Centellian24 Madeca Derma Shield Safe Moisture Sun Cream SPF 50+

Centellian24 Madeca Derma Shield Safe Moisture Sun Cream SPF 50+

This chemical sunscreen covers the full UV range and blocks ~98% of UVB at SPF 50.

Worth noting

Contains EU-listed fragrance allergens, including Pelargonium Graveolens Flower Oil and Limonene.

We independently verify ingredients, backed by peer-reviewed research. Suggest an update.

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What's inside

Ingredients List

48
20
10

Water

Skin Conditioning

Dibutyl Adipate

Emollient

Propanediol

Solvent
Helps hydrate Dry Skin IconGood for Barrier Repair Icon

Diethylamino Hydroxybenzoyl Hexyl Benzoate

UV Filter
Chemical UV Filter Icon

Butyloctyl Salicylate

Skin Conditioning
Non-Reef-Safe Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconGood for Barrier Repair Icon

Ethylhexyl Triazone

UV Absorber
UV Protection IconChemical UV Filter Icon

Niacinamide

Smoothing
Niacinamide IconHelps fight Acne IconHelps with Anti-Aging IconHelps brighten skin IconHelps reduce irritation IconGood for Oily Skin IconGood for Minimizing Pores IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Dark Spots IconGood for Skin Texture IconGood for Barrier Repair Icon

Methylene Bis-Benzotriazolyl Tetramethylbutylphenol

UV Filter
Chemical UV Filter Icon

Polymethylsilsesquioxane

Silicon Icon

1,2-Hexanediol

Skin Conditioning
Helps hydrate Dry Skin Icon

Caprylyl Methicone

Skin Conditioning
Silicon Icon

Diethylhexyl Butamido Triazone

UV Absorber
UV Protection IconChemical UV Filter Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin IconGood for Barrier Repair Icon

Centella Asiatica Extract

Cleansing
Helps with Anti-Aging IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Skin Texture IconGood for Barrier Repair Icon

Agave Tequilana Leaf Extract

Astringent

Opuntia Ficus-Indica Stem Extract

Skin Conditioning
Helps reduce irritation Icon

Centella Asiatica Flower/Leaf/Stem Extract

Skin Conditioning
Helps reduce irritation IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Anastatica Hierochuntica Extract

Astringent

Chrysanthemum Parthenium Extract

Skin Conditioning

Hydrolyzed Manihot Esculenta Tuber Extract

Skin Conditioning

Centella Asiatica Root Extract

Skin Conditioning
Helps reduce irritation IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Citrus Aurantium Bergamia Fruit Oil

Masking
Oil IconEssential Oil IconFragrance IconMay worsen Perioral Dermatitis IconMay worsen Psoriasis Icon

Pelargonium Graveolens Flower Oil

Masking
Oil IconEssential Oil IconFragrance IconMay cause irritation IconMay worsen Perioral Dermatitis IconMay worsen Psoriasis IconEU Allergen Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Pentylene Glycol

Skin Conditioning
Good for Barrier Repair Icon

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Poly C10-30 Alkyl Acrylate

Emulsion Stabilising

Polyacrylate Crosspolymer-6

Emulsion Stabilising

Dipropylene Glycol

Humectant

Polyglyceryl-3 Methylglucose Distearate

Emulsifying
May worsen Seborrheic Dermatitis IconNot safe for Fungal Acne Icon

Decyl Glucoside

Cleansing
Coconut Derived Icon

Tromethamine

Buffering

Carbomer

Emulsion Stabilising
1 / 0

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Emulsion Stabilising

Hydroxyacetophenone

Antioxidant
Antioxidant Icon

Ethylhexylglycerin

Skin Conditioning

Sodium Stearoyl Glutamate

Cleansing

Adenosine

Skin Conditioning
Helps with Anti-Aging IconHelps hydrate Dry Skin IconHelps reduce irritation Icon

Xanthan Gum

Emulsifying

Madecassic Acid

Skin Conditioning
Helps with Anti-Aging IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Barrier Repair Icon

Asiaticoside

Antioxidant
Antioxidant IconHelps with Anti-Aging IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Skin Texture IconGood for Barrier Repair Icon

Asiatic Acid

Skin Conditioning
Helps with Anti-Aging IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Barrier Repair Icon

Panthenol

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Scar Healing IconGood for Barrier Repair Icon

Xylitylglucoside

Humectant
Helps hydrate Dry Skin Icon

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconHelps brighten skin IconHelps reduce Skin Redness IconGood for Dark Spots IconGood for Barrier Repair Icon

Methylpropanediol

Solvent

Anhydroxylitol

Humectant
Helps hydrate Dry Skin Icon

Xylitol

Humectant
Helps hydrate Dry Skin IconGood for Barrier Repair Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps reduce Skin Redness IconGood for Barrier Repair Icon

