Versus

Dermaquest Advanced Dermaclear Serum Versus Naturium Quadruple Hyaluronic Acid Serum 5%

Serum
Serum
American Brand United States
American Brand United States

Updated on May 01, 2025

Overview

What they are

These products are both reef safe serums. They have a total of 11 ingredients in common

Cool Features

They both contain hyaluronic acid and Vitamin E

Suited For

They're both likely to be good for anti aging, dry skin, brightening skin, reducing pores, scar healing and better texture

Free From

They both do not contain any parabens or sulfates

What's Inside

They both contain oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside (and what isn't)

What's inside (and what isn't)

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Ingredients Side-by-side

found in both products
Advanced Dermaclear Serum

Water

Skin Conditioning

Sd Alcohol 40-B

Astringent
Alcohol IconCan worsen Dry Skin Icon

Caprylic/Capric Triglyceride

Masking
Helps hydrate Dry Skin Icon

Glycolic Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Azelaic Acid

Buffering
Good for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Skin Texture IconGood for Minimizing Pores IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne Icon

Hexyl Laurate

Emollient
Not safe for Fungal Acne Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Cetearyl Olivate

Not safe for Fungal Acne Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Sorbitol

Humectant
0 / 0 Helps hydrate Dry Skin Icon

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Lactic Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Sorbitan Olivate

Emulsifying
Not safe for Fungal Acne Icon

PPG-12/Smdi Copolymer

Emollient

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Cetyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

Dicetyl Phosphate

Emulsifying

Ceteth-10 Phosphate

Cleansing

Stearic Acid

Cleansing
2-3 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon

PEG-100 Stearate

0 / 0 Not safe for Fungal Acne Icon

Sea Water

Humectant

Aminosuberic Acid

Emollient

Sebacic Acid

Buffering

Undecanoic Acid

Antiseborrhoeic
Not safe for Fungal Acne Icon

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant Icon

Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer

Isopentyldiol

Humectant
Helps hydrate Dry Skin Icon

Laminaria Digitata Extract

Skin Protecting
Helps hydrate Dry Skin IconHelps reduce irritation Icon

Chlorella Vulgaris Extract

Skin Conditioning
Helps hydrate Dry Skin Icon

Saccharide Isomerate

Humectant
Helps hydrate Dry Skin Icon

Trifolium Pratense Flower Extract

Astringent
Good for Minimizing Pores Icon

Backhousia Citriodora Leaf Extract

Astringent

Butyrospermum Parkii Nut Extract

Emollient
Helps hydrate Dry Skin Icon

Mangifera Indica Seed Butter

Skin Conditioning
Not safe for Fungal Acne Icon

Retinyl Linoleate

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconNot safe for Fungal Acne Icon

Dimethicone

Emollient
1 / 0 Silicon Icon

Ethyl Linoleate

Emollient
Fragrance IconNot safe for Fungal Acne Icon

Hexylresorcinol

Antimicrobial
Good for Dark Spots Icon

Yeast Polysaccharides

Skin Conditioning

Propylene Glycol

Humectant
0 / 0 Helps hydrate Dry Skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Hedera Helix Leaf Extract

Skin Conditioning

Cucumis Sativus Fruit Extract

Emollient
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Sambucus Nigra Flower Extract

Refreshing

Arnica Montana Flower Extract

Masking
Fragrance Icon

Parietaria Officinalis Extract

Emollient

Phenoxyethanol

Preservative
Preservative Icon

Caprylyl Glycol

Emollient

Ethylhexylglycerin

Skin Conditioning

Hexylene Glycol

Emulsifying
0-2 / 0-1

Melaleuca Alternifolia Leaf Oil

Antioxidant
Antioxidant IconFragrance IconOil IconHelps hydrate Dry Skin IconGood for Oily Skin IconMay worsen Eczema Icon

