Bielenda Supremelab Time-Resist Extra Lifting Cream
A moisturizer with 68 ingredients, including vitamin C, vitamin E, and hyaluronic acid.
This anti-aging moisturizer is formulated around Squalane and Carnosine to soften the look of wrinkles and hydrate skin.
Worth noting
Contains EU-listed fragrance allergens, including Tetramethyl Acetyloctahydronaphthalenes and Linalyl Acetate.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningGlycerin
HumectantPolyglyceryl-3 Methylglucose Distearate
EmulsifyingSqualane
EmollientPrunus Amygdalus Dulcis Oil
Skin ConditioningCoco-Caprylate/Caprate
EmollientPentaerythrityl Tetraethylhexanoate
EmollientTripelargonin
EmollientCetyl Alcohol
EmollientDimethicone
EmollientGlyceryl Glucoside
HumectantButylene Glycol
HumectantHydrolyzed Soy Protein
HumectantAminobutyric Acid
Caesalpinia Spinosa Fruit Extract
Skin ProtectingHydrolyzed Glycosaminoglycans
HumectantDipalmitoyl Hydroxyproline
Skin ConditioningCarnosine
Skin ConditioningKappaphycus Alvarezii Extract
Skin ConditioningLactobacillus Ferment
Skin ConditioningHydroxypropyl Cyclodextrin
MaskingMethylsilanol Mannuronate
Skin ConditioningPolyglutamic Acid
Skin ConditioningSodium Hyaluronate Crosspolymer
HumectantCaprylyl Glycol
EmollientBeta-Sitosterol
Emulsion StabilisingAcetyl Dipeptide-1 Cetyl Ester
Skin ConditioningHyaluronic Acid
HumectantSh-Polypeptide-69
Skin ProtectingN-Prolyl Palmitoyl Tripeptide-56 Acetate
Skin ConditioningSodium Hyaluronate
HumectantAcetyl Hexapeptide-8
HumectantPalmitoyl Tripeptide-38
Skin ConditioningSodium DNA
Skin ConditioningPalmitoyl Tripeptide-5
Skin ConditioningEthylhexyl Hydroxystearate
EmollientEthylhexyl Palmitate
EmollientEthylhexyl Stearate
EmollientGlycine Soja Oil
EmollientPalmitic Acid
EmollientSqualene
EmollientPolysorbate 60
EmulsifyingSorbitan Isostearate
EmulsifyingSorbitan Laurate
EmulsifyingPolyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate
EmulsifyingSodium Isostearate
CleansingAcacia Senegal Gum
MaskingHydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingPullulan
Xanthan Gum
EmulsifyingPolysilicone-11
Pentylene Glycol
Skin ConditioningAscorbyl Palmitate
AntioxidantTocopherol
AntioxidantSilica Dimethyl Silylate
EmollientHydroxyethylcellulose
Emulsion StabilisingHexylene Glycol
EmulsifyingCitric Acid
Buffering1,2-Hexanediol
Skin ConditioningPhenoxyethanol
PreservativeEthylhexylglycerin
Skin ConditioningSodium Benzoate
MaskingSorbic Acid
PreservativeParfum
MaskingTetramethyl Acetyloctahydronaphthalenes
MaskingLinalyl Acetate
MaskingDimethyl Phenylethyl Carbinyl Acetate
PerfumingPogostemon Cablin Leaf Oil
MaskingWater, Glycerin, Polyglyceryl-3 Methylglucose Distearate, Squalane, Prunus Amygdalus Dulcis Oil, Coco-Caprylate/Caprate, Pentaerythrityl Tetraethylhexanoate, Tripelargonin, Cetyl Alcohol, Dimethicone, Glyceryl Glucoside, Butylene Glycol, Hydrolyzed Soy Protein, Aminobutyric Acid, Caesalpinia Spinosa Fruit Extract, Hydrolyzed Glycosaminoglycans, Dipalmitoyl Hydroxyproline, Carnosine, Kappaphycus Alvarezii Extract, Lactobacillus Ferment, Hydroxypropyl Cyclodextrin, Methylsilanol Mannuronate, Polyglutamic Acid, Sodium Hyaluronate Crosspolymer, Caprylyl Glycol, Beta-Sitosterol, Acetyl Dipeptide-1 Cetyl Ester, Hyaluronic Acid, Sh-Polypeptide-69, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Sodium Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-38, Sodium DNA, Palmitoyl Tripeptide-5, Ethylhexyl Hydroxystearate, Ethylhexyl Palmitate, Ethylhexyl Stearate, Glycine Soja Oil, Palmitic Acid, Squalene, Polysorbate 60, Sorbitan Isostearate, Sorbitan Laurate, Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate, Sodium Isostearate, Acacia Senegal Gum, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Pullulan, Xanthan Gum, Polysilicone-11, Pentylene Glycol, Ascorbyl Palmitate, Tocopherol, Silica Dimethyl Silylate, Hydroxyethylcellulose, Hexylene Glycol, Citric Acid, 1,2-Hexanediol, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Sorbic Acid, Parfum, Tetramethyl Acetyloctahydronaphthalenes, Linalyl Acetate, Dimethyl Phenylethyl Carbinyl Acetate, Pogostemon Cablin Leaf Oil
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPolyglyceryl-3 Methylglucose Distearate is a plant-derived emulsifier whose only job is to keep the oily and watery parts of a formula blended so it doesn't separate into layers.
