Dr. Dennis Gross Skincare Alpha Beta® Pore Perfecting & Refining Serum
A serum with 55 ingredients, including AHA, BHA, and retinoid.
This pore-care serum is formulated around Mandelic Acid and Salicylic Acid to refine the look of pores and refine skin texture.
Worth noting
Contains EU-listed fragrance allergens, including Farnesol and Lavandula Angustifolia Extract.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningPropylene Glycol
HumectantEthoxydiglycol
HumectantGlycerin
HumectantPolysorbate 80
EmulsifyingButylene Glycol
HumectantMandelic Acid
AntimicrobialCarnitine Hcl
HumectantSalicylic Acid
MaskingFarnesol
PerfumingGlycolic Acid
BufferingLactic Acid
BufferingAdipic Acid
BufferingFomes Officinalis Extract
Skin ProtectingOpuntia Ficus-Indica Stem Extract
Skin ConditioningSalix Alba Bark Extract
AstringentPhytic Acid
Siraitia Grosvenorii Fruit Extract
Skin ConditioningHamamelis Virginiana Water
AstringentBisabolol
AntioxidantPentasodium Pentetate
Camellia Sinensis Leaf Extract
AntimicrobialHexylresorcinol
AntimicrobialQuercetin
AntioxidantTocopherol
AntioxidantSodium Hyaluronate
HumectantDimethyl Isosorbide
SolventPanthenol
Skin ConditioningUrea
BufferingIsopropyl Jojobate
EmollientJojoba Alcohol
EmollientJojoba Esters
EmollientRetinol
Skin ConditioningHydroxyethylcellulose
Emulsion StabilisingPolysorbate 20
EmulsifyingPotassium Hydroxide
BufferingOctoxynol-9
EmulsifyingCaprylic/Capric Triglyceride
MaskingCucumis Sativus Fruit Extract
EmollientPrunus Persica Fruit Extract
AbrasiveVaccinium Macrocarpon Fruit Extract
AstringentLavandula Angustifolia Extract
Skin ConditioningCitrus Aurantium Bergamia Fruit Extract
Skin ConditioningRose Extract
Skin ConditioningRosmarinus Officinalis Leaf Extract
AntimicrobialRubus Idaeus Fruit Extract
AstringentCitrus Limon Fruit Extract
MaskingTriethyl Citrate
MaskingFucus Vesiculosus Extract
EmollientJasminum Officinale Flower Extract
MaskingVanilla Planifolia Fruit Extract
Skin ConditioningCoriandrum Sativum Seed Extract
Skin ConditioningBenzoic Acid
MaskingPhenoxyethanol
PreservativeSodium Benzoate
MaskingWater, Propylene Glycol, Ethoxydiglycol, Glycerin, Polysorbate 80, Butylene Glycol, Mandelic Acid, Carnitine Hcl, Salicylic Acid, Farnesol, Glycolic Acid, Lactic Acid, Adipic Acid, Fomes Officinalis Extract, Opuntia Ficus-Indica Stem Extract, Salix Alba Bark Extract, Phytic Acid, Siraitia Grosvenorii Fruit Extract, Hamamelis Virginiana Water, Bisabolol, Pentasodium Pentetate, Camellia Sinensis Leaf Extract, Hexylresorcinol, Quercetin, Tocopherol, Sodium Hyaluronate, Dimethyl Isosorbide, Panthenol, Urea, Isopropyl Jojobate, Jojoba Alcohol, Jojoba Esters, Retinol, Hydroxyethylcellulose, Polysorbate 20, Potassium Hydroxide, Octoxynol-9, Caprylic/Capric Triglyceride, Cucumis Sativus Fruit Extract, Prunus Persica Fruit Extract, Vaccinium Macrocarpon Fruit Extract, Lavandula Angustifolia Extract, Citrus Aurantium Bergamia Fruit Extract, Rose Extract, Rosmarinus Officinalis Leaf Extract, Rubus Idaeus Fruit Extract, Citrus Limon Fruit Extract, Triethyl Citrate, Fucus Vesiculosus Extract, Jasminum Officinale Flower Extract, Vanilla Planifolia Fruit Extract, Coriandrum Sativum Seed Extract, Benzoic Acid, Phenoxyethanol, Sodium Benzoate
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterPropylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolEthoxydiglycol (aka Diethylene Glycol Monoethyl Ether) is one of the cosmetic world's quiet problem solvers.
