Proya Ruby Series Advanced Firming Nourishing Essence
A highly rated essence with 62 ingredients, including vitamin C, retinoid, and niacinamide.
This anti-aging essence is formulated around Acetyl Glucosamine and Hydroxypinacolone Retinoate to soften the look of wrinkles and refine skin texture.
Worth noting
Contains a retinoid, which is best introduced gradually.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningDimethicone
EmollientAcetyl Glucosamine
Skin ConditioningPhytosteryl/Octyldodecyl Lauroyl Glutamate
Skin ConditioningGlycerin
HumectantIsotridecyl Isononanoate
EmollientPanthenol
Skin ConditioningAmmonium Acryloyldimethyltaurate/Vp Copolymer
Dimethyl Isosorbide
Solvent1,2-Hexanediol
Skin ConditioningButylene Glycol
HumectantHydroxyacetophenone
AntioxidantCaprylic/Capric Triglyceride
MaskingHydroxypropyl Cyclodextrin
MaskingHydrogenated Lecithin
EmulsifyingHexyldecanol
EmollientPentylene Glycol
Skin ConditioningPolyglyceryl-3 Methylglucose Distearate
EmulsifyingBisabolol
AntioxidantAllantoin
Skin ConditioningNiacinamide
SmoothingSilybum Marianum Fruit Extract
Skin ConditioningCitrus Limon Fruit Extract
MaskingGlycine Soja Extract
Skin ConditioningHydroxypinacolone Retinoate
Skin ConditioningRetinol
Skin ConditioningTetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Skin ConditioningCyclopeptide-161
Palmitoyl Tripeptide-5
Skin ConditioningLinum Usitatissimum Seed Extract
PerfumingDipalmitoyl Hydroxyproline
Skin ConditioningAscorbyl Palmitate
AntioxidantMadecassoside
AntioxidantCentella Asiatica Extract
CleansingAsiaticoside
AntioxidantCeramide NP
Skin ConditioningCeramide AP
Skin ConditioningAvena Sativa Bran
AbrasiveBeta-Glucan
Skin ConditioningPhytosphingosine
Skin Conditioning4-T-Butylcyclohexanol
MaskingSuperoxide Dismutase
AntioxidantMauritia Flexuosa Fruit Oil
Skin ConditioningTocopherol
AntioxidantLecithin
EmollientHydroxypropyl Methylcellulose Stearoxy Ether
Polysorbate 80
EmulsifyingDivinyldimethicone/Dimethicone Crosspolymer
Skin ConditioningPentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
AntioxidantTrehalose
HumectantSucrose Laurate
EmollientCholesterol
EmollientPEG/PPG/Polybutylene Glycol-8/5/3 Glycerin
HumectantHydroxyphenyl Propamidobenzoic Acid
Skin ConditioningPEG-40 Hydrogenated Castor Oil
EmulsifyingCaramel
Cosmetic ColorantSorbitan Trioleate
EmulsifyingEthylhexylglycerin
Skin ConditioningXanthan Gum
EmulsifyingDisodium EDTA
Phenethyl Alcohol
MaskingParfum
MaskingWater, Dimethicone, Acetyl Glucosamine, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Glycerin, Isotridecyl Isononanoate, Panthenol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Dimethyl Isosorbide, 1,2-Hexanediol, Butylene Glycol, Hydroxyacetophenone, Caprylic/Capric Triglyceride, Hydroxypropyl Cyclodextrin, Hydrogenated Lecithin, Hexyldecanol, Pentylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Bisabolol, Allantoin, Niacinamide, Silybum Marianum Fruit Extract, Citrus Limon Fruit Extract, Glycine Soja Extract, Hydroxypinacolone Retinoate, Retinol, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Cyclopeptide-161, Palmitoyl Tripeptide-5, Linum Usitatissimum Seed Extract, Dipalmitoyl Hydroxyproline, Ascorbyl Palmitate, Madecassoside, Centella Asiatica Extract, Asiaticoside, Ceramide NP, Ceramide AP, Avena Sativa Bran, Beta-Glucan, Phytosphingosine, 4-T-Butylcyclohexanol, Superoxide Dismutase, Mauritia Flexuosa Fruit Oil, Tocopherol, Lecithin, Hydroxypropyl Methylcellulose Stearoxy Ether, Polysorbate 80, Divinyldimethicone/Dimethicone Crosspolymer, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trehalose, Sucrose Laurate, Cholesterol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Hydroxyphenyl Propamidobenzoic Acid, PEG-40 Hydrogenated Castor Oil, Caramel, Sorbitan Trioleate, Ethylhexylglycerin, Xanthan Gum, Disodium EDTA, Phenethyl Alcohol, Parfum
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeAcetyl Glucosamine is an antioxidant and humectant. It is an amino acid sugar and is naturally found in our skin.