It's compatible with a wide-range of active ingredients and especially good at making emulsions survive heat/freeze cycles.
Typical use concentrations range from 2-3% and it works across a pH of 4.5-8.5.
This ingredient has been found safe to use in cosmetics and has a low irritation profile.
Because it's build on stearic acid, it may not be fungal acne safe. Stearic acid is a C18 fatty acid that falls within the range (C11-24) that Malassezia can feed on.
Learn more about Polyglyceryl-3 Methylglucose DistearateSqualane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Learn more about SqualaneThis ingredient is also known as sweet almond oil. It is a lightweight, cold-pressed oil from the ripe seeds of the sweet almond tree.
Sweet almond oil is rich in skin-nourishing fatty acids such as oleic acid (55-86%) and linolenic acid (7-35%).
As an emollient, it softens and hydrates skin by forming a thin barrier that locks in moisture.
Clinical studies have found it to be non-irritating and non-sensitizing. The CIR Expert Panel has evaluated the available safety data and concluded it is safe for topical use.
Because of the oleic acid content, this ingredient may not be fungal acne safe.
This ingredient does have a comedogenic rating of 3, but this doesn't mean a formula with this ingredient will clog pores.
Human testing has proved that any finished product with a comedogenic ingredient won't automatically make you break out; it really comes down to concentration, formula, and your skin.
Learn more about Prunus Amygdalus Dulcis OilCoco-Caprylate/Caprate is a lightweight ester created from coconut oil fatty acids, caprylic acid, and capric acid.
It is an emollient that helps soften skin and reduce transepidermal water loss (TEWL). What sets it apart from heavier emollients is its ultralight, non-greasy feel.
Once applied, this ingredient dries down quickly and leaves a dry, silky finish behind. This also helps improve spreadability and texture.
This ingredient has an excellent safety-record and is non-irritating.
Typical concentrations for cosmetics range from 0.5-62%.
Research on Malassezia growth found no growth on fatty acid esters with chain lengths shorter than 12 carbons (it prefers C11-24).
Since Coco-Caprylate/Caprate is built on C8 and C10 fatty acids, it is out of the range that Malassezia metabolizes, and therefore safe for fungal acne.
Learn more about Coco-Caprylate/CapratePentaerythrityl Tetraethylhexanoate is an emollient that helps make your skin smooth and hydrated. It specializes in creating a non-oily and "wet" feeling on skin.
This ingredient comes from isostearic acid, a saturated fatty acid. It is a synthetic ingredient.
We don't have a description for Tripelargonin yet.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Learn more about Cetyl AlcoholDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeGlyceryl Glucoside is made from glycerol and glucose.
It is a humectant. Humectants help hydrate your skin by drawing moisture to it from the air.
Some foods that contain glyceryl glucoside include sake, miso, and wines.
Learn more about Glyceryl GlucosideButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolHydrolyzed Soy Protein is a water-soluble blend of peptides and amino acids made by breaking down the protein from soybeans into smaller proteins.
It's the most widely used hydrolyzed vegetable protein in cosmetics and it acts mainly as a skin and hair conditioning agent.