Glycine

Buffering
Helps hydrate Dry Skin Icon

Aspartic Acid

Masking
Helps hydrate Dry Skin Icon

Leucine

Skin Conditioning

Alanine

Masking
Helps hydrate Dry Skin Icon

Lysine

Skin Conditioning

Arginine

Masking
Helps hydrate Dry Skin IconGood for Scar Healing Icon

Tyrosine

Masking

Phenylalanine

Masking
Helps hydrate Dry Skin Icon

Valine

Masking

Proline

Skin Conditioning
Helps hydrate Dry Skin Icon

Isoleucine

Skin Conditioning

Histidine

Humectant
Helps with Anti-Aging IconHelps hydrate Dry Skin Icon

Cysteine

Antioxidant
Antioxidant Icon

Methionine

Skin Conditioning

Dimethylsilanol Hyaluronate

Humectant
Hyaluronic Acid Icon

Hydrolyzed Sodium Hyaluronate

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Scar Healing Icon

Hydrolyzed Hyaluronic Acid

Humectant
Hyaluronic Acid IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconGood for Scar Healing Icon

Potassium Hyaluronate

Skin Conditioning

Hyaluronic Acid

Humectant
Hyaluronic Acid IconHelps with Anti-Aging IconHelps hydrate Dry Skin IconGood for Scar Healing IconGood for Barrier Repair Icon

Sodium Hyaluronate Crosspolymer

Humectant
Hyaluronic Acid IconHelps hydrate Dry Skin IconGood for Scar Healing Icon

Hydroxypropyltrimonium Hyaluronate

Helps hydrate Dry Skin Icon

Sodium Hyaluronate Dimethylsilanol

Humectant

Sodium Acetylated Hyaluronate

Humectant
Hyaluronic Acid IconHelps with Anti-Aging Icon

Limonene

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Perioral Dermatitis IconMay worsen Psoriasis IconMay worsen Rosacea IconEU Allergen Icon

Linalool

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Perioral Dermatitis IconMay worsen Psoriasis IconMay worsen Rosacea IconEU Allergen Icon

Citronellol

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Perioral Dermatitis IconMay worsen Psoriasis IconMay worsen Rosacea IconEU Allergen Icon

Geraniol

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Perioral Dermatitis IconMay worsen Psoriasis IconMay worsen Rosacea IconEU Allergen Icon

Citral

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Perioral Dermatitis IconMay worsen Rosacea IconEU Allergen Icon

Water, Dibutyl Adipate, Propanediol, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Butyloctyl Salicylate, Glycerin, Ethylhexyl Triazone, Niacinamide, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Polymethylsilsesquioxane, 1,2-Hexanediol, Caprylyl Methicone, Diethylhexyl Butamido Triazone, Butylene Glycol, Centella Asiatica Extract, Agave Tequilana Leaf Extract, Opuntia Ficus-Indica Stem Extract, Centella Asiatica Flower/Leaf/Stem Extract, Anastatica Hierochuntica Extract, Chrysanthemum Parthenium Extract, Hydrolyzed Manihot Esculenta Tuber Extract, Centella Asiatica Root Extract, Citrus Aurantium Bergamia Fruit Oil, Pelargonium Graveolens Flower Oil, Sodium Hyaluronate, Pentylene Glycol, Behenyl Alcohol, Poly C10-30 Alkyl Acrylate, Polyacrylate Crosspolymer-6, Dipropylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Decyl Glucoside, Tromethamine, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Hydroxyacetophenone, Ethylhexylglycerin, Sodium Stearoyl Glutamate, Adenosine, Xanthan Gum, Madecassic Acid, Asiaticoside, Asiatic Acid, Panthenol, Xylitylglucoside, Tocopherol, Methylpropanediol, Anhydroxylitol, Xylitol, Ceramide NP, Glycine, Aspartic Acid, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Valine, Proline, Isoleucine, Histidine, Cysteine, Methionine, Dimethylsilanol Hyaluronate, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Potassium Hyaluronate, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Acetylated Hyaluronate, Limonene, Linalool, Citronellol, Geraniol, Citral

Key Ingredients

Benefits

Concerns

Ingredients Explained

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Learn more about Water
Emollient, Skin Conditioning, Solvent

Dibutyl Adipate is a lightweight, oil-soluble ester that acts as an emollient and solvent. It helps products spread more easily and leaves a soft, silky, dry-touch finish without being greasy.

You'll likely see this ingredient in sunscreens because it does a nice job dissolving UV filters and keeping them evenly distributed.

This ingredient has been found to be safe as used in cosmetics, wasn't a skin or eye irritant in clinical patch testing, and wasn't phototoxic.

In a clinical comedogenicity test, this ingredient tested negative so it isn't likely to clog pores.

Typical use levels are about 5-8% for sunscreens + nail products, but can range from 0.005%-8% depending on the product.

Learn more about Dibutyl Adipate
Solvent

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin. 

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Learn more about Propanediol

Diethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB) is a chemical UV-A absorber. It is formulated for high UVA protection (320-400 nm).

