MediCube PDRN Pink Hyaluronic Moisturizing Cream Versus Peter Thomas Roth Peptide Skinjection Amplified Wrinkle-Fix Serum
This anti-aging moisturizer is formulated around Sodium DNA and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Pentapeptide-18 to soften the look of wrinkles.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningDisodium EDTA
Betaine
HumectantNiacinamide
SmoothingAdenosine
Skin ConditioningCitric Acid
BufferingPanthenol
Skin ConditioningGlycereth-26
HumectantGlycerin
HumectantGlyceryl Acrylate/Acrylic Acid Copolymer
HumectantButylene Glycol
HumectantHydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingSorbitan Isostearate
EmulsifyingCetearyl Olivate
Sorbitan Olivate
EmulsifyingCaprylic/Capric Triglyceride
MaskingLimnanthes Alba Seed Oil
Skin ConditioningHydrogenated Polydecene
EmollientIsononyl Isononanoate
EmollientHydrogenated Lecithin
EmulsifyingCetearyl Alcohol
EmollientStearic Acid
CleansingCeramide EOP
Skin ConditioningCeramide Ns
Skin ConditioningCeramide NP
Skin ConditioningCeramide As
Skin ConditioningCeramide AP
Skin ConditioningPhytosphingosine
Skin ConditioningCholesterol
EmollientCyclopentasiloxane
EmollientSodium DNA
Skin ConditioningEthylhexyl Olivate
Skin ConditioningSodium Acrylates Copolymer
Polyglyceryl-4 Oleate
Emulsifying1,2-Hexanediol
Skin ConditioningCopper Tripeptide-1
Skin ConditioningAcetyl Hexapeptide-8
HumectantPalmitoyl Pentapeptide-4
Skin ConditioningPalmitoyl Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningSodium Hyaluronate
HumectantHydroxypropyltrimonium Hyaluronate
Sodium Acetylated Hyaluronate
HumectantHydrolyzed Hyaluronic Acid
HumectantHyaluronic Acid
HumectantSodium Hyaluronate Crosspolymer
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningPotassium Hyaluronate
Skin ConditioningFucus Vesiculosus Extract
EmollientPrunella Vulgaris Extract
AntioxidantMomordica Charantia Fruit Extract
Skin ConditioningHibiscus Esculentus Fruit Extract
Skin ConditioningMorinda Citrifolia Fruit Extract
Skin ConditioningCentella Asiatica Leaf Extract
Skin ConditioningEthylhexylglycerin
Skin ConditioningParfum
MaskingCyanocobalamin
Skin ConditioningSodium Polyacryloyldimethyl Taurate
Emulsion StabilisingWater, Disodium EDTA, Betaine, Niacinamide, Adenosine, Citric Acid, Panthenol, Glycereth-26, Glycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Isostearate, Cetearyl Olivate, Sorbitan Olivate, Caprylic/Capric Triglyceride, Limnanthes Alba Seed Oil, Hydrogenated Polydecene, Isononyl Isononanoate, Hydrogenated Lecithin, Cetearyl Alcohol, Stearic Acid, Ceramide EOP, Ceramide Ns, Ceramide NP, Ceramide As, Ceramide AP, Phytosphingosine, Cholesterol, Cyclopentasiloxane, Sodium DNA, Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Oleate, 1,2-Hexanediol, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Fucus Vesiculosus Extract, Prunella Vulgaris Extract, Momordica Charantia Fruit Extract, Hibiscus Esculentus Fruit Extract, Morinda Citrifolia Fruit Extract, Centella Asiatica Leaf Extract, Ethylhexylglycerin, Parfum, Cyanocobalamin, Sodium Polyacryloyldimethyl Taurate
Water
Skin ConditioningDimethicone
EmollientSqualane
EmollientButylene Glycol
HumectantGlycerin
HumectantSaccharomyces Lysate
Skin ConditioningPolysilicone-11
Acetyl Hexapeptide-8
HumectantPentapeptide-18
Skin ConditioningN-Prolyl Palmitoyl Tripeptide-56 Acetate
Skin ConditioningPalmitoyl Tripeptide-38
Skin ConditioningCollagen
MoisturisingSodium Hyaluronate
HumectantTocopherol
AntioxidantPhytosterols
Skin ConditioningHydrogenated Lecithin
EmulsifyingLeuconostoc/Radish Root Ferment Filtrate
AntimicrobialCitric Acid
BufferingCaprylic/Capric Triglyceride
MaskingPolyglyceryl-10 Myristate
Skin ConditioningPentylene Glycol
Skin ConditioningCaprylyl Glycol
EmollientSodium Benzoate
MaskingSodium Phytate
Sodium Hydroxide
BufferingPotassium Sorbate
PreservativeEthylhexyl Palmitate
EmollientHydroxypropyl Cyclodextrin
MaskingTrihydroxystearin
Skin ConditioningLauroyl Lysine
Skin ConditioningGlucomannan
Skin ConditioningEthylhexylglycerin
Skin ConditioningAmmonium Acryloyldimethyltaurate/Vp Copolymer
Carbomer
Emulsion StabilisingGlyceryl Stearate
EmollientStearyl Alcohol
EmollientBehenyl Alcohol
EmollientMica
Cosmetic ColorantPhenoxyethanol
PreservativeWater, Dimethicone, Squalane, Butylene Glycol, Glycerin, Saccharomyces Lysate, Polysilicone-11, Acetyl Hexapeptide-8, Pentapeptide-18, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Collagen, Sodium Hyaluronate, Tocopherol, Phytosterols, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Citric Acid, Caprylic/Capric Triglyceride, Polyglyceryl-10 Myristate, Pentylene Glycol, Caprylyl Glycol, Sodium Benzoate, Sodium Phytate, Sodium Hydroxide, Potassium Sorbate, Ethylhexyl Palmitate, Hydroxypropyl Cyclodextrin, Trihydroxystearin, Lauroyl Lysine, Glucomannan, Ethylhexylglycerin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Carbomer, Glyceryl Stearate, Stearyl Alcohol, Behenyl Alcohol, Mica, Phenoxyethanol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Read more about some other popular AHA's here:
Learn more about Citric AcidEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water