Versus

Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment Versus Isntree Hyper Retinol EX 1.0 Serum

Facial Treatment
Serum
American Brand United States
Korean Brand South Korea

Updated on December 10, 2024

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 11 ingredients in common

Cool Features

They both contain ceramides, peptides, retinoid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside (and what isn't)

What's inside (and what isn't)

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Clinical 0.3% Retinol + 2% Bakuchiol Treatment

Water

Skin Conditioning

Dimethicone

Emollient
1 / 0 Silicon Icon

Pentaerythrityl Tetraisostearate

Emollient
2 / 0 Not safe for Fungal Acne Icon

Isononyl Isononanoate

Emollient

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Bakuchiol

Antimicrobial
Antioxidant IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging IconGood for Dark Spots IconHelps brighten skin Icon

Arachidyl Alcohol

Emollient

Glyceryl Polymethacrylate

Dimethicone Crosspolymer

Emulsion Stabilising

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

PEG-75 Shea Butter Glycerides

Emulsifying
Not safe for Fungal Acne Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

C12-15 Alkyl Benzoate

Antimicrobial

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Tetrahexyldecyl Ascorbate

Antioxidant
Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores IconHelps brighten skin Icon

Retinol

Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconMay worsen Rosacea Icon

Ceramide Ng

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Palmitoyl Tetrapeptide-7

Skin Conditioning
Peptide IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Palmitoyl Hexapeptide-12

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps hydrate Dry Skin Icon

Dipotassium Glycyrrhizate

Humectant
Helps reduce Skin Redness IconHelps reduce irritation IconGood for Dark Spots Icon

Glycyrrhiza Glabra Root Extract

Bleaching
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Dark Spots Icon

Avena Sativa Kernel Extract

Abrasive
Exfoliant IconAntioxidant IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Arctium Lappa Root Extract

Skin Conditioning
Helps reduce irritation Icon

Salix Alba Bark Extract

Astringent
Good for Oily Skin IconHelps reduce irritation Icon

Glycine Soja Sterols

Emollient
0 / 0 Helps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Lecithin

Emollient
Helps hydrate Dry Skin Icon

Allantoin

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Tocopheryl Acetate

Antioxidant
0 / 0 Vitamin E IconAntioxidant Icon

Hydrolyzed Soy Protein

Humectant
Helps hydrate Dry Skin Icon

Palmitoyl Tripeptide-1

Skin Conditioning
Peptide IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Sodium Hydroxide

Buffering

Tribehenin

Emollient
0 / 0 Not safe for Fungal Acne Icon

Caprylyl Glycol

Emollient

Dipeptide-2

Skin Conditioning
Peptide IconHelps with Anti-Aging Icon

Polygonum Cuspidatum Root Extract

Antioxidant
Antioxidant Icon

PEG-10 Phytosterol

Emulsifying

PEG-8

Humectant

Magnesium Aluminum Silicate

Absorbent
0 / 0

Arachidyl Glucoside

Emulsifying

Chrysin

Skin Conditioning

Pentylene Glycol

Skin Conditioning

Sodium Acrylates Copolymer

Steareth-20

Cleansing
2 / 1

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Coco-Glucoside

Cleansing

Hesperidin Methyl Chalcone

Antioxidant
Antioxidant IconSilicon Icon

N-Hydroxysuccinimide

Skin Conditioning

Disodium EDTA

Phenoxyethanol

Preservative
Preservative Icon

Benzoic Acid

Masking
Preservative IconMay worsen Eczema Icon

Ethylhexylglycerin

Skin Conditioning
Hyper Retinol EX 1.0 Serum

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Antimicrobial, Antioxidant, Emollient

Bakuchiol is a plant-derived antioxidant (it's vegan!). It is often called the replacement for retinol although it is not part of the same family.

It has similar effects as retinol: skin smoothing, reducing discoloration, and preventing wrinkles. It does not cause as much irritation as traditional retinoids.

Bakuchiol works by breaking down free radicals and stimulating collagen production in skin.

Combining bakuchiol with retinol will not have adverse side effects. Studies show using them will just boost the benefits. Bakuchiol is also found to help stabilize retinol.

While bakuchiol does not make the skin more sun sensitive, we recommend wearing SPF on a daily basis.

Read more about traditional retinol

Learn more about Bakuchiol
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emulsifying

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20
Skin Conditioning

Retinol is a gold-standard ingredient for anti-aging. It is a form of Vitamin A and belongs to the class of retinoids that also includes tretinoin.

Why is retinol famous?

It has the most scientific studies backing up its skin benefits out of all the non-prescription ingredients.

Retinol is proven to:

This is why retinol is effective at removing wrinkles, fading dark spots, treating acne, and reducing the appearance of pores.

Studies show retinol is less effective when exposed to UV. Be sure to look for appropriate packaging to keep your retinol potent (similar to Vitamin C).

Using retinol or any retinoids will increase sun-sensitivity in the first few months. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.

We recommend speaking with a medical professional about using this ingredient during pregnancy.

Retinol may cause irritation in some people, so be sure to patch test. Experts recommend 'ramping up' retinol use: start using this ingredient once a week and work up to using it daily.

Read about Tretinoin

Learn more about Retinol
Skin Conditioning

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7
Skin Conditioning, Skin Protecting, Soothing

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

Some studies have shown this ingredient can promote wound healing with higher concentrations.

Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.

Learn more about Allantoin
Skin Conditioning

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

This ingredient is a signal peptide, meaning it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1
Emollient, Emulsifying, Emulsion Stabilising

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.

Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne.

Due to the fatty acid base, this ingredient may not be Malassezia folliculitis safe.

Learn more about Cetearyl Alcohol

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA

When to use

131 Routines
5% use in am
95% use in pm
60% use every day
When to use See routines that use it ->
156 Routines
6% use in am
94% use in pm
54% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment 54 ingredients

3.7 /5
from 3 ratings
Doesn't Work (1)
alexandria111's avatar

Alexandra

2 months ago
Review

Did absolutely nothing and it was $60😭😭

#doesn't work

Isntree Hyper Retinol EX 1.0 Serum 42 ingredients

4.0 /5
from 2 ratings
Absorbs Well (1) Expensive (1) Hydrating (1)
sjordan74's avatar

Shane Jordan

7 months ago
Review

6 Month Update: I liked the feel of this product on my skin. I don’t reach for it as much because I feel like Taz has taken over in the ACTIVES category. It definitely gets a thumbs up from me and I did use the entire bottle.

While I really like this serum, the size is a major turn-off, and here’s why.

At almost 20.00 USD for just over half an ounce, it feels like a cheapskate move not Show more

#expensive
#hydrating
#light
#absorbs well
ChienYun_CY's avatar

Chien Yun Ang

5 days ago
Review

My skin liked it in the beginning. But after a few uses, my acne always worsened a little after applying this. It doesn't sting or burn. It just further irritated my skin

#broke me out
#absorbs well
#light scent