DHHB is well-liked for:

DHHB has been approved by the EU, Japan, Taiwan, and South America for use up to 10%. Unfortunately, it has not been approved for use in the US or Canada due to slow regulatory processes.

This ingredient is soluble in oils, fats, and lipids.

Learn more about Diethylamino Hydroxybenzoyl Hexyl Benzoate
Skin Conditioning, Solvent, UV Filter

Butyloctyl Salicylate is a chemical UV filter structurally similar to octisalate. It is a photostabilizer, SPF booster, emollient and solvent. This ingredient helps evenly spread out ingredients.

According to a manufacturer, it is suitable for pairing with micro Titanium Dioxide, Zinc Oxide, and pigments.

Photostabilizers help stabilize UV-filters and prevents them from degrading quickly.

Learn more about Butyloctyl Salicylate
Humectant, Skin Conditioning, Skin Protecting

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
UV Absorber, UV Filter

Ethylhexyl Triazone (aka Octyl Triazone) is an oil-soluble organic UVB filter. It has peak absorption around 314 nm, right in the middle of the UVB range.

This ingredient is described as one of the most effective UVB filters available and small concentrations are enough to deliver a high SPF thanks to its strong UV absorbing power.

Formulators love it for its stability; its ability to filter UV stays practically unchanged even under intense radiation and it can also help boost the photostability of less stable filters like avobenzone.

It's also a great pick for water resistant products because it's insoluble in water and has a good affinity for keratin.

Because it's a big, heavy molecule, the European Scientific Committee has found to to have very low dermal penetration and negative results for allergenicity.

In vitro testing also showed a low absorption rate and clean results on irritation.

Typical use levels are 1-5% with 5% being the maximum in the EU, Japan, and other markets that allow it. However, this ingredient is not approved yet in the US or Canada.

Learn more about Ethylhexyl Triazone
Smoothing

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Learn more about Niacinamide

This ingredient is also known as Tinosorb M or Bisoctrizole and is a bit of an overachiever in the sunscreen world.

It's a hybrid broad-spectrum filter that covers UVA and UVB (~280-400nm) with peak absorption around 305nm for UVB or 360nm for UVA (and a tiny bit in blue-light territory as well).

One of its best party tricks is photostability; it doesn't break down with repeated sun exposure and doesn't generate free radicals in the process either. You'll also see it paired with wobbly filters like avobenzone because it helps stabilize them.

The safety profile is assuring as well. Because it's a large molecule, it doesn't easily absorb into skin and rarely causes irritation.

It's approved in the EU, Asia, and Australia up to 10% and most formulas land somewhere in the 2-10% range.

You won't find it as a sunscreen active in the US, but it can make an appearance as a formula-protecting UV-absorber.

Learn more about Methylene Bis-Benzotriazolyl Tetramethylbutylphenol

Polymethylsilsesquioxane is a silicone used as a film forming agent.

When applied to the skin, this ingredient creates an invisible film on the surface. This film still allows oxygen to pass through, but prevents moisture from escaping. This can help condition and hydrate the skin. It also leaves a silky feel when applied.

Polymethylsilsesquioxane has not been shown to clog pores. It has been deemed safe to use up to 55%, but most cosmetics use much less.

If you have concerns about using this ingredient, we recommend speaking with a professional.

Learn more about Polymethylsilsesquioxane
Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservatives 
Skin Conditioning

Caprylyl Methicone is a synthetic and lightweight silicone fluid. It gives products a silky, dry-touch finish without the heaviness of pure oils.

Though the EU CosIng Database lists this ingredient as a skin conditioner, it is also used for sensory reasons. It spreads easily, cuts greasiness, and reduces tackiness.

This ingredient is volatile which means it will mostly evaporate (but it evaporates slower than older cyclomethicones, like Cyclotetrasiloxane).

Typical concentration ranges from 1-30% depending on if it's being used to tweak the feel of a product or acting as the main emollient.

Learn more about Caprylyl Methicone
UV Absorber, UV Filter

Diethylhexyl Butamido Triazone (aka Iscotrizinol) is an oil-soluble organic UV filter that mainly absorbs UVB and a bit of UVA II light.

This ingredient is great at preventing sunburn but doesn't cover the deep UVA I range. This is why it's often paired with a UVA filter like Avobenzone or Bemotrizinol.

Two of its biggest selling points are efficiency and stability:

Most of the other chemical filters are considered "photostable" if they can last for two hours.

Because this ingredient is oil-loving, it can sit neatly into the oil phase of emulsions and shines in water-repellent/water-resistant formulations.

The EU and Canada allow it to be used up to 10% and Japan allows it up to 5%.

Unfortunately, it's not yet an FDA approved sunscreen agent so you won't be able to find it in sunscreens in the US.

Safety-wise, it has a pretty solid record: the EU's Scientific Committee on Consumer Safety (SCCS) has reviewed it and found low skin absorption, no capacity to produce skin irritation or photo-irritation.