In a formula, it is a solvent that dissolves tricky ingredients that don't want to mix in and helps spread ingredients evenly across your skin without leaving a greasy or sticky feeling
This makes it great for hard-to-dissolve actives like vitamin C, benzoyl peroxide, and self-tanner DHA.
It also has mild humectant and penetration enhancer abilities so it can help some actives absorb a little deeper.
The penetration boost is backed by lab research: studies using human skin samples found it improved how well an active dissolves into the upper layer of skin rather than tearing down your skin barrier. Reviews of its mechanism also describe it interacting gently with the lipids and water in your outermost layer of skin.
Just know this penetration-enhancing effect is not universal. It helps a lot in some formulas and did very little in others (so the benefit really depends on the specific product).
Safety-wise, the evidence is reassuring. The Cosmetic Ingredient Review Expert Panel reviewed it and concluded it's safe for use in cosmetics and recognized it as non-irritating, non-sensitizing, and non-comedogenic in skincare.
Typical leave-on skincare usage lands around 1-10%. The EU has sets caps of 2.6% in non-spray products, 10% in rinse-offs, 7% in oxidative hair dye, and 5% in non-oxidative hair dye.
Learn more about EthoxydiglycolGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPolysorbate 80 is a synthetic surfactant and emulsifier derived from sorbitol and oleic acid.
It reduces the surface tension between oil and water phases to help them stay mixed and stable in a formulation. In other words, it prevents your formulas from separating into an oily mess.
The CIR Expert Panel has evaluated the scientific data and found this ingredient to be safe, non-irritating, and non-sensitizing at concentrations up to 5% (it's even approved by the FDA as an OTC eye drop ingredient).
Learn more about Polysorbate 80Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolMandelic Acid is an alpha hydroxy acid (AHA).
Like other AHAs, it helps exfoliate the surface of the skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
Mandelic acid helps with:
Due to it having a larger molecular size than glycolic acid, mandelic acid is able to penetrate the skin more slowly and evenly. This makes it gentler and less irritating, making it a great option for sensitive or beginner skin.
Despite being milder, mandelic acid is still an effective exfoliant that improves skin texture and tone over time.
What makes mandelic acid stand out from other AHAs? It has antibacterial and antioxidant properties.
These traits make it a great option for acne-prone or problem skin by reducing active breakouts and fading post-acne marks. Studies show that mandelic acid (especially when combined with salicylic acid) can significantly reduce pimples and hyperpigmentation while causing fewer side effects than stronger acids.
Mandelic acid is effective in concentrations of 5% and up with an ideal pH range of 3-4 for at-home use.
Like other AHAs, it’s important to wear sunscreen daily to protect your newly exfoliated skin.
However, unlike glycolic acid, mandelic acid is light-sensitive. Be sure your mandelic acid is packaged in opaque containers to ensure it stays stable and effective.
In short, mandelic acid is a gentle yet powerful AHA that exfoliates, brightens, and helps clarify skin while keeping irritation low. Its antibacterial action makes it especially beneficial for those with acne-prone, sensitive, or uneven skin, offering smoother, clearer, and more even-toned results over time.
Read more about some other popular AHA's here:
Learn more about Mandelic AcidWe don't have a description for Carnitine Hcl yet.
Salicylic Acid (also known as beta hydroxy acid or BHA) is a well-known ingredient for treating skin that struggles with acne and clogged pores. It exfoliates both the skin's surface and deep within the pores to help clear out buildup, control oil, and reduce inflammation.
