Versus

Medik8 Crystal Retinal - 3 Versus Dermalogica Smart Response Serum

Serum
Serum
British Brand
American Brand

Updated on June 18, 2025

Overview

What they are

These products are both vegan, cruelty-free, and reef safe serums. They have a total of 5 ingredients in common

Cool Features

They both contain exfoliants, hyaluronic acid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

They both do not contain any harsh alcohols, parabens, silicones or sulfates

What's Inside

They both contain common allergens, fragrances and oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

Medik8 Crystal Retinal 43 ingredients

Dermalogica Smart Response Serum 48 ingredients

What's inside (and what isn't)

What's inside (and what isn't)

At a glance

Click on any of the items below to learn more

Medik8 Crystal Retinal 43 ingredients

Dermalogica Smart Response Serum 48 ingredients

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Crystal Retinal
Smart Response Serum

Water

Skin Conditioning

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Coco-Caprylate/Caprate

Emollient
Not safe for Fungal Acne Icon

PPG-24-Glycereth-24

Emulsifying

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Masking, Buffering

Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).

As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.

If you spot Citric Acid near the end of an ingredient list, it's likely there as a pH adjuster rather than an active ingredient.

Read more about some other popular AHA's here:

Learn more about Citric Acid
Perfuming

Coumarins are a group of substances found naturally in plants. There are over 1300 types of coumarins identified. It has a natural vanilla scent.

Coumarin is an identified EU known allergy, meaning it may cause an allergic reaction when applied to the skin.

In many countries, coumarin is banned as a food additive. However, it can be found in soaps, tobacco products, and some alcohol drinks.

Plants use coumarins as a chemical defense. Some plants that have coumarins include lavender, tonka beans, and yellow clovers.

Learn more about Coumarin
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Antioxidant

Hydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.

This ingredient is not irritating or sensitizing.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

When to use

Medik8 Crystal Retinal 43 ingredients

Dermalogica Smart Response Serum 48 ingredients

224 Routines
2% use in am
98% use in pm
58% use every day
When to use See routines that use it ->
7 Routines
57% use in am
43% use in pm
86% use every day

Reviews

Here's what our community thinks

Medik8 Crystal Retinal 43 ingredients

4.60
Overall rating
5
4
3
2
1
What people say
Expensive 60% Absorbs Well 40% Broke Me Out 40%
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