In vitro testing has found less than 0.1% of the applied dose is absorbed by the skin over 24 hours (mostly due to its large molecule size).

Fun fact: This ingredient even has anti-inflammatory properties similar to those of ketoprofe, an anti-inflammatory medication.

Learn more about Diethylhexyl Butamido Triazone
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Cleansing, Skin Conditioning, Smoothing

Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.

That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.

These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.

Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.

Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.

Here is the short version of what they do in the skin:

So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.

Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:

Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.

Centella is one of the most easygoing actives out there.

It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.

On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.

Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.

But as with any new active, a patch test is still a smart move for very reactive skin.

Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).

The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.

Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Learn more about Centella Asiatica Extract

Agave Tequilana comes from the Blue Agave plant native to Mexico, and is a base ingredient in the alcohol Tequila.

It is an astringent, meaning it draws water out of pores to constrict them temporarily.

This ingredient comes from the stem of the Prickly Pear cactus. The stem is rich in polyphenols, a potent source of antioxidants. It is anti-aging and soothing properties.

Prickly Pear stem is made up mostly of water (85%). The rest is composed of skin nourishing compounds: protein, fiber, fatty acid, simple sugars, Vitamin C, and some minerals.

Polyphenols help mitigate the effects of aging. Studies show polyphenols protect the skin from oxidative stress, UV-induced damage, and inflammation.

Prickly pear is often compared to Aloe.

Learn more about Opuntia Ficus-Indica Stem Extract

Centella Asiatica Flower/Leaf/Stem Extract can be good for sensitive skin. It can help to reduce redness.

Astringent, Skin Conditioning

Anastatica Hierochuntica Extract is from a plant called the Rose of Jericho. This plane is found in the deserts of the Middle East and North Africa.

Anastatica Hierochuntica Extract has antioxidant properties. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells.

We don't have a description for Chrysanthemum Parthenium Extract yet.

We don't have a description for Hydrolyzed Manihot Esculenta Tuber Extract yet.

Skin Conditioning

Centella Asiatica Root Extract can be good for sensitive skin. It can help to reduce redness.

Citrus Aurantium Bergamia Fruit Oil is the oil from the bergamot orange and is primarily used as a fragrance. It has a "fresh" and "bright orange" scent.

The main aroma compounds found in this ingredient are limonene (~27-52%), linalool (~2-22%), and linalyl acetate (~27-40%). These are known EU fragrance allergens.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.

When used topically, Citrus Aurantium Bergamia Fruit Oil is a photosensitizer due to the furanocoumarin content. Furanocoumarins absorb UV-A and cause phytophotodermatitis; this can look like redness, blistering, and lasting brown pigmentation on sun-exposed skin.

Due to this, this ingredient is capped at 0.4% in leave-on products applied to sun exposed skin.

Many modern formulas used a "furanocoumarin-free" version that sidesteps the phototoxicity issue, but still contains the fragrance allergens.

Learn more about Citrus Aurantium Bergamia Fruit Oil

Pelargonium Graveolens Flower Oil is the pressed oil of the Rose Geranium plant. It is volatile, meaning it evaporates off the skin.

Fragrant components of Rose Geranium include citronellol and geraniol. These may cause allergies and skin-sensitivity. We recommend speaking with a professional if you have any concerns.

The scent of Rose Geranium closely resembles traditional roses.

Learn more about Pelargonium Graveolens Flower Oil
Humectant, Skin Conditioning

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Learn more about Sodium Hyaluronate
Skin Conditioning, Solvent

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Learn more about Pentylene Glycol
Emollient, Emulsion Stabilising

Behenyl Alcohol is a type of fatty alcohol (these are different from the drying, solvent alcohols).

Fatty Alcohols have hydrating properties and are most often used as an emollient or to thicken a product. They are usually derived from natural fats and oils; behenyl alcohol is derived from the fats of vegetable oils.

Emollients help keep your skin soft and hydrated by creating a film that traps moisture in.

In 2000, Behenyl Alcohol was approved by the US as medicine to reduce the duration of cold sores.

Learn more about Behenyl Alcohol
Emulsion Stabilising

Poly C10-30 Alkyl Acrylate is a synthetic polymer. It's a long chain built from acrylic acid units and each unit carries a fatty "tail" derived form a C10-30 alcohol.

Those oil-loving tails allow this ingredient to thicken oil phases, hold emulsions together, and cuts the tacky/greasy feel of heavy formulas.

Typical use levels sit around 0.1-3%, with 0.3-3% more common in leave-on emulsions.

This ingredient was reviewed as part of a group of 126 acrylates and concluded to be safe by the Cosmetic Ingredient Review Expert Panel.

Though acrylate contact allergy is real and well-documented, allergy risk is quite low. The cases of documented contact allergy are caused by unreacted monomers (more commonly found in gel nails, dental resins, and adhesives).

