConditioningNiacinamide
Smoothing
Gluconolactone
Skin Conditioning
Butylene Glycol
Humectant
PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin
HumectantAlcohol Denat.
Antimicrobial
Pentylene Glycol
Skin Conditioning
Methyl Gluceth-20
Humectant
Glycerin
Humectant
Potassium Hydroxide
BufferingHydroxyethylcellulose
Emulsion StabilisingSalicylic Acid
Masking
Chlorphenesin
Antimicrobial
Phytic Acid
Adenosine
Skin Conditioning
Sodium Benzoate
Masking
Laminaria Digitata Extract
Skin Protecting
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Skin Conditioning
Acetyl Hexapeptide-8
Humectant
Water, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolThis small molecule peptide has similar benefits to Argireline, the "botox" peptide.
According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.
While this seems promising, research is lacking in proving this ingredient to be as effective as botox.
Learn more about Dipeptide Diaminobutyroyl Benzylamide DiacetateGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water