The smaller fragments are water-loving so it forms a thin, moisture-retentive film on skin that helps reduce water loss and leaves things feeling softer and smoother.
You'll often see it credited with "firming" or "anti-aging" benefits as well; this claim traces back to lab research like Tokudome et al. (2012). This study added low-molecular-weight soybean peptides to cultured human skin fibroblasts and saw increased type I collagen gene expression + collagen content.
The caveat is that this is in-vitro and oral-peptide research so the only solid, well-established role for the topical ingredient is skin conditioning.
Typical use concentrations go up to 3.5% in mascara but this ingredient is typically used at low levels well under 1%.
It has a reassuring safety profile as well; it's not a skin irritant in testing up to 20% and has limited skin penetration due to its large size and water-loving nature.
Anyone with a known soy allergy should definitely patch test or skip this ingredient. There's also a single case of a soy-containing product aggravating rosacea via protein contact dermatitis, but this is very rare.
Learn more about Hydrolyzed Soy ProteinAminobutyric Acid is an antioxidant. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
Studies have shown Gamma-Aminobutyric Acid may reduce hyperpigmentation.
We don't have a description for Caesalpinia Spinosa Fruit Extract yet.
We don't have a description for Hydrolyzed Glycosaminoglycans yet.
Dipalmitoyl Hydroxyproline isn't fungal acne safe.
Carnosine is a dipeptide made from two amino acids.
This ingredient helps:
Glycation is the process of sugars binding to and damaging proteins. Too much sugar in our skin can lead to damaged collagen, contributing to factors of aging.
Carnosine is water-soluble and is not able to travel deeper layers of skin. This leads to some doubt about whether it can boost collagen in skin, since collagen is located in the deeper layers of skin.
Fun fact: Carnosine can be naturally found in our muscles and brain.
Learn more about CarnosineThis is an extract from a red seaweed and the world's main source of kappa-carrageenan (that's the gelling sugar you've probably eaten in ice cream).
In cosmetics, it's a skin conditioning agent that works like most seaweed sugars: it grabs onto water and forms a light, flexible film on the surface. This keeps the skin hydrated and helps it feel smoother right away.
A small 2026 trial (28 people) found a serum with 1.5% of the seaweed gel bumped up hand hydration for at least an hour compared to the hyaluronic acid control.
There's also some anti-aging research with an asterisk: scientists chopped the polysaccharide down to a tiny 4 kDa version and found it soaked into skin better than hyaluronic acid, calmed inflammation markers, reduced collagen-degrading MMPs, and improved wrinkles in UV-exposed mice.
While this is encouraging, it's way too big to go anywhere so it mostly stays on the surface of skin doing hydration duty.
It has a pretty solid safety profile: low cytotoxicity at its use level, negative genotoxicity data, human sensitization testing done at 0.8%, and no allergy case reports floating around.
You'll see algae listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to.
The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally.
And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter.
What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of studies that found algae compounds may actually help acne.
However, plenty of people do report breaking out from algae-containing products. Skin is individual and it's worth avoiding if yours has reacted to algae before.
Learn more about Kappaphycus Alvarezii ExtractThis ingredient is made when the Lactobacillus bacteria (the same kind that makes yogurt and kimchi) are allowed to ferment a nutrient medium.
As it ferments, it collects lactic acid, peptides, enzymes, and other bioactive metabolites to provide:
A 2023 review noted that probiotic fermentation ingredients like this one can enhance antioxidant capacity, reduce UV-induced oxidative damage, and support barrier function.
One clinical study from the same year showed a Lactobacillus ferment lysate significantly reduced transepidermal water loss and improved skin hydration.
Another review highlighted that topical Lactobacillus-based preparations can improve ceramide levels in the stratum corneum, support barrier integrity, and even help reduce S. aureus colonization in atopic dermatitis.
Why is this so cool?
Basically, your skin's outer layer works as a brick wall; skin cells are bricks and ceramides are the mortar holding it together. Moisture escapes, irritants get in, and your skin gets dry and reactive when ceramide levels drop. On top of that, "bad" skin bacteria S. aureus loves to move in when your barrier is weak to make inflammation and irritation worse.
So Lactobacillus ferment is basically patching the wall and evicting the troublemaker when it boosts ceramide production and help keep S. aureus in check.