The cool thing about this ingredient? It helps the skin produce hyaluronic acid and boost hydration. It also has antioxidant benefits to protect skin cells.
When paired with niacinamide, Acetyl Glucosamine has been shown to be effective at reducing discoloration.
Learn more about Acetyl GlucosamineWe don't have a description for Phytosteryl/Octyldodecyl Lauroyl Glutamate yet.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinWe don't have a description for Isotridecyl Isononanoate yet.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolAmmonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.
The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:
Due to its large molecular size, it sits on the surface of skin rather than penetrating it.
Learn more about Ammonium Acryloyldimethyltaurate/Vp CopolymerDimethyl Isosorbide (often shortened to DMI) is a sugar-derived solvent made from sorbitol. It's used to dissolve tricky ingredients and help them mix smoothly into a formula.
Many actives sit as gritty crystals when undissolved, so DMI swoops in to full dissolve them. This helps improve texture, stability, and how evenly an active is distributed.
It does have a penetration-enhancing reputation that is a bit more nuanced than marketing suggests; a cell study on human skin found that 10% DMI didn't significantly boost the permeation of Hydroquinone, Salicylic Acid, or Octadecenedioic Acid compared to controls (though it did improve their solubility in the formula itself).
Typical usage concentrations usually range from 1-10% depending on the formula's needs; this ingredient is also well tolerated at these levels.
Learn more about Dimethyl Isosorbide1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolHydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
Learn more about HydroxyacetophenoneCaprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideThis ingredient is used in skincare as a delivery system.
It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.
According to a manufacturer, it also offer some moisturizing effects.
Learn more about Hydroxypropyl CyclodextrinHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinHexyldecanol is a fatty alcohol that is basically the "light" version of cetyl alcohol. It is an emollient and skin conditioning agent that leaves a silky feeling on skin without tackiness.
Because it is stable across a wide pH range, it plays nicely with most actives. Typical use concentrations range from 1-10% and it can be either plant derived or synthetically created.
Overall, this is a well-tolerated ingredient and only a few cases of contact dermatitis have been reported.
The closest tested cousin of this ingredient, Octyldodecanol, did not support Malassezia growth in vitro. The Malassezia yeast responsible for fungal acne prefers straight-chain substrates whereas Hexyldecanol and Octyldodecanol are branched. While this ingredient is unlikely to cause fungal acne, be sure to patch test if you're unsure.
Learn more about HexyldecanolPentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolPolyglyceryl-3 Methylglucose Distearate is a plant-derived emulsifier whose only job is to keep the oily and watery parts of a formula blended so it doesn't separate into layers.
It's compatible with a wide-range of active ingredients and especially good at making emulsions survive heat/freeze cycles.
Typical use concentrations range from 2-3% and it works across a pH of 4.5-8.5.
This ingredient has been found safe to use in cosmetics and has a low irritation profile.
Because it's build on stearic acid, it may not be fungal acne safe. Stearic acid is a C18 fatty acid that falls within the range (C11-24) that Malassezia can feed on.
