Versus

Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Versus Murad Vitamin C Glycolic Brightening Serum

Serum
Serum
American Brand United States
American Brand United States

Updated on August 20, 2024

Overview

What they are

These products are both cruelty-free and reef safe serums. They have a total of 16 ingredients in common

Cool Features

They both contain exfoliants, Vitamin C and Vitamin E

Suited For

They're both likely to be good for anti aging, dry skin, brightening skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any common allergens, oils, parabens or sulfates

What's Inside

They both contain silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
25% Vitamin C + Glutathione Clinical Serum
Vitamin C Glycolic Brightening Serum

Water

Skin Conditioning

Glycolic Acid

Buffering
AHA IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin IconMay worsen Rosacea Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Caprylic/Capric Triglyceride

Masking

Dimethicone

Emollient
1 / 0 Silicon Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Antioxidant, Skin Conditioning

Tetrahexyldecyl Ascorbate (THD) is a stable and oil-soluble form of Vitamin C.

THD is special in that it has the ability to travel deeper into skin than traditional ascorbic acid while maintaining the same skin benefits (double win!).

Because it’s oil-soluble, THD dives deep into your skin’s fatty layers (think ceramides and cholesterol) to fight off the kind of free radicals that mess with your skin barrier. This makes it a great pair with water-based vitamin C (ascorbic acid) that mainly works on the surface.

Even at just 0.1%, THD is already showing great antioxidant activity. When used up to 2%, it helps keep your skin happy and calm, especially when it’s stressed from pollution or sun.

Want to fade dark spots or tackle hyperpigmentation? You’ll want 5% or more. Pairing it with brightening buddies like niacinamide or licorice root gives even better results. One study even used 30% THD with other brighteners and saw real results on stubborn discoloration, even in melasma-prone skin.

A note on THD: It’s has a slightly silky, oily texture and usually shows up colorless or pale yellow (though the exact shade can vary by supplier).

While you can sneak it into water-based formulas, it really shines when paired with silicones or oils, which help your skin soak it up better.

THD is pretty stable, but it’s still vulnerable to degradation like ascorbic acid. Too much light or heat (above 113°F / 45°C) can break it down over time. Go for dark and opaque packaging that keeps it safe and shady!

Read more about other types of Vitamin C:

Learn more about Tetrahexyldecyl Ascorbate
Emollient, Skin Conditioning, Skin Protecting

Dimethicone is a type of synthetic silicone created from natural materials such as quartz.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Learn more about Dimethicone
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Abrasive, Absorbent

Silica is a mineral naturally found in our skin. It helps to thicken and smooth the texture of a product. It also acts as an agent for other ingredients by increasing the absorption of other ingredients into the skin.

Silica is often used for absorption and can help reduce shine when products are applied. Silica occurs in naturally in materials like clay and sandstone, and it can also be produced synthetically.

Silica is present naturally within the skin during collagen production and when reducing inflammation.

Learn more about Silica
Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol

Glutathione is an antioxidant naturally found in our bodies. It is made up of three amino acids: glycine, cysteine, and glutamic acid.

As an antioxidant, it prevents oxidative damage to parts of our cell.

While glutathione is said to help with fading dark spots, the results from research are inconclusive. Further studies are needed. With that said, gluthatione has been shown to protect our skin from UV-B induced damage.

This ingredient is naturally occurring in plants, animals, fungi, and some bacteria.

Learn more about Glutathione
Emulsifying, Skin Conditioning, Solvent

Hexylene Glycol is a surfactant. Glycols are a class of alcohols. Hexylene Glycol is a surfactant and emulsifier.

As a surfactant, Hexylene Glycol helps gather dirt and oil on your skin to be washed away.

As an emulsifier, Hexylene Glycol helps keep water and oil together. This prevents them from separating in a product. Hexylene Glycol also thins out the texture of a product by lessening viscosity.

Hexylene Glycol has a small molecular weight.

Learn more about Hexylene Glycol
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Buffering, Humectant, Skin Conditioning

Urea is also called carbamide and is the diamide of carbonic acid. In cosmetics, urea is used to hydrate the skin. It also provides exfoliation in higher concentrations.

As a humectant, urea helps draw moisture from the air and from deep within the skin. This helps hydrate your skin. Studies show urea is an effective moisturizer for dry skin conditions. 40% urea is typical in medications for treating eczema and other skin conditions.

Urea has the strongest exfoliation effect in concentrations higher than 10%. It is a keratolytic agent, meaning it breaks down the keratin protein in the top layer of skin. This helps remove dead skin cells and flaking skin.

In medicine, urea has been shown to help increase the potency of other ingredients, such as fungal treatments.

Humans and animals use urea to metabolize nitrogen-containing compounds. Urea is highly soluble in water. Once dissolved, it is neither acidic nor alkaline.

Learn more about Urea
Masking, Skin Conditioning

This ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.

Learn more about Caprylic/Capric Triglyceride
Humectant, Moisturising

Trehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.

As a humectant, trehalose helps draw moisture from the air to your skin. This helps keep your skin hydrated.

Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.

In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.

Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.

Learn more about Trehalose
Antioxidant, Buffering, Masking

Ascorbic Acid is is pure Vitamin C. This form makes up the largest amount of vitamin C found naturally in our skin.

Not only is vitamin C great for your overall health and immune system, it also has plenty of benefits on your skin.

Vitamin C is best used for brightening skin. It improves dark spots, acne scars, and hyperpigmentation. This is because it blocks the process of skin darkening when exposed to UV.

Remember: Vitamin C should not replace sunscreen!

Your skin uses vitamin C to build collagen. Collagen is one key component in having a strong skin barrier and plump skin. Vitamin C also plays a role in regulating collagen, thus making it effective in improving wrinkles and fine lines.

Ascorbic acid shows potent antioxidant activity. As an antioxidant, it helps fight free-radicals. Free-radicals are molecules that may damage your skin cells. These antioxidants also protect skin against UV damage.

The best formulations include Vitamin E and/or ferulic acid. These two ingredients help stabilize and provide a boost in the benefits of ascorbic acid. This is because ascorbic acid becomes unstable when exposed to UV and air. In fact, you can tell your ascorbic acid has oxidized when it turns an orange-yellow color.

Ascorbic acid is generally compatible with other ingredients. However, using ascorbic acid with other active ingredients might cause irritation. Two ingredients: copper ions and benzoyl peroxide, will inactivate ascorbic acid completely.

Read more about other types of Vitamin C:

Foods rich with vitamin C include oranges, strawberries, broccoli, bell peppers, and more. When consuming Vitamin C, your skin receives a portion of the nutrients.

Learn more about Ascorbic Acid
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

When to use

113 Routines
81% use in am
19% use in pm
90% use every day
When to use See routines that use it ->
55 Routines
76% use in am
24% use in pm
87% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Paula's Choice 25% Vitamin C + Glutathione Clinical Serum 41 ingredients

25% Vitamin C + Glutathione Clinical Serum hasn't been rated yet.
Rate it now

Murad Vitamin C Glycolic Brightening Serum 53 ingredients

5.0 /5
from 1 rating
Absorbs Well (1) Expensive (1) Light (1)
Skincareforthewincare's avatar

Aileen

1 month ago
Review

So good! Perfect for combo skin. Definitely felt my face looked brighter and less dull.

#expensive
#light
#absorbs well
#light scent