On top of all this, it also acts as a mild antimicrobial preservative booster.
Just so you know, most studies focus on specific strains or the lysate form rather than this generic "Lactobacillus Ferment", so results can vary.
Though it's a promising ingredient, it doesn't have decades of robust clinical data behind it just yet.
Lactobacillus Ferment is generally considered safe for fungal-acne prone skin. The key thing to understand is that it comes from bacteria, not yeast or fungus.
Yeast-derived ferments (like galactomyces) have been shown to activate a protein that's linked to Malassezia-related skin issues whereas lactobacillus doesn't have that problem.
Its byproducts also don't contain the types of fatty acids (C11-24 chain lengths) that Malassezia feeds on.
Learn more about Lactobacillus FermentThis ingredient is used in skincare as a delivery system.
It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.
According to a manufacturer, it also offer some moisturizing effects.
Learn more about Hydroxypropyl CyclodextrinWe don't have a description for Methylsilanol Mannuronate yet.
Polyglutamic Acid is made up many glutamic acids chained together. It is created from bacterial fermentation.
This ingredient is an effective skin hydrator and may help speed up wound healing. As a humectant, it draws and holds water to the skin. This ingredient is often compared to hyaluronic acid or glycerin. Similarly to hyaluronic acid, it can vary in molecular weights. This means polyglutamic acid is capable of bringing hydration to lower levels of the skin.
Fun fact: Polyglutamic Acid is found in the Japanese food, natto. It is also being used in cancer treatment studies.
Learn more about Polyglutamic AcidSodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.
A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.
A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.
More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.
Learn more about Sodium Hyaluronate CrosspolymerCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolBeta-Sitosterol is a plant-derived fatty acid with a structure similar to cholesterol (which naturally occurs in skin). It helps hydrate the skin and stabilize formulations.
This ingredient can be naturally found in fruits, veggies, nuts, and seeds.
Acetyl Dipeptide-1 Cetyl Ester is a peptide composed of amino acids arginine and tyrosine.
This peptide is considered a neurotransmitter peptide, meaning it has pain-relieving and relaxing properties. It has the ability to calm skin irritation from external factors such as chemical stinging or heat.
Neurotransmitter peptides are also often called "botox in a bottle". This is because these peptides have the ability to relax the muscles.
Though relaxing the muscles can prevent expression lines (as we have seen in botox), the studies do not show these peptides to be a botox replacement. The effects of this muscle relaxation is also short-term, as opposed to longer-term results from botox.
Learn more about Acetyl Dipeptide-1 Cetyl EsterHyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Learn more about Hyaluronic AcidSh-Polypeptide-69 is a peptide.
N-Prolyl Palmitoyl Tripeptide-56 Acetate is a peptide.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateAcetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8This synthetic, signal peptide has unique skin conditioning properties in that is a matrikine-mimetic compound.
First of all, Palmitoyl Tripeptide-38 is a signal peptide; signal peptides tell the body to create more collagen.
What is a matrikine-mimetic compound?
This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.
Matrikines play a role in:
Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The results found improvement in skin roughness and skin tone.
This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.
Learn more about Palmitoyl Tripeptide-38Sodium DNA is an emerging anti-aging ingredient.
It is created by taking deoxyribonucleic acid (DNA) and purifying it with sodium hydroxide.
The DNA is extracted from several different animal sources, including: calf thymus, the gonadic tissue of a male sturgeon, or herring / salmon sperm.
You have probably seen this ingredient in anti-aging skincare. But what is it?
DNA is composed of nucleotides, or chemical building blocks. Nucleotides include adenine (A), thymine (T), guanine (G), and cytosine (C). Talk about a flashback to biology! Nucleosides are formed from these nucleotides.
The science behind Sodium DNA is based on an ingredient called Polydeoxyribonucleotide or PDRN.
PDRN are DNA fragments mainly extracted from the sperm cells of trout or salmon. Meaning, PDRN can be derived from Sodium DNA.
PDRN consists of chains of nucleotides and nucleosides mentioned above. They can range anywhere from 80 - 2000 pairs.
Studies show PDRN has the following properties:
Most of the research on PDRN has been done using injectable forms. That’s important, because PDRN is a large molecule and doesn’t absorb well through the skin. So if you’re applying it topically, the effects are likely to be much milder.