Learn more about Polyglyceryl-3 Methylglucose DistearateBisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Learn more about BisabololAllantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Learn more about AllantoinNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideThis ingredient is also known as milk thistle extract. It has antioxidant that can help soothe skin and even out skin tone.
Clinical studies found topical milk thistle extract can help improve the appearance of discoloration over time. This is most likely because it can help calm inflammation and supports more balanced pigment activity in the skin.
In real-world studies, products containing this extract were associated with fewer clogged pores and fewer acne lesions.
Lab studies show milk thistle has been shown to:
Research on this ingredient also found a sustained and significant decrease in acne lesion counts (a ~45% improvement after 6 months and ~59% at 12 months).
Learn more about Silybum Marianum Fruit ExtractCitrus Limon Fruit Extract comes from lemons. While lemon extract is exfoliating and antimicrobial, it can also cause skin sensitivity.
Lemons contains antioxidants, which may help with anti-aging. They are also rich in citric acid, an AHA.
And of course, lemons are rich in Vitamin C. Vitamin C helps with skin-brightening and increasing collagen production.
The acidity of lemons may work as an astringent for acne.
However, lemons can also cause skin sensitivity due to its limonene content. It can also increase photosensitivity, or sensitivity to the sun.
This ingredient is also used to add a lemon scent to products.
Learn more about Citrus Limon Fruit ExtractThis ingredient comes from the wild soybean. It has skin conditioning and moisturizing properties due to its interesting bioactive compounds.
The two key bioactive compounds like genistein, daidzein, soybean trypsin inhibitor, Bowman-Birk inhibitor, and phenolic acids give it a broad range of studied effects.
Studies have shown soy proteins can inhibit melanin transfer to the skin's surface to potentially help with uneven skin tone. There's also some in-vitro evidence that soybean extract stimulate collagen and elastin synthesis. A 2025 mouse study found Glycine Soja leaf/stem extract reduced markers of atopic dermatitis-like inflammation and improved skin barrier function.
Just remember this ingredient still lacks robust human clinical trials. However, it would be a great supportive ingredient in any routine unless you have a known soy allergy.
Learn more about Glycine Soja ExtractHydroxypinacolone Retinoate (aka Granactive Retinoid or HPR) is a retinoid that is part of the same vitamin A family as retinol.
It is an ester of retinoic acid that binds directly to your skin's retinoic acid receptors so it doesn't need your skin to convert it through several steps before it can do anything.
In practice, this means it does the classic retinoid jobs in a formula:
The best part is that it can do all this with noticeably less redness, flaking, and stinging than traditional retinoids.
That gentle reputation is backed by lab work as well; a 2018 study on skin models found that HPR triggered higher retinoid-gene activity than retinol, retinal, or retinyl propionate at the same concentrations while being less irritating to cells.
It also boosted procollagen production to levels similar to retinoic acid itself.
A 2023 study showed HPR works synergistically with retinyl propionate to switch on collagen-building pathways and a 2025 clinical serum study in women with mild photoaging saw improvements in wrinkles and elasticity (though that formula also contained retinol, peptides, and Silybin).
One naming quirk worth mentioning:
You'll likely see this ingredient sold under the trade name "Granactive Retinoid", which is actually only 10% HPR blended with 90% Dimethyl Isosorbide solvent. This means a 5% Granactive Retinoid really only means about 0.5% HPR.
Finished products typically land somewhere between 0.05-1% and it's happiest formulated at a mildly acidic to neutral pH (~5.5-6.5).
Another perk is that this is one of the more light- and temperature-stable retinoids which is a nice bonus for shelf life.
Learn more about Hydroxypinacolone RetinoateRetinol is one of the most studied anti-aging ingredients in skincare (and for good reason!).
It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells.
That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid.
Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process.
Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family.
Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid.
Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating.
The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle spot. It's more effective than the esters, gentler than prescription options.
Once it becomes Retinoic Acid, it binds to receptors inside your cells' nuclei (called RARs and RXRs). These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off.