Learn more about Poly C10-30 Alkyl Acrylate
Emulsion Stabilising

Polyacrylate Crosspolymer-6 is a texture enhancer and pH adjuster.

It is be used to thicken water-based products and create a gel-texture with a velvet feel.

One manufacturer claims this ingredient to have a pH range of 2-8 and to be biodegradable.

This ingredient is also known as Sepimax Zen.

Learn more about Polyacrylate Crosspolymer-6
Humectant, Masking, Solvent

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Learn more about Dipropylene Glycol

Polyglyceryl-3 Methylglucose Distearate is a plant-derived emulsifier whose only job is to keep the oily and watery parts of a formula blended so it doesn't separate into layers.

It's compatible with a wide-range of active ingredients and especially good at making emulsions survive heat/freeze cycles.

Typical use concentrations range from 2-3% and it works across a pH of 4.5-8.5.

This ingredient has been found safe to use in cosmetics and has a low irritation profile.

Because it's build on stearic acid, it may not be fungal acne safe. Stearic acid is a C18 fatty acid that falls within the range (C11-24) that Malassezia can feed on.

Learn more about Polyglyceryl-3 Methylglucose Distearate
Cleansing, Emulsion Stabilising, Surfactant

Decyl Glucoside is a plant-derived surfactant and emulsion stabilizer. It is created by reacting glucose with the fatty acids from plants.

Like all surfactants, it works by lowering the surface tension between water and oil. This makes it so that dirt, sebum, and makeup can be lifted off your skin and rinsed away. It also produces a dense and creamy foam.

Because it has a neutral charge, it is compatible with a wide range of ingredients and stays stable across a broad pH range/water hardiness conditions.

Patch testing has shown it to have the lowest irritation potential among common cleansing surfactants (like SLS).

Typical use levels range from 5-20% in rinse-off cleansers.

One thing worth knowing: The American Contact Dermatitis Society named the parent family, alkyl glucosides, "Allergen of the Year" in 2017. The prevalence of allergy is pretty low but be sure to patch test if you've reacted to "gentle" or sulfate-free cleansers before.

This ingredient is fungal acne safe because the fatty alcohol portion of this ingredient is not within the C11-24 chain length that Malassezia can metabolize.

Learn more about Decyl Glucoside
Buffering, Masking

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Learn more about Tromethamine
Emulsion Stabilising, Gel Forming

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Learn more about Carbomer

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Learn more about Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Antioxidant

Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.

As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.

Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.

You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.

An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.

Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.

Learn more about Hydroxyacetophenone
Skin Conditioning

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Learn more about Ethylhexylglycerin
Cleansing, Emulsifying, Skin Conditioning

Sodium Stearoyl Glutamate is an amino-acid based emulsifier. It is made by combining stearic acid with L-glutamic acid and neutralizing it to a sodium salt.

As an emulsifier, it works mainly as an oil-in-water one and helps keep the oil and water in your formulas blended. It also contributes to a smooth, non-greasy skin feel.

This ingredient is biodegradable and commonly available in natural/COSMOS-certified grades.

Learn more about Sodium Stearoyl Glutamate
Skin Conditioning

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Learn more about Adenosine
Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Skin Conditioning

Madecassic Acid is one of the four star actives in Centella Asiatica. In skincare, it earns its keep as a calming and repairing ingredient.

It works through the same core pathways as the rest of the centella family.

First, it turns down inflammation so it helps with things like redness and general upset skin.

Second, it acts as an antioxidant which means it helps protect skin from daily stress and damage.

And third, it nudges the skin to make more collagen and rebuild its support structure.

That combination is why the whole Centella family is known for calming skin, strengthening the barrier, fading redness, and giving anti-aging benefits.

It's worth being honest about the evidence here; a lot of the strongest data is on the full extract or a Madecassoside/Asiaticoside rather than Madecassic Acid alone. Reviewers also note more long-term clinical trials are needed to confirm the full potential.

Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%.

Finished products typically run somewhere in the 0.1-10% range depending on the format.

In real-world tolerance tests, a repeat-insult patch test on an eye lotion with 0.2% Centella extract showed no irritation or allergic contact dermatitis in 54 subjects. And a mascara with 0.5% Madecassoside caused neither irritation nor sensitization in 109 subjects.

Allergy risk is very low, but not zero. Centella and its constituents are classified as weak contact sensitizers and some rare cases of allergic contact dermatitis exist.

Learn more about Madecassic Acid
Antioxidant, Skin Conditioning

Asiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica. It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside.

Research from 2016-2025 supports its role in:

You'll usually find this in concentrations between 0.2-5%.

Learn more about Asiaticoside
Skin Conditioning, Stabilising

Asiatic Acid is one of the four main actives found in Centella Asiatica. Its headline job is stimulating collagen.

Lab tests on human skin cells show Asiatic Acid tells your skin to make more collagen, the protein that keeps skin firm and bouncy.