Unlike AHAs (alpha hydroxy acids), salicylic acid is oil-soluble. This allows it to penetrate into pores which makes it especially effective for treating blackheads and preventing future breakouts.
Salicylic acid is also known for its soothing properties. It has a similar structure to aspirin and can calm inflamed or irritated skin, making it a good option for acne-prone skin that is also sensitive.
Concentrations of 0.5-2% are recognized by the U.S. FDA as an over-the-counter topical acne product.
It can cause irritation and/or dryness if one's skin already has a compromised moisture barrier, so it's best to focus on repairing that before introducing this ingredient into your routine.
While salicylic acid does not increase sun sensitivity, it’s still important to wear sunscreen daily to protect your skin.
If you are looking for the ingredient called BHA or Butylated Hydroxyanisole, click here.
Learn more about Salicylic AcidFarnesol is a compound extracted from essential oils such as lemongrass, rose, and more. It is used as a fragrance in products to help boost floral scents.
Farnesol is a known EU allergen and causes contact dermatitis.
This ingredient is hydrophobic, meaning it is not soluble in water.
Learn more about FarnesolGlycolic Acid is arguably the most famous alpha hydroxy acid (AHA) with tons of research backing its benefits.
It is found naturally in sugar cane but the form used in skincare is usually synthetic for purity and stability.
Glycolic acid removes the top layer of dead skin cells to allow newer and fresher ones to emerge.
AHAs work by breaking down the structural “glue” that holds old skin cells in place. When that buildup is gone, your skin can renew itself more efficiently.
Research also shows glycolic acid stimulates collagen production, helping to firm and thicken the skin over time. This is one of its biggest advantages over other AHAs.
Overall, glycolic acid helps with:
Fun fact: Glycolic acid boosts skin hydration by helping it produce molecules that increase hyaluronic acid naturally.
To work best, glycolic acid products should have a pH between 3-4 (that’s where exfoliation is most effective but still gentle on skin).
The pH and concentration of a product are key to its effectiveness:
It is normal to feel a slight stinging sensation when using glycolic acid. This usually fades as your skin adjusts.
Because glycolic acid has the smallest molecular size in the AHA family, it can penetrate deeper, which enhances its effectiveness but also makes it more likely to irritate sensitive skin.
If your skin is very sensitive or prone to rosacea, glycolic acid may be too strong; in that case, try milder options like lactic acid or a PHA instead.
Recent studies suggest glycolic acid might even help protect against UV damage. But don’t skip sunscreen! Freshly exfoliated skin is more sensitive to the sun.
Glycolic acid is a skincare superstar. It smooths, brightens, hydrates, and firms the skin. Unless you’re highly sensitive, it’s well worth adding to your routine.
Read more about some other popular AHA's here:
Learn more about Glycolic AcidLactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.
Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.
Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.
Like glycolic acid, it can:
Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.
Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.
To get results, choose products with a pH between 3-4.
Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.
Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.
When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.
Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.
Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.
Read more about some other popular AHA's here:
Learn more about Lactic AcidAdipic Acid is an organic dicarboxylic acid. It is used for pH adjustment and masking.
Many ingredients depend on a specific pH range in order to be effective.
As a masking ingredient, adipic acid is used to obscure or block properties of other ingredients. They are commonly used to block the scent of a product.
Learn more about Adipic AcidWe don't have a description for Fomes Officinalis Extract yet.
This ingredient comes from the stem of the Prickly Pear cactus. The stem is rich in polyphenols, a potent source of antioxidants. It is anti-aging and soothing properties.
Prickly Pear stem is made up mostly of water (85%). The rest is composed of skin nourishing compounds: protein, fiber, fatty acid, simple sugars, Vitamin C, and some minerals.
Polyphenols help mitigate the effects of aging. Studies show polyphenols protect the skin from oxidative stress, UV-induced damage, and inflammation.
Prickly pear is often compared to Aloe.
Learn more about Opuntia Ficus-Indica Stem ExtractSalix Alba Bark Extract comes from the bark of the white willow tree. The official CosIng listing states this ingredient to have astringent, skin conditioning, soothing, and tonic properties.
