Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Ingredients Explained
Updated on September 07, 2023 Submitted by RavenLee_123
Overview
What it is
Serum with 40 ingredients that contains exfoliants, Vitamin C and Vitamin E
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for anti aging, dry skin, brightening skin, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates
Fun facts
Paula's Choice is from United States. This product is used in 36 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
Ingredient List (40)
Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Oryza Sativa Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate, Tocopherol, Glutathione , Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract, Urea, Mannitol, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Phenoxyethanol
You should know
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Ingredient Info
Alcohol Free
This product is free of harsh alcohols 🎉
Contains Silicon
Ingredients in this product that are types of silicon:
Fragrance Free
This product is free of fragrances 🎉
Sulfate Free
This product is free of sulfates 🎉
Paraben Free
This product is free of parabens 🎉
Oil Free
This product is free of oils 🎉
Not Malassezia Safe
Ingredients in this product that are not malassezia safe:
Reef Safe
This product is free of ingredients that damage reefs 🎉
EU Allergen Free
This product is free of EU allergens 🎉
Non Vegan
This product is not vegan 😥
Cruelty Free
This product is cruelty-free 🎉
Ingredients Overview
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. Talk about multi-purpose! If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterTetrahexyldecyl Ascorbate is a form of Vitamin C.
Vitamin C helps reduce redness, improve skin texture, reduce the effects of aging, reduce the visibility of dark spots, and brighten skin.
Your skin uses Vitamin C to produce collagen and collagen production plays a role in having a strong skin barrier and having plump skin. As an antioxidant, Sodium Ascorbyl Phosphate also helps reduce the signs of aging such as fine-lines and wrinkles.
Studies show Tetrahexyldecyl Ascorbate is more stable when combined with stabilizing ingredients.
VItamin C helps brighten skin by blocking the process of skin darkening.
Read more about other types of Vitamin C:
Learn more about Tetrahexyldecyl AscorbateDimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.
Dimethicone has been found increase absorption in skin, boosting the benefits of other ingredients. While there is concern for the safety of dimethicone, the levels used in skincare are safe for use.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinC9-12 Alkane is synethically created using alkanes, or paraffins. It is added to products as a solvent. This means its main purpose is to help dissolve ingredients and create even texture.
Ascorbyl Glucoside is a stable form of Vitamin C. It is created by combining glucose from starch.
When applied to skin, Ascorbyl Glucoside turns into Ascorbic Acid.
Ascorbyl Glucoside is an antioxidant. Antioxidants help fight free-radicals, or molecules that may damage skin cells.
It can help to reduce redness, improve skin texture, reduce the effects of aging, reduce the visibility of dark spots, and brighten skin.
Read more about other types of Vitamin C:
Learn more about Ascorbyl GlucosideSilica is a mineral naturally found in our skin. It helps to thicken and smooth the texture of a product. It also acts as an agent for other ingredients by increasing the absorption of other ingredients into the skin.
Silica is often used for absorption and can help reduce shine when products are applied. Silica occurs in naturally in materials like clay and sandstone, and it can also be produced synthetically.
Silica is present naturally within the skin during collagen production and when reducing inflammation.
Learn more about SilicaPyrus Malus Fruit Extract is extract from Apples. Apples are rich in Vitamin C, sugars, and antioxidants.
The sugar in Apples are humectants and help hydrate the skin. On top of that, apples also contain some acids, such as malic acid. These acids may have a mild exfoliating effect.
Last, the phytochemicals found in apples are strong antioxidants. These antioxidants help with anti-aging as they protect your skin cells against oxidative damage.
Learn more about Pyrus Malus Fruit ExtractHydrogenated Lecithin is created from the hydrogenation of lecithin. Hydrogenation is a chemical reaction between molecule hydrogen and another element.
Hydrogenated Lecithin is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within.
The phospholipids in Hydrogenated Lecithin can produce liposomes. Liposomes help other ingredients get through the skin barrier to be better absorbed.
As an emulsifier, it prevents oil and water ingredients from separating.
Learn more about Hydrogenated LecithinPolyglyceryl-6 Polyricinoleate isn't fungal acne safe.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken and improve the texture of products.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is also an emulsifier. Due to its properties, it can prevent water and oil ingredients from separating.
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumOryza Sativa Bran Extract comes from the outer layer of a rice kernel. It is a byproduct of milling rice, or the operation to produce a whole grain rice product.
