Advanced Clinicals Peptide Facial Serum Versus MEDI-PEEL Peptide 9 Volume All In One Essence
Updated on January 14, 2025
Overview
What they are
These products are both cruelty-free and reef safe . They have a total of 12 ingredients in common
Cool Features
They both contain hyaluronic acid and peptides
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, reducing pores and scar healing
Free From
They both do not contain any harsh alcohols, common allergens, parabens or sulfates
What's Inside
They both contain fragrances and silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Advanced Clinicals Peptide Facial Serum 29 ingredients
MEDI-PEEL Peptide 9 Volume All In One Essence 84 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Advanced Clinicals Peptide Facial Serum 29 ingredients
MEDI-PEEL Peptide 9 Volume All In One Essence 84 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Glycerin
Humectant
Pyrus Malus Fruit Extract
Skin Conditioning
PEG-12 Dimethicone
Skin Conditioning
Soluble Collagen
Humectant
Sodium Hyaluronate
Humectant
Tocopheryl Acetate
Antioxidant
Aloe Barbadensis Leaf Juice Powder
Skin Conditioning
Rosa Damascena Flower Extract
MaskingChenopodium Quinoa Seed Extract
Skin ConditioningButylene Glycol
Humectant
Xanthan Gum
EmulsifyingCamellia Sinensis Leaf Extract
Antimicrobial
Centella Asiatica Extract
Cleansing
Palmitoyl Tripeptide-37
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
1,2-Hexanediol
Skin Conditioning
Carbomer
Emulsion StabilisingPhenoxyethanol
Preservative
Caprylyl Glycol
EmollientParfum
Masking
Hexylene Glycol
EmulsifyingEthylhexylglycerin
Skin ConditioningTetrasodium Glutamate Diacetate
Citric Acid
Buffering
Sodium Benzoate
Masking
Polysorbate 20
Emulsifying
Sodium Lactate
BufferingSodium Citrate
BufferingGlycerin, Pyrus Malus Fruit Extract, PEG-12 Dimethicone, Soluble Collagen, Sodium Hyaluronate, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice Powder, Rosa Damascena Flower Extract, Chenopodium Quinoa Seed Extract, Butylene Glycol, Xanthan Gum, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Palmitoyl Tripeptide-37, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, 1,2-Hexanediol, Carbomer, Phenoxyethanol, Caprylyl Glycol, Parfum, Hexylene Glycol, Ethylhexylglycerin, Tetrasodium Glutamate Diacetate, Citric Acid, Sodium Benzoate, Polysorbate 20, Sodium Lactate, Sodium Citrate
Water
Skin ConditioningMethylpropanediol
SolventGlycerin
Humectant
Hydrogenated Polyisobutene
EmollientMethyl Perfluoroisobutyl Ether
SolventCaprylic/Capric Triglyceride
Masking
Methyl Perfluorobutyl Ether
SolventCyclopentasiloxane
Emollient
Niacinamide
Smoothing
Butylene Glycol Dicaprylate/Dicaprate
EmollientCetearyl Alcohol
Emollient
Cyclohexasiloxane
Emollient
Elaeis Guineensis Oil
Emollient
Decyl Glucoside
CleansingSodium Myristoyl Glutamate
CleansingStearic Acid
Cleansing
Glyceryl Stearate
Emollient
PEG-100 Stearate
Betaine
Humectant
Hydroxyethyl Urea
Humectant
Elaeis Guineensis Kernel Oil
Emollient
Hydroxyacetophenone
Antioxidant
Dimethicone
Emollient
Arginine
Masking
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Carbomer
Emulsion StabilisingHydrogenated Lecithin
Emulsifying
Propanediol
Solvent
Juniperus Communis Fruit Extract
Perfuming
Eucalyptus Globulus Leaf Extract
Perfuming
Dimethicone/Vinyl Dimethicone Crosspolymer
Skin Conditioning
Glyceryl Acrylate/Acrylic Acid Copolymer
HumectantSodium Hyaluronate Crosspolymer
Humectant
Ethylhexylglycerin
Skin ConditioningAllantoin
Skin Conditioning
Ammonium Lactate
BufferingUrea
Buffering
Parfum
Masking
Adenosine
Skin Conditioning
Sodium Hyaluronate
Humectant
Laureth-23
CleansingPropylene Glycol
Humectant
Disodium EDTA
Hydrolyzed Glycosaminoglycans
HumectantButylene Glycol
Humectant
Camellia Sinensis Leaf Extract
Antimicrobial
Taraxacum Officinale Rhizome/Root Extract
Skin ConditioningSodium Guaiazulene Sulfonate
Argania Spinosa Kernel Oil
Emollient
Magnolia Officinalis Bark Extract
AntimicrobialAnthemis Nobilis Flower Water
Masking
Fructan
Skin ConditioningBenzyl Glycol
SolventHydrolyzed Hyaluronic Acid
Humectant
Desamido Collagen
Skin Conditioning
Hydrolyzed Elastin
EmollientHydrolyzed Collagen
Emollient
Decylene Glycol
Skin ConditioningSodium Polyacrylate
Absorbent
Caprylyl Glycol
EmollientTrideceth-6
EmulsifyingPentylene Glycol
Skin ConditioningHydrogenated Polydecene
EmollientGlyceryl Polymethacrylate
Anemarrhena Asphodeloides Root Extract
Skin Conditioning
1,2-Hexanediol
Skin Conditioning
Raspberry Ketone
Masking
Hyaluronic Acid
Humectant
Sorbitan Laurate
Emulsifying
Nonoxynol-9
EmulsifyingPhenoxyethanol
Preservative
Hydroxyethylcellulose
Emulsion StabilisingAcetyl Dipeptide-1 Cetyl Ester
Skin Conditioning
Astaxanthin
Skin Conditioning