Its star compound is salicin, a natural glucoside that is chemically related to salicylic acid. That's why you'll often see it marketed as a "natural BHA alternative" but that's a bit of a stretch.
Your skin can't convert salicin to salicylic acid because it needs specific enzymes that aren't present on the skin's surface. It won't behave like true salicylic acid, especially at the concentrations used in cosmetics.
However, this ingredient has its own perks. It contains flavonoids, polyphenols, and tannins that give it proven antioxidant and soothing properties.
An 8-week clinical study found a cream with 2% of this extract improved skin microcirculation, elasticity, and dark circles. This is most likely due to its role in increasing hyaluronic acid synthesis in fibroblasts and improved vascular integrity.
Another study found a topical serum with 0.5% salicin showed improvements in visible signs of aging, hyperpigmentation, and texture.
Just be careful if you have a known aspirin/salicylate allergy and be sure to consult with a medical professional about using this ingredient if you do.
Fun fact: Willow Bark extract has been used for thousands of years and ancient civilizations used white willow to help treat pain and fevers.
Learn more about Salix Alba Bark ExtractPhytic Acid is a gentle AHA and antioxidant. AHAs are chemical exfoliants that help remove dead skin cells. Phytic Acid has a slight and mild exfoliating effect.
The chemical makeup makes it classified as an AHA, much like lactic acid.
In some cases, it is a chelating agent. Chelating agents help prevent metals from binding to water, helping to stabilize the ingredients in a product.
An interesting fact about phytic acid is that it is considered an antinutrient. People do not have the enzyme needed to properly breakdown and digest phytic acid. When ingested, phytic acid binds to minerals and prevents them from being absorbed.
Read more about some other popular AHA's here:
Learn more about Phytic AcidWe don't have a description for Siraitia Grosvenorii Fruit Extract yet.
Hamamelis Virginiana Water is made by distilling parts of the witch hazel plant. You can also call this ingredient "witch hazel water".
The name 'Hamamelis Virginiana Water' refers to the distillation product used in cosmetics. On the other hand, 'Witch Hazel' refers to the active drug ingredient.
Unless it is specified to be non-alcohol, many types of witch hazel ingredients are distilled in denatured alcohol.
Witch Hazel water is an astringent, anti-inflammatory antioxidant, and antibacterial ingredient.
It contains tannins. Tannins have a drying effect when used on skin by constricting proteins. The constriction also minimizes the appearance of pores.
Both the tannins and fragrance found in witch hazel may be skin-sensitizing.
Witch hazel water gets anti-inflammatory and antibacterial properties from its catechin and gallic acid content.
Indigenous groups have used witch hazel to help treat inflammation in North America for centuries.
Learn more about Hamamelis Virginiana WaterBisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Learn more about BisabololWe don't have a description for Pentasodium Pentetate yet.
Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.
Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.
Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.
In lab-grown skin models, this translated to younger, healthier, and stronger skin.
There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.
Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.
A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.
The quality of the extract matters a lot here:
Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.
Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).
Learn more about Camellia Sinensis Leaf ExtractAnother popular name for this ingredient is Synovea HR. This ingredient is a skin lightener and antioxidant.
Like other skin lighteners, it blocks the process of skin darkening. Specifically, this ingredient blocks tyrosinase, the enzyme responsible for darkening skin when exposed to UV.
Hexylresorcinol works well with other ingredients. Studies show this ingredient boosts the effect of niacinamide, various forms of vitamin C, and retinoids.
Many consider this to be a safer alternative to hydroquinone. In fact, this ingredient produces the same results as hydroquinone in lower amounts.
Fun fact: This ingredient can also be found food and medicine for treating skin infections.
Gentle reminder from SkinSort: all skin tones are beautiful!
Learn more about HexylresorcinolQuercetin is a polyphenol flavonoid that can be naturally found in plants like apples, onions, berries, and broccoli. It has antioxidant and skin soothing properties.