Oryza Sativa Bran Extract is moisturizing. This is due to its components of polysaccharides and omega-3 fatty acids. It also contains calcium, selenium, phosphorus, iron, and zinc.
Oryza Sativa Bran Extract contains numerous antioxidants such as ferulic acid. Antioxidants help fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material.
Learn more about Oryza Sativa Bran ExtractThis is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Cetyl Alcohol is not related to SD alcohol, denatured alcohol, or ethyl alcohol. The FDA allows products labeled "alcohol-free" to have fatty alcohols.
Its main roles are:
Learn more about Cetyl AlcoholCaprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolWe don't have a description for Lysine Carboxymethyl Cysteinate.
Coco-Caprylate is created from fatty coconut alcohol and caprylic acid.
It is a lightweight emollient. Emollients create a thin barrier on the skin to trap moisture in. This helps keep your skin hydrated and soft.
Once applied, Coco-Caprylate is absorbed quickly and leaves a silky feel. It may help solubilize other ingredients, or help other ingredients be dispersed evenly.
Coco-Caprylate may not be fungal acne safe.
Learn more about Coco-CaprylateTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolGlutathione is an antioxidant naturally found in our bodies. It is also naturally occurring in plants, animals, fungi, and some bacteria. As an antioxidant, Glutathione helps prevent oxidative damage to parts of our cell.
While Glutathione is said to help with skin lightening, the results from research are inconclusive. Further studies are needed.
Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.
Sodium Citrate helps maintain the pH of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Sodium Citrate is a chelating agent. It neutralizes metal ions from water and prevents them from binding to other ingredients. This ensures the other ingredients will not be altered.
Learn more about Sodium CitrateSodium Phytate is the synthetic salt form of phytic acid. Phytic acid is an antioxidant and can be found in plant seeds.
Sodium Phytate is a chelating agent. Chelating agents help prevent metals from binding to water. This helps stabilize the ingredients and the product.
Hexylene Glycol is a surfactant. Glycols are a class of alcohols. Hexylene Glycol is a surfactant and emulsifier.
As a surfactant, Hexylene Glycol helps gather dirt and oil on your skin to be washed away.
As an emulsifier, Hexylene Glycol helps keep water and oil together. This prevents them from separating in a product. Hexylene Glycol also thins out the texture of a product by lessening viscosity.
Hexylene Glycol has a small molecular weight.
Learn more about Hexylene GlycolEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Helianthus Annuus Seed Extract comes from sunflower seeds.
Sunflower seeds are rich in vitamin E. Studies show sunflowers contain antimicrobial and antioxidant properties.
The fatty acids found in sunflower seeds include (from highest amount to least): linoleic acid, myristic acid, palmitic acid, stearic acid, arachidic acid, oleic acid, and linolenic acid.
These fatty acids hydrate your skin. Emollients create a film on the skin to prevent moisture from escaping.
Learn more about Helianthus Annuus Seed ExtractUrea is also called carbamide and is the diamide of carbonic acid. In cosmetics, urea is used to hydrate the skin. It also provides exfoliation in higher concentrations.
As a humectant, urea helps draw moisture from the air and from deep within the skin. This helps hydrate your skin. Studies show urea is an effective moisturizer for dry skin conditions. 40% urea is typical in medications for treating eczema and other skin conditions.
Urea has the strongest exfoliation effect in concentrations higher than 10%. It is a keratolytic agent, meaning it breaks down the keratin protein in the top layer of skin. This helps remove dead skin cells and flaking skin.
In medicine, urea has been shown to help increase the potency of other ingredients, such as fungal treatments.
Humans and animals use urea to metabolize nitrogen-containing compounds. Urea is highly soluble in water. Once dissolved, it is neither acidic nor alkaline.
Learn more about UreaMannitol is a sugar alcohol. It is a humectant and moisturizes the skin. In vitro (not tested on a living organism), mannitol displays antioxidant properties.
When found in aqueous solutions, mannitol tends to become acidic. This is because it loses a hydrogen ion. This is why mannitol can often be found with pH adjusting ingredients, such as sodium bicarbonate.
Fun fact: Mannitol can be found in foods as a sweetener. It can be naturally found in mushrooms, algae, fruits, and veggies.
Learn more about MannitolCaprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
Within a product, Caprylic Triglyceride can thicken the product and make spreadability easier by dissolving clumping compounds. An added benefit of Caprylic Triglyceride is its antioxidant properties.
Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid. Caprylic Triglyceride has not been found to be toxic for human use in concentrations under 50%.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.
Learn more about Caprylic/Capric TriglycerideSodium PCA is the sodium salt of pyroglutamic acid and is naturally occurring on human skin.
The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.
Sodium PCA is a has conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.
Learn more about Sodium PCARosmarinus Officinalis Leaf Extract comes from rosemary. Rosemary is native to the Mediterranean.
While Rosmarinus Officinalis Leaf Oil can be volatile due to its fragrant properties, this component is usually removed in the leaf extract.
Rosemary Leaf Extract can help protect your skin against damage from free-radical molecules. It contains many antioxidants such as rosmarinic acid and caffeic acid. Rosemarinic acid has been found to help soothe skin conditions such as eczema and acne.
Learn more about Rosmarinus Officinalis Leaf ExtractPolysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.
As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.
Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.
Learn more about Sorbitan IsostearateTrehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.
As a humectant, trehalose helps draw moisture from the air to your skin. This helps keep your skin hydrated.
Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.
In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.
Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.
Learn more about TrehaloseAscorbic Acid is is pure Vitamin C. This form makes up the largest amount of vitamin C found naturally in our skin.
Not only is vitamin C great for your overall health and immune system, it also has plenty of benefits on your skin.
Vitamin C is best used for brightening skin. It improves dark spots, acne scars, and hyperpigmentation. This is because it blocks the process of skin darkening when exposed to UV.
Remember: Vitamin C should not replace sunscreen!
Your skin uses vitamin C to build collagen. Collagen is one key component in having a strong skin barrier and plump skin. Vitamin C also plays a role in regulating collagen, thus making it effective in improving wrinkles and fine lines.
Ascorbic acid shows potent antioxidant activity. As an antioxidant, it helps fight free-radicals. Free-radicals are molecules that may damage your skin cells. These antioxidants also protect skin against UV damage.
The best formulations include Vitamin E and/or ferulic acid. These two ingredients help stabilize and provide a boost in the benefits of ascorbic acid. This is because ascorbic acid becomes unstable when exposed to UV and air. In fact, you can tell your ascorbic acid has oxidized when it turns an orange-yellow color.
Ascorbic acid is generally compatible with other ingredients. However, using ascorbic acid with other active ingredients might cause irritation. Two ingredients: copper ions and benzoyl peroxide, will inactivate ascorbic acid completely.
Read more about other types of Vitamin C:
Foods rich with vitamin C include oranges, strawberries, broccoli, bell peppers, and more. When consuming Vitamin C, your skin receives a portion of the nutrients.
Learn more about Ascorbic AcidGlucose is a simple sugar and is the most important source of energy in all organisms. In skincare, glucose is used to hydrate the skin. It also acts as a prebiotic for our natural biome.
As a humectant, glucose draws moisture from the air and from deeper levels in the skin. This helps hydrate skin.
Our skin's natural microbiome contains many saccharides that act as prebiotics. These prebiotics help strengthen our skin's microbiome. Having a healthy microbiome helps protect our skin from harmful bacteria and other contaminants.
Studies show glucose may help with fading discoloration and pigmentation. This is because our skin metabolizes glucose into lactic acid. Lactic acid is an AHA that helps exfoliate the top layer of skin.
Plants and algae make glucose during the process of photosynthesis. It is then used to make cellulose, the building blocks of cell walls.
Learn more about GlucoseVanilla Planifolia Fruit Extract comes from the vanilla orchid native to central America. It is a skin-soothing ingredient.
This ingredient is skin-soothing and contains polyphenols that give it antioxidant properties.
This ingredient is not known to sensitize or irritate skin (unlike Vanilla Tahitensis).
Vanilla tahitensis has shown to irritate skin in low amounts!
Learn more about Vanilla Planifolia Fruit ExtractPolyquaternium-51 is a polymer salt. It helps hydrate the skin by creating a film on top. This film traps moisture in, keeping your skin soft and hydrated.
Triacetin comes from glycerin and acetic acid. It has antimicrobial properties.
Due to its ability to kill off microorganisms, it can help reduce odor caused by bacteria. Hence, it is a masking ingredient.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
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When to use
We've created a guide with info on when you should use Paula's Choice 25% Vitamin C + Glutathione Clinical Serum. We've also included some recommended products to use it with, as well as some routine inspiration!
Read our guide on when to use 25% Vitamin C + Glutathione Clinical Serum ->We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about usCompared With
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