In practice, this means a few things happen in a formula. It:
That last two are worth a closer look.
A study that tested Retinol directly (not just prescription Retinoic Acid) found that four weeks of retinol thickened the epidermis and switched on the genes for Collagen I and Collagen III, with more procollagen I and III showing up in the skin. And after twelve weeks, facial wrinkles were visibly reduced.
Retinoids more broadly stimulate the skin's synthesis of hyaluronan and other glycosaminoglycans, part of what gives skin a plumper, more hydrated look over time.
So even the gentler OTC form is doing real structural work (not just sitting on the surface).
It's also worth knowing Retinol isn't only a wrinkle ingredient; it can help with uneven tone, dark spots, rough texture, and the look of pores as well because it speeds up turnover and influences pigment.
The research backs this up as well.
A pooled analysis of six clinical studies found that 0.1% stabilized retinol improved all signs of photoaging versus vehicle as early as week 4 and through 12 weeks, with only a few mild cases of irritation.
Another study comparing concentrations found that 0.3% and 1% Retinol were similarly effective at remodeling photodamaged skin, but 0.3% caused fewer adverse reactions when used daily (a useful reminder that more isn't always better).
Retinol is about tenfold less potent than Retinoic Acid. This is why it works as a gentler, non-prescription option that builds results over time.
Typical concentrations range from 0.1-1%, with 0.1% to 0.3% being a well-supported sweet spot for visible benefits with good tolerability.
One quirk worth mentioning: Retinol is famously unstable.
It's highly sensitive to light and oxygen, and UV exposure breaks it down into a range of degradation products.
Real-world testing bears this out, with retinoid content in some products dropping anywhere from 0% to 80% after six months at room temperature, and even more at higher temperatures.
This is why good formulations lean on opaque, air-tight packaging (think tubes and pumps, not clear jars) and often "encapsulate" the Retinol to shield it.
Signs of oxidation include your product turning yellow or smelling "off". Keeping it somewhere cool and dark, and using it up within a few months of opening helps it stay effective.
The most common side effects are mild and temporary: usually some dryness, redness, or light peeling as your skin adjusts. These tend to settle with consistent and lower-frequency use.
Like all retinoids, Retinol works best with nightly use, a good moisturizer, and daytime sunscreen.
The "ramp up" method works well: start with Retinol once a week to give your skin time to adjust, which keeps irritation low. Slowly add more nights until you reach your goal frequency once your skin feels comfortable.
Retinoids also make your skin more sensitive to the sun in the first few weeks, so wear sunscreen every morning and protect your skin from direct sun while you build up tolerance.
One safety note: topical Retinoids aren't recommended during pregnancy or breastfeeding. Systemic absorption from creams is low but because high oral vitamin A is a known teratogen and topical safety data are limited, most clinicians recommend stopping retinoids when pregnant or trying to conceive.
Learn more about RetinolWe don't have a description for Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate yet.
This is a patented ingredient from Proya designed to enhance skin elasticity and firmness.
Palmitoyl Tripeptide-5 is a synthetic signal lipopeptide. This just means it is a three amino acid chain bolted onto a palmitic acid tail so it can slip through the skin's lipid barrier.
This peptide has a "build more, lose less" approach.
It's designed to mimic the collagen-stimulating activity in your skin by copying a snippet of one of your skin's own matrix proteins. This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein.
The manufacturer's in vivo study of 45 volunteers found 1% and 2.5% reduced the appearance of wrinkles by 7% and 12% respectively, after using it twice daily for 84 days.
This is in the expected range for peptides; they're slow and cumulative actives and not overnight fixers.
Typical use levels range from 1-3% and this ingredient gets along with pretty much everything.
On the fungal acne front:
Although palmitic acid sits in the chain length that Malassezia can feed on, this ingredient has it locked in an amine bond. This makes it hard for Malassezia to access as a source of food, and therefore fungal acne safe.