The anti-inflammatory research for this ingredient is pretty solid:
It also looks promising for anti-aging; it activates pathways tied to cellular "youthfulness" by helping the cells that produce collagen and elastin do their job better. It also switches on the "longevity" gene that keeps cells acting young.
As of right now, most of the anti-aging research has been done on animals or cells in petri dishes, but there's no harm in trying this ingredient in your routine.
Another cool perk of this ingredient?
It does a great job stabilizing the chemical UV filters avobenzone and octinoxate against sun degradation. One study found it outperformed both tocopherol and octocrylene as a photostabilizer.
The only downside (if you can even call it that) is that quercetin doesn't dissolve well in water and cannot penetrate skin easily on its own. This just means formulators pair it with delivery systems to actually get it into skin.
There is some recent buzz about this ingredient having brightening effects, but the research hasn't backed this up.
Learn more about QuercetinTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateDimethyl Isosorbide (often shortened to DMI) is a sugar-derived solvent made from sorbitol. It's used to dissolve tricky ingredients and help them mix smoothly into a formula.
Many actives sit as gritty crystals when undissolved, so DMI swoops in to full dissolve them. This helps improve texture, stability, and how evenly an active is distributed.
It does have a penetration-enhancing reputation that is a bit more nuanced than marketing suggests; a cell study on human skin found that 10% DMI didn't significantly boost the permeation of Hydroquinone, Salicylic Acid, or Octadecenedioic Acid compared to controls (though it did improve their solubility in the formula itself).
Typical usage concentrations usually range from 1-10% depending on the formula's needs; this ingredient is also well tolerated at these levels.
Learn more about Dimethyl IsosorbidePanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolUrea is also called carbamide and is the diamide of carbonic acid. In cosmetics, urea is used to hydrate the skin. It also provides exfoliation in higher concentrations.
As a humectant, urea helps draw moisture from the air and from deep within the skin. This helps hydrate your skin. Studies show urea is an effective moisturizer for dry skin conditions. 40% urea is typical in medications for treating eczema and other skin conditions.
Urea has the strongest exfoliation effect in concentrations higher than 10%. It is a keratolytic agent, meaning it breaks down the keratin protein in the top layer of skin. This helps remove dead skin cells and flaking skin.
In medicine, urea has been shown to help increase the potency of other ingredients, such as fungal treatments.
Humans and animals use urea to metabolize nitrogen-containing compounds. Urea is highly soluble in water. Once dissolved, it is neither acidic nor alkaline.
Urea is actually one of the more well-studied and well-supported ingredients out there if you have eczema.
Clinical trials have shown that urea creams in the 5 - 10% range can:
Higher concentrations (20 -30%) can also help with thickened, scaly patches but is also more likely to sting on active flares.
Skip urea if you have rosacea. The AAD (American Academy of Dermatology) lists it alongside alcohol, menthol, and fragrance as a potential irritant for rosacea-prone skin. Urea's keratolytic and penetration-enhancing properties can trigger stinging, burning, and redness.
As always, your skin is unique, so definitely check in with your dermatologist.
Learn more about UreaWe don't have a description for Isopropyl Jojobate yet.
Jojoba Alcohol is a fatty alcohol.
Jojoba Esters is a wax created from Jojoba oil. It is an emollient and film-forming ingredient. In bead form, it is an exfoliator.
This ingredient has high oxidative stability, meaning it doesn't break down when exposed to oxygen.
Its similarity to our skin's natural oils makes it a great emollient. Emollients help soften and soothe our skin by creating a barrier on top. This barrier helps trap moisture in, keeping skin hydrated.
It is created using either the hydrogenation or transesterification processes on jojoba oil.
Learn more about Jojoba EstersRetinol is one of the most studied anti-aging ingredients in skincare (and for good reason!).
It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells.
That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid.
Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process.
Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family.
Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid.
Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating.
The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle spot. It's more effective than the esters, gentler than prescription options.
Once it becomes Retinoic Acid, it binds to receptors inside your cells' nuclei (called RARs and RXRs). These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off.