Imperata Cylindrica Root Extract

Skin Conditioning

Carbomer

Emulsion Stabilising
1 / 0

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Emulsion Stabilising

Malva Sylvestris Flower/Leaf/Stem Extract

Skin Conditioning

Mentha Piperita Leaf Extract

Skin Conditioning

Primula Veris Flower Extract

Skin Conditioning

Alchemilla Vulgaris Flower/Leaf/Stem Extract

Astringent

Veronica Officinalis Flower/Leaf/Stem Extract

Astringent

Melissa Officinalis Leaf Extract

Skin Conditioning

Achillea Millefolium Flower/Leaf/Stem Extract

Skin Conditioning

Hydrolyzed Vegetable Protein

Skin Conditioning

Salix Alba Bark Extract

Astringent
Good for Oily Skin IconHelps reduce irritation Icon

Arctostaphylos Uva Ursi Leaf Extract

Skin Conditioning
Good for Dark Spots Icon

Mitracarpus Scaber Extract

Skin Conditioning

PEG-60 Almond Glycerides

Emulsifying
Not safe for Fungal Acne Icon

Nordihydroguaiaretic Acid

Antioxidant
Antioxidant Icon

Oleanolic Acid

Skin Conditioning

Glycine

Buffering
Helps hydrate Dry Skin Icon

Hydrolyzed Wheat Protein

Skin Conditioning

Hydrolyzed Wheat Starch

Skin Conditioning

Maltodextrin

Absorbent
Helps hydrate Dry Skin Icon

Syringa Vulgaris Leaf Cell Culture Extract

Skin Conditioning

Xanthan Gum

Emulsifying

Magnesium Aluminum Silicate

Absorbent
0 / 0

Ammonium Hydroxide

Buffering

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Disodium EDTA

Sodium Hydroxide

Buffering

Alcohol

Antimicrobial
Alcohol IconCan worsen Dry Skin IconMay worsen Oily Skin IconMay cause irritation IconMay worsen Eczema IconMay worsen Rosacea Icon

Potassium Sorbate

Preservative
Preservative Icon

Sodium Metabisulfite

Antioxidant
Antioxidant IconPreservative Icon

Limonene

Perfuming
Fragrance IconMay cause irritation IconEU Allergen IconMay worsen Eczema IconMay worsen Rosacea Icon

Salicylic Acid

Masking
BHA IconPreservative IconGood for Oily Skin IconGood for Minimizing Pores IconHelps fight Acne IconHelps brighten skin IconCan worsen Dry Skin IconMay worsen Eczema IconMay worsen Rosacea Icon

Water, Sd Alcohol 40-B, Caprylic/Capric Triglyceride, Glycolic Acid, Glycerin, Azelaic Acid, Hexyl Laurate, Glyceryl Stearate, Cetearyl Olivate, Cetearyl Alcohol, Butylene Glycol, Sorbitol, Squalane, Lactic Acid, Sorbitan Olivate, PPG-12/Smdi Copolymer, Niacinamide, Cetyl Alcohol, Sodium Hyaluronate, Dicetyl Phosphate, Ceteth-10 Phosphate, Stearic Acid, PEG-100 Stearate, Sea Water, Aminosuberic Acid, Sebacic Acid, Undecanoic Acid, Tocopheryl Acetate, Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer, Isopentyldiol, Laminaria Digitata Extract, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifolium Pratense Flower Extract, Backhousia Citriodora Leaf Extract, Butyrospermum Parkii Nut Extract, Mangifera Indica Seed Butter, Retinyl Linoleate, Dimethicone, Ethyl Linoleate, Hexylresorcinol, Yeast Polysaccharides, Propylene Glycol, Hedera Helix Leaf Extract, Cucumis Sativus Fruit Extract, Sambucus Nigra Flower Extract, Arnica Montana Flower Extract, Parietaria Officinalis Extract, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Melaleuca Alternifolia Leaf Oil, Imperata Cylindrica Root Extract, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Malva Sylvestris Flower/Leaf/Stem Extract, Mentha Piperita Leaf Extract, Primula Veris Flower Extract, Alchemilla Vulgaris Flower/Leaf/Stem Extract, Veronica Officinalis Flower/Leaf/Stem Extract, Melissa Officinalis Leaf Extract, Achillea Millefolium Flower/Leaf/Stem Extract, Hydrolyzed Vegetable Protein, Salix Alba Bark Extract, Arctostaphylos Uva Ursi Leaf Extract, Mitracarpus Scaber Extract, PEG-60 Almond Glycerides, Nordihydroguaiaretic Acid, Oleanolic Acid, Glycine, Hydrolyzed Wheat Protein, Hydrolyzed Wheat Starch, Maltodextrin, Syringa Vulgaris Leaf Cell Culture Extract, Xanthan Gum, Magnesium Aluminum Silicate, Ammonium Hydroxide, Tocopherol, Disodium EDTA, Sodium Hydroxide, Alcohol, Potassium Sorbate, Sodium Metabisulfite, Limonene, Salicylic Acid

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Antioxidant, Skin Conditioning

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

Learn more about Tocopheryl Acetate
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol
Emulsifying, Skin Conditioning, Solvent

Hexylene Glycol is a surfactant. Glycols are a class of alcohols. Hexylene Glycol is a surfactant and emulsifier.

As a surfactant, Hexylene Glycol helps gather dirt and oil on your skin to be washed away.

As an emulsifier, Hexylene Glycol helps keep water and oil together. This prevents them from separating in a product. Hexylene Glycol also thins out the texture of a product by lessening viscosity.

Hexylene Glycol has a small molecular weight.

Learn more about Hexylene Glycol

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken and improve the texture of products. Due to its properties, it can prevent water and oil ingredients from separating.

Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Learn more about Sodium Hydroxide
Preservative

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Learn more about Potassium Sorbate

When to use

1 Routine
0% use in am
100% use in pm
100% use every day
108 Routines
44% use in am
56% use in pm
94% use every day
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