It also calms inflammation and acts as an antioxidant so it can help skin heal faster, rebuild itself, and repair a damaged barrier.

And on naming, even though "acid" is in the name, it's nothing like an AHA or BHA exfoliant. It's a gentle firming and soothing ingredient that supports your skin barrier.

Concentration-wise, Asiatic Acid is potent at very low doses and usually shows up as a small fraction of a broader centella extract.

Analyses of centella material put Asiatic Acid reported in the range of 0.2-3% of the extract.

This ingredient is non-sensitizing and guinea pig sensitization testing also found it to be a weak sensitizer. That means the risk of acquiring contact sensitivty is quite low.

Allergic contact dermatitis does exist but is also very rare; documented cases tend to involve prolonged use on broken skin plus co-sensitization to fragrance ingredients.

Learn more about Asiatic Acid
Skin Conditioning

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Learn more about Panthenol
Humectant, Skin Conditioning

Xylitylglucoside is created from xylitol and glucose, two humectants.

Not surprisingly, this ingredient is also a humectant. It attracts and holds water in your skin, helping to maintain hydration.

This ingredient is most commonly found in a popular trio called Aquaxyl. Aquaxyl is made up of anhydroxylitol(24 - 34%), xylitylglucoside (35 - 50%), and xylitol (5 - 15%).

According to a manufacturer, Aquaxyl is known for a 3-D hydration concept and an anti-dehydration shield to reinforce the outer layer of skin.

Learn more about Xylitylglucoside
Antioxidant, Masking, Skin Conditioning

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Learn more about Tocopherol

Methylpropanediol is a synthetic solvent and humectant.

As a solvent, it helps dissolve other ingredients, helping to evenly distribute ingredients throughout the product. This ingredient has also been shown to have antimicrobial properties which makes it a preservative booster.

Methylpropanediol is able to add a bit of moisture to the skin. It also helps other ingredients be better absorbed into the skin, such as salicylic acid.

Learn more about Methylpropanediol
Humectant, Skin Conditioning

This ingredient is created from dehydrating xylitol in acidic conditions. Xylitol is a famous sugar and humectant.

Much like its predecessor, anhydroxylitol is a humectant. Humectants attract and hold water to moisturize the skin.

This ingredient is most commonly found in a popular trio called Aquaxyl. Aquaxyl is made up of anhydroxylitol (24 - 34%), xylitylglucoside (35 - 50%), and xylitol (5 - 15%).

According to a manufacturer, Aquaxyl is known for a 3-D hydration concept and an anti-dehydration shield to reinforce the outer layer of skin.

This ingredient is often derived from plants such as wood and sugarcane.

Learn more about Anhydroxylitol
Humectant, Skin Conditioning

Xylitol is a humectant and prebiotic. It can help with dry skin.

In studies, xylitol has been shown to improve dry skin. It decreased transepidermal water loss, or when water passes through the skin and evaporates. Xylitol also showed to help improve the biomechanical properties of the skin barrier.

The prebiotic property of xylitol may also help reinforce our skin's natural microbiome. Having a healthy microbiome prevents infection by bad bacteria and helps with hydration.

As a humectant, Xylitol helps draw moisture from both the air and from deeper skin layers. This helps keep skin hydrated.

Xylitol is a sugar alcohol and commonly used as a sugar substitute. It is naturally occurring in plants such as strawberries and pumpkin.

Learn more about Xylitol
Skin Conditioning

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Learn more about Ceramide NP
Buffering, Skin Conditioning

Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.

Masking, Skin Conditioning

Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.

Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.

Skin Conditioning

Leucine is a small amino acid and one of the building blocks your body uses to make proteins.

It's also naturally found in your skin as part of your Natural Moisturizing Factor (NMF). Your NMF is a mix of water-binding molecules that keeps the outer skin layer hydrated and flexible.

In skincare, it's mainly used as a skin conditioning ingredient that helps reinforce the same moisture-retention function.

You'll usually see it used at low percentages (generally under 5%) which is in line with how amino acids are used in cosmetics.

Learn more about Leucine
Masking, Skin Conditioning

Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.

Skin Conditioning

Lysine is an essential amino acid (your body cannot make it on its own). It has skin conditioning properties and one of the key players in collagen synthesis.

When your body creates collagen, lysine is basically the glue that holds everything together. It helps collagen fibers lock into each other and stay strong, with vitamin C being its trusty sidekick. Without enough lysine, this glue gets flimsy and less firm, resulting in less bouncy skin.

In skincare, lysine is mostly there to help keep your skin moisturized. It carries water through your skin's layers so everything stays plump.

So will putting lysine on your face create bouncier skin?

It's hard to say; most of the exciting collagen research on lysine comes from oral supplements or lab studies on mice. Further research is needed to truly understand what role topical lysine plays in skincare and your skin.

However, there's no harm in adding lysine to your routine as a supportive and hydrating ingredient.