Still, topical Sodium DNA is emerging as a trendy anti-aging ingredient. It’s generally well-tolerated and offers good biocompatibility with human skin, making it a low-risk addition to most routines.
Further studies are needed to truly confirm this ingredients anti-aging ability (Remember, retinol has decades of research!).
Sodium DNA may be sourced from fish, animal tissue, or plants. Since this isn’t always disclosed, we recommend asking the brand directly if the ingredient’s origin is important to you.
Learn more about Sodium DNAPalmitoyl Tripeptide-5 is a synthetic signal lipopeptide. This just means it is a three amino acid chain bolted onto a palmitic acid tail so it can slip through the skin's lipid barrier.
This peptide has a "build more, lose less" approach.
It's designed to mimic the collagen-stimulating activity in your skin by copying a snippet of one of your skin's own matrix proteins. This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein.
The manufacturer's in vivo study of 45 volunteers found 1% and 2.5% reduced the appearance of wrinkles by 7% and 12% respectively, after using it twice daily for 84 days.
This is in the expected range for peptides; they're slow and cumulative actives and not overnight fixers.
Typical use levels range from 1-3% and this ingredient gets along with pretty much everything.
On the fungal acne front:
Although palmitic acid sits in the chain length that Malassezia can feed on, this ingredient has it locked in an amine bond. This makes it hard for Malassezia to access as a source of food, and therefore fungal acne safe.
Ethylhexyl Hydroxystearate isn't fungal acne safe.
Ethylhexyl Palmitate, also known as octyl palmitate, is created from 2-ethylhexyl alcohol and palmitic acid.
In cosmetics, it plays many roles:
One thing worth noting: a controlled study found this ingredient applied under occlusion to acne-prone subjects increased microcomedones. Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day.
For most people, this is a well-tolerated and lightweight ingredient.
This ingredient may not be fungal acne safe because it is an ester of palmitic acid, a C16 fatty acid that falls within the C11-24 range that Malassezia can metabolize.
You'll see this one rated 4 comedogenic all over the internet. That number isn't from a single study, and the actual research is more interesting.
The original rating comes from 1980s rabbit ear tests (which are a shaky basis for anything). But Ethylhexyl Palmitate is one of the few ingredients with real human data behind it. A 2021 controlled trial found this ingredient increased microcomedones by an average of 365% over four weeks.
Just know that test used the pure ingredient under an occlusive pad on back skin; most products use it at much lower levels alongside other ingredients and plenty of people use those with no issue.
Learn more about Ethylhexyl PalmitateEthylhexyl Stearate is a simplease ester made fby reacting stearic acid (a fatty acid from plant or animal fats) with 2-ethylhexanol (a branched alcohol).
The result is a clear, low-viscosity, almost odorless oily liquid. Think of it as a lightweight synthetic oil that sits on the skin's surface, softens it, and slows water loss. It also works as a solvent that helps dissolve pigments and UV filters so they spread evenly.
Older ingredient lists label it as "Octyl Stearate" and it turns up the most often in makeup products.
Industry data shows usage concentration goes up to ~40% in makeup and up to 10% in moisturizer or sunscreen.
Human repeat insult patch tests with a 25.9% lip gloss and 38.8% eyebrow pencil found no sensitization. A formula with 7.6% was also not an irritant, sensitizer, and was found to be non-phototoxic across 56, 19, and 27 subjects respectively.
True contact allergy to it is rare.
This ingredient shows up on a lot of "pore-clogging" lists but there's no real evidence behind that. It doesn't even have a comedogenic rating from an actual study; the numbers you'll find online come from blogs citing other blogs.
Ratings for other ingredients mostly come from a 1980s rabbit ear test. This test doesn't translate well to human skin or to real products because the ingredient sits at a much lower percentage.
Some people still find it breaks them out. So if that's you, definitely trust your skin.
The Malassezia yeast has been found to grow in the presence of fatty acids, fatty acid esters, and fatty alcohols with chains longer than 12 carbons. Ethylhexyl Stearate releases stearic acid, an 18-carbon chain, which is right inside that range; this ingredient may not be fungal acne safe.
Learn more about Ethylhexyl StearateGlycine Soja Oil is a plant-derived oil from soybean seeds. Like other oils, it is rich in essential fatty acids (mostly linoleic and oleic) that support skin hydration and barrier function.