Ethyl Hexanediol
SolventAcetyl Hexapeptide-8
Humectant
Copper Tripeptide-1
Skin Conditioning
Oligopeptide-29
Antioxidant
Oligopeptide-32
Antiseborrhoeic
Palmitoyl Pentapeptide-4
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Palmitoyl Tripeptide-5
Skin Conditioning
Palmitoyl Oligopeptide
Cleansing
Water, Methylpropanediol, Glycerin, Hydrogenated Polyisobutene, Methyl Perfluoroisobutyl Ether, Caprylic/Capric Triglyceride, Methyl Perfluorobutyl Ether, Cyclopentasiloxane, Niacinamide, Butylene Glycol Dicaprylate/Dicaprate, Cetearyl Alcohol, Cyclohexasiloxane, Elaeis Guineensis Oil, Decyl Glucoside, Sodium Myristoyl Glutamate, Stearic Acid, Glyceryl Stearate, PEG-100 Stearate, Betaine, Hydroxyethyl Urea, Elaeis Guineensis Kernel Oil, Hydroxyacetophenone, Dimethicone, Arginine, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Carbomer, Hydrogenated Lecithin, Propanediol, Juniperus Communis Fruit Extract, Eucalyptus Globulus Leaf Extract, Dimethicone/Vinyl Dimethicone Crosspolymer, Glyceryl Acrylate/Acrylic Acid Copolymer, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Allantoin, Ammonium Lactate, Urea, Parfum, Adenosine, Sodium Hyaluronate, Laureth-23, Propylene Glycol, Disodium EDTA, Hydrolyzed Glycosaminoglycans, Butylene Glycol, Camellia Sinensis Leaf Extract, Taraxacum Officinale Rhizome/Root Extract, Sodium Guaiazulene Sulfonate, Argania Spinosa Kernel Oil, Magnolia Officinalis Bark Extract, Anthemis Nobilis Flower Water, Fructan, Benzyl Glycol, Hydrolyzed Hyaluronic Acid, Desamido Collagen, Hydrolyzed Elastin, Hydrolyzed Collagen, Decylene Glycol, Sodium Polyacrylate, Caprylyl Glycol, Trideceth-6, Pentylene Glycol, Hydrogenated Polydecene, Glyceryl Polymethacrylate, Anemarrhena Asphodeloides Root Extract, 1,2-Hexanediol, Raspberry Ketone, Hyaluronic Acid, Sorbitan Laurate, Nonoxynol-9, Phenoxyethanol, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Ethyl Hexanediol, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Palmitoyl Oligopeptide
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCamellia Sinensis Leaf Extract is derived from the leaves of the tea plant. Black tea, green tea, and oolong tea are all harvested from this plant.
This ingredient has many skin benefits:
This ingredient contains polyphenols, a strong antioxidant. Antioxidants help fight off molecules that damage skin cells.
On top of that, the antioxidants in green tea neutralize free-radicals from the sun. This gives the skin some extra UV protection, but should not replace sunscreen.
Many components of tea have anti-inflammatory properties.
Polyphenols and L-theanine help soothe the skin and reduce irritation. The caffeine in Camellia Sinensis Leaf Extract helps calm inflamed blood vessels.
Other compounds found in tea include: Vitamin Bs, linoleic acid, magnesium, calcium, iron, and zinc.
Research has shown both drinking Camellia Sinensis Leaf Tea and applying it to the skin can help boost skin elasticity and hydration. Studies also show using tea extract may reduce sebum, or oil, production.
Learn more about Camellia Sinensis Leaf ExtractCaprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolCarbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPalmitoyl Tetrapeptide-7 is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).
This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.
Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.
Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.
Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).
Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Palmitoyl Tripeptide-1 is also known as pal-GHK. It is made up of 3 amino acids and palmitic acid, a fatty acid that helps it absorb into skin more easily.
This peptide is as a signal peptide, meaning it tells the skin to produce more collagen. Collagen is the key protein that helps form the skin's structure and keep it plump, firm, and hydrated.
By boosting collagen production, this ingredient supports a stronger skin barrier and helps reduce the appearance of wrinkles.
You'll most likely see this ingredient paired with Palmitoyl Tetrapeptide-7 in the well-known Matrixyl 3000 complex. While results from in-house testing should be viewed cautiously, this peptide duo is among the most studied and widely used in modern skincare.
Due to its palmitic acid base, this ingredient may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tripeptide-1Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateIngredient Ratings
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When to use
Advanced Clinicals Peptide Facial Serum 29 ingredients
MEDI-PEEL Peptide 9 Volume All In One Essence 84 ingredients
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