Advanced Clinicals Complete 5-in-1 Eye Serum Versus Tula Skincare Instant De-Puff Eye Renewal Serum
Updated on April 14, 2025
Overview
What they are
These products are both cruelty-free and reef safe eye moisturizers. They have a total of 19 ingredients in common
Cool Features
They both contain exfoliants, hyaluronic acid, peptides, Vitamin C and Vitamin E
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any harsh alcohols, common allergens, parabens, silicones or sulfates
What's Inside
They both contain fragrances and oils
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Advanced Clinicals Complete 5-in-1 Eye Serum 45 ingredients
Tula Skincare Instant De-Puff Eye Renewal Serum 47 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Advanced Clinicals Complete 5-in-1 Eye Serum 45 ingredients
Tula Skincare Instant De-Puff Eye Renewal Serum 47 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningIsopropyl Myristate
Emollient
Pyrus Malus Fruit Extract
Skin Conditioning
Glycerin
Humectant
Hydrogenated Ethylhexyl Olivate
EmollientCetearyl Alcohol
Emollient
Retinol
Skin Conditioning
Aloe Barbadensis Leaf Juice
Skin Conditioning
Sodium Hyaluronate
Humectant
Dipotassium Glycyrrhizate
Humectant
Tocopherol
Antioxidant
Chlorella Vulgaris Extract
Skin Conditioning
Acetyl Hexapeptide-8
Humectant
Ferulic Acid
Antimicrobial
Colloidal Gold
AntimicrobialCaulerpa Lentillifera Extract
Chenopodium Quinoa Seed Extract
Skin ConditioningOryza Sativa Bran Extract
Skin Conditioning
Hydrogenated Olive Oil Unsaponifiables
Emollient
Daucus Carota Sativa Root Extract
Skin Conditioning
Glycine Max Seed Extract
Skin ConditioningOryza Sativa Extract
Absorbent
Panax Ginseng Root Extract
Emollient
Citrus Aurantium Dulcis Peel Extract
Emulsion Stabilising
Helianthus Annuus Extract
Emollient
Rosmarinus Officinalis Leaf Extract
AntimicrobialTocopheryl Acetate
Antioxidant
Aminopropyl Ascorbyl Phosphate
Antioxidant
Argania Spinosa Kernel Oil
Emollient
Cocos Nucifera Oil
Masking
Glycine Soja Oil
Emollient
Honey Extract
Humectant
Cyamopsis Tetragonoloba Gum
Emulsion StabilisingAvena Sativa Bran Extract
Abrasive
Pentylene Glycol
Skin ConditioningPolyurethane Crosspolymer-1
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Butylene Glycol
Humectant
Sodium Benzoate
Masking
Tetrasodium Glutamate Diacetate
Sodium Hydroxide
BufferingPhenoxyethanol
Preservative
Caprylyl Glycol
EmollientEthylhexylglycerin
Skin ConditioningHexylene Glycol
EmulsifyingWater, Isopropyl Myristate, Pyrus Malus Fruit Extract, Glycerin, Hydrogenated Ethylhexyl Olivate, Cetearyl Alcohol, Retinol, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Tocopherol, Chlorella Vulgaris Extract, Acetyl Hexapeptide-8, Ferulic Acid, Colloidal Gold, Caulerpa Lentillifera Extract, Chenopodium Quinoa Seed Extract, Oryza Sativa Bran Extract, Hydrogenated Olive Oil Unsaponifiables, Daucus Carota Sativa Root Extract, Glycine Max Seed Extract, Oryza Sativa Extract, Panax Ginseng Root Extract, Citrus Aurantium Dulcis Peel Extract, Helianthus Annuus Extract, Rosmarinus Officinalis Leaf Extract, Tocopheryl Acetate, Aminopropyl Ascorbyl Phosphate, Argania Spinosa Kernel Oil, Cocos Nucifera Oil, Glycine Soja Oil, Honey Extract, Cyamopsis Tetragonoloba Gum, Avena Sativa Bran Extract, Pentylene Glycol, Polyurethane Crosspolymer-1, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Butylene Glycol, Sodium Benzoate, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol
Water
Skin ConditioningCaprylic/Capric Triglyceride
Masking
Hydrogenated Ethylhexyl Olivate
EmollientGlycerin
Humectant
Butylene Glycol
Humectant
Cetearyl Alcohol
Emollient
Lactococcus Ferment Lysate
Skin ConditioningSodium Potassium Aluminum Silicate
Carthamus Tinctorius Seed Oil
Masking
Camelina Sativa Seed Oil
Skin Conditioning
Silybum Marianum Seed Oil
Skin Conditioning
Curcuma Longa Root Extract
Masking
Citrus Aurantium Dulcis Peel Extract
Emulsion Stabilising
Albizia Julibrissin Bark Extract
MaskingAvena Sativa Bran Extract
Abrasive
Camellia Sinensis Leaf Extract
Antimicrobial
Vaccinium Angustifolium Fruit Extract
Skin Protecting
Cichorium Intybus Root Extract
MaskingAlgae Extract
Emollient
Bacillus Ferment
Skin Conditioning
Olus Oil
Emollient
Hydrogenated Olive Oil Unsaponifiables
Emollient
Acetyl Hexapeptide-8
Humectant
Lactic Acid
Buffering
Yogurt Powder
Hydrolyzed Rice Protein
Skin ConditioningTocopheryl Acetate
Antioxidant
Ascorbyl Palmitate