The fatty acids are able to integrate into the lipid matrix of the stratum corneum to help soften skin and reduce water loss.
On top of that, soybean oil is rich in vitamins like vitamin E, a potent antioxidant.
Research on soybean's active components also point to anti-inflammatory, collagen-stimulating, antioxidant activity, and protection against UV-induced oxidative damage.
Most of this research applies to the broader soybean plant and not just the oil fraction alone.
This ingredient does carry a comedogenic rating of 3 from the old rabbit-ear assay. Just remember testing finished products in humans showed that formulas built with "comedogenic" ingredients are not necessarily comedogenic themselves. It's worth patch testing if you're breakout prone, and always listen to your skin.
Because this ingredient is a saturated triglyceride, it may not be fungal acne safe. This is because Malassezia breaks down sebum triglycerides into fatty acids it can consume, making this ingredient a possible source for the yeast.
Learn more about Glycine Soja OilPalmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.
In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.
Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.
The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.
The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.
In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.
It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.
This ingredient does have a comedogenic rating of 2, but this doesn't mean a formula with this ingredient will clog pores.
Human testing has proved that any finished product with a comedogenic ingredient won't automatically make you break out; it really comes down to concentration, formula, and your skin.
Learn more about Palmitic AcidSqualene is one of the main components of skin surface lipids. It is naturally found in our skin and makes up about 13% of sebum.
Topically, it is an emollient and skin conditioning agent.
Research highlights its role in antioxidant activity, anti-inflammatory effects, skin barrier protection, and wound healing support.
In vivo research has shown that transepidermal water loss (TEWL) caused by irritant exposure can be reverse with squalene supplementation (pointing to barrier recovery support).
Its antioxidant activity is backed by ex vivo and cell-based evidence showing it can scavenge free radicals but large-scale human clinical trials isolating this effect remain limited.
One study found squalene regulated proinflammatory behavior in ways relevant to wound healing, and in vitro fibroblast studies also shows it stimulates cell migration which is a key step in skin repair.
There's just one nuance to know about this ingredient:
Squalene is particularly vulnerable to oxidation; it breaks down from UV exposure 10x faster than the other lipids on your skin's surface. The byproducts of that breakdown can clog pores and trigger inflammation, potentially worsening acne.
This is why squalene is often hydrogenated into its stable counterpart: squalane (with an "a"). Most great formulations will have alreadu kept this in mind.
Squalene has shown no significant clinical evidence of sensitization and is a great hydrating ingredient.
Learn more about SqualenePolysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Learn more about Sorbitan IsostearateSorbitan Laurate is created from lauric acid and derivatives from sorbitol. It is an emulsifier.
This ingredient is a water-in-oil emulsifier and is sometimes known by its trade name, Isolan GPS. It helps create stable emulsions by bridging oil and water phases without adding a greasy feel.
Common usage levels sit between 2-5% for this ingredient.
We don't have a description for Sodium Isostearate yet.
Acacia Senegal Gum has skin soothing, thickening, and formulation stabilizing properties. It comes from the Acacia tree that is native to sub-Saharan Africa.
This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Pullulan is a low viscosity polysaccharide (a long chain carbohydrate) with binding and film forming properties when dissolved in water. It is used to create a "silicone-like" or silky feel in cosmetics without adding viscosity.
According to a manufacturer, this ingredient's ability to easily dissolves makes it a great carrier for active ingredients.
Due to it being edible and tasteless, you'll likely find this ingredient in breath freshener strips. This ingredient is produced from the starch of the fungus, Aureobasidium pullulans.
Pullulan is stable over a broad-range of pH.
Learn more about PullulanXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumPolysilicone-11 is a film-forming silicone that creates a non-tacky and matte finish on the skin. It's commonly used to improve texture, absorb excess oil, and help active ingredients spread evenly.
Due to its "rubber-like" structure, it stays on the skin's surface instead of being absorbed. On the skin, it creates a flexible layer that enhances wearability and stability.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolAscorbyl Palmitate is a fat-soluble form of vitamin C (Ascorbic Acid) made by combining it with palmitic acid.
It is able to blend easily into creams and oil-based formulas because it dissolves in oils rather than water.