This ingredient is also known as flaxseed extract. It has skin conditioning and perfuming properties.
Flaxseed naturally contains polysaccharides (sugars) and small amounts of fatty acid-related compounds to help hydrate the skin. The seed also contains antioxidants being studied for its effects on inflammation pathways.
A small clinical trial found topical flaxseed oil improved hand eczema over the course of 4 weeks. In an animal study, topical flaxseed cream supported wound-healing outcomes.
Overall, flaxseed is a great hydrating and barrier supporting ingredient. Like other plant extracts, some rare cases of allergic reactions can occur.
Though flaxseed has a perfuming function according to INCI, this doesn't mean the ingredient is added as a fragrance. It just means the material can contribute an odor or modify the scent of a formula.
Learn more about Linum Usitatissimum Seed ExtractDipalmitoyl Hydroxyproline isn't fungal acne safe.
Ascorbyl Palmitate is a fat-soluble form of vitamin C (Ascorbic Acid) made by combining it with palmitic acid.
It is able to blend easily into creams and oil-based formulas because it dissolves in oils rather than water.
As you may know, regular vitamin C is notorious for breaking down when exposed to sunlight and air. Ascorbyl Palmitate is more stable and degrades at a slower rate.
Research on whether it converts efficiently into active vitamin C once it's applied on your skin is still limited.
Some in-vitro studies suggest it may support collagen production, but it is not considered one of the stronger vitamin C derivatives, like:
Due to the palmitic acid base, this ingredient may not be fungal acne safe. Comedogenic studies have also shown this ingredient to have a rating of 2.
It's also worth keeping in mind that comedogenic and irritancy ratings are tested on individual ingredients, not finished formulas. The final product's formulation, concentration, and other ingredients all play a role in how something actually behaves on your skin.
Learn more about Ascorbyl PalmitateMadecassoside is one of four active compounds found in Centella asiatica and is one of the main reasons Centella is so effective at calming irritated skin and supporting the moisture barrier.
There's a solid body of peer-reviewed research backing Madecassoside for several skin benefits. Studies have found:
Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.
Learn more about MadecassosideCentella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.
That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.
These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.
Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.
Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.
Here is the short version of what they do in the skin:
So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.
Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:
Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.
Centella is one of the most easygoing actives out there.
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.
On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.
Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.
But as with any new active, a patch test is still a smart move for very reactive skin.
Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).
The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).
In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.
Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractAsiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica. It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside.
Research from 2016-2025 supports its role in:
You'll usually find this in concentrations between 0.2-5%.
Learn more about AsiaticosideCeramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Learn more about Ceramide NPCeramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.
You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.
The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.
Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.
Learn more about Ceramide APAvena Sativa Bran is created from oatmeal. Bran is the outer shell of oatmeal.
This ingredient is an exfoliant.
Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.
It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.
On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin
The more interesting story is underneath:
Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.
A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.
It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.
This ingredient gets along with pretty much everything and is typically used around 0.1-1%.
Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.
Learn more about Beta-GlucanPhytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.
Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.
Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.
Fun fact: Phytosphingosine is abundant in plants and fungi.
More ingredients that help boost collagen in skin:
Learn more about Phytosphingosine4-T-Butylcyclohexanol has skin soothing and perfuming/masking properties.
A study from 2016 found it to have skin-soothing properties both in-vivo and in-vitro. It works by intercepting the signals of irritation and can soothe the skin in a few minutes.
According to a manufacturer, this ingredient has a scent similar to musk or patchouli. Besides having a skin soothing effect, it can also help cover other unpleasant scents as a masking ingredient.
Learn more about 4-T-ButylcyclohexanolSuperoxide Dismutase is found in all living cells. This ingredient is AKA as 'SOD'.
SOD is a strong antioxidant. It protects living cells against oxidative damage by breaking down radical molecules into regular oxygen and hydrogen peroxide.
Antioxidants help fight free-radical molecules that may damage your skin's DNA. This may help with the signs of aging. Due to its antioxidant property, it is used to help treat chronic inflammation.
