Versus

SKIN1004 Madagascar Centella Probio-Cica Intensive Ampoule Versus Numbuzin No. 2 Protein 43% Creamy Serum

Ampoule
Serum
Korean Brand South Korea
Korean Brand South Korea

Updated on January 27, 2025

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 13 ingredients in common

Cool Features

They both contain ceramides and niacinamide

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

What's Inside

They both contain oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside (and what isn't)

What's inside (and what isn't)

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Madagascar Centella Probio-Cica Intensive Ampoule

Centella Asiatica Extract

Cleansing
Helps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Water

Skin Conditioning

Propanediol

Solvent
Helps hydrate Dry Skin Icon
No. 2 Protein 43% Creamy Serum

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Smoothing

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Learn more about Niacinamide
Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservatives 
Skin Conditioning, Skin Protecting, Soothing

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

Some studies have shown this ingredient can promote wound healing with higher concentrations.

Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.

Learn more about Allantoin
Skin Conditioning

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Learn more about Panthenol
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Skin Conditioning

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine
Cleansing, Emulsifying, Emulsion Stabilising

Stearic Acid is a fatty acid. It is an emollient, emulsifier, and texture enhancer.

As an emollient, stearic acid helps soften skin. It aids the skin's protective barrier by preventing water loss. It also provides a gentle cleansing effect without stripping away natural oils.

Stearic acid may also be used to enhance the texture of products. It can add volume and stabilize ingredients such as water and oil. This can help water and oil ingredients from separating.

Sources of stearic acid include animal or vegetable fats/oils such as coconut or shea. It can be naturally found in butter, cocoa butter, shea butter, vegetable fats, and animal tallow.

This ingredient may not be Malassezia folliculitis, or fungal-acne safe.

Learn more about Stearic Acid
Skin Conditioning

Ceramide NP is a type of ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.

If you would like to eat ceramides, sweet potatoes contain a small amount.

Read more about other common types of ceramides here: Ceramide AP Ceramide EOP

Learn more about Ceramide NP
Humectant

Glucose is a simple sugar and is the most important source of energy in all organisms.

In skincare, glucose is used to hydrate the skin. It also acts as a prebiotic for our natural biome.

Glucose is hydrating due to its humectant property. As a humectant, glucose draws moisture from the air and from deeper levels in the skin.

Our skin contains many sugars that act as prebiotics and help strengthen our natural microbiome. Having a healthy microbiome helps protect our skin from harmful bacteria and other contaminants.

Studies show glucose may help with fading discoloration and pigmentation. This is because our skin metabolizes glucose into lactic acid. Lactic acid is an AHA that helps exfoliate the top layer of skin.

Learn more about Glucose
Cleansing, Emulsifying

Lauric Acid is a fatty acid or lipid. About half of fatty acids in coconut oil is lauric acid.

This ingredient helps hydrate and sooth skin. As a humectant, it helps trap moisture. It also aids in cleaning and enhancing the texture of products.

Lauric acid may not be Malassezia folliculitis, or fungal acne, safe.

Learn more about Lauric Acid

When to use

984 Routines
36% use in am
64% use in pm
90% use every day
When to use See routines that use it ->
59 Routines
46% use in am
54% use in pm
80% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

SKIN1004 Madagascar Centella Probio-Cica Intensive Ampoule 44 ingredients

4.3 /5
from 19 ratings
Works Well (14) Hydrating (13) Great Value (11)
Cheeks's avatar

Cheeks

5 months ago
Review

This has been my favourite barrier supporting ampoule/serum to date! My skin soaks this up I use this both am and pm (with a little more in the pm). I have dry, sensitive and rosacea prone skin and this hasn’t ever aggravated anything, no reactions, blends effortlessly and just gives me a hydrated glowy look! Love it! It’s a creamy ampoule but not super thick and just melts into the skin. It’s so Show more

#great value
#hydrating
#light
#absorbs well
m.evstigneev's avatar

M. Evstigneev

5 months ago
Review

Lovely texture and a good value. Unfortunately, my skin reacted violently to it, it was very irritating, especially around my cheekbones. It is ironic because it’s marketed as soothing and calming for sensitive skin, and I’m not even that sensitive. My suspicion is that I can’t tolerate fermented ingredients because it happened with some other fermented products as well.

#great value
#irritating
#light
#no scent

Numbuzin No. 2 Protein 43% Creamy Serum 45 ingredients

5.0 /5
from 2 ratings
Hydrating (2) Works Well (2) Absorbs Well (1)
CourtneyChristopher's avatar

CourtneyChristopher

9 months ago
Review

Gives a nice glossy finish to skin and keeps dry skin hydrated

#hydrating
#absorbs well
#works well
magalymajano's avatar

Magaly Majano

1 month ago
Review

Love how hydrated it leaves me. Very good for people on acne meds.

#hydrating
#light
#works well