Learn more about Lysine
Masking, Skin Conditioning

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Learn more about Arginine
Masking, Skin Conditioning

Tyrosine is one of the amino acids your body already uses as a protein building block. In skincare, it shows up as a skin-conditioning agent.

It's most notable for being the raw material that your skin's tyrosinase enzyme converts into melanin (skin pigment); this is why it's sometimes marketed as a "tan accelerator" in products.

However, the tanning claim is shaky. Lab studies on isolated skin cells show tyrosine can boost melanin production at fairly high concentrations but hasn't shown to speed up/deepen a tan when applied directly to skin in animal studies (up to 0.05%).

Finished cosmetic products use it at low levels (generally well under 1%). At these amounts, it's considered non-irritating and non-sensitizing based on repeat-use patch testing.

Allergy-wise, plain tyrosinase hasn't shown sensitization issues but a chemically modified relative called Oleoyl Tyrosine has had a handful of cases.

Learn more about Tyrosine
Masking, Skin Conditioning

Phenylalanine is an amino acid. It is a skin soothing and hydrating ingredient. Amino acids play a crucial role in wound healing and skin hydration.

This ingredient is also used to help even out skin tone due to its ability to disrupt the melanin production process.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

Learn more about Phenylalanine
Masking, Skin Conditioning

Valine is one of the essential amino acids (meaning your body can't make it on its own and has to get it from food).

In skincare, it's usually synthetically-made or pulled from plant proteins like soy.

It's one of the small building blocks that make up your skin's natural moisturizing factor (NMF), or the built-in system that helps skin hold onto water. So its main job in a formula is to give the skin gentle hydration and help it feel more comfortable.

Typical amounts are very tiny: roughly 0.00004%-0.5% in leave on products and up to 1% in rinse-off ones.

The Cosmetic Ingredient Review panel has looked at this ingredient and found no evidence of it being a skin irritant or allergen at cosmetic levels.

Learn more about Valine
Skin Conditioning

Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.

It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Learn more about Proline
Skin Conditioning

Isoleucine is an amino acid that helps reinforce our skin barrier. This amino acid plays a role in creating protein for the body.

Fun fact: Isoleucine is found in meat, fish, dairy, legumes, and nuts.

Humectant, Skin Conditioning

Histidine is a semi-essential amino acid used by our bodies to create protein. It has humectant and skin conditioning properties.

Our bodies use histidine to create filaggrin - filaggrin is a structural protein that the skin uses in maintaining skin barrier.

One study found histidine and carnosine to be a dynamic duo for your skin:

Oral histidine has also been found to help with filaggrin-deficit skin disorders such as atopic dermatitis.

Why is it considered a semi-essential amino acid? This is because adults are able to create it but children must get it from their diet.

Learn more about Histidine
Antioxidant, Masking

Cysteine is a sulfur-containing amino acid that your body naturally makes and uses to build keratin (the protein in your hair, skin, and nails) and gluthatione (a major internal antioxidant).

In skincare, it's mostly added as an antioxidant. Some emerging research is also looking at its role in wound healing + evening out pigmentation though most of the pigmentation data comes from oral supplements rather than topical use).

Typical use concentrations for this ingredient are usually quite low (under 5% in leave-on skincare).

Safety data on cysteine specifically shows it's not a skin or eye irritant.

Learn more about Cysteine
Skin Conditioning

Methionine is a natural amino acid your skin already uses to make proteins and gluthatione (one of the body's key defense molecules against environmental stress like sun + pollution).

Its sulfur content makes it especially reactive with the free radicals that damage skin, giving it genuine antioxidant properties.

Usage percentages are usually under 1%, and usually as part of an amino acid mix designed to mimic what's naturally in skin.

One study used a combination of essential amino acids at 0.2% with supplemental methionine added and found significantly boosted collagen production in human skin.

Cosmetic industry reviewers have looked closely at methionine and other amino acids and found them well tolerated. Methionine is actually used as a "negative control" in lab tests designed to spot irritating ingredients because it doesn't cause a reaction.

Learn more about Methionine
Humectant, Moisturising, Skin Conditioning

Dimethylsilanol Hyaluronate is a type of hyaluronic acid.

Skin Conditioning

This ingredient is created by putting sodium hyaluronate through hydrolysis.

You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.

According to studies, low molecular-weight hyaluronic acid can:

One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.

Hydrolysis is a process of changing a molecule using water or enzymes.

This ingredient is water-soluble.

Learn more about Hydrolyzed Sodium Hyaluronate
Humectant, Skin Conditioning

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Learn more about Hydrolyzed Hyaluronic Acid
Skin Conditioning

Potassium hyaluronate (PH) is a salt form of hyaluronic acid and has similar skin hydrating benefits.

Similar to hyaluronic acid, PH is able to draw and hold moisture to your skin. This helps keep skin soft and hydrated.

Fun fact: PH is used in eye drops and injectable treatments for joint disorders. It has lubricating and tissue-repair properties.