In cosmetics, SOD is usually obtained from marine phytoplankton, bovine liver, horseradish, cantaloupe, and certain bacteria.
The three major families of SOD include: Copper/Zinc, Iron/Manganese, and Nickel.
When eating SOD-rich foods, our bodies break it down into amino acids before absorption. Foods that contain SOD include: melons, citrus, spinach, broccoli, kale, almonds, sunflower seeds, and blue-green algae.
Learn more about Superoxide DismutaseThis oil comes from the pulp of the buriti palm fruit. It's made mostly of oleic acid (~65-90%) with palmitic acid as the second biggest component, then some carotenoids and vitamin E.
This is why it's often marketed as an antioxidant-rich and moisturizing oil.
Because it's dominated by oleic acid, this ingredient may not be fungal acne safe as the Malassezia yeast has been shown to feed on it.
Learn more about Mauritia Flexuosa Fruit OilTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolLecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Learn more about LecithinWe don't have a description for Hydroxypropyl Methylcellulose Stearoxy Ether yet.
Polysorbate 80 is a synthetic surfactant and emulsifier derived from sorbitol and oleic acid.
It reduces the surface tension between oil and water phases to help them stay mixed and stable in a formulation. In other words, it prevents your formulas from separating into an oily mess.
The CIR Expert Panel has evaluated the scientific data and found this ingredient to be safe, non-irritating, and non-sensitizing at concentrations up to 5% (it's even approved by the FDA as an OTC eye drop ingredient).
Learn more about Polysorbate 80Divinyldimethicone/Dimethicone Crosspolymer is a type of silicone.
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate (long name, huh?) is a synthetic antioxidant.
It is used to help stabilize other antioxidants or prevent the color from changing in a product.
As an antioxidant, it helps fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material. Thus, antioxidants may reduce the signs of aging.
This ingredient is oil-soluble.
Learn more about Pentaerythrityl Tetra-Di-T-Butyl HydroxyhydrocinnamateTrehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.
As a humectant, trehalose helps draw moisture from the air to your skin. This helps keep your skin hydrated.
Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.
In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.
Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.
Learn more about TrehaloseSucrose Laurate isn't fungal acne safe.
Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.
It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).
This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.
Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.
Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.
Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.
Learn more about CholesterolThis ingredient is a water-soluble emollient and is derived from glycerin. It also has surfactant properties and can help dissolve oils or actives in water-based products.
According to the manufacturer, this ingredient:
- Moisturizes without stickiness or greasiness.
- Improves the penetration of water-based ingredients while reducing penetration of oil-based ones to help balance delivery in formulations
We don't have a description for Hydroxyphenyl Propamidobenzoic Acid yet.
PEG-40 Hydrogenated Castor Oil is an emulsifier derived from castor oil.
As an emulsifying agent, it helps other ingredients like fragrances and fat-soluble vitamins dissolve cohesively.
Due to its large molecule size, it doesn't penetrate beyond the skin's surface.
This ingredient has a solid regulatory track record; the CIR Expert Panel first concluded it was safe for use in cosmetics at concentrations up to 100% in 1997. A 2012 reassessment reaffirmed that finding. Safety studies have also found no irritation or evidence of toxicity.
A 2019 study did find this ingredient to grow Malassezia, so this ingredient may not be fungal acne safe.
Learn more about PEG-40 Hydrogenated Castor OilWe don't have a description for Caramel yet.
Sorbitan Trioleate isn't fungal acne safe.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAPhenethyl Alcohol is a colorless and aromatic alohol. It is naturally occuring in essential oils.
The scent of this ingredient is floral and often compared to rose.
Like other alcohols, this ingredient helps prevent the growth of bacteria. However, its main purpose is to impact a fragrance.
Learn more about Phenethyl AlcoholParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumReviews
Average rating of all formulations of this product: 5.0
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Read more about us· Updated February 25, 2026 • Added by crysv2797