In practice, this means a few things happen in a formula. It:
That last two are worth a closer look.
A study that tested Retinol directly (not just prescription Retinoic Acid) found that four weeks of retinol thickened the epidermis and switched on the genes for Collagen I and Collagen III, with more procollagen I and III showing up in the skin. And after twelve weeks, facial wrinkles were visibly reduced.
Retinoids more broadly stimulate the skin's synthesis of hyaluronan and other glycosaminoglycans, part of what gives skin a plumper, more hydrated look over time.
So even the gentler OTC form is doing real structural work (not just sitting on the surface).
It's also worth knowing Retinol isn't only a wrinkle ingredient; it can help with uneven tone, dark spots, rough texture, and the look of pores as well because it speeds up turnover and influences pigment.
The research backs this up as well.
A pooled analysis of six clinical studies found that 0.1% stabilized retinol improved all signs of photoaging versus vehicle as early as week 4 and through 12 weeks, with only a few mild cases of irritation.
Another study comparing concentrations found that 0.3% and 1% Retinol were similarly effective at remodeling photodamaged skin, but 0.3% caused fewer adverse reactions when used daily (a useful reminder that more isn't always better).
Retinol is about tenfold less potent than Retinoic Acid. This is why it works as a gentler, non-prescription option that builds results over time.
Typical concentrations range from 0.1-1%, with 0.1% to 0.3% being a well-supported sweet spot for visible benefits with good tolerability.
One quirk worth mentioning: Retinol is famously unstable.
It's highly sensitive to light and oxygen, and UV exposure breaks it down into a range of degradation products.
Real-world testing bears this out, with retinoid content in some products dropping anywhere from 0% to 80% after six months at room temperature, and even more at higher temperatures.
This is why good formulations lean on opaque, air-tight packaging (think tubes and pumps, not clear jars) and often "encapsulate" the Retinol to shield it.
Signs of oxidation include your product turning yellow or smelling "off". Keeping it somewhere cool and dark, and using it up within a few months of opening helps it stay effective.
The most common side effects are mild and temporary: usually some dryness, redness, or light peeling as your skin adjusts. These tend to settle with consistent and lower-frequency use.
Like all retinoids, Retinol works best with nightly use, a good moisturizer, and daytime sunscreen.
The "ramp up" method works well: start with Retinol once a week to give your skin time to adjust, which keeps irritation low. Slowly add more nights until you reach your goal frequency once your skin feels comfortable.
Retinoids also make your skin more sensitive to the sun in the first few weeks, so wear sunscreen every morning and protect your skin from direct sun while you build up tolerance.
One safety note: topical Retinoids aren't recommended during pregnancy or breastfeeding. Systemic absorption from creams is low but because high oral vitamin A is a known teratogen and topical safety data are limited, most clinicians recommend stopping retinoids when pregnant or trying to conceive.
Learn more about RetinolHydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.
This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.
This ingredient can also be found in pill medicines to help our bodies digest other ingredients.
Learn more about HydroxyethylcellulosePolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Potassium hydroxide is commonly known as caustic potash. It is used to fix the pH of a product or as a cleaning agent in soap. In cleansers, it is used for the saponification of oils.
Sapnification is the process of creating fatty acid metal salts from triglycerides and a strong base. During this process, Potassium Hydroxide is used up and is not present in the final product.
Using high concentrations of Potassium Hydroxide have shown to irritate the skin.
Learn more about Potassium HydroxideOctoxynol-9 are part of a group called ethoxylated alkyl phenols. Octoxynols are usually found in hair-coloring products.
As an emulsifier, it helps keep other ingredients together.
The 9 stands for the average number of ethylene oxide units used to create this ingredient.
Learn more about Octoxynol-9Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Learn more about Caprylic/Capric TriglycerideThis extract comes from cucumber. Cucumbers are mostly made up of water (95%), and the other 5% is composed of: vitamin C, caffeic acid, fatty acids, amino acids, and other minerals.
Cucumbers have anti-inflammatory, barrier repair, and hydrating properties.