Learn more about Potassium Hyaluronate
Humectant, Moisturising, Skin Conditioning

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Learn more about Hyaluronic Acid
Humectant, Skin Conditioning

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Learn more about Sodium Hyaluronate Crosspolymer

Hydroxypropyltrimonium Hyaluronate is a positively charged version of hyaluronic acid.

This small change does a lot in a formula:

Regular hyaluronic acid carries a negative charge and so does the surface of your skin. This means the two repel each other and hyaluronic acid can be washed away easily. The positive charge here does the opposite: it makes the ingredient cling to your skin (also called "substantivity") so it keeps hydrating even in rinse-off products where it lays down a light, moisture-holding film.

The research backs this up too; a 2025 clinical study on a shower gel containing 0.1% positively charged hyaluronic acid increased skin hydration by 6.6% versus the baseline and 11.1% versus the placebo. This was measured 6 hours after 1 minute of contact and rinse, and on volunteers with very dry skin.

The same team's lab work showed it adhered to skin far better than unmodified hyaluronic acid (+107% vs. low molecular weight, +23% versus high molecular weight). They also found it increased two proteins tied to skin hydration, aquaporin-3 by 16% and filaggrin by 35%.

A separate 2024 study reached a similar conclusion and credited the hydrating benefits to its film-forming properties.

Both studies used the ingredient at 0.1% which also matches how much it usually shows up in products (at fractions of a percent).

One honesty note worth keeping in mind: the published research comes from the company that manufactures the ingredient so independent data would strengthen the picture. However, the results are consistent and the mechanism makes sense.

As a Hyaluronic Acid derivative, it has a well-tolerated profile and suits most skin types.

Learn more about Hydroxypropyltrimonium Hyaluronate
Humectant, Skin Conditioning

We don't have a description for Sodium Hyaluronate Dimethylsilanol yet.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Read about common types of Hyaluronic Acid here:

Learn more about Sodium Acetylated Hyaluronate
Perfuming, Solvent

Limonene is a fragrance that adds scent and taste to a formulation.

It's found in the peel oil of citrus fruits and other plants such as lavender and eucalyptus. The scent of limonene is generally described as "sweet citrus".

Limonene acts as an antioxidant, meaning it helps neutralize free radicals.

When exposed to air, oxidized limonene may sensitize the skin. Because of this, limonene is often avoided by people with sensitive skin.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.

Learn more about Limonene
Perfuming

Linalool is a fragrance and helps add scent to products. It's derived from common plants such as cinnamon, mint, citrus, and lavender.

Like Limonene, this ingredient oxidizes when exposed to air. Oxidized linalool can cause allergies and skin sensitivity.

This ingredient has a scent that is floral, spicy tropical, and citrus-like.

Learn more about Linalool
Perfuming

Citronellol is used to add fragrance/parfum to a product. It is often derived from plants such as roses. In fact, it can be found in many essential oils including geranium, lavender, neroli, and more. The scent of Citronellol is often described as "fresh, grassy, and citrus-like".

Since the Citronellol molecule is already unstable, Citronellol becomes irritating on the skin when exposed to air.

Citronellol is a modified terpene. Terpenes are unsaturated hydrocarbons found in plants. They make up the primary part of essential oils.

Citronellol is not able to be absorbed into deeper layers of the skin. It has low permeability,

Citronellol is also a natural insect repellent.

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Perfuming, Tonic

Geraniol is used to add fragrance/parfum to a product. It is the main component of citronellol. It is a monoterpenoid and an alcohol.

Monoterpenes are naturally found in many parts of different plants.

Geraniol can be found in many essential oils including Rose Oil and Citronella Oil. The scent of Geraniol is often described as "rose-like". Many foods also contain Geraniol for fruit flavoring.

Geraniol can irritate the skin when exposed to air. However, irritation depends on the ability of geraniol to penetrate into the skin. In general, geraniol is not able to penetrate skin easily.

Geraniol is colorless and has low water-solubility. However, it is soluble in common organic solvents.

Like citronellol, it is a natural insect repellent.

2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-

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Perfuming

Citral is the molecule responsible for the fresh lemon scent in lemon, lime, and lemongrass. It is a fragrance ingredient that can be created from plant essential oils or synthetically.

Though Citral has documented antimicrobial activity against acne bacteria (which is where the marketing claims about it being good for acne-prone skin originate), real formulas use it at fragrance-level concentrations under 1% so there's likely no skin benefit.

You should know this ingredient is a known EU fragrance allergen.

Animal studies classifies this ingredient as a weak-to-moderate skin sensitizer and clinical patch testing on eczema patients confirmed it to be both a contact allergen and irritant.

The term 'citral' is a collective term for two geometric isomers: geranial/Citral A and neral/Citral B.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.

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Where it's from

Centellian24 is a Korean brand

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50 SPF Rating

With an SPF rating of 50, this product protects against 98.0% of UVB rays

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· Updated April 27, 2026 Added by crescendolls