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Product Comparison

Here's our complete breakdown comparing the ingredients, attributes, and more of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum versus Drunk Elephant Protini Polypeptide Cream .

Last updated on September 12, 2023. Published on April 19, 2021

Overview

What they are

These products are both reef safe . They have a total of 14 ingredients in common

Cool Features

They both contain hyaluronic acid, peptides and Vitamin E

Suited For

They're both likely to be good for dry skin and brightening skin

Free From

They both do not contain any harsh alcohols, common allergens or parabens

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that need an update? Let us know.

Serum American Brand United States
General Moisturizer American Brand United States

Serum

Serums are highly concentrated with ingredients to provide skin with benefits. They should be used after cleansing and before moisturizing.

General Moisturizer

All-purpose moisturizers hydrate the top layer of skin cells.

Price

Shop

Buy Peptide 21 Wrinkle Resist Serum

Starts at $57.95
Shop

Buy Protini Polypeptide Cream

Starts at $60.00

Ingredient Info

Click any item below to learn more and view relevant ingredients.
alcohol-free
silicon-free
fragrance-free
sulfate-free
paraben-free
oil-free
fungal-acne safe
reef-safe
eu-allergen-free
vegan
cruelty-free
alcohol-free
silicon-free
fragrance-free
sulfate-free
paraben-free
oil-free
fungal-acne safe
reef-safe
eu-allergen-free
vegan
cruelty-free

At a glance

Click on any of the items below to learn more

Notable Ingredients

Retinoid
Vitamin C
Vitamin E
Exfoliators
Hyaluronic Acid

Benefits

Hydrating (2)
Good For Oily Skin
Redness Reducing
Skin Texture (2)
Reduces Large Pores
Anti-Aging (2)
Dark Spots (2)
Scar Healing (2)
Acne Fighting
Brightening (3)

Concerns

Drying
May Worsen Oily Skin
Acne Trigger
Irritating
Rosacea
Eczema

Notable Ingredients

Vitamin E
Hyaluronic Acid
Peptides (9)

Benefits

Hydrating (2)
Brightening (2)

Concerns

May Worsen Oily Skin (2)
Acne Trigger (2)
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Ingredients Compared

Ingredients that are highlighted in purple are present in both products.

Ingredients Side-by-side

Ingredients that are highlighted in purple are present in both products.

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Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1
What it does: Skin Conditioning, Solvent
Community Rating: Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. Talk about multi-purpose! If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 1.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 1.

2
What it does: Humectant, Skin Conditioning, Skin Protecting, Solvent
Community Rating: Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 2.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 3.

3
What it does: Humectant, Masking, Skin Conditioning, Solvent
Community Rating: Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 7.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 37.

4
What it does: Skin Conditioning
Community Rating: Loved

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 19.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 17.

5
What it does: Skin Conditioning
Community Rating: Liked

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tripeptide-1 is a signal peptide. This means it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 24.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 18.

6
What it does: Humectant, Skin Conditioning
Community Rating: Loved

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 26.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 32.

7
What it does: Emollient, Emulsifying, Skin Conditioning
Community Rating: Disliked

Lecithin is a term for a group of substances found in plants, animals, and humans. They are made up of mixture of fatty acids. These fatty acids usually are a mixture of phosphoric acid's choline ester connected to stearic, oleic, and palmitic acids. Most lecithins are created from plant ingredients scuh as sunflower.

Lecithin is an emollient. Emollients help soften the skin and creates a barrier to keep moisture in.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can help ingredients be better absorbed by the skin. The phospholipids in Lecithin can produce liposomes. Liposomes help other ingredients get through the skin barrier.

Learn more about Lecithin

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 32.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 36.

8
What it does: Emulsifying
Community Rating: Very Disliked

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 36.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 44.

9
What it does: Emulsion Stabilising, Gel Forming
Community Rating: Disliked

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

Carbomer is commonly found in many types of cosmetics products. It is found to be safe in concentrations up to 15%. However, a high amount of carbomer can cause pilling or balling up of products. Most products contain 1% of less of carbomer.

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 42.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 43.

10
What it does: Buffering, Humectant
Community Rating: Liked

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and used to adjust the pH of a product.

Sodium Lactate is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin.

It also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

Our NMF is formed from amino acids, lactic acid, sugars, minerals, peptides, and electrolytes. As we age, our NMF naturally depletes. Other sources of NMF depletion include harsh and drying ingredients such as denatured alcohol. Sodium lactate can help replenish our NMF, leading to more hydrated and plump skin.

High percentages of Sodium Lactate can have an exfoliating effect.

Sodium Lactate is produced from fermented sugar.

Learn more about Sodium Lactate

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 44.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 39.

11
What it does: Emulsifying, Emulsion Stabilising, Gel Forming, Skin Conditioning
Community Rating: Disliked

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 46.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 48.

12
What it does: Emollient, Humectant, Skin Conditioning
Community Rating: Liked

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 53.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 51.

13
What it does: Masking, Preservative
Community Rating: Disliked

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

Sodium Benzoate is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Learn more about Sodium Benzoate

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 55.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 55.

14
What it does: Preservative
Community Rating: Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum contains this as ingredient number 56.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 53.

Here's what our community thinks of the ingredients in these two products.

50% are loved or liked
7% have mixed ratings
30% are disliked or very disliked
13% have no rating yet
50% are loved or liked
12% have mixed ratings
29% are disliked or very disliked
9% have no rating yet

Usage

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Reviews

Here's what our community thinks

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 56 ingredients

Peptide 21 Wrinkle Resist Serum hasn't been rated yet.
Rate it now

Drunk Elephant Protini Polypeptide Cream 58 ingredients

4.2 /5
from 11 reviews
sillygirl's Avatar'
Mar 2, 2024

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and i found that the 2 worked well with each other. it’s a really nice almost gel-like cream...

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and i found that the 2 worked well with each other. it’s a really nice almost gel-like cream texture with a light fragrance. i found it a little hard to blend while my face was still damp which is when i usually apply moisturizer. i don’t feel like it did much for my skin but moisturize it.. lol definitely wouldn’t pay $70 for it again

Expensive
Hydrating
Works Well
zankhaft's Avatar'
Dec 21, 2023

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight "chemical" smell that I tend to like. I love the pump as well. I use this when I need a...

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight "chemical" smell that I tend to like. I love the pump as well. I use this when I need a good hit of luxury.

Expensive
Hydrating
Light
Absorbs Well
Strong Scent
Works Well
screamadelica's Avatar'
Feb 12, 2023

i wish i didn’t like this
i just finished a free sample of this moisturizer, and i loved it. it wasn’t too thick or heavy at all, wore well under makeup, and didn’t pill.
it also costs $68 for a full size. while not entirely...

i wish i didn’t like this
i just finished a free sample of this moisturizer, and i loved it. it wasn’t too thick or heavy at all, wore well under makeup, and didn’t pill.
it also costs $68 for a full size. while not entirely non-justifiable like La Mer or something, it’s still quite costly. perhaps in the future i’ll bite the bullet on a full size.

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