They contain shikimate dehydrigenase, an enzyme shown to help reduce inflammation and soothe the skin.
The amino acids found in cucumbers help nourish our skin's natural acid mantle (it's an important part of our skin barrier). This slightly acidic film acts as a barrier to protect us from bacteria, viruses, and other contaminants.
Unless you have an allergy to cucumbers, this is generally a non-irritating ingredient.
Fun fact: Cucumis Sativus is native to South Asia and can now be found on every continent.
Learn more about Cucumis Sativus Fruit ExtractPrunus Persica Fruit Extract comes from peaches.
Peaches are rich in antioxidants, such as Vitamins C, E and A. Antioxidants help reduce the signs of aging. These vitamins also have plenty of skin benefits on their own (for instance, Vitamin C, E helps with skin brightening).
Peach extract is also an abrasive. Abrasives are an agent used to wear away the surface of skin. They are used to help polish or exfoliate skin.
Emerging research shows Peach extract may help protect UV-B induced skin damage. However, further research is needed.
Learn more about Prunus Persica Fruit ExtractVaccinium Macrocarpon Fruit Extract comes from the cranberry fruit. Vaccinium Macrocarpon is the North American species of cranberries native to eastern Canada.
As an astringent, cranberry extract helps tighten the pores by constricting the cells.
Cranberries contain Vitamin E and Vitamin C, both potent antioxidants. It also contains minerals such as manganese and copper.
Learn more about Vaccinium Macrocarpon Fruit ExtractLavandula Angustifolia Extract comes from the flowers and leaves of the lavender plant. It's mostly used in skincare for its scent plus a bit of skin conditioning properties.
Lab research credits it with soothing, antioxidant, and wound-supporting effects. This is largely thanks to a compound called rosmarinic acid.
Rosmarinic acid has been shown to calm inflammation signaling in skin cells (the same pathways that flare up in conditions like eczema and psoriasis). It also has real antimicrobial and antifungal activity in test-tube studies.
This ingredient is typically used in low concentrations (generally well under 1%) where it acts as a light fragrance + mild skin soother extract.
The main thing to know is that lavender contains two naturally fragrant molecules: Linalool and Linalyl Acetate. Some people's skin does perfectly fine with fragrance while others don't.
Just be sure to patch test if you have reactive skin or known plant allergies.
Linalool and Linalyl Acetate are gentle when fresh but oxidize into compounds that can cause allergic contact dermatitis when exposed to air. Patch-test studies of patients already being investigated for skin allergies found about 5-7% of patients had reactions to oxidized linalool, and 2.8% of patients reacted to oxidized lavender oil.
Learn more about Lavandula Angustifolia ExtractCitrus Aurantium Bergamia Fruit Extract comes from the bergamot orange.
Bergamot oranges contain antioxidants, dietary fiber, vitamins such as Vitamin C, and minerals.
Rose extract comes from various species of the Rosa genus. It has skin conditioning and antioxidant properties due to its polyphenol, flavonoid, and phenolic acid content.
Rosa damascena, Rosa centifolia, and Rosa gallica.
Just keep in mind that rose extracts contain known fragrance allergens like citronellol, geraniol, linalool, and limonene.
Learn more about Rose ExtractThis is a botanical extract from the rosemary plant (the same one you cook with). In skincare, it mostly works as a skin conditioning agent.
Its activity comes from a handful of polyphenols, carnosic acid, carnosol, and rosmarinic acid. Almost 90% of the antioxidant activity of this ingredient can be attributed to canosol and carnosic acid.
These compounds protect your skin two ways:
1) They fight off free radicals, or the unstable molecules from things like sun and pollution that age and damage skin.
2) They help calm inflammation by switching off the chemical signals that tell skin to get red and irritated.
Lab studies also suggest that rosmarinic acid may help protect collagen and slow sugar-related damage to it.
The Cosmetic Ingredient Review has concluded rosemary-derived ingredients to be safe when formulated to be non-sensitizing.
