Peter Thomas Roth Peptide Skinjection Moisture Infusion Cream Versus Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
Updated on February 06, 2025
Overview
What they are
These products are both reef safe . They have a total of 47 ingredients in common
Cool Features
They both contain hyaluronic acid, peptides and Vitamin E
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin and scar healing
Free From
They both do not contain any harsh alcohols, common allergens, fragrances or parabens
What's Inside
They both contain silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Peter Thomas Roth Peptide Skinjection Moisture Infusion Cream 71 ingredients
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 56 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Peter Thomas Roth Peptide Skinjection Moisture Infusion Cream 71 ingredients
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 56 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinSqualane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.
Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.
Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.
Research shows that squalane is non-irritating (even at 100% concentration).
In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.
The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.
Is squalane vegan?
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Is squalane an oil?
Squalane is often called an oil, but it’s technically not; it’s a hydrocarbon, meaning it’s only made of carbon and hydrogen, unlike true oils which are triglycerides made of fatty acids and glycerol.
The term “oil-free” isn’t regulated, so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
While some people avoid oils thinking they cause breakouts, the right kind of oil (or oil-like ingredient like squalane) can actually help balance and hydrate your skin. It’s worth testing out simple oils or squalane to see what works best for your skin.
Learn more about SqualaneButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolThis synthetic peptide is known as a signal peptide. Signal peptides tell your skin to create more collagen, elastin and protein.
Hexapeptide-11 is composed of several amino acids, including alanine.
This small molecule peptide has similar benefits to Argireline, the "botox" peptide.
According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.
While this seems promising, research is lacking in proving this ingredient to be as effective as botox.
Learn more about Dipeptide Diaminobutyroyl Benzylamide DiacetateThis synthetic peptide is created from lysine, valine, and palmitic acid.
According to the manufacturer, in-vitro studies show tissue growth and collagen synthesis. Another in-vivo study found 60 volunteers saw a significant reduction in wrinkles after 84 days.
Due to its palmitic acid base, this peptide may not be fungal-acne safe.
Learn more about Palmitoyl Tripeptide-5Tripeptide-10 Citrulline is a peptide.
Acetyl Hexapeptide-1 is a peptide.
This synthetic peptide is a signal peptide, meaning it tells your skin to create more collagen and elastin.
According to a manufacturer, Acetyl Tetrapeptide-11 helps improve skin elasticity and firmness.
Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.
Argireline has a similar function to botox; it prevents muscle movement and contractions slightly. By preventing muscles from moving, argireline also prohibits the formation of fine lines and wrinkles. However, research is lacking in proving this ingredient to be as effective as botox.
On the other hand, argireline tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Acetyl Hexapeptide-8Palmitoyl Hexapeptide-12 is a synthetic peptide made with glycine, histidine, lysine, and palmitic acid.
The sequence of this peptide matches that of elastin, a key protein that plays a role in how firm our skin is.
Due to its palmitic acid base, this ingredient may not be fungal-acne safe.
Learn more about Palmitoyl Hexapeptide-12Acetyl Tetrapeptide-9 is a signal peptide. Signal peptides tell your skin to create collagen or start tissue repair.
This peptide plays a role in key skin components such as collagen, lumican, and glycosaminoglycans (GAGs). Lumican is used in collagen organization and regulation, while GAGs are a component that holds water in our skin.
The manufacturer claims this ingredient is effective at firming the skin and enhancing skin hydration.
Learn more about Acetyl Tetrapeptide-9Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.
This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.
This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.
By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.
Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7This peptide is more commonly known as Thymulen 4 BG.
It is derived from a youth hormone called thymopoietin. Thymopoietin helps regulate the immune system and decreases naturally with age.
According to the manufacturer, this peptide boosts the skin's immune defenses and regenerates the outer layers of skin.
Learn more about Acetyl Tetrapeptide-2Acetyl Octapeptide-3 is a synthetic peptide. It is often called a botox alternative due to its ability to restrict the movement of muscles, and thus reduce the appearance of fine-lines.
While this peptide can help reduce wrinkles and fine-lines, the research is lacking in it being as effective as botox.
All current studies for this ingredient are either from manufacturers or look at amounts far greater than in actual products.
Learn more about Acetyl Octapeptide-3Trifluoroacetyl Tripeptide-2 is a peptide.
