MediCube Retinol-Some 1.9% NMN Boosting Serum Versus Round Lab Camellia Deep Collagen Firming Ampoule
This anti-aging serum is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture.
This anti-aging ampoule is formulated around Hydroxypinacolone Retinoate to soften the look of wrinkles.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycereth-26
HumectantNiacinamide
SmoothingGlycerin
HumectantCaprylic/Capric Triglyceride
MaskingMacadamia Ternifolia Seed Oil
EmollientButylene Glycol
HumectantHydrogenated Lecithin
EmulsifyingRetinol
Skin ConditioningBrassica Campestris Sterols
Emollient1,2-Hexanediol
Skin ConditioningCholesterol
EmollientPolyglyceryl-10 Laurate
Skin ConditioningPhytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Skin ConditioningAluminum/Magnesium Hydroxide Stearate
Emulsion StabilisingPentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
AntioxidantPotassium Cetyl Phosphate
EmulsifyingTris(Tetramethylhydroxypiperidinol)Citrate
StabilisingGlyceryl Citrate/Lactate/Linoleate/Oleate
EmulsifyingElaeis Guineensis Oil
EmollientCetyl Ethylhexanoate
EmollientHydroxyacetophenone
AntioxidantAmmonium Acryloyldimethyltaurate/Vp Copolymer
Polyacrylate Crosspolymer-6
Emulsion StabilisingAluminum Starch Octenylsuccinate
AbsorbentRetinal
Skin ConditioningSqualane
EmollientPolyquaternium-51
Skin ConditioningTocopherol
AntioxidantPanthenol
Skin ConditioningAllantoin
Skin ConditioningAdenosine
Skin ConditioningDisodium EDTA
ChelatingBifida Ferment Lysate
Skin ConditioningLactobacillus Ferment Lysate
Skin ConditioningLactococcus Ferment Lysate
Skin ConditioningDipropylene Glycol
HumectantCentella Asiatica Leaf Extract
Skin ConditioningAsiaticoside
AntioxidantAsiatic Acid
Skin ConditioningMadecassic Acid
Skin ConditioningBeta-Glucan
Skin ConditioningCeramide NP
Skin ConditioningPropanediol
SolventEriobotrya Japonica Leaf Extract
Skin ConditioningMentha Viridis Extract
MaskingSodium Hyaluronate Crosspolymer
HumectantPentylene Glycol
Skin ConditioningEthylhexylglycerin
Skin ConditioningNicotinamide Mononucleotide
AntioxidantAkebia Quinata Extract
Skin ConditioningCaprylyl/Capryl Glucoside
CleansingCamellia Japonica Flower Extract
EmollientPolyglyceryl-10 Oleate
Skin ConditioningAcetyl Hexapeptide-8
HumectantAcetyl Tetrapeptide-5
HumectantCarnosine
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningPalmitoyl Tripeptide-5
Skin ConditioningYeast Beta-Glucan
Skin ConditioningFerulic Acid
Antimicrobial3-O-Ethyl Ascorbic Acid
Skin ConditioningAscorbic Acid
AntioxidantWater, Glycereth-26, Niacinamide, Glycerin, Caprylic/Capric Triglyceride, Macadamia Ternifolia Seed Oil, Butylene Glycol, Hydrogenated Lecithin, Retinol, Brassica Campestris Sterols, 1,2-Hexanediol, Cholesterol, Polyglyceryl-10 Laurate, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Aluminum/Magnesium Hydroxide Stearate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Potassium Cetyl Phosphate, Tris(Tetramethylhydroxypiperidinol)Citrate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Elaeis Guineensis Oil, Cetyl Ethylhexanoate, Hydroxyacetophenone, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Polyacrylate Crosspolymer-6, Aluminum Starch Octenylsuccinate, Retinal, Squalane, Polyquaternium-51, Tocopherol, Panthenol, Allantoin, Adenosine, Disodium EDTA, Bifida Ferment Lysate, Lactobacillus Ferment Lysate, Lactococcus Ferment Lysate, Dipropylene Glycol, Centella Asiatica Leaf Extract, Asiaticoside, Asiatic Acid, Madecassic Acid, Beta-Glucan, Ceramide NP, Propanediol, Eriobotrya Japonica Leaf Extract, Mentha Viridis Extract, Sodium Hyaluronate Crosspolymer, Pentylene Glycol, Ethylhexylglycerin, Nicotinamide Mononucleotide, Akebia Quinata Extract, Caprylyl/Capryl Glucoside, Camellia Japonica Flower Extract, Polyglyceryl-10 Oleate, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-5, Carnosine, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Yeast Beta-Glucan, Ferulic Acid, 3-O-Ethyl Ascorbic Acid, Ascorbic Acid
Water
Skin ConditioningGlycerin
HumectantButylene Glycol
HumectantSqualane
Emollient1,2-Hexanediol
Skin ConditioningBetaine
HumectantNiacinamide
SmoothingDipentaerythrityl Hexa C5-9 Acid Esters
Skin ConditioningCamellia Japonica Flower Extract
EmollientSimmondsia Chinensis Seed Oil
EmollientPanthenol
Skin ConditioningChondrus Crispus Extract
Skin ConditioningHydrogenated Lecithin
EmulsifyingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingChlorella Vulgaris Extract
Skin ConditioningGlucose