Rosemary can occasionally cause allergic contact dermatitis (due to carnosol), so be sure to patch test if you have reactive or fragrance-sensitive skin.
Learn more about Rosmarinus Officinalis Leaf ExtractWe don't have a description for Rubus Idaeus Fruit Extract yet.
Citrus Limon Fruit Extract comes from lemons. While lemon extract is exfoliating and antimicrobial, it can also cause skin sensitivity.
Lemons contains antioxidants, which may help with anti-aging. They are also rich in citric acid, an AHA.
And of course, lemons are rich in Vitamin C. Vitamin C helps with skin-brightening and increasing collagen production.
The acidity of lemons may work as an astringent for acne.
However, lemons can also cause skin sensitivity due to its limonene content. It can also increase photosensitivity, or sensitivity to the sun.
This ingredient is also used to add a lemon scent to products.
Learn more about Citrus Limon Fruit ExtractTriethyl Citrate comes from citric acid. It has masking, perfuming, and solvent properties. As a solvent, this ingredient helps disperse ingredients evenly in skincare.
One manufacturer claims this ingredient can:
According to perfume manufacturers, this ingredient is almost odorless but has a mild fruity, wine and plum scent. It can be used to mask the scent of other ingredients.
This ingredient can be plant-sourced or synthetic; it can naturally be found in cabbage and white wine.
Learn more about Triethyl CitrateFucus Vesiculosus Extract is derived from a type of brown algae.
Algae is an informal term for a group of aquatic organisms that can photosynthesize. It is estimated there are at least 30,000 types of Algae.
Fucus Vesiculosus Extract contains antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
Fucus Vesiculosus Extract is also rich in sodium, potassium, and amino acids.
Many different types of algae have different benefits.
Learn more about Fucus Vesiculosus ExtractJasmine flower extract is a fragrance. The flower also has antioxidant and antimicrobial properties.
The antioxidant activity in Jasmine comes from flavonoids - a compound found in many plants. While antioxidants are great - Jasmine flowers also contain coumarin, a known EU allergen.
This ingredient can also help mask unpleasant scents from other ingredients.
Learn more about Jasminum Officinale Flower ExtractVanilla Planifolia Fruit Extract comes from the vanilla orchid native to central America. It is a skin-soothing ingredient.
This ingredient is skin-soothing and contains polyphenols that give it antioxidant properties.
This ingredient is not known to sensitize or irritate skin (unlike Vanilla Tahitensis). Vanilla tahitensis has shown to irritate skin in low amounts.
Learn more about Vanilla Planifolia Fruit ExtractCoriander seed is rich in fatty acids and minerals such as calcium, selenium, iron, magnesium, and manganese.
Benzoic Acid is an organic acid that shows up in cosmetics as a preservative. It helps keep a product from spoiling by holding back the growth of yeast, mold, and some bacteria.
This ingredient also functions as a fragrance ingredient that helps mask the unpleasant scent of other ingredients.
The way it works is worth understanding; benzoic acid works when the formula is acidic. It is able to sneak into a microbe's cell and mess up how it functions to stop it from growing in an acidic product.
However, the acid switches to an inactive form and stops working if a product isn't acidic enough (above ~5 pH). This is why you'll often see it in low pH products or teamed up with other preservatives to cover the gap.
Safety wise, it's one of the better studied preservatives out there.
The Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe for use in cosmetic formulations at concentrations up to 5%.
A large international review found this ingredient had no effects on the human body and had low irritation potential.
Just so you know, real world use is usually much lower than the 5% ceiling (usually 1% of less).
The EU caps it at 2.5% in rinse-off products, 1.7% in oral care, and 0.5% in leave-on products.
One thing worth mentioning (it's nothing to worry about): some people get a little stinging or flushing where they apply it. This isn't a true allergy; it's a temporary and harmless reaction. This is the same kind of mild tingle you might notice from sorbic acid.
Learn more about Benzoic AcidPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateReviews
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Read more about us· Published October 3, 2021 • Added by mkmiller1