Tripeptide-1 is a peptide. It can help to reduce the effects of aging.
Palmitoyl Oligopeptide is a form of peptide. It is created by blending peptides with palmitic acid. Peptides are building blocks for protein.
Due to the palmitic acid base, it may not be malassezia folliculitis safe.
This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Palmitoyl OligopeptidePalmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.
This ingredient is a signal peptide, meaning it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tripeptide-1Natto Gum is created by fermenting a soy protein using Bacillus natto (a bacteria). It is used as a texture enhancer.
Natto gum contains nattokinase, an enzyme. It is currently being studied for its ability to improve blood circulation.
Studies also show fermented soy-based ingredients help boost antioxidant activity.
Learn more about Natto GumWe don't have a description for Sodium Polyglutamate yet.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronatePseudoalteromonas Ferment Extract isn't fungal acne safe.
Leuconostoc/Radish Root Ferment Filtrate is a natural preservative. It comes from fermenting radish roots with a bacteria called leuconostoc.
Leuconostoc comes from lactic acid.
This ingredient has antimicrobial properties and helps prevent the growth of bacteria in a product.
Leuconostoc is used to make the traditional Korean side-dish, kimchi. It is also used to make sourdough bread (both incredibly yummy foods).
Learn more about Leuconostoc/Radish Root Ferment FiltrateWe don't have a description for Magnesium Chloride yet.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Mannitol is a sugar alcohol. It is a humectant and moisturizes the skin. In vitro (not tested on a living organism), mannitol displays antioxidant properties.
When found in aqueous solutions, mannitol tends to become acidic. This is because it loses a hydrogen ion. This is why mannitol can often be found with pH adjusting ingredients, such as sodium bicarbonate.
Fun fact: Mannitol can be found in foods as a sweetener. It can be naturally found in mushrooms, algae, fruits, and veggies.
Learn more about MannitolAcrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken and improve the texture of products. Due to its properties, it can prevent water and oil ingredients from separating.
Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Dimethyl Isosorbide is a solvent and helps deliver actives into your skin. It is created from sorbitol.
As a solvent, dimethyl isosorbide helps dissolve other ingredients. This helps ensure even distribution of an ingredient. It may also be used to decrease the thickness of a product.
Studies show dimethyl isosorbide is able to penetrate skin to deliver other ingredients into the skin, making them more effective.
Learn more about Dimethyl IsosorbideSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoatePotassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateCaprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideWe don't have a description for Hydrolyzed Wheat Protein yet.
Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of mixture of phospholipids.
This ingredient has emollient and emulsifying properties.
As an emollient, lecithen helps soften the skin and creates a barrier to keep moisture in.
As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can also help ingredients be better absorbed by the skin.
This is because the phospholipids in lecithin produce liposomes. Liposomes help other ingredients get through the skin barrier.
Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that feeds fungal acne.
We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.
Learn more about LecithinDisodium Phosphate is a water-soluble powder used as a pH adjuster.
Hydrolyzed Soy Protein is a vegan protein made to mimic hydrolyzed collagen. It is created from soy, or glycine soja.
This ingredient is a humectant, meaning it helps hydrate the skin by binding to water. According to a manufacturer, it is also a great hair conditioner.
Read more about hydrolyzed collagen here.
Learn more about Hydrolyzed Soy ProteinCarbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Dextran is a sugar (polysaccharide) with skin hydrating properties.
Fun fact: Louis Pasteur first discovered this ingredient as a microbial product in wine.
Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.
This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.
High percentages of Sodium Lactate can have an exfoliating effect.
Fun fact: Sodium Lactate is produced from fermented sugar.
Learn more about Sodium LactateWe don't have a description for Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate yet.
We don't have a description for Sodium Phosphate yet.
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumTriethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.
As an emulsifier, it prevents ingredients from separating and enhances texture by adding volume to a product.
PH adjusters are common in cosmetic products. The pH of a product can affect the effectiveness of other ingredients. A product with a high pH may also irritate the skin.
Learn more about TriethanolamineAcrylates Copolymer is used as a film-forming agent and texture enhancer.
After applied, Acrylates Copolymer forms a thin film cover that helps skin feel more soft. It can help sunscreens become more water-resistant.
It is also used to make a product more thick.
Learn more about Acrylates CopolymerIngredient Ratings
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