HumectantMethylpropanediol
SolventSaccharum Officinarum Extract
MoisturisingTromethamine
BufferingHydrolyzed Collagen
EmollientFructooligosaccharides
HumectantFructose
HumectantInositol
HumectantTheobroma Cacao Extract
Skin ConditioningBeta-Glucan
Skin ConditioningCeramide NP
Skin ConditioningAdenosine
Skin ConditioningHydroxypinacolone Retinoate
Skin ConditioningCyanocobalamin
Skin ConditioningQuercetin
AntioxidantSoluble Collagen
HumectantArginine
MaskingTocopherol
AntioxidantPolyacrylate Crosspolymer-6
Emulsion StabilisingXanthan Gum
EmulsifyingSodium Dilauramidoglutamide Lysine
HumectantEthylhexylglycerin
Skin ConditioningCaprylic/Capric Triglyceride
MaskingDiethylhexyl Syringylidenemalonate
Skin ProtectingSodium Phytate
ChelatingDimethyl Isosorbide
SolventDextrin
AbsorbentWater, Glycerin, Butylene Glycol, Squalane, 1,2-Hexanediol, Betaine, Niacinamide, Dipentaerythrityl Hexa C5-9 Acid Esters, Camellia Japonica Flower Extract, Simmondsia Chinensis Seed Oil, Panthenol, Chondrus Crispus Extract, Hydrogenated Lecithin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Chlorella Vulgaris Extract, Glucose, Methylpropanediol, Saccharum Officinarum Extract, Tromethamine, Hydrolyzed Collagen, Fructooligosaccharides, Fructose, Inositol, Theobroma Cacao Extract, Beta-Glucan, Ceramide NP, Adenosine, Hydroxypinacolone Retinoate, Cyanocobalamin, Quercetin, Soluble Collagen, Arginine, Tocopherol, Polyacrylate Crosspolymer-6, Xanthan Gum, Sodium Dilauramidoglutamide Lysine, Ethylhexylglycerin, Caprylic/Capric Triglyceride, Diethylhexyl Syringylidenemalonate, Sodium Phytate, Dimethyl Isosorbide, Dextrin
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineBeta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.
It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.
On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin
The more interesting story is underneath:
Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.
A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.
It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.
This ingredient gets along with pretty much everything and is typically used around 0.1-1%.
Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.
Learn more about Beta-GlucanButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCamellia Japonica Flower Extract comes from the Japanese Camellia plant (a cousin of the green tea plant). This plant is native to East Asia and known as "Tsubaki" in Japanese.
It's a flower extract packed with flavonoids and phenolic acids that give it most of its skincare value. In lab tests on human skin cells, the ethanol extract of the flower mopped up free radicals and boosted the skin's own antioxidant enzymes.
A separate study found the flower extract had solid antioxidant activity and reduced the reactive oxygen species that urban air pollution triggers in skin cells.
Newer work also points at anti-aging and calming effects:
One 2025 paper tied the extract and its component hyperoside to collagen III and elastin production plus better skin-barrier protein expression. A mouse study on eczema-like skin found four weeks of topical camellia extract reduced inflammation and itch-related markers.
Just know that most of these studies are cell-culture and animal work and not human trials. For now, it's best to treat it as a nice supporting antioxidant rather than a headline active.
At this time, there's no published regulatory use-level for this specific ingredient; suppliers usually sell it as a water/glycerin-based extract used in the low single-digit percent range.
There's no published contact-allergy case reports for this ingredient but as with any botanical, a patch test is sensible if you react to plant extracts generally.
Learn more about Camellia Japonica Flower ExtractCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideCeramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Learn more about Ceramide NPEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolPolyacrylate Crosspolymer-6 is a texture enhancer and pH adjuster.
It is be used to thicken water-based products and create a gel-texture with a velvet feel.
One manufacturer claims this ingredient to have a pH range of 2-8 and to be biodegradable.
This ingredient is also known as Sepimax Zen.
Learn more about Polyacrylate Crosspolymer-6Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Learn more about SqualaneTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water