As you may know, regular vitamin C is notorious for breaking down when exposed to sunlight and air. Ascorbyl Palmitate is more stable and degrades at a slower rate.
Research on whether it converts efficiently into active vitamin C once it's applied on your skin is still limited.
Some in-vitro studies suggest it may support collagen production, but it is not considered one of the stronger vitamin C derivatives, like:
Due to the palmitic acid base, this ingredient may not be fungal acne safe. Comedogenic studies have also shown this ingredient to have a rating of 2.
It's also worth keeping in mind that comedogenic and irritancy ratings are tested on individual ingredients, not finished formulas. The final product's formulation, concentration, and other ingredients all play a role in how something actually behaves on your skin.
Learn more about Ascorbyl PalmitateTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolThis silica is mainly used to thicken oils and suspend particles in oils. It is not water soluble.
According to the manufacturer, it:
The manufacturer also claims this ingredient to be useful in makeup.
In lipstick formulations, this ingredient improves color payoff, reduces pigment settling, and reduces oil bleeding. This ingredient also improves the grip of powder products such as dry shampoos.
Learn more about Silica Dimethyl SilylateHydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.
This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.
This ingredient can also be found in pill medicines to help our bodies digest other ingredients.
Learn more about HydroxyethylcelluloseHexylene Glycol is a multitasker ingredient that works as a solvent, humectant, emulsifier, viscosity reducer, and preservative booster.
It is able to dissolve both water and oil-soluble ingredients to stabilize tricky actives and make products spread more easily.
As a humectant, it pulls water into the skin. But it's a pretty minor moisturizing ingredient compared to other humectants, like glycerin.
Interestingly, it can act as a mild penetration enhancer. One in vitro study on human skin found a 12% concentration upped the absorption of mometasone furoate (a medicinal ingredient used to treat inflammatory skin conditions) up to 7%.
This ingredient is typically used at levels of 0.1-10% depending on the role it's playing.
A patch test study on eczema patients didn't find a significant increase in irritation versus the control group, but the potential for irritation rises at higher concentrations.
Learn more about Hexylene GlycolCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Learn more about Citric Acid1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateSorbic Acid is a preservative that stops your product from spoiling by stopping microbes from growing.
As a preservative, it's kind of a specialist: it has a broad spectrum of activity against yeast and molds but is weaker against bacteria. That's why it's often paired with another preservative to cover that gap.
This ingredient is also pretty picky about pH; it performs best at pH 6.5 or below.
At the right pH level, sorbic acid is "active" and can slip through the outer wall of a microbe. Once inside, it turns the cell's interior more acidic to shut down the microbe from the inside.
The EU caps this ingredient at 0.6% while the CIR has concluded it's safe at concentrations up to 1%. It's most often used around 0.05-0.2% in cosmetics.
Though this ingredient is considered low-sensitizing and well-tolerated, a very small number of people may have a contact allergy to it. Be sure to patch test if you have a history of allergies towards preservatives.
Learn more about Sorbic AcidParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumThis ingredient is also known as ISO E Super. It is a synthetic perfuming and masking ingredient.
The manufacturer describes this scnet as amber and woody.
According to the EU, this ingredient is a known allergen and some people may develop skin sensitivity from repeated exposure.
Learn more about Tetramethyl AcetyloctahydronaphthalenesLinalyl Acetate is the acetate ester of linalool and can be naturally found in many flowers and spice plants.
This ingredient is often used to add a scent or mask an unpleasant one in products.
Linalyl acetate is mildly toxic to humans and toxic to fish.
Learn more about Linalyl AcetateDimethyl Phenylethyl Carbinyl Acetate is a fragrance.
This ingredient is also known as Patchouli oil. Its main role is to add a warm, earthy, and musky scent to products.
Patchouli exhibits slight antioxidant, antibacterial and antifungal activity from its patchoulol, beta-caryophyllene, pogostone content.
Like all essential oils, this ingredient is a known sensitizer at higher concentrations. This is because this oil also contains known skin-irritating fragrances, limonene and camphor. Limonene and camphor are both known EU allergens.
While patchouli oil holds FDA GRAS ("generally recognized as safe") status, it is typically used at low levels and subject to usage guidelines.
Those with sensitive skin should patch test before using.
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Read more about us· Updated September 2, 2026 • Added by RosesSkincare