Clinique Smart Night Clinical MD Multi-Dimensional Repair Treatment Retinol Versus RoC Retinol Correxion Deep Wrinkle Night Face Cream

It has the most scientific studies backing up its skin benefits out of all the non-prescription ingredients.

Retinol is proven to:

This is why retinol is effective at removing wrinkles, fading dark spots, treating acne, and reducing the appearance of pores.

Studies show retinol is less effective when exposed to UV. Be sure to look for appropriate packaging to keep your retinol potent (similar to Vitamin C).

Using retinol or any retinoids will increase sun-sensitivity in the first few months. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.

We recommend speaking with a medical professional about using this ingredient during pregnancy.

Retinol may cause irritation in some people, so be sure to patch test. Experts recommend 'ramping up' retinol use: start using this ingredient once a week and work up to using it daily.

Read about Tretinoin

Vitamin C is best used for brightening skin. It improves dark spots, acne scars, and hyperpigmentation. This is because it blocks the process of skin darkening when exposed to UV.

Remember: Vitamin C should not replace sunscreen!

Your skin uses vitamin C to build collagen. Collagen is one key component in having a strong skin barrier and plump skin. Vitamin C also plays a role in regulating collagen, thus making it effective in improving wrinkles and fine lines.

Ascorbic acid shows potent antioxidant activity. As an antioxidant, it helps fight free-radicals. Free-radicals are molecules that may damage your skin cells. These antioxidants also protect skin against UV damage.

The best formulations include Vitamin E and/or ferulic acid. These two ingredients help stabilize and provide a boost in the benefits of ascorbic acid. This is because ascorbic acid becomes unstable when exposed to UV and air. In fact, you can tell your ascorbic acid has oxidized when it turns an orange-yellow color.

Ascorbic acid is generally compatible with other ingredients. However, using ascorbic acid with other active ingredients might cause irritation. Two ingredients: copper ions and benzoyl peroxide, will inactivate ascorbic acid completely.

Read more about other types of Vitamin C:

Foods rich with vitamin C include oranges, strawberries, broccoli, bell peppers, and more. When consuming Vitamin C, your skin receives a portion of the nutrients.

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

As an emollient, it helps soften skin and supports barrier-replenishing ingredients.

In cosmetics, Glyceryl Stearate is often made from vegetable oils or synthetically produced.

This ingredient may not be fungal-acne safe

Fun fact: The human body also creates Glyceryl Stearate naturally.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.