Antioxidant
Darutoside
Skin ConditioningAmmonium Acryloyldimethyltaurate/Vp Copolymer
Silica
Abrasive
Xanthan Gum
EmulsifyingInulin
Skin ConditioningAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingSodium Hydroxide
BufferingCitric Acid
Buffering
Sodium Chloride
Masking
Sodium Hyaluronate
Humectant
Sorbic Acid
Preservative
Hexylene Glycol
EmulsifyingCaprylyl Glycol
EmollientEthylhexylglycerin
Skin ConditioningPentylene Glycol
Skin ConditioningSodium Benzoate
Masking
Potassium Sorbate
Preservative
Phenoxyethanol
Preservative
CI 77891
Cosmetic ColorantWater, Caprylic/Capric Triglyceride, Hydrogenated Ethylhexyl Olivate, Glycerin, Butylene Glycol, Cetearyl Alcohol, Lactococcus Ferment Lysate, Sodium Potassium Aluminum Silicate, Carthamus Tinctorius Seed Oil, Camelina Sativa Seed Oil, Silybum Marianum Seed Oil, Curcuma Longa Root Extract, Citrus Aurantium Dulcis Peel Extract, Albizia Julibrissin Bark Extract, Avena Sativa Bran Extract, Camellia Sinensis Leaf Extract, Vaccinium Angustifolium Fruit Extract, Cichorium Intybus Root Extract, Algae Extract, Bacillus Ferment, Olus Oil, Hydrogenated Olive Oil Unsaponifiables, Acetyl Hexapeptide-8, Lactic Acid, Yogurt Powder, Hydrolyzed Rice Protein, Tocopheryl Acetate, Ascorbyl Palmitate, Darutoside, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Silica, Xanthan Gum, Inulin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Citric Acid, Sodium Chloride, Sodium Hyaluronate, Sorbic Acid, Hexylene Glycol, Caprylyl Glycol, Ethylhexylglycerin, Pentylene Glycol, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol, CI 77891
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8, commonly known as Argireline, is a popular peptide in skincare. It’s often referred to as a “Botox-like” ingredient because it helps reduce muscle movement.
By relaxing these micro-movements, Argireline may help minimize the appearance of fine lines and wrinkles. That said, it’s not as powerful as Botox, and research on its long-term effectiveness is still limited.
Beyond smoothing, Argireline may also support collagen production. Collagen is the protein that helps keep your skin firm, bouncy, and well-hydrated by strengthening the skin barrier.
So while Argireline isn’t a miracle fix, it can be a helpful addition to a routine focused on both prevention and skin health.
Read more about other common types of peptides here:
Learn more about Acetyl Hexapeptide-8Ammonium Acryloyldimethyltaurate/Vp Copolymer (let's call it AAVC for short) is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
AAVC is able to increase the consistency and viscosity of products due to its large molecule size. It also prevents ingredients from separating.
Avena Sativa Bran Extract comes from oatmeal. The bran is the shell covering the oat.
This ingredient is an abrasive, meaning it exfoliates the top layer of your skin.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolCetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.
Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.
Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne.
Due to the fatty acid base, this ingredient may not be Malassezia folliculitis safe.
Learn more about Cetearyl AlcoholCitrus Aurantium Dulcis Peel Extract comes from the peels of the bitter orange. This orange is native to Southeast Asia. It is commonly used in foods such as marmalade.
Citrus peels are often made up of mainly limonene. Limonene is a fragrance with a citrus scent. They also contain flavonoids, which have anti-inflammatory properties.
Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHexylene Glycol is a surfactant. Glycols are a class of alcohols. Hexylene Glycol is a surfactant and emulsifier.
As a surfactant, Hexylene Glycol helps gather dirt and oil on your skin to be washed away.
As an emulsifier, Hexylene Glycol helps keep water and oil together. This prevents them from separating in a product. Hexylene Glycol also thins out the texture of a product by lessening viscosity.
Hexylene Glycol has a small molecular weight.
Learn more about Hexylene GlycolWe don't have a description for Hydrogenated Ethylhexyl Olivate yet.
Hydrogenated Olive Oil Unsaponifiables is an oil and isn't fungal acne safe.
Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateSodